Gene

KWMTBOMO15313  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005142

Annotation

PREDICTED:_alpha-mannosidase_2_[Papilio_machaon]

Location

Bomo_Chr25(-):8843838-8853916      View in EpiBrowser

Full name

Alpha-mannosidase      

Location in the cell

Cytoplasmic   Reliability : 1.352 Nuclear   Reliability : 1.204

CDS

ATGAGGATCAGACGTTTATCGGCGTTTTTTTGGATGACGTGTATTATAGCTTTTATTTTTATTTTATACGTGATGACAGACTTAAGTTTTAATTTACCTAGTGTTAAACCAGCGATAAACATAGATGAGAACAAGTGGTCTGCCTTTGAATCAAAATTACGTCATATTGAAAATGAACTTGATCAACATCATGCTGTTGTTGGTGAAATAAAATCAGCCATGAGCCAAATTATAGAACAGTCAAATGAATATCACCCGCCACAGAAAAGACCAAGGCAAATGGAGAAAAACAAAAAAATAAGAGAGTTCAAAGTAGTAGGAGATGAGCCACCAAGGATGCACATAAAATTGAATGAATCAACTTGTCCCATTCAGAAATACTCAGTTCCAAAAACTGATGTGCAGATGTTATCCTTGTATGAAAGGATTATGTTTGATGACAAAGATGGAGGTGTTTGGAAACAAGGATGGAATATAGAATACAATGAAAACCAATGGAGTCAGAAAAACAAATTGAAAGTTTTTATTGTACCACATTCACACAATGACCCAGGTTGGTTAAAAACCTTCGAAAATTATTACAAGTCACAAACAAGAGCAATATTCAATAATATGATAGAGAAATTGAACGAGGGTGTAGGGCGTAAGTTTATATGGGCCGAAATAAGTTTTCTATCGCTGTGGTGGAATAACGATGCTACTGAGAAAGACAAGACTGCTTTCCTGAATTTATTGAAATCAAAGAAACTTGAAATCGTGACAGGCGGATGGGTTATGAACGACGAGGCAAATTCACATTGGCTGTCTGTAGTGCAACAATTGACCACCGGACATCAGTGGCTACTCGACAATTTGGGATATGTACCCAAAAACGCATGGTCCATTGATCCGTTCGGTTATTCCAGCGCGCAACCCTACCTCCTCAAGATAGCCGGTTTCGATAATTCCATGATACAGAGGGTACACTATAGAATTAAGAAAGAATTGGCTTCGAATAGACAGTTGGAATTTAGATGGAGACAGTTATGGGATGGTGTTGGGAAAACTGATATGTTCACACATTTGTTCCCGTTTTATTCGTACGATGTTCCTCACTCGTGCGGTCCGGATCCTAAGATATGTTGTCAATTTGATTTCAAACGTCTACCCGGTAACGGGGTTACTTGTCCGTGGGGCGTTGCACCTCAGAGGATAACCCAGAAGAATGTGGATGAAAGAGCGTTCAAGATATTAGATCAGTGGAGGAAGAAGGCTCAACTCTACAGAAGTAACGTGTTGTTCTTCCCTCTCGGTGACGACTTCCGGTACGACCACGCCAACGAGTGGGACAATCAGTACCAGAACTACGACATGCTGATAGAGTACATCAACAGTAACGATGCTTGGAACACTGAGGTACAATACGGTACACTCGAAGATTACTTCAAAGCATTACACGATGAAGTGAAATTATCAAACTTTCCGGTTCTGTCCGGGGACTTTTTCACGTACGCCGATCGGAACCAGCACTACTGGAGCGGGTACTACACCTCCAGACCGTTTTATAAGAACATGGATAGAGTTTTACTGGCCTATGTCAGGGCAGCCGAAATAATAACAGCTCAAGCGACGGACACGCATGCTGTGTCGTACATAATGTCGCTTCAGCTGAGGGACCGGGTCGAGCAGGCCCGCAGGTCGCTCTCCCTGTTCCAGCATCACGACGGCATCACCGGCACCTCCAGGGACGAGGTCAGGGAGGACTACGCCAAGAAGATGCTAACAGCAATAAAATACAGTCAATCCGCCATCCAACAAGCTGCCTACTACTTGCTGAAGCAGCCGCATATACAGGATCAAACGCAAGAGGACATATTCCTCGATGTGGACGACATCTGGCGGCGGCACGACGAAATACCCTCCAGGATCACGATTGCCTTGGACGTGGTGTCTCCTTCCAGGCGCCTCGTGCTTTACAACGCGCTGGCGTTCAGAAGACAAGAAATATTAACAGTGCTAGTGTCAACCCCGCACGTTGAAGTTAGTAAGAAACCAATATCGGGGTATTAA

Protein

MRIRRLSAFFWMTCIIAFIFILYVMTDLSFNLPSVKPAINIDENKWSAFESKLRHIENELDQHHAVVGEIKSAMSQIIEQSNEYHPPQKRPRQMEKNKKIREFKVVGDEPPRMHIKLNESTCPIQKYSVPKTDVQMLSLYERIMFDDKDGGVWKQGWNIEYNENQWSQKNKLKVFIVPHSHNDPGWLKTFENYYKSQTRAIFNNMIEKLNEGVGRKFIWAEISFLSLWWNNDATEKDKTAFLNLLKSKKLEIVTGGWVMNDEANSHWLSVVQQLTTGHQWLLDNLGYVPKNAWSIDPFGYSSAQPYLLKIAGFDNSMIQRVHYRIKKELASNRQLEFRWRQLWDGVGKTDMFTHLFPFYSYDVPHSCGPDPKICCQFDFKRLPGNGVTCPWGVAPQRITQKNVDERAFKILDQWRKKAQLYRSNVLFFPLGDDFRYDHANEWDNQYQNYDMLIEYINSNDAWNTEVQYGTLEDYFKALHDEVKLSNFPVLSGDFFTYADRNQHYWSGYYTSRPFYKNMDRVLLAYVRAAEIITAQATDTHAVSYIMSLQLRDRVEQARRSLSLFQHHDGITGTSRDEVREDYAKKMLTAIKYSQSAIQQAAYYLLKQPHIQDQTQEDIFLDVDDIWRRHDEIPSRITIALDVVSPSRRLVLYNALAFRRQEILTVLVSTPHVEVSKKPISGY

Cofactor

Zn(2+)

Similarity

Belongs to the glycosyl hydrolase 38 family.

Uniprot

A0A2A4JW66   A0A2W1BFQ4   A0A194RKL8   A0A194PGJ2   A0A212F8Y0   H9J6K0   + More
A0A067R639   D6WTA9   A0A1Y1L0D7   V5GX04   N6TR79   A0A2P8Z8I7   A0A026WXN3   A0A195DUT2   A0A151I6B5   A0A158NSN6   A0A0N0BDG4   A0A195CCN0   A0A0L7R1D6   A0A195EXK8   A0A151WJA6   A0A1B6LSU4   E2C820   E2AKY7   A0A0C9R4X5   A0A087ZZQ3   A0A2A3EQ80   A0A232FIH3   A0A1B6CBG0   K7J1I1   A0A0C9RFU8   E9IUM4   A0A023F1Z6   A0A0P4VK91   A0A224X5V1   A0A2M3ZE22   A0A182IRW0   A0A0V0G6A5   A0A0P4ZKB6   A0A0P5LI91   A0A0P6BXP3   A0A0P4ZQ30   A0A0P5CYJ7   A0A0P6IIZ0   A0A0P5DBH3   A0A0P4ZIN8   A0A0P5J864   A0A2M4BAW1   A0A0P6EAM1   A0A0P5EAM2   A0A0P5DAP0   A0A0P5DW21   A0A0P4ZSN2   A0A0P5HTF8   A0A0P5D5J5   A0A2M4BBI3   A0A0P5JH22   A0A0P5D6W5   A0A0P5S8D1   A0A0P5CLK9   A0A0N8AE08   A0A0P5AKD0   A0A0P5AKF7   A0A0P5CQT8   A0A0P5UDR8   A0A0P5J1W0   A0A0P5IWE5   E0VV82   T1HHY4   A0A2M4AC47   A0A2M4ACL9   A0A084VTM1   A0A0J7KHF7   W5JK63   A0A182P424   U5EZM2   A0A182JSW1   A0A182GXK5   A0A182FPQ5   A0A182YG16   A0A182I875   A0A182KML8   Q7PMM6   A0A1Z5LHE7   A0A2R5LA05   Q16NG2   A0A1Q3FDG5   F4W8A6   A0A182UAA6   A0A182V343   B0WS34   A0A1Y9J179   A0A1W4XMZ0   A0A1W4XNT9   A0A0P5A1B3   A0A1Y9HF01   A0A182VWZ0   A0A1B0CQQ4   A0A182NDY6  

EC Number

3.2.1.-

Pubmed

28756777    26354079    22118469    19121390    24845553    18362917    + More
19820115    28004739    23537049    29403074    24508170    30249741    21347285    20798317    28648823    20075255    21282665    25474469    27129103    20566863    24438588    20920257    23761445    26483478    25244985    20966253    12364791    14747013    17210077    28528879    17510324    21719571   

EMBL

NWSH01000562    PCG75640.1    KZ150095    PZC73618.1    KQ460045    KPJ18082.1    + More
KQ459604    KPI92422.1    AGBW02009658    OWR50206.1    BABH01019831    KK852934    KDR13614.1    KQ971352    EFA06316.1    GEZM01071358    JAV65870.1    GALX01002174    JAB66292.1    APGK01057855    APGK01057856    APGK01057857    KB741282    ENN70826.1    PYGN01000147    PSN52814.1    KK107078    QOIP01000011    EZA60501.1    RLU16846.1    KQ980322    KYN16606.1    KQ976400    KYM92668.1    ADTU01025073    ADTU01025074    ADTU01025075    KQ435863    KOX70418.1    KQ978023    KYM97981.1    KQ414667    KOC64685.1    KQ981948    KYN32614.1    KQ983043    KYQ47914.1    GEBQ01013209    JAT26768.1    GL453506    EFN75938.1    GL440425    EFN65904.1    GBYB01005913    GBYB01011354    GBYB01013488    GBYB01013723    JAG75680.1    JAG81121.1    JAG83255.1    JAG83490.1    KZ288194    PBC33888.1    NNAY01000155    OXU30485.1    GEDC01026500    JAS10798.1    GBYB01005906    JAG75673.1    GL765999    EFZ15726.1    GBBI01003636    JAC15076.1    GDKW01003685    JAI52910.1    GFTR01008561    JAW07865.1    GGFM01006002    MBW26753.1    GECL01002524    JAP03600.1    GDIP01211271    JAJ12131.1    GDIQ01169247    JAK82478.1    GDIP01008771    JAM94944.1    GDIP01211270    JAJ12132.1    GDIP01163766    JAJ59636.1    GDIQ01005472    JAN89265.1    GDIP01163767    JAJ59635.1    GDIP01212278    JAJ11124.1    GDIQ01203735    JAK47990.1    GGFJ01001026    MBW50167.1    GDIQ01145858    GDIQ01065542    JAN29195.1    GDIP01162821    JAJ60581.1    GDIP01162820    JAJ60582.1    GDIP01156672    JAJ66730.1    GDIP01212279    JAJ11123.1    GDIQ01246032    JAK05693.1    GDIP01160925    JAJ62477.1    GGFJ01001027    MBW50168.1    GDIQ01252080    GDIQ01250680    GDIQ01247419    GDIQ01205391    GDIQ01202240    GDIQ01099829    GDIQ01098480    GDIQ01086140    JAK46334.1    GDIP01176215    GDIP01141337    JAJ47187.1    GDIQ01252081    GDIQ01250679    GDIQ01247420    GDIQ01205390    GDIQ01203734    GDIQ01202241    GDIQ01187751    GDIQ01099830    GDIQ01098479    GDIQ01096821    JAL51896.1    GDIP01168720    JAJ54682.1    GDIP01156673    JAJ66729.1    GDIP01198078    JAJ25324.1    GDIP01198077    JAJ25325.1    GDIP01168070    JAJ55332.1    GDIP01131684    LRGB01000031    JAL72030.1    KZS21240.1    GDIQ01208140    JAK43585.1    GDIQ01208141    JAK43584.1    DS235804    EEB17288.1    ACPB03005842    GGFK01005036    MBW38357.1    GGFK01005027    MBW38348.1    ATLV01016361    KE525079    KFB41315.1    LBMM01007530    KMQ89646.1    ADMH02001205    ETN63703.1    GANO01000532    JAB59339.1    JXUM01095509    JXUM01095510    KQ564200    KXJ72595.1    APCN01002661    AAAB01008978    EAA13579.5    GFJQ02000144    JAW06826.1    GGLE01002206    MBY06332.1    CH477824    EAT35901.1    GFDL01009486    JAV25559.1    GL887898    EGI69601.1    DS232064    EDS33653.1    GDIP01205412    JAJ17990.1    AJWK01023876   

Proteomes

UP000218220    UP000053240    UP000053268    UP000007151    UP000005204    UP000027135    + More
UP000007266    UP000019118    UP000245037    UP000053097    UP000279307    UP000078492    UP000078540    UP000005205    UP000053105    UP000078542    UP000053825    UP000078541    UP000075809    UP000008237    UP000000311    UP000005203    UP000242457    UP000215335    UP000002358    UP000075880    UP000076858    UP000009046    UP000015103    UP000030765    UP000036403    UP000000673    UP000075885    UP000075881    UP000069940    UP000249989    UP000069272    UP000076408    UP000075840    UP000075882    UP000007062    UP000008820    UP000007755    UP000075902    UP000075903    UP000002320    UP000076407    UP000192223    UP000075900    UP000075920    UP000092461    UP000075884   

PRIDE

H9J6K0   

Pfam

PF09261   Alpha-mann_mid        + More
PF07748   Glyco_hydro_38C
PF01074   Glyco_hydro_38N
PF18230   Glyc_hyd_38C_2
PF00060   Lig_chan
PF13621   Cupin_8
PF03416   Peptidase_C54

Interpro

IPR011330   Glyco_hydro/deAcase_b/a-brl        + More
IPR000602   Glyco_hydro_38_N       
IPR015341   Glyco_hydro_38_cen       
IPR011013   Gal_mutarotase_sf_dom       
IPR027291   Glyco_hydro_38_N_sf       
IPR037094   Glyco_hydro_38_cen_sf       
IPR011682   Glyco_hydro_38_C       
IPR013780   Glyco_hydro_b       
IPR028995   Glyco_hydro_57/38_cen_sf       
IPR041566   AManII_C       
IPR003347   JmjC_dom       
IPR001320   Iontro_rcpt       
IPR041667   Cupin_8       
IPR038765   Papain-like_cys_pep_sf       
IPR005078   Peptidase_C54       

SUPFAM

SSF74650   SSF74650        + More
SSF88688   SSF88688       
SSF88713   SSF88713       
SSF54001   SSF54001       

Gene 3D

1.20.1270.50     2.60.40.1180     3.20.110.10    

ProteinModelPortal

A0A2A4JW66   A0A2W1BFQ4   A0A194RKL8   A0A194PGJ2   A0A212F8Y0   H9J6K0   + More
A0A067R639   D6WTA9   A0A1Y1L0D7   V5GX04   N6TR79   A0A2P8Z8I7   A0A026WXN3   A0A195DUT2   A0A151I6B5   A0A158NSN6   A0A0N0BDG4   A0A195CCN0   A0A0L7R1D6   A0A195EXK8   A0A151WJA6   A0A1B6LSU4   E2C820   E2AKY7   A0A0C9R4X5   A0A087ZZQ3   A0A2A3EQ80   A0A232FIH3   A0A1B6CBG0   K7J1I1   A0A0C9RFU8   E9IUM4   A0A023F1Z6   A0A0P4VK91   A0A224X5V1   A0A2M3ZE22   A0A182IRW0   A0A0V0G6A5   A0A0P4ZKB6   A0A0P5LI91   A0A0P6BXP3   A0A0P4ZQ30   A0A0P5CYJ7   A0A0P6IIZ0   A0A0P5DBH3   A0A0P4ZIN8   A0A0P5J864   A0A2M4BAW1   A0A0P6EAM1   A0A0P5EAM2   A0A0P5DAP0   A0A0P5DW21   A0A0P4ZSN2   A0A0P5HTF8   A0A0P5D5J5   A0A2M4BBI3   A0A0P5JH22   A0A0P5D6W5   A0A0P5S8D1   A0A0P5CLK9   A0A0N8AE08   A0A0P5AKD0   A0A0P5AKF7   A0A0P5CQT8   A0A0P5UDR8   A0A0P5J1W0   A0A0P5IWE5   E0VV82   T1HHY4   A0A2M4AC47   A0A2M4ACL9   A0A084VTM1   A0A0J7KHF7   W5JK63   A0A182P424   U5EZM2   A0A182JSW1   A0A182GXK5   A0A182FPQ5   A0A182YG16   A0A182I875   A0A182KML8   Q7PMM6   A0A1Z5LHE7   A0A2R5LA05   Q16NG2   A0A1Q3FDG5   F4W8A6   A0A182UAA6   A0A182V343   B0WS34   A0A1Y9J179   A0A1W4XMZ0   A0A1W4XNT9   A0A0P5A1B3   A0A1Y9HF01   A0A182VWZ0   A0A1B0CQQ4   A0A182NDY6  

PDB

3EJU     E-value=4.7361e-171,     Score=1545

KEGG

101742043    K01231 alpha-mannosidase II [EC:3.2.1.114] | (RefSeq) alpha-mannosidase 2

PATHWAY

00510    N-Glycan biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0016021   GO:0030246   GO:0006013   GO:0004559   GO:0000139   GO:0006517   GO:0006491   GO:0004970   GO:0004553   GO:0008270   GO:0005975   GO:0003824   GO:0003688   GO:0005634   GO:0006270   GO:0042555   GO:0015930  

Length:

682

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

20.35005

Exp number, first 60 AAs:

20.34669

Total prob of N-in:

0.99993

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  26

outside

27  -  682

 

 

Pi

231.484862

Theta

194.695063

Tajima's D

1.102676

CLR

0.000516

CSRT

0.689815509224539

Interpretation

Uncertain