Gene

KWMTBOMO15282  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005158

Annotation

PREDICTED:_DNA_polymerase_alpha_subunit_B_[Papilio_polytes]

Location

Bomo_Chr25(-):8387099-8398242      View in EpiBrowser

Full name

DNA polymerase alpha subunit B      

Alternative Name

DNA polymerase alpha 70 kDa subunit

Location in the cell

Extracellular   Reliability : 1.112 Nuclear   Reliability : 1.367

CDS

ATGGCCTCCGAAGAGTTGGTGACTGAGCAATTTAAATTTTTTGGCATAAACGTTGAACAAGATGTTTTATTAAAATGTGTAAATTTATGTGAAGAGAACAATATTGATGCTGAAACTTTTATCGAACAATGGATGGCATTCAGTTTGAATTATGTAAACGGTGCTTCACCAAACTTGGAAAACTTAGATTTATTCGTAAGAAAGGAATTTTCCAAGCGCCGAACTAACGCGTCCGCTAAAGAAACCACACGACCAGCTGCCGGTAAAAGTCTTACCGTTTATGGAGCAAAAGCCACTTCGCCTCCAGACAGTGAAGTACTGTCAAGTTATGTTGCCGTAACGCCCAAGAGAGTCAAAATCGAAAAAGACGCGACGACAAATCCGAATAACATAGTTCCTGCAACTTATTCACCGACCGTCGGTTCAGCGAAGTACGCGTCGAGAACAAACGCAGGCACGGTGGTCCATTCTTATGGAGATGAGAAATTACTACAAGAATTAGGTAAAGCGAACAGCTCGAATGATGTGCTCAGTTTGAAAATCACGCAAGTGCCTAATGACGATGACGAAGTTTACACAAAGGCGATGTTGGGTTTTGAACTTCTCCACGAAAAAGCCAGTACGTTTGATAATCACATTCGATACATATCGCAGTACATAATGAAGAAGGCGGGTGTAAAGGAAAGTACCTCAGTTAGACACAAAACACAGACAAACGTATACGTTGCTGGACGTATAGAATGTGATGCAGATGCGAGGTTAAATGCAAAATGTGTGGTGCTTCAAGGTACGTGGGAGGAGTCACTCAGTCAGTCGGTACCGGTGGACTTTGACAATGTATATCAGTATTCCTTATTCCCTGGTCAAGTGGTGGTGCTGCGCGGAATAAATCCCCGCGGTGATAGGTTTATAGCACAAGAAGTTTATTGTGACGCAATCCAACCATTACCTGACCATAAGTTCGATATAGCCGGTAAATTGTCGATGGTCGCTGTGGCGGGCCCGTACACGACGTCGGACAACATGGCCTACGAACCTCTCAAGGACATGGTGACGTACATAAACACGCACAAACCGCACGTAGTCATAATGACGGGGCCGTTTATTGACAGTGAACACTCCAAAGTCAAAGACAATACGATGGCCGAGACATTTAGCTCGTTGTTTGGGAAAATTCTCGATAGTCTGGGAGAATTGAGCAACACGAGTCCGGTCACGAAAATCTATATCGTATCGAATTTGAAGGACGCTTTCCATGTTAATGTCTACCCCACGCCGCCGTACGTGAGCCGAAGGAAACACCCCAACATACATTTTGTACCGGATCCCTGCACTCTTACCATTAATGGTATCCACGTGGGAGTTACTAGTACAGATATCCTCATGCACATTAGCCAGGAAGAAATATCACTAGGCACCGGCGGCGACAAGCTGTCCCGCTTAGCGAGCCACGTGCTGTCGCAGCAGACGTACTACCCGCTGTGTCCGGCGCCCGTCCCGCTGGACGCCGCGCTGTGGGCCGCGCACGCACAGCTTCAGGCATCTCCGCATCTGCTCGTACTACCCTCCAATTTCAGATATTTTGTTAAGGATGTCAACGGATGTGTAGTTGTCAATCCAGAACATTTAACAAAAGGCACCGGCGGAGGGACCTTCACTCGTGTATTAATCGATAGCGACAACGCCACGAAACGAATTGCAGCACAAATTGTCCGCATTTAA

Protein

MASEELVTEQFKFFGINVEQDVLLKCVNLCEENNIDAETFIEQWMAFSLNYVNGASPNLENLDLFVRKEFSKRRTNASAKETTRPAAGKSLTVYGAKATSPPDSEVLSSYVAVTPKRVKIEKDATTNPNNIVPATYSPTVGSAKYASRTNAGTVVHSYGDEKLLQELGKANSSNDVLSLKITQVPNDDDEVYTKAMLGFELLHEKASTFDNHIRYISQYIMKKAGVKESTSVRHKTQTNVYVAGRIECDADARLNAKCVVLQGTWEESLSQSVPVDFDNVYQYSLFPGQVVVLRGINPRGDRFIAQEVYCDAIQPLPDHKFDIAGKLSMVAVAGPYTTSDNMAYEPLKDMVTYINTHKPHVVIMTGPFIDSEHSKVKDNTMAETFSSLFGKILDSLGELSNTSPVTKIYIVSNLKDAFHVNVYPTPPYVSRRKHPNIHFVPDPCTLTINGIHVGVTSTDILMHISQEEISLGTGGDKLSRLASHVLSQQTYYPLCPAPVPLDAALWAAHAQLQASPHLLVLPSNFRYFVKDVNGCVVVNPEHLTKGTGGGTFTRVLIDSDNATKRIAAQIVRI

Description

May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.

Subunit

DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A and B, and the DNA primase large and small subunits. Subunit B binds to subunit A.

Similarity

Belongs to the DNA polymerase alpha subunit B family.

Keywords

3D-structure   Alternative splicing   Complete proteome   DNA replication   Nucleus   Phosphoprotein   Polymorphism   Reference proteome  

Feature

chain  DNA polymerase alpha subunit B
splice variant  In isoform 2.
sequence variant  In dbSNP:rs487989.

Uniprot

H9J6L6   A0A2W1BRT2   A0A2H1WZ21   A0A212FJ97   A0A194RL19   A0A2A4J3A7   + More
A0A0L7LH06   A0A067RAB1   A0A2J7QE41   A0A1B6FG21   A0A1B6IGW6   A0A2J7QE45   A0A1Y1KDB5   V4BAC9   A0A1S3KAP8   A0A2C9KJI2   K1QC65   A0A3Q1B401   A0A0P4YM17   A0A0P5SBQ0   A0A0P5T8G3   A0A0P5JWK6   A0A1B6I9E5   A0A0P5ZC15   A0A0P5U1H3   A0A0P5UWM6   A0A3Q1GQ62   A0A0P6DXJ9   A0A0P5ZUI8   A0A3Q1H2G5   A0A0P6G296   A0A0P5GDL7   Q6DCZ1   A0A0P5QYW1   A0A0N8D2B4   A0A0P6DWS8   A0A3B4XTK1   A0A0P5KCV0   A0A3P8SRS3   A0A0P5U0R4   A0A0P5YIT1   A0A0K8UDF0   A0A0P5LFC7   Q6DEY9   A0A3B4UV79   A0A1L8GJG1   A0A0P6E102   A0A0K8VVQ6   A0A0P5KPI2   A0A2K6NHA0   Q28C83   A0A0P5QYR9   A0A0P6FQT0   A0A0N8AC26   A0A131YQB6   A0A0P5HRH2   A0A1A8GFA3   A0A1S3FKI4   A0A3P8V2I6   A0A3Q1IDT2   A0A2J8TZ97   A0A0P5TKX2   A0A1A8I5X5   A0A2Y9PPQ4   A0A0P5BBU8   Q7ZVB6   A0A293LR25   A0A3Q3JP60   A0A340XPG9   H2Q426   A0A1A8SGG2   G3QKN0   A0A1A8QBU2   A0A2K6EC81   Q14181   A0A3P8Q138   A0A3B3V0V0   B0S687   A0A3P9B644   K7B9Q6   A0A341BQ96   A0A1Y1KGH6   A0A250Y3E0   Q6P0S9   A0A3Q3KHA9   A0A383Z747   A0A1A7WRM5   A0A087XZJ9   A0A2K5DY80   H0XBR5   A0A0N8A356   A0A0P5TH20   A0A2Y9PV55   A0A3B3WHP3   A0A2G8KDD6   A0A2K5KER4  

Pubmed

19121390    28756777    22118469    26354079    26227816    24845553    + More
28004739    23254933    15562597    22992520    20431018    27762356    25362486    26830274    24487278    16136131    22398555    8223465    14702039    16554811    15489334    1902230    18669648    19413330    19690332    20068231    21269460    21406692    23186163    23594743    25186727    28087693    29023486   

EMBL

BABH01019869    KZ149994    PZC75490.1    ODYU01012138    SOQ58278.1    AGBW02008295    + More
OWR53813.1    KQ460045    KPJ18114.1    NWSH01003726    PCG65883.1    JTDY01001220    KOB74491.1    KK852590    KDR20724.1    NEVH01015328    PNF26859.1    GECZ01020613    JAS49156.1    GECU01021548    GECU01017099    JAS86158.1    JAS90607.1    PNF26860.1    GEZM01086413    JAV59469.1    KB200129    ESP02897.1    JH817954    EKC28759.1    GDIP01225380    JAI98021.1    GDIQ01094238    JAL57488.1    GDIQ01203914    GDIP01131789    GDIQ01029930    JAK47811.1    JAL71925.1    GDIQ01192457    JAK59268.1    GECU01024142    GECU01005906    JAS83564.1    JAT01801.1    GDIP01058706    JAM45009.1    GDIP01121332    JAL82382.1    GDIP01107787    JAL95927.1    GDIQ01070799    JAN23938.1    GDIP01039403    JAM64312.1    GDIQ01039558    JAN55179.1    GDIQ01249749    GDIQ01186556    GDIQ01121321    GDIQ01067658    JAK01976.1    BC077841    AAH77841.1    GDIQ01108292    JAL43434.1    GDIQ01203913    GDIQ01203912    GDIQ01144080    GDIP01075735    JAK47812.1    JAM27980.1    GDIQ01071653    JAN23084.1    GDIQ01192456    JAK59269.1    GDIP01121333    JAL82381.1    GDIP01058707    JAM45008.1    GDHF01027622    JAI24692.1    GDIQ01170423    JAK81302.1    AAMC01070934    BC076954    AAH76954.1    CM004472    OCT83985.1    GDIQ01070798    JAN23939.1    GDHF01009352    JAI42962.1    GDIQ01186557    GDIQ01186555    GDIQ01158118    GDIQ01121320    GDIQ01067659    JAK65168.1    CR942408    CAJ82570.1    GDIQ01108337    JAL43389.1    GDIQ01044559    JAN50178.1    GDIP01162129    JAJ61273.1    GEDV01007769    JAP80788.1    GDIQ01229748    JAK21977.1    HAEB01013914    HAEC01000987    SBQ69064.1    NDHI03003478    PNJ38347.1    GDIP01126340    JAL77374.1    HAED01006241    SBQ92272.1    GDIP01187090    JAJ36312.1    BC045928    AAH45928.1    GFWV01005581    MAA30311.1    AACZ04016215    AACZ04016216    GABF01008635    JAA13510.1    HAEH01015582    HAEI01014534    SBS17003.1    CABD030079717    CABD030079718    CABD030079719    HAEF01013133    HAEG01011844    SBR90802.1    L24559    AK297842    CR456737    AP000944    BC002990    BC001347    BX465215    GABC01007951    GABD01007067    GABE01007284    NBAG03000050    JAA03387.1    JAA26033.1    JAA37455.1    PNI93838.1    GEZM01086412    JAV59471.1    GFFV01001839    JAV38106.1    BC065460    AAH65460.1    HADW01006993    SBP08393.1    AYCK01003857    AAQR03147612    AAQR03147613    AAQR03147614    AAQR03147615    AAQR03147616    AAQR03147617    AAQR03147618    AAQR03147619    AAQR03147620    GDIP01187089    JAJ36313.1    GDIP01126339    JAL77375.1    MRZV01000670    PIK46017.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000218220    UP000037510    UP000027135    + More
UP000235965    UP000030746    UP000085678    UP000076420    UP000005408    UP000257160    UP000257200    UP000261360    UP000265080    UP000008143    UP000261420    UP000186698    UP000233200    UP000081671    UP000265120    UP000265040    UP000248483    UP000261600    UP000265300    UP000002277    UP000001519    UP000233120    UP000005640    UP000265100    UP000261500    UP000000437    UP000265160    UP000252040    UP000261640    UP000261681    UP000028760    UP000233020    UP000005225    UP000261480    UP000230750    UP000233080   

PRIDE

H9J6L6    Q14181    B0S687   

Pfam

PF04051   TRAPP        + More
PF04042   DNA_pol_E_B
PF08418   Pol_alpha_B_N

Interpro

IPR007185   DNA_pol_a/d/e_bsu        + More
IPR024096   NO_sig/Golgi_transp_ligand-bd       
IPR007194   TRAPP_component       
IPR016722   DNA_pol_alpha_bsu       
IPR037992   TRAPPC6/Trs33       
IPR013627   Pol_alpha_B_N       

SUPFAM

SSF111126   SSF111126       

CDD

cd14944  TRAPPC6A_Trs33

ProteinModelPortal

H9J6L6   A0A2W1BRT2   A0A2H1WZ21   A0A212FJ97   A0A194RL19   A0A2A4J3A7   + More
A0A0L7LH06   A0A067RAB1   A0A2J7QE41   A0A1B6FG21   A0A1B6IGW6   A0A2J7QE45   A0A1Y1KDB5   V4BAC9   A0A1S3KAP8   A0A2C9KJI2   K1QC65   A0A3Q1B401   A0A0P4YM17   A0A0P5SBQ0   A0A0P5T8G3   A0A0P5JWK6   A0A1B6I9E5   A0A0P5ZC15   A0A0P5U1H3   A0A0P5UWM6   A0A3Q1GQ62   A0A0P6DXJ9   A0A0P5ZUI8   A0A3Q1H2G5   A0A0P6G296   A0A0P5GDL7   Q6DCZ1   A0A0P5QYW1   A0A0N8D2B4   A0A0P6DWS8   A0A3B4XTK1   A0A0P5KCV0   A0A3P8SRS3   A0A0P5U0R4   A0A0P5YIT1   A0A0K8UDF0   A0A0P5LFC7   Q6DEY9   A0A3B4UV79   A0A1L8GJG1   A0A0P6E102   A0A0K8VVQ6   A0A0P5KPI2   A0A2K6NHA0   Q28C83   A0A0P5QYR9   A0A0P6FQT0   A0A0N8AC26   A0A131YQB6   A0A0P5HRH2   A0A1A8GFA3   A0A1S3FKI4   A0A3P8V2I6   A0A3Q1IDT2   A0A2J8TZ97   A0A0P5TKX2   A0A1A8I5X5   A0A2Y9PPQ4   A0A0P5BBU8   Q7ZVB6   A0A293LR25   A0A3Q3JP60   A0A340XPG9   H2Q426   A0A1A8SGG2   G3QKN0   A0A1A8QBU2   A0A2K6EC81   Q14181   A0A3P8Q138   A0A3B3V0V0   B0S687   A0A3P9B644   K7B9Q6   A0A341BQ96   A0A1Y1KGH6   A0A250Y3E0   Q6P0S9   A0A3Q3KHA9   A0A383Z747   A0A1A7WRM5   A0A087XZJ9   A0A2K5DY80   H0XBR5   A0A0N8A356   A0A0P5TH20   A0A2Y9PV55   A0A3B3WHP3   A0A2G8KDD6   A0A2K5KER4  

PDB

5EXR     E-value=2.05184e-79,     Score=754

KEGG

101735774    K02321 DNA polymerase alpha subunit B | (RefSeq) DNA polymerase alpha subunit B

PATHWAY

03030    DNA replication - Bombyx mori (domestic silkworm)

GO

GO:0006260   GO:0003677   GO:0048193   GO:0003887   GO:0005634   GO:0043087   GO:0046982   GO:0006270   GO:0005658   GO:0006606   GO:0005829   GO:0005654   GO:0000082   GO:0032201   GO:0030942   GO:0048500   GO:0016020   GO:0008408   GO:0005112   GO:0015930  

PANTHER

PTHR23061  

Subcellular location

Nucleus  

Length:

573

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00298

Exp number, first 60 AAs:

0.00017

Total prob of N-in:

0.00078

outside

1  -  573

 

 

Pi

194.678767

Theta

156.189658

Tajima's D

0.94853

CLR

1.001405

CSRT

0.650917454127294

Interpretation

Uncertain