Gene

KWMTBOMO15314  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005058

Annotation

Na?K-ATPase_alpha-subunit_[Bombyx_mori]

Location

Bomo_Chr25(+):8855697-8900742      View in EpiBrowser

Full name

Sodium/potassium-transporting ATPase subunit alpha      

Alternative Name

Sodium pump subunit alpha

Location in the cell

PlasmaMembrane   Reliability : 3.589

CDS

ATGGGCGAGACGCGCAGAAAACCTCCCGCGAAAAAACGGAAACCAGGAGATTTAGAAGATCTCAAACAGGAGCTGGATATTGATTACCATAAAGTCACTCCTGAGGAACTCTACCAAAGATTTCAAACGCACCCGGAAAATGGCCTTAGTCACGCAAAAGCGAAAGAGAACTTAGAAAGAGACGGCCCCAATGCTCTTACACCACCTAAACAAACACCCGAATGGGTGAAGTTTTGTAAAAATCTATTCGGCGGCTTTGCATTGTTACTCTGGATTGGTGCTATTCTATGCTTTATCGCCTACGGTATTCAGGCTAGTACCGTAGAGGAGCCCGCTGATGACAATCTGTACCTGGGCATCGTGCTCGCGGCCGTCGTGATCGTTACTGGTATCTTCTCGTACTACCAAGAGAGCAAGTCGTCTAAAATCATGGAATCTTTCAAGAACATGGTCCCCCAATTCGCCACCGTCATCCGTGAAGGAGAGAAACTTACGCTCCGAGCCGAGGACCTGGTGCTTGGTGATATTGTCGAGGTTAAATTCGGTGACCGGATTCCCGCCGACATCCGTATTATCGAAGCGCGAGGCTTTAAAGTCGACAACTCTAGCTTGACCGGCGAATCTGAACCCCAATCCCGAGGAGCCGAATTCACAAATGAGAACCCACTCGAGACCAAGAACTTGGCCTTCTTCTCGACCAACGCCGTTGAGGGTACCGCTAAAGGAATAGTCATCTGCTGTGGAGACAATACTGTGATGGGCCGCATTGCTGGTCTCGCTTCCGGTCTGGACACTGGTGAAACTCCGATCGCTAAGGAGATCCATCACTTTATTCATCTTATCACCGGCGTGGCTGTCTTCCTCGGAGTGACTTTCTTCGTTATTGCTTTCATTCTCGGATACCACTGGCTCGACGCTGTCATCTTCCTCATCGGTATCATCGTAGCTAACGTGCCTGAAGGGCTCTTGGCCACCGTGACTGTGTGCTTGACTCTCACTGCCAAACGAATGGCTTCCAAGAACTGCCTGGTCAAGAATCTCGAAGCCGTCGAAACTCTGGGTTCCACTTCCACGATTTGCTCCGACAAAACCGGAACCCTCACTCAGAACAGAATGACTGTTGCTCACATGTGGTTCGACAACCAGATCATTGAAGCTGATACAACTGAAGATCAATCCGGCGTACAGTACGACCGCACTAGCCCTGGCTTCAAGGCTCTTGCCAAAATTGCTTCGCTCTGCAACCGAGCTGAGTTCAAGGGTGGTCAGGATGGTGTTCCGATTCTGAAGAAGGAAGTCGCCGGTGACGCCTCTGAAGCCGCTTTACTGAAATGCATGGAGCTGGCTCTCGGTGATGTCTTGTCGATCAGGAAGCGCAACAAGAAAGTCTGCGAAATTCCCTTCAACTCTACTAACAAGTACCAGGTATCGATCCACGAGAGCGACGACCCCAGCGACCCCCGCCACCTGCTGGTGATGAAGGGAGCACCCGAAAGAATCCTGGAACGTTGTAGCACTATCTTCATTGGCGGAAAGGAAAAGGTATTAGACGAGGAAATGAAGGAGGCGTTCAACAACGCTTACCTTGAACTCGGTGGTCTTGGCGAGCGTGTGCTCGGCTTCTGCGACCTTCAGCTGCCCTCCGACAAGTACCCCATCGGCTACAAGTTCAACACTGACGACCCTAACTTCCCCTTGGACAACTTGCGCTTTGTTGGTCTGATGAGCATGATTGATCCTCCCCGCGCTGCTGTACCAGATGCCGTGGCCAAGTGCCGCTCCGCCGGTATCAAGGTTATCATGGTAACCGGAGACCACCCCATCACTGCCAAGGCTATTGCCAAATCTGTAGGTATAATTTCTGAAGGTAACGAGACCGTAGAGGACATTGCTGCGCGCTTGAATATCCCCGTTTCCGAGGTGAATCCCCGCGAAGCCAAAGCCGCTGTCGTCCACGGAACCGAGCTCCGCGAACTGAACTCCGACCAGCTCGATGAGATCCTCAAGTTCCACACCGAAATCGTGTTCGCCCGCACCTCCCCGCAACAGAAGTTGATCATCGTTGAGGGTTGCCAGCGTCTCGGCGCCATCGTGGCTGTGACCGGCGACGGTGTCAACGACTCGCCCGCCCTCAAGAAGGCCGACATCGGTGTCGCTATGGGTATCGCCGGCTCCGACGTTTCCAAGCAGGCCGCTGACATGATTCTACTCGACGACAACTTCGCGTCCATCGTGACCGGTGTCGAAGAAGGCCGACTGATCTTTGACAACTTGAAGAAGTCAATCGCCTACACCCTAACCTCGAACATTCCAGAAATCTCCCCCTTCCTTGCCTTCATCCTTTGCGACATTCCTCTGCCCCTGGGTACAGTAACCATCCTCTGCATCGATCTGGGAACGGACATGGTGCCTGCTATATCATTGGCGTACGAGGCGCCCGAGTCTGATATCATGAAGCGGCAGCCGCGGGACCCTTACCGCGACAACCTCGTCAACAGAAGGTTGATCTCTATGGCTTACGGACAAATCGGAATGATCCAAGCCGCGGCTGGCTTCTTCGTCTACTTCGTGATCATGGCTGAAAACGGATTCCTCCCGATGAAGCTTTTCGGTATCAGGAAGCAGTGGGACTCGAAGGCCATCAACGATTTGACTGACTCCTATGGACAGGAATGGACCTACCGTGACCGCAAGGCGCTCGAGTTTACTTGCCACACCGCATTCTTCGTATCTATTGTCGTTGTGCAATGGGCCGACTTGATTATCTGCAAGACCCGCCGTAACTCGATCATTCACCAGGGCATGCGCAACTGGGCCCTCAACTTTGGTCTCATATTTGAAACCGCGCTGGCGGCGTTCCTCTCGTACACTCCCGGTATGGACAAGGGCTTGAGGATGTACCCACTCAAGTTCGTGTGGTGGCTGCCCGCCATTCCGTTCATGCTGTCCATCTTCATCTACGACGAGATCAGGCGCTTCTACCTGCGCCGCAACCCCGGCGGCTGGCTCGAACAAGAGACTTATTATTAA

Protein

MGETRRKPPAKKRKPGDLEDLKQELDIDYHKVTPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFALLLWIGAILCFIAYGIQASTVEEPADDNLYLGIVLAAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGDIVEVKFGDRIPADIRIIEARGFKVDNSSLTGESEPQSRGAEFTNENPLETKNLAFFSTNAVEGTAKGIVICCGDNTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALAKIASLCNRAEFKGGQDGVPILKKEVAGDASEAALLKCMELALGDVLSIRKRNKKVCEIPFNSTNKYQVSIHESDDPSDPRHLLVMKGAPERILERCSTIFIGGKEKVLDEEMKEAFNNAYLELGGLGERVLGFCDLQLPSDKYPIGYKFNTDDPNFPLDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAARLNIPVSEVNPREAKAAVVHGTELRELNSDQLDEILKFHTEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEAPESDIMKRQPRDPYRDNLVNRRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPMKLFGIRKQWDSKAINDLTDSYGQEWTYRDRKALEFTCHTAFFVSIVVVQWADLIICKTRRNSIIHQGMRNWALNFGLIFETALAAFLSYTPGMDKGLRMYPLKFVWWLPAIPFMLSIFIYDEIRRFYLRRNPGGWLEQETYY

Description

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic Activity

ATP + H2O + K(+)(out) + Na(+)(in) = ADP + H(+) + K(+)(in) + Na(+)(out) + phosphate

Subunit

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Miscellaneous

Ouabain-sensitive electrogenic ion pump.

Similarity

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

Keywords

Alternative splicing   ATP-binding   Cell membrane   Complete proteome   Ion transport   Membrane   Nucleotide-binding   Phosphoprotein   Potassium   Potassium transport   Reference proteome   RNA editing   Sodium   Sodium transport   Translocase   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Sodium/potassium-transporting ATPase subunit alpha
splice variant  In isoform 2, isoform 3, isoform 6 and isoform 7.

Uniprot

A0A0K2S4Y7   K0G7C8   K0GEX0   K0GM01   A0A2A4JVC3   K0GEX4   + More
K0GG88   A0A2W1BK20   A0A2A4JV07   A0A2A4JUC5   A0A2H1VI27   K0GLY7   K0GG86   K0GEX7   K0G7C4   K0G7B9   A0A158NIT2   Q7PGN1   A0A1W4X4P7   K0GLY2   A0A182QT13   A0A182XW64   A0A1L8DEW0   A0A182PSN6   A0A3L8D359   V9I6B8   N6T2P0   A0A2A3E444   U4UIT1   E9IZS4   A0A158NIT1   E2AIZ4   F5HKJ1   F5HKJ2   A0A1Q3G4G9   A0A1Q3FUU5   A0A182LGE6   A0A0K8TRD8   A0A182IU13   F5HKJ4   A0A151IUE3   A0A1W4WV71   A0A0Q9X358   A0A0C9R0I4   A0A1L8DF50   A0A0Q9WBH9   Q27766   A0A1W4X5W5   A0A2M3ZZE0   A0A1W4WUY0   A0A1W4WV42   I5ANS6   A0A1Y0AWP8   A0A1W4X5V6   A0A2M4CSX9   A0A2M4CUW4   A0A182RQ21   A0A1W4X5S4   A0A2M4A020   A0A2M4A3F2   A0A1L8DEU4   A0A2M4CUE1   A0A1W4X5Q8   A0A1W4WV39   K0GG97   A0A2M4CIP8   A0A182N737   A0A0M4F6Q7   A0A0Q9X2S3   A0A026W561   A0A1I8MBT4   A0A0R1E150   A0A087ZTA6   A0A1I8PAR6   A0A0A1X4H1   A0A182VYR9   A0A1J1J616   A0A0N8P1E9   A0A2M3ZZK0   Q16N74   P13607-7   T1E1Y4   A0A0R1E1E2   A0A1J1J6V9   A0A0A1WY87   K0GLX7   A0A1Q3FV87   V9I6A9   K0GEZ1   A0A0Q9XCU5   A0A0Q9WBZ0   A0A1Q3FV30   A0A1Q3G4J5   K0GEX8   K0GEY8   A0A0K8UY58   A0A034W1V5   A0A1Q3FV07   A0A1B6MM45   A0A0Q9W0Q7  

EC Number

7.2.2.13

Pubmed

23019645    28756777    21347285    12364791    14747013    17210077    + More
25244985    30249741    23537049    21282665    20798317    20966253    26369729    17994087    8397036    15632085    28341416    24508170    25315136    17550304    25830018    17510324    2540956    9648860    10731132    12537572    12537569    12598616    9680312    2557235    17018572    24330624    25348373   

EMBL

LC029030    BAS22117.1    JQ771512    AFU25681.1    JQ771498    AFU25667.1    + More
JQ771525    AFU25694.1    NWSH01000562    PCG75638.1    JQ771506    AFU25675.1    JQ771509    AFU25678.1    KZ150095    PZC73617.1    PCG75639.1    PCG75637.1    ODYU01002679    SOQ40480.1    JQ771510    AFU25679.1    JQ771504    AFU25673.1    JQ771508    AFU25677.1    JQ771507    AFU25676.1    JQ771502    AFU25671.1    ADTU01017127    ADTU01017128    AAAB01008859    EAA44868.4    JQ771505    AFU25674.1    AXCN02000326    GFDF01009103    JAV04981.1    QOIP01000014    RLU14937.1    JR035472    JR035478    AEY56435.1    AEY56441.1    APGK01054932    APGK01054933    KB741253    ENN71823.1    KZ288428    PBC25851.1    KB632340    ERL92967.1    GL767232    EFZ13954.1    GL439921    EFN66583.1    EGK96744.1    EGK96743.1    GFDL01000352    JAV34693.1    GFDL01003664    JAV31381.1    GDAI01000902    JAI16701.1    EGK96746.1    KQ980960    KYN11056.1    CH933806    KRG02333.1    GBYB01000331    JAG70098.1    GFDF01009104    JAV04980.1    CH940652    KRF78692.1    S66043    AAB28239.1    GGFK01000592    MBW33913.1    CM000070    EIM52611.1    KY921817    ART29406.1    GGFL01004278    MBW68456.1    GGFL01004964    MBW69142.1    GGFK01000778    MBW34099.1    GGFK01001996    MBW35317.1    GFDF01009105    JAV04979.1    GGFL01004280    MBW68458.1    JQ771524    AFU25693.1    GGFL01001054    MBW65232.1    CP012526    ALC47775.1    CH964232    KRF99409.1    KK107405    EZA51212.1    CM000160    KRK02982.1    GBXI01008719    JAD05573.1    CVRI01000070    CRL07212.1    CH902617    KPU79732.1    GGFK01000581    MBW33902.1    CH477835    EAT35802.1    X14476    AF044974    AE014297    AY069184    AY174097    AY174098    U55767    X17471    GALA01001249    JAA93603.1    KRK02985.1    CRL07214.1    GBXI01010944    JAD03348.1    JQ771500    AFU25669.1    GFDL01003659    JAV31386.1    JR035470    JR035477    AEY56433.1    AEY56440.1    JQ771526    AFU25695.1    KRG02334.1    KRF78687.1    GFDL01003657    JAV31388.1    GFDL01000313    JAV34732.1    JQ771511    AFU25680.1    JQ771523    AFU25692.1    GDHF01020773    JAI31541.1    GAKP01010640    GAKP01010638    JAC48312.1    GFDL01003660    JAV31385.1    GEBQ01003038    JAT36939.1    KRF78691.1   

Proteomes

UP000218220    UP000005205    UP000007062    UP000192223    UP000075886    UP000076408    + More
UP000075885    UP000279307    UP000019118    UP000242457    UP000030742    UP000000311    UP000075882    UP000075880    UP000078492    UP000009192    UP000008792    UP000001819    UP000075900    UP000075884    UP000092553    UP000007798    UP000053097    UP000095301    UP000002282    UP000005203    UP000095300    UP000075920    UP000183832    UP000007801    UP000008820    UP000000803   

PRIDE

P13607   

Pfam

PF00690   Cation_ATPase_N        + More
PF00689   Cation_ATPase_C

Interpro

IPR018303   ATPase_P-typ_P_site        + More
IPR004014   ATPase_P-typ_cation-transptr_N       
IPR023299   ATPase_P-typ_cyto_dom_N       
IPR006068   ATPase_P-typ_cation-transptr_C       
IPR008250   ATPase_P-typ_transduc_dom_A_sf       
IPR023298   ATPase_P-typ_TM_dom_sf       
IPR005775   P-type_ATPase_IIC       
IPR001757   P_typ_ATPase       
IPR023214   HAD_sf       
IPR036412   HAD-like_sf       

SUPFAM

SSF81665   SSF81665        + More
SSF81660   SSF81660       
SSF81653   SSF81653       
SSF56784   SSF56784       

Gene 3D

3.40.1110.10     3.40.50.1000    

CDD

cd02608  P-type_ATPase_Na-K_like

ProteinModelPortal

A0A0K2S4Y7   K0G7C8   K0GEX0   K0GM01   A0A2A4JVC3   K0GEX4   + More
K0GG88   A0A2W1BK20   A0A2A4JV07   A0A2A4JUC5   A0A2H1VI27   K0GLY7   K0GG86   K0GEX7   K0G7C4   K0G7B9   A0A158NIT2   Q7PGN1   A0A1W4X4P7   K0GLY2   A0A182QT13   A0A182XW64   A0A1L8DEW0   A0A182PSN6   A0A3L8D359   V9I6B8   N6T2P0   A0A2A3E444   U4UIT1   E9IZS4   A0A158NIT1   E2AIZ4   F5HKJ1   F5HKJ2   A0A1Q3G4G9   A0A1Q3FUU5   A0A182LGE6   A0A0K8TRD8   A0A182IU13   F5HKJ4   A0A151IUE3   A0A1W4WV71   A0A0Q9X358   A0A0C9R0I4   A0A1L8DF50   A0A0Q9WBH9   Q27766   A0A1W4X5W5   A0A2M3ZZE0   A0A1W4WUY0   A0A1W4WV42   I5ANS6   A0A1Y0AWP8   A0A1W4X5V6   A0A2M4CSX9   A0A2M4CUW4   A0A182RQ21   A0A1W4X5S4   A0A2M4A020   A0A2M4A3F2   A0A1L8DEU4   A0A2M4CUE1   A0A1W4X5Q8   A0A1W4WV39   K0GG97   A0A2M4CIP8   A0A182N737   A0A0M4F6Q7   A0A0Q9X2S3   A0A026W561   A0A1I8MBT4   A0A0R1E150   A0A087ZTA6   A0A1I8PAR6   A0A0A1X4H1   A0A182VYR9   A0A1J1J616   A0A0N8P1E9   A0A2M3ZZK0   Q16N74   P13607-7   T1E1Y4   A0A0R1E1E2   A0A1J1J6V9   A0A0A1WY87   K0GLX7   A0A1Q3FV87   V9I6A9   K0GEZ1   A0A0Q9XCU5   A0A0Q9WBZ0   A0A1Q3FV30   A0A1Q3G4J5   K0GEX8   K0GEY8   A0A0K8UY58   A0A034W1V5   A0A1Q3FV07   A0A1B6MM45   A0A0Q9W0Q7  

PDB

3WGV     E-value=0,     Score=3968

KEGG

101743662    K01539 sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13] | (RefSeq) sodium/potassium-

GO

GO:0046872   GO:0008556   GO:0016021   GO:0005524   GO:0006813   GO:0036376   GO:1990573   GO:0005391   GO:0030007   GO:0006883   GO:0005623   GO:0015991   GO:0005918   GO:0007630   GO:0005634   GO:0051124   GO:0001894   GO:0007268   GO:0016323   GO:0060439   GO:0008340   GO:0035158   GO:0009266   GO:0007605   GO:0009612   GO:0050905   GO:0019991   GO:0005886   GO:0008344   GO:0005890   GO:0006812   GO:0035159   GO:0005737   GO:0007626   GO:0000166   GO:0006814   GO:0006270   GO:0042555   GO:0015930  

Subcellular location

Membrane  
Cell membrane  

Length:

1009

Number of predicted TMHs:

8

Exp number of AAs in TMHs:

172.12338

Exp number, first 60 AAs:

0

Total prob of N-in:

0.99690

inside

1  -  80

TMhelix

81  -  103

outside

104  -  115

TMhelix

116  -  135

inside

136  -  275

TMhelix

276  -  298

outside

299  -  307

TMhelix

308  -  330

inside

331  -  835

TMhelix

836  -  858

outside

859  -  898

TMhelix

899  -  918

inside

919  -  937

TMhelix

938  -  960

outside

961  -  969

TMhelix

970  -  987

inside

988  -  1009

 

 

Pi

241.608966

Theta

198.924669

Tajima's D

0.794025

CLR

0.392542

CSRT

0.604669766511674

Interpretation

Uncertain