Gene

KWMTBOMO15285

Pre Gene Modal

BGIBMGA005157

Annotation

Single-strand_selective_monofunctional_uracil_DNA_glycosylase_[Operophtera_brumata]

Location

Bomo_Chr25(-):8410311-8413882      View in EpiBrowser

Full name

tRNA-specific adenosine deaminase 2      

Alternative Name

Deaminase domain-containing protein 1
tRNA-specific adenosine-34 deaminase subunit ADAT2

Location in the cell

Cytoplasmic   Reliability : 1.074 Extracellular   Reliability : 1.383

CDS

ATGGTTGATCATATGAGAAGGTGTCTTGAATTAGCAGCTGAAGCTCTGGCTCTTAAAGAGGTGCCTGTTGGTTGTGTATTCACAGTTAACGGACAAATTATTGCAGAATCAAAAAACAGTGTAAACGCCACACACAACCCAACTAGACATGCGGAAATCAACTGCATTGATCAAATTCTAGAATACTGTAGATTAAACAACATCGATTACAAGCTATATTTCAAGAACGTAATTGTGTATGTGACCGTTGAACCGTGCATAATGTGCGCGGCAGCGCTCAACAATCTAAACATCCGTGAGGTGGTATATGGTTGCCCCAATGACAGGTTTGGCGGAAATACCGTTTTAGATGTCAGTAACTTTTATGAACAAAATTATATTTTAAATGGAAACTTGTTGGCAGATGAAGCTATGATGTTGCTCAAAGAGTTTTATAAAGGGATAAACCCTAATGCCCCTGAATCAAAAGTGAAGAAAGATAAAAAAGTTTAA

Protein

MVDHMRRCLELAAEALALKEVPVGCVFTVNGQIIAESKNSVNATHNPTRHAEINCIDQILEYCRLNNIDYKLYFKNVIVYVTVEPCIMCAAALNNLNIREVVYGCPNDRFGGNTVLDVSNFYEQNYILNGNLLADEAMMLLKEFYKGINPNAPESKVKKDKKV

Description

Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

Catalytic Activity

adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)

Cofactor

Zn(2+)

Similarity

Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.

Keywords

Alternative splicing   Complete proteome   Hydrolase   Metal-binding   Reference proteome   tRNA processing   Zinc  

Feature

chain  tRNA-specific adenosine deaminase 2
splice variant  In isoform 2.

Uniprot

H9J6L5   A0A2W1BQT7   A0A0L7LP27   S4PG78   A0A194PMP7   A0A194RLB6   + More
A0A2P8YEP2   A0A158NRL4   F4WBM2   E2BD38   E9J8N2   A0A195DJH2   A0A026W8G4   A0A0L7QMC3   A0A0L0CJL7   E2AU84   A0A2A3ED01   A0A3L8DIW5   A0A232EXS9   A0A1I8N7I7   A0A1I8Q9F0   B4PU62   B3LWT1   A0A0N0BI14   A0A034WM03   B3P3G1   Q16JL7   A0A3B0K093   A0A182FR23   B4IBK4   A0A151I7A9   A0A195BDZ8   A0A2J7QJF8   A0A0M4EPY8   B4G6C8   A0A1Y1KIB2   B4N9S2   B4K7K0   Q29AK1   A0A0P4VU62   A0A1W4UT85   B4LXV1   A0A151X5R2   A0A195FSD7   A0A1B0FN56   A0A0A1XSH8   A0A0P4VVY7   Q9VEM0   B4JTW9   A0A2M4DRV6   A0A0K8US03   A0A023EHU2   A0A2L2YE73   A0A1A9V8R1   A0A084VK30   W5JF89   T1ICE9   B7PUW5   A0A131Y175   A0A067QZN2   A0A182SQ08   A0A212FJC7   A0A1B6C6X7   A0A1B6GDQ6   A0A1B6JV05   A0A1B6GFZ5   A0A3B1KK55   A0A091EV79   A0A182XW74   E0VUF9   A0A218UFE7   A0A091QIU2   A0A146ZVU0   A0A093QPT6   A0A1E1WZY7   A0A091UUI9   B0W6L7   A0A087ZTD6   A0A091FNZ0   A0A1Q3FBZ4   A0A0A9YIX6   A0A093PHQ6   A0A091IN07   A0A182P816   A0A146KSV7   A0A091K944   A0A1Q3FBT7   Q5RIV4   A0A091PIF1   A0A096M7K0   A0A1J1HWG4   A0A1S2ZSG5   U3KE28   H0ZL52   H3A0K0   A0A2C9JGD1   A0A2I0MTG6   A0A3B4DBB2   A0A182UHX1   A0A087YGG7  

EC Number

3.5.4.33

Pubmed

19121390    28756777    26227816    23622113    26354079    29403074    + More
21347285    21719571    20798317    21282665    24508170    26108605    30249741    28648823    25315136    17994087    17550304    25348373    17510324    28004739    15632085    27129103    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    24945155    26561354    24438588    20920257    23761445    24845553    22118469    25329095    25244985    20566863    28503490    25401762    26823975    23594743    20360741    9215903    15562597    23371554   

EMBL

BABH01019869    KZ149994    PZC75487.1    JTDY01000432    KOB77197.1    GAIX01006275    + More
JAA86285.1    KQ459604    KPI92395.1    KQ460045    KPJ18110.1    PYGN01000661    PSN42644.1    ADTU01024048    GL888066    EGI68300.1    GL447563    EFN86380.1    GL769036    EFZ10789.1    KQ980824    KYN12634.1    KK107364    EZA51936.1    KQ414894    KOC59699.1    JRES01000310    KNC32392.1    GL442815    EFN62941.1    KZ288292    PBC29089.1    QOIP01000007    RLU20374.1    NNAY01001737    OXU23079.1    CM000160    EDW97712.1    CH902617    EDV42719.1    KQ435736    KOX77018.1    GAKP01003560    JAC55392.1    CH954181    EDV48741.1    CH478003    EAT34467.1    OUUW01000013    SPP87727.1    CH480827    EDW44762.1    KQ978430    KYM94011.1    KQ976511    KYM82439.1    NEVH01013555    PNF28731.1    CP012526    ALC46272.1    CH479179    EDW23886.1    GEZM01084972    GEZM01084971    JAV60358.1    CH964232    EDW80637.1    CH933806    EDW15344.1    CM000070    EAL27348.2    GDKW01002236    JAI54359.1    CH940650    EDW67910.1    KQ982498    KYQ55674.1    KQ981280    KYN43378.1    CCAG010020972    GBXI01000784    JAD13508.1    GDRN01104295    JAI57939.1    AE014297    AY075489    AAF55401.1    AAL68299.1    CH916374    EDV91548.1    GGFL01016106    MBW80284.1    GDHF01022953    JAI29361.1    GAPW01005164    JAC08434.1    IAAA01022101    LAA06419.1    ATLV01014083    KE524939    KFB38324.1    ADMH02001676    ETN61469.1    ACPB03019764    ABJB010066969    DS795953    EEC10387.1    GEFM01004020    JAP71776.1    KK853067    KDR11844.1    AGBW02008295    OWR53810.1    GEDC01028071    JAS09227.1    GECZ01009184    JAS60585.1    GECU01031439    GECU01008420    GECU01004668    JAS76267.1    JAS99286.1    JAT03039.1    GECZ01008420    JAS61349.1    KK719040    KFO60906.1    AAZO01005490    DS235786    EEB17015.1    MUZQ01000344    OWK52465.1    KK799126    KFQ27455.1    GCES01016266    JAR70057.1    KL749126    KFW88400.1    GFAC01006832    JAT92356.1    KL410062    KFQ93620.1    DS231848    EDS36691.1    KL447256    KFO71303.1    GFDL01010013    JAV25032.1    GBHO01026183    GBHO01012033    GBHO01004822    JAG17421.1    JAG31571.1    JAG38782.1    KL411822    KFW73775.1    KL218012    KFP01046.1    GDHC01019894    JAP98734.1    KK547783    KFP32866.1    GFDL01010025    JAV25020.1    BX088644    BC135109    KK674124    KFQ07435.1    AYCK01016234    AYCK01016235    CVRI01000027    CRK92408.1    AGTO01010148    ABQF01014416    AFYH01238738    AFYH01238739    AFYH01238740    AFYH01238741    AFYH01238742    AFYH01238743    AFYH01238744    AFYH01238745    AFYH01238746    AKCR02000002    PKK32965.1   

Proteomes

UP000005204    UP000037510    UP000053268    UP000053240    UP000245037    UP000005205    + More
UP000007755    UP000008237    UP000078492    UP000053097    UP000053825    UP000037069    UP000000311    UP000242457    UP000279307    UP000215335    UP000095301    UP000095300    UP000002282    UP000007801    UP000053105    UP000008711    UP000008820    UP000268350    UP000069272    UP000001292    UP000078542    UP000078540    UP000235965    UP000092553    UP000008744    UP000007798    UP000009192    UP000001819    UP000192221    UP000008792    UP000075809    UP000078541    UP000092444    UP000000803    UP000001070    UP000078200    UP000030765    UP000000673    UP000015103    UP000001555    UP000027135    UP000075901    UP000007151    UP000018467    UP000052976    UP000076408    UP000009046    UP000197619    UP000053258    UP000053283    UP000002320    UP000005203    UP000053760    UP000054308    UP000075885    UP000000437    UP000028760    UP000183832    UP000079721    UP000016665    UP000007754    UP000008672    UP000076420    UP000053872    UP000261440    UP000075902   

PRIDE

H9J6L5    Q9VEM0   

Pfam

PF00383   dCMP_cyt_deam_1        + More
PF03167   UDG
PF14437   MafB19-deam

Interpro

IPR036895   Uracil-DNA_glycosylase-like_sf        + More
IPR016193   Cytidine_deaminase-like       
IPR002125   CMP_dCMP_dom       
IPR039134   SMUG1       
IPR005122   Uracil-DNA_glycosylase-like       
IPR028883   tRNA_aden_deaminase       
IPR016192   APOBEC/CMP_deaminase_Zn-bd       

SUPFAM

SSF53927   SSF53927        + More
SSF52141   SSF52141       

Gene 3D

3.40.470.10    

ProteinModelPortal

H9J6L5   A0A2W1BQT7   A0A0L7LP27   S4PG78   A0A194PMP7   A0A194RLB6   + More
A0A2P8YEP2   A0A158NRL4   F4WBM2   E2BD38   E9J8N2   A0A195DJH2   A0A026W8G4   A0A0L7QMC3   A0A0L0CJL7   E2AU84   A0A2A3ED01   A0A3L8DIW5   A0A232EXS9   A0A1I8N7I7   A0A1I8Q9F0   B4PU62   B3LWT1   A0A0N0BI14   A0A034WM03   B3P3G1   Q16JL7   A0A3B0K093   A0A182FR23   B4IBK4   A0A151I7A9   A0A195BDZ8   A0A2J7QJF8   A0A0M4EPY8   B4G6C8   A0A1Y1KIB2   B4N9S2   B4K7K0   Q29AK1   A0A0P4VU62   A0A1W4UT85   B4LXV1   A0A151X5R2   A0A195FSD7   A0A1B0FN56   A0A0A1XSH8   A0A0P4VVY7   Q9VEM0   B4JTW9   A0A2M4DRV6   A0A0K8US03   A0A023EHU2   A0A2L2YE73   A0A1A9V8R1   A0A084VK30   W5JF89   T1ICE9   B7PUW5   A0A131Y175   A0A067QZN2   A0A182SQ08   A0A212FJC7   A0A1B6C6X7   A0A1B6GDQ6   A0A1B6JV05   A0A1B6GFZ5   A0A3B1KK55   A0A091EV79   A0A182XW74   E0VUF9   A0A218UFE7   A0A091QIU2   A0A146ZVU0   A0A093QPT6   A0A1E1WZY7   A0A091UUI9   B0W6L7   A0A087ZTD6   A0A091FNZ0   A0A1Q3FBZ4   A0A0A9YIX6   A0A093PHQ6   A0A091IN07   A0A182P816   A0A146KSV7   A0A091K944   A0A1Q3FBT7   Q5RIV4   A0A091PIF1   A0A096M7K0   A0A1J1HWG4   A0A1S2ZSG5   U3KE28   H0ZL52   H3A0K0   A0A2C9JGD1   A0A2I0MTG6   A0A3B4DBB2   A0A182UHX1   A0A087YGG7  

PDB

3DH1     E-value=4.32249e-31,     Score=331

KEGG

101735362    K15441 tRNA-specific adenosine deaminase 2 [EC:3.5.4.-] | (RefSeq) tRNA-specific adenosine deaminase

GO

GO:0003824   GO:0006284   GO:0017065   GO:0002100   GO:0008251   GO:0016787   GO:0052718   GO:0052717   GO:0003908   GO:0008270   GO:0005634   GO:0005737   GO:0017069   GO:0016020   GO:0003677   GO:0008408   GO:0005112   GO:0015930  

PANTHER

PTHR13235  

Length:

163

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.96993

Exp number, first 60 AAs:

0.07499

Total prob of N-in:

0.47216

outside

1  -  163

 

 

Pi

184.068268

Theta

191.128918

Tajima's D

-0.53219

CLR

1.454577

CSRT

0.238638068096595

Interpretation

Uncertain