Gene

KWMTBOMO15271

Pre Gene Modal

BGIBMGA005034

Annotation

PREDICTED:_uncharacterized_protein_LOC101737092_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr25(+):8227933-8229684      View in EpiBrowser

Full name

Lipid droplet-associated hydrolase      

Alternative Name

Lipid droplet-associated serine hydrolase

Location in the cell

Cytoplasmic   Reliability : 1.2 Mitochondrial   Reliability : 1.321 Nuclear   Reliability : 1.058

CDS

ATGGACGTTTACGAAACCCTTAATAATGTTCCAACTCAGTTGATCGCATGGGGTGATCCATTCGCCAACAATAGTGACTCTGATGTTATTGTGATCATACCCGGCTGTCCAGGGATACCAGAATTTTATAGGGAATTCGGTGCTGAATTATACGAGAACACAAAGCTGTCAGTCTGCATTGTGGGTCATGCAGGTCACGGCTTACCTTCAAAACAATTAATGTATATGGAGAACAAAAAGCACTTGTTCAACGTGAGAGGACAACTCTGTCATAAGCTTGATCTCTTGACCAATTTCATAAGTCATAGACGAAAATTACATTTAATAGGACACTCGAGTGGCTCCTGGTTACTGGTCGAATTACTGGACAGAAACAAACAACTGACAAAACGGACTGTATCCGTGAATCTGCTGTTCCCAACACTACAAAAGATCGCAGAGACACTGAAAAAGATAATTGGACTCCAGCCAGTCACATTGAAGATCTGA

Protein

MDVYETLNNVPTQLIAWGDPFANNSDSDVIVIIPGCPGIPEFYREFGAELYENTKLSVCIVGHAGHGLPSKQLMYMENKKHLFNVRGQLCHKLDLLTNFISHRRKLHLIGHSSGSWLLVELLDRNKQLTKRTVSVNLLFPTLQKIAETLKKIIGLQPVTLKI

Description

Serine lipid hydrolase associated with lipid droplets (By similarity). Required for lipid droplet positioning and fat storage (PubMed:23525007).

Miscellaneous

Mainly present in lipid storing tissues such as the fat body or midgut.

Similarity

Belongs to the AB hydrolase superfamily. LDAH family.
Belongs to the argonaute family.

Keywords

Complete proteome   Endoplasmic reticulum   Hydrolase   Lipid droplet   Membrane   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Lipid droplet-associated hydrolase

Uniprot

H9J693   A0A0N1IHB2   A0A2W1BKI2   A0A194PQ03   A0A2A4K512   A0A2H1VVA7   + More
A0A2A4JN28   A0A3S2M517   A0A2W1BPG6   A0A212EPV9   B4IXH4   D6WVV7   A0A0M4EFG5   K7J1W9   B4N543   B4LG72   V5I959   B4L0N8   B4QLZ9   B4HVR5   K7J1W8   B3M524   B4PD70   B3NB91   Q9W0H3   A0A1W4VV35   A0A1B6CN59   A0A1B6C330   A0A0K8WKP4   J9K2K3   A0A0L0CPN0   Q29EW0   B4H5L3   A0A131YM31   U5EJC0   C4WSR5   A0A1I8NG96   Q1HQE6   B0WIV0   A0A3B0JWD8   A0A224YFS6   A0A182PLJ3   A0A1I8PWQ8   A0A0K8RNG9   L7LVS1   A0A0K8REK9   L7LXW2   A0A1Q3FGL8   B7QA78   A0A023EMA4   A0A131Y1H3   A0A182HEN4   A0A1B6LBZ0   K7J1X1   D3TPK1   A0A336M4G2   A0A2S2NP79   A0A1E1XGB1   A0A0A1WE73   A0A1B6EXL2   A0A023F6M9   A0A1B6FDH4   A0A034W8A1   A0A1B6J474   A0A0C9RLH7   A0A182NL34   A0A2H8TIW9   A0A2S2QLF2   A0A182Y8Y5   A0A182HYI0   A0A182U2Z8   A0A1E1XKS0   A0A182UQA6   A0A182XF88   A0A182JZR4   A0A1B0DQA2   Q7QA52   A0A182KZQ6   A0A2P8Y2I4   A0A0T6AX84   A0A2R7WT12   E9FY64   A0A084WP97   A0A336LZP8   A0A182W3A6   A0A182RT16   A0A131YAP2   V5IJM9   A0A2P8Y2K7   A0A182Q650   R4G835  

EC Number

3.1.1.-

Pubmed

19121390    26354079    28756777    22118469    17994087    18362917    + More
19820115    20075255    22936249    17550304    10731132    12537572    12537569    23525007    26108605    15632085    26830274    25315136    17204158    17510324    28797301    25576852    24945155    26483478    20353571    28503490    25830018    25474469    25348373    25244985    29209593    12364791    14747013    17210077    20966253    29403074    21292972    24438588    25765539   

EMBL

BABH01019883    KQ460226    KPJ16453.1    KZ149992    PZC75549.1    KQ459597    + More
KPI95048.1    NWSH01000167    PCG78863.1    ODYU01004659    SOQ44777.1    NWSH01000959    PCG73381.1    RSAL01000038    RVE51105.1    KZ149994    PZC75504.1    AGBW02013358    OWR43535.1    CH916366    EDV96411.1    KQ971358    EFA08623.1    CP012525    ALC42990.1    CH964101    EDW79482.1    CH940647    EDW69380.1    GALX01003505    JAB64961.1    CH933809    EDW18115.1    CM000363    CM002912    EDX08785.1    KMY96788.1    CH480817    EDW50030.1    CH902618    EDV39503.1    CM000159    EDW92818.1    CH954178    EDV50144.1    AE014296    AY061530    GEDC01022455    GEDC01012456    JAS14843.1    JAS24842.1    GEDC01029377    JAS07921.1    GDHF01000652    JAI51662.1    ABLF02039255    ABLF02062514    JRES01000080    KNC34320.1    CH379070    EAL29949.2    CH479211    EDW33065.1    GEDV01008929    JAP79628.1    GANO01002285    JAB57586.1    AK340305    BAH70935.1    DQ440498    CH477193    ABF18531.1    EAT48525.1    DS231953    EDS28776.1    OUUW01000009    SPP84752.1    GFPF01004679    MAA15825.1    GADI01001198    JAA72610.1    GACK01010041    JAA54993.1    GADI01004292    JAA69516.1    GACK01008597    JAA56437.1    GFDL01008345    JAV26700.1    ABJB010257966    DS892726    EEC15750.1    GAPW01003643    JAC09955.1    GEFM01003069    JAP72727.1    JXUM01132223    KQ567815    KXJ69269.1    GEBQ01018775    JAT21202.1    EZ423353    ADD19629.1    UFQT01000328    SSX23287.1    GGMR01006384    MBY19003.1    GFAC01000881    JAT98307.1    GBXI01017296    JAC96995.1    GECZ01027050    JAS42719.1    GBBI01001814    JAC16898.1    GECZ01021503    JAS48266.1    GAKP01007166    JAC51786.1    GECU01013729    JAS93977.1    GBYB01009150    JAG78917.1    GFXV01001423    MBW13228.1    GGMS01009308    MBY78511.1    APCN01005372    GFAA01003853    JAT99581.1    AJVK01008534    AAAB01008898    EAA09138.3    PYGN01001014    PSN38475.1    LJIG01022592    KRT79756.1    KK855469    PTY22703.1    GL732527    EFX87830.1    ATLV01024994    KE525367    KFB52041.1    UFQS01000328    SSX02923.1    SSX23290.1    GEFM01000286    JAP75510.1    GANP01001157    JAB83311.1    PSN38471.1    AXCN02000087    ACPB03019759    GAHY01001662    JAA75848.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000283053    UP000007151    + More
UP000001070    UP000007266    UP000092553    UP000002358    UP000007798    UP000008792    UP000009192    UP000000304    UP000001292    UP000007801    UP000002282    UP000008711    UP000000803    UP000192221    UP000007819    UP000037069    UP000001819    UP000008744    UP000095301    UP000008820    UP000002320    UP000268350    UP000075885    UP000095300    UP000001555    UP000069940    UP000249989    UP000075884    UP000076408    UP000075840    UP000075902    UP000075903    UP000076407    UP000075881    UP000092462    UP000007062    UP000075882    UP000245037    UP000000305    UP000030765    UP000075920    UP000075900    UP000075886    UP000015103   

PRIDE

H9J693    Q9W0H3   

Pfam

PF10230   LIDHydrolase        + More
PF02170   PAZ
PF02171   Piwi

Interpro

IPR019363   LDAH        + More
IPR029058   AB_hydrolase       
IPR003165   Piwi       
IPR003100   PAZ_dom       
IPR036397   RNaseH_sf       
IPR036085   PAZ_dom_sf       
IPR012337   RNaseH-like_sf       

SUPFAM

SSF53474   SSF53474        + More
SSF53098   SSF53098       
SSF101690   SSF101690       

Gene 3D

3.40.50.1820     3.30.420.10    

ProteinModelPortal

H9J693   A0A0N1IHB2   A0A2W1BKI2   A0A194PQ03   A0A2A4K512   A0A2H1VVA7   + More
A0A2A4JN28   A0A3S2M517   A0A2W1BPG6   A0A212EPV9   B4IXH4   D6WVV7   A0A0M4EFG5   K7J1W9   B4N543   B4LG72   V5I959   B4L0N8   B4QLZ9   B4HVR5   K7J1W8   B3M524   B4PD70   B3NB91   Q9W0H3   A0A1W4VV35   A0A1B6CN59   A0A1B6C330   A0A0K8WKP4   J9K2K3   A0A0L0CPN0   Q29EW0   B4H5L3   A0A131YM31   U5EJC0   C4WSR5   A0A1I8NG96   Q1HQE6   B0WIV0   A0A3B0JWD8   A0A224YFS6   A0A182PLJ3   A0A1I8PWQ8   A0A0K8RNG9   L7LVS1   A0A0K8REK9   L7LXW2   A0A1Q3FGL8   B7QA78   A0A023EMA4   A0A131Y1H3   A0A182HEN4   A0A1B6LBZ0   K7J1X1   D3TPK1   A0A336M4G2   A0A2S2NP79   A0A1E1XGB1   A0A0A1WE73   A0A1B6EXL2   A0A023F6M9   A0A1B6FDH4   A0A034W8A1   A0A1B6J474   A0A0C9RLH7   A0A182NL34   A0A2H8TIW9   A0A2S2QLF2   A0A182Y8Y5   A0A182HYI0   A0A182U2Z8   A0A1E1XKS0   A0A182UQA6   A0A182XF88   A0A182JZR4   A0A1B0DQA2   Q7QA52   A0A182KZQ6   A0A2P8Y2I4   A0A0T6AX84   A0A2R7WT12   E9FY64   A0A084WP97   A0A336LZP8   A0A182W3A6   A0A182RT16   A0A131YAP2   V5IJM9   A0A2P8Y2K7   A0A182Q650   R4G835  

KEGG

101737092    no KO assigned | (RefSeq) UPF0554 protein C2orf43-like

GO

GO:0016021   GO:0005811   GO:0005783   GO:0034389   GO:0030730   GO:0012505   GO:0016787   GO:0003676   GO:0031047  

PANTHER

PTHR13390  

Subcellular location

Lipid droplet   Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction.   With evidence from 5 publications.
Endoplasmic reticulum   Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction.   With evidence from 5 publications.
Membrane   Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction.   With evidence from 5 publications.

Length:

162

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02009

Exp number, first 60 AAs:

0.00763

Total prob of N-in:

0.19710

outside

1  -  162

 

 

Pi

193.768131

Theta

159.024521

Tajima's D

0.553833

CLR

0

CSRT

0.528973551322434

Interpretation

Uncertain