Gene

KWMTBOMO15290

Pre Gene Modal

BGIBMGA005046

Annotation

UDP-glycosyltransferase_UGT47A1_precursor_[Bombyx_mori]

Location

Bomo_Chr25(+):8460433-8468071      View in EpiBrowser

Full name

UDP-glucuronosyltransferase      

Location in the cell

PlasmaMembrane   Reliability : 2.522

CDS

ATGCGGGTGGCGTGGCTGCTGTGGTTAGCGACGGTCGCACGCGCTGCTCGTCTGCTCGTGGTGCTGCCCACAAACACTAAGAGCCATTACGCCATGTATAGCAGGCTTATTGAGGCGCTAGCGAAAAGGGACCATCAACTTACCGTTATCACACACTTCCCTGTGGACGCACCGCAACCTAACATTAATCAAATAAGCTTAGCTGGAACAATACCGGAGATCACTAATAATCTTACAAGAAAATATGATTCTTTGAAGCCGAACTTCATCCGCAATTTGGAACAAATCATCAGTGAATGCGTTAATGCTTGCGAAACAGTAGTACAGCAAGATTCCTTCAAAGAGTTACTTAATTCGACCGCTTCTTTTGATTTAATTATCGTAGAAGTCTTCGGAAGTGATTGTTTTTTACCTTTAGGTCATAGATTCCGGGCCCCCGTTGTCGGATTATTGTCTAGCGTCCCGCTACCTTGGGTCAATGATTACCTTGGCAACCCAGAAACAGCGTCTTACATACCGTCCTACATGATGGGTTATGGACAACACATGAGCCTATGGGAACGATTATCAAACACAATAGCTATTATATTAGCTAAGATTTTATACACATACAAATCAAGGATTCCTTCACAAGTGATAGTAGACAGAGTCTTCGGACATGGAAATAACTTACAAAAGCTCGCGAAAAACTACAGTGTGATTTTATCTAACAGTCACTTTAGCATTAACGAAGTCCGACCTCTTGTGCCTGGTCTAGTAGAAGTAGGCGGTCTACATTTGGATCACAGTCAAACACTTCCTAAGAATATGAAGAAACTTTTAGATGCGTCAACAGACGGTGTCATCTACTGGAGCTTTGGCTCGATGTCCAGAATAGAAACGATACCTAGCGAAAAGCTTTCAGGTATATTTGAAGCAATATCTGAACTACCACAATTGGTCTTCGTGAAGATGGATAGAAGAAGGCTCACAAAGAATATCACTGTGCCTGACAATGTATATACTATGGATTGGATTCCGCAGTATGCTACATTATGTCACCCAAACGTCAAGTTATTCATTTCTCATGGAGGCTTGCTTGGCACACAGGAAGCAGTGGCTTGTGGGGTACCTATGTTAATGGTGCCTCTATATGCTGACCAAGCTCTTAATTCTCAGTCTATGTTTGATAAAAACGTTGCCAGAATTCTGGATCTACACGAGGCTGATAAATATGAATGGAAGAGAGCTTTACATGATTTATTGAGTAACAAAAAGTATAGAGAAAATTCAAAAACGCTAAAAGAAATATTTTTAGATAGACCAATAAATCCTTTAGATATGGGCGTCTACTGGATTGAATATGTGCTGAGATACCGAGATATTAAAAATAAATAA

Protein

MRVAWLLWLATVARAARLLVVLPTNTKSHYAMYSRLIEALAKRDHQLTVITHFPVDAPQPNINQISLAGTIPEITNNLTRKYDSLKPNFIRNLEQIISECVNACETVVQQDSFKELLNSTASFDLIIVEVFGSDCFLPLGHRFRAPVVGLLSSVPLPWVNDYLGNPETASYIPSYMMGYGQHMSLWERLSNTIAIILAKILYTYKSRIPSQVIVDRVFGHGNNLQKLAKNYSVILSNSHFSINEVRPLVPGLVEVGGLHLDHSQTLPKNMKKLLDASTDGVIYWSFGSMSRIETIPSEKLSGIFEAISELPQLVFVKMDRRRLTKNITVPDNVYTMDWIPQYATLCHPNVKLFISHGGLLGTQEAVACGVPMLMVPLYADQALNSQSMFDKNVARILDLHEADKYEWKRALHDLLSNKKYRENSKTLKEIFLDRPINPLDMGVYWIEYVLRYRDIKNK

Catalytic Activity

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP

Similarity

Belongs to the UDP-glycosyltransferase family.
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.

Feature

chain  UDP-glucuronosyltransferase

Uniprot

G9LPW3   G9LPR9   A0A2W1BMF5   A0A2A4IYW0   A0A2H1W3F1   A0A286MXP7   + More
A0A194PG87   A0A1L8D6T1   A0A194RJU8   A0A212F8W5   A0A2J7QFA7   A0A067RIR8   A0A139WIV0   D2A2K6   A0A2P8ZG63   A0A2J7R4S8   A0A1W4XRE9   A0A2J7QFA8   J3JYV9   A0A067RAD1   A0A1W4W691   A0A1W4W6Y1   A0A2J7R4W8   A0A139WIV3   A0A139WIR0   A0A0T6BCY2   A0A2P8YRX1   A0A2J7R4V4   V5H2B2   A0A1W4WNP2   A0A2J7R4T0   A0A2J7R4V3   A0A0L7QTK6   A0A2J7R4V1   A0A1B6F5J1   A0A087ZQF4   D2A2V5   A0A2P8ZG78   A0A2J7R4W4   A0A1B6EZ83   A0A2A3EGP2   A0A2P8ZG70   A0A1B6KW89   A0A0C9RNU1   A0A1W4X720   A0A1B6CX28   A0A1B6LEK5   E2C3N6   K7JB17   A0A067RFX2   A0A139WIW7   A0A151WM71   F4WPC2   A0A067RAP7   A0A067QGQ4   A0A2J7R4W2   A0A1B6K0J6   A0A1B6K3R7   A0A1B6FAC1   A0A2P8ZG71   A0A232EQT2   A0A195E5I6   A0A1B6KV12   A0A158NQX4   A0A1B6LAB9   A0A3L8DPI9   A0A026WNX0   A0A1B6I336   A0A3L8DXJ2   A0A151WXP6   A0A1B6EUC3   A0A1B6FW51   A0A2J7Q396   A0A195B191   A0A026WYL1   A0A2S2NJQ5   A0A0L7QNV9   A0A1W4WYE4   E0VGC0   A0A2S2NGA3   A0A1B6KXR8   E2BN43   A0A2H8TPC9   A0A2D1GSK1   A0A151ICV8   J9JN70   A0A182F4M1   A0A1B6JYM7   W5J9T2   A0A2D1GSK5   A0A3L8DYP6   A0A1B6ET74   A0A026WMH2   A0A026WPZ7   A0A1B6IMF2   A0A1B6IK98   A0A0L7QNF8   A0A1W4WMC9   E9IV89  

EC Number

2.4.1.17

Pubmed

19121390    22155036    28756777    19954531    25299618    26354079    + More
29027758    22118469    24845553    18362917    19820115    29403074    22516182    20798317    20075255    21719571    28648823    21347285    30249741    24508170    20566863    20920257    23761445    21282665   

EMBL

BABH01019867    JQ070270    AEW43186.1    JQ070226    AEW43142.1    KZ149994    + More
PZC75471.1    NWSH01005189    PCG64370.1    ODYU01006049    SOQ47563.1    MF684365    ASX93999.1    KQ459604    KPI92401.1    KY202926    GEYN01000075    AUC64270.1    JAV02054.1    KQ460045    KPJ18103.1    AGBW02009658    OWR50184.1    NEVH01015300    PNF27275.1    KK852607    KDR20346.1    KQ971338    KYB27844.1    EFA02010.1    PYGN01000068    PSN55493.1    NEVH01007402    PNF35836.1    PNF27276.1    BT128440    AEE63397.1    KK852590    KDR20744.1    PNF35870.1    KYB27842.1    KYB27843.1    LJIG01001838    KRT85102.1    PYGN01000401    PSN46987.1    PNF35866.1    GALX01001513    JAB66953.1    PNF35837.1    PNF35864.1    KQ414747    KOC61874.1    PNF35863.1    GECZ01024322    GECZ01008492    JAS45447.1    JAS61277.1    EFA02977.2    PSN55501.1    PNF35869.1    GECZ01026545    JAS43224.1    KZ288262    PBC30389.1    PSN55494.1    GEBQ01024251    JAT15726.1    GBYB01008756    JAG78523.1    GEDC01019423    GEDC01014974    JAS17875.1    JAS22324.1    GEBQ01017854    JAT22123.1    GL452328    EFN77459.1    AAZX01012567    KK852488    KDR22771.1    KYB27856.1    KQ982944    KYQ48964.1    GL888243    EGI64017.1    KDR20745.1    KK853490    KDR07235.1    PNF35872.1    GECU01002730    JAT04977.1    GECU01001605    JAT06102.1    GECZ01022678    JAS47091.1    PSN55491.1    NNAY01002740    OXU20656.1    KQ979608    KYN20423.1    GEBQ01024697    JAT15280.1    ADTU01023695    GEBQ01019317    JAT20660.1    QOIP01000005    RLU22281.1    KK107139    EZA57757.1    GECU01026373    JAS81333.1    QOIP01000003    RLU24953.1    KQ982668    KYQ52547.1    GECZ01028213    JAS41556.1    GECZ01015337    JAS54432.1    NEVH01019069    PNF23054.1    KQ976691    KYM77969.1    KK107063    EZA61120.1    GGMR01004776    MBY17395.1    KQ414851    KOC60176.1    DS235135    EEB12426.1    GGMR01003614    MBY16233.1    GEBQ01023933    JAT16044.1    GL449382    EFN82947.1    GFXV01004222    MBW16027.1    MF471423    ATN96029.1    KQ978002    KYM98244.1    ABLF02040513    GECU01003693    JAT04014.1    ADMH02001962    ETN60168.1    MF471449    ATN96055.1    RLU24928.1    GECZ01028564    JAS41205.1    KK107151    EZA57272.1    EZA57756.1    RLU24627.1    GECU01019610    JAS88096.1    GECU01020359    JAS87347.1    KOC60177.1    GL766176    EFZ15506.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000235965    + More
UP000027135    UP000007266    UP000245037    UP000192223    UP000053825    UP000005203    UP000242457    UP000008237    UP000002358    UP000075809    UP000007755    UP000215335    UP000078492    UP000005205    UP000279307    UP000053097    UP000078540    UP000009046    UP000078542    UP000007819    UP000069272    UP000000673   

PRIDE

G9LPW3   

Pfam

PF00201   UDPGT        + More
PF04101   Glyco_tran_28_C
PF01699   Na_Ca_ex

Interpro

IPR002213   UDP_glucos_trans        + More
IPR035595   UDP_glycos_trans_CS       
IPR007235   Glyco_trans_28_C       
IPR004837   NaCa_Exmemb       
IPR000834   Peptidase_M14       

ProteinModelPortal

G9LPW3   G9LPR9   A0A2W1BMF5   A0A2A4IYW0   A0A2H1W3F1   A0A286MXP7   + More
A0A194PG87   A0A1L8D6T1   A0A194RJU8   A0A212F8W5   A0A2J7QFA7   A0A067RIR8   A0A139WIV0   D2A2K6   A0A2P8ZG63   A0A2J7R4S8   A0A1W4XRE9   A0A2J7QFA8   J3JYV9   A0A067RAD1   A0A1W4W691   A0A1W4W6Y1   A0A2J7R4W8   A0A139WIV3   A0A139WIR0   A0A0T6BCY2   A0A2P8YRX1   A0A2J7R4V4   V5H2B2   A0A1W4WNP2   A0A2J7R4T0   A0A2J7R4V3   A0A0L7QTK6   A0A2J7R4V1   A0A1B6F5J1   A0A087ZQF4   D2A2V5   A0A2P8ZG78   A0A2J7R4W4   A0A1B6EZ83   A0A2A3EGP2   A0A2P8ZG70   A0A1B6KW89   A0A0C9RNU1   A0A1W4X720   A0A1B6CX28   A0A1B6LEK5   E2C3N6   K7JB17   A0A067RFX2   A0A139WIW7   A0A151WM71   F4WPC2   A0A067RAP7   A0A067QGQ4   A0A2J7R4W2   A0A1B6K0J6   A0A1B6K3R7   A0A1B6FAC1   A0A2P8ZG71   A0A232EQT2   A0A195E5I6   A0A1B6KV12   A0A158NQX4   A0A1B6LAB9   A0A3L8DPI9   A0A026WNX0   A0A1B6I336   A0A3L8DXJ2   A0A151WXP6   A0A1B6EUC3   A0A1B6FW51   A0A2J7Q396   A0A195B191   A0A026WYL1   A0A2S2NJQ5   A0A0L7QNV9   A0A1W4WYE4   E0VGC0   A0A2S2NGA3   A0A1B6KXR8   E2BN43   A0A2H8TPC9   A0A2D1GSK1   A0A151ICV8   J9JN70   A0A182F4M1   A0A1B6JYM7   W5J9T2   A0A2D1GSK5   A0A3L8DYP6   A0A1B6ET74   A0A026WMH2   A0A026WPZ7   A0A1B6IMF2   A0A1B6IK98   A0A0L7QNF8   A0A1W4WMC9   E9IV89  

PDB

2O6L     E-value=5.53725e-18,     Score=224

KEGG

100862823    K00699 glucuronosyltransferase [EC:2.4.1.17] | (RefSeq) UGT47A1; UDP-glycosyltransferase UGT47A1

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00830    Retinol metabolism - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
00980    Metabolism of xenobiotics by cytochrome P450 - Bombyx mori (domestic silkworm)
00982    Drug metabolism - cytochrome P450 - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0016758   GO:0015020   GO:0008194   GO:0043231   GO:0055085   GO:0016757   GO:0004181   GO:0008270   GO:0008152   GO:0005634   GO:0005737   GO:0017069   GO:0016020   GO:0003677   GO:0008408   GO:0005112   GO:0015930  

Subcellular location

Membrane  

SignalP

Position:   1 - 15,         Likelihood:  0.928762

 

 

Length:

458

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.956679999999997

Exp number, first 60 AAs:

0.75059

Total prob of N-in:

0.03387

outside

1  -  458

 

 

Pi

250.764053

Theta

185.680697

Tajima's D

0.876538

CLR

0.175301

CSRT

0.619069046547673

Interpretation

Uncertain