SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO15243  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA005014
Annotation
PREDICTED:_proteasome_activator_complex_subunit_4-like_[Bombyx_mori]
Full name
Proteasome activator complex subunit 4      
Alternative Name
Proteasome activator PA200
Location in the cell
Nuclear   Reliability : 1.312 PlasmaMembrane   Reliability : 1.353
 

Sequence

CDS
ATGATACAGGACGATGAATATGAACTTCTGGTAACTACCCCAGAGCGAATTAAAGCTCTGGGGTTCAAACCTCAGAAGGAATTTTTGACGAATCACTTATTGCCATATGCCAGTGAGCTTGACGAAGAATCGACCAGATTTTTAGGACAAGTGAAGATAAACTTGGCGAAGTCTGTTATGTTACGAGAGATGAAGCCAGCATGTGGAGTCTGGCTTTCTAGATTAATGAAGTACATAAGAATTTATGGACTAAAGTTCAGTAAAGCTGACCACATAGACCTCATCAAATTGGCATATGAGCTTATTATCATTCCAGATCTTGAACCTAGCAAAGTTCATAAGTTTAGTACAATGTTCATTATGCTCACAAAAAAGAGACAACTGATTTCACCAGAAGAACTGAAACTTCCCTGGAGACCTCTATATGACTTAGGACAAAGAATATTCGATAAGAATGCGCTTCATGTTGGAATGTTTCATTATATTAGTTCTCTGGAAAGTTCATATGTTGCATTGGTGAAGTGCGCAAGACCATATTTCGAATTGAGCGCAACAAAGGAGATATTAGACTTGTTACTACCTCGAATCAACCCCTGGACAGCGGACTCGTATGTATTGAGTCAACTGGTAGTATTTCTTCCTGTTGCATTACATCCCCGGAACTCGGCGTTAGGTCACGAACTTTGGTTTGAGAAGCTGATGGTTTTATGGGACACTTGCTACAATGCTCAGTGTGGAGTATGGGATCTGATGATAATATTTACTGGTCTGGCAAAGAGAAATCCCGGTGTGATAAACTGGTCACAGTATGCTCCTAGAATATTCTCGAGATTCCTTCATGCATTAAATCTTCCCGTCAGTTATAAAGATATGCAAATTAACAATCACTACACTCTTGATACAAAACACATGGCCTCGTGGATTGTATGGAGTATCTGCCCCGATGGAGTGGTTCTTAAACACCTGCGTTGTTTTATGGGAGGCGTAGAAAGTTACTTGCACAGTGCGAACTCGGGTCGATGGTCATATAAACTTAGGGACTTTCTAAAAAAGCTTACCAAAGAATTCCTAAACAGGTATCGTCGAGAAACTGAGCACAAATTTAAAGAGAGCTGGGAGAATCAAGTACCTGAACATTACAAACTGAGAGAAGAAGATATAACTGAGTTCATAAACATAGTTTTAGAACCTACATTGCAAGCTTTGTATAATCGAGTCGACAGTCTTGAAGTATCATTTGCCTTACAAAATTTAGCTACACTGCGACCTGCTATCGTTATTCCACCGTTGCTGGAAAAATTTAAGACTTCCTTGAATTCCCTGACCGAGCCCCATAGAGTCACGGCCGCCATGTCCGGGCTGGCCGCAGTCGCCAGGCCGATGGTGCGAGGTCCCGACGCCGGTTATTTGGAAGGTCCCACTCATATCGTCCACATCCTGATGGCCGTGCTCCCAGGTCTCGATCCGAACGATATCAAGAAAACATTGGTTTCCCTTCATTTTATTTTGTTCTTCAGTTGGATGGTGCCGTTGATAGATTGTAGTTCGGCTCACGAATACTGGCCGGATCTGACCGAGGAGGAATTGCTGACGTGCGAGTCGACCGCGCAGATTGAAGACTTCGTTTTAGTTTTCTTTGAGAAGATTTTCTCGATCGTAGAATCCAGTGTACTAGAACACGTGCGCTTGGACACCAAAGAGTCGGACGGGATGCGAAGTAAGGCTGATGCGGTCATGGAGGCGGCGTTGTCTTCTGCTACAACTGCTGTGCTAATGCAGTGCTCTCCTAAAATATTTAAGGAGGCTCTGAGGAAGTTCAAATCGTTCGCCACGCAGACCACGTTTGAGACAAACGTGTCTGGCAGTATGGTCGGGGTGTTGCTCCGTGTGTTTGCTCGAGTCGACCCCGAATCGACATTAGCCGCATTTCTGCCTCTTCTTTGTGATGAACTCGACGAGTTATTAGCGAGCGACGATGCTCTCAAGGAAGAGAATCCCCCACGAGACCTGATGTACAGACTAGTACTATTGATGCATTTAGTAGAATGCGATGGGACGGTTCTCTTAAAGTATGTCCCCAGAATTATTCCTGTACTGGATCGGGCACTTAAAATTCAAACGTATTACGCATTGAATCGGGCCTCCGAAATCCTCGCCCACATGCTGATTTCGTTCAACTGCATTGAGCTGAAAGAATGGAAGAGTTCGACTAAGGATTACAGTGCAGCGCCTCAAACGTGGCTGCCGGTCAGGGAGTGGGGCCACGGCTGCAAGCTCAAAGACCTTAGTTTCAAATGGCACGTCCCCTGCAAGGAGGAGGCCGAATGCGCCCAAATGCTTTTGGACAGATACATGAAGCCCGAGATATCGAAGTTAAAGCAGTGGGTGAACGGTGACTGTGAAATGAGTCGCGAGGAGAGATGCAGGTGTTTCTATGTTCTGGTGGCTGTGTTATCATGCGGGAATTTCTTACCGCAACCCAACGAAGAGCCAGTGTTGTTATTGGAAACTCAAGTGCCGTCGACGAGTATACCGTACACGAACGGAGTTAAGTTTTCTATAACACTGGACGGCGAGAACGTTCGCGTCGCCGTCACGCGGCTATTAGTCCGAGTGCAGGAGCGGATGTTGGCCGACAAGTCGGACGACACGCGCGGCCTCGAGCTACTCACGAAGGTATGGGAACGTGTGGTGGTGATGAAGGGTTCCAGAGTCGGTCCCAGTCTAGAAGAGCGTCTGATATCGTACGGCGCGCTGGACCGCGTGCTGGACGGACGCGCAGGGCCCACCAATCGGTTCGGAGGCGCCGGGACCTCCAGACTGCGGATGTTGACGGCCGAAGCGGCGAGGATACACGATGAGTCGAGGGTGAACCTGGTGTGCGAGGCGGGGATCACGCCCATAGCCTTAAAGGCGCTGCACGCATTGGCCGAGTTGTCCGTCAACACGTACACTTCTGTTCGAATGCTCTCCCAAATCAGACTGTACTGGATGCTCAATCATTATCCTTACTCCTACCGCACTCTGGTGCCAAAGTTGGCTGAATTGTTGATCAAAGGCGGCGAAGGCGACGAATGGCACGCCCGTCACAAAGGGACGTTATACATGATGCTCGGTCCGAGGAATGCACCGTTGATTGCTAAACAGGACTGGGAAGTGGCCAGAACGTTGTGGCCTGCCATACTGAAGGCCCCCCTCAGCGAGAAACCAAGTATACTAAAGTTAGAACAAGCATTTGGGGACACGATACACCGTAACTTCCCAGCAGTCAACACGCGTTTGGTGATACCGCAATCGGCAATAGATGCGGCCGCCCGCCTCCTCACCGAGGAACAACTCAACGATGCCGAGTTTGTCGAAATGCTGAAGAAGGCCAAACAAAACGAGACGGCGTTTTCCGATCGAAATGAGAGATTGTACAATGAATTAATATTGGAACTGGTCGATTTAGCGGAGACGCCTAACATACCGTGGCGGCGGCTGGAGCTGGCGTTCAACATGGCGGTGTACTGCCCGTCGCTGCAGACGGCGTACCCGGCGCGCGCGGTGCGGCTGGCGGCGCGCGGGCTGCTGCACGACGACGTGGCGGTGCGCAGGTCGGCGCAGCGGCTCGCGCACTACGCGCTCAAGCAGCGCAAGCGCCCGCTGCACAAGATACACGTCGACCCGTACGAGCTGGCCGGACTGCCGCGCCCCGCACAGCACATACCCGGTTACAGAAAAGATGTGGAGTGGGTCATGTGGTCTGAAGACAGGATACCAAAGAACGATGAAGAATGGGATAGACCGTGGCTGAGAAGTCCTTCTTTTGGATTTTATCAGTGGCCCGAGAAATTGGTGGTAGCCGCCCCGATAAGTCAACAGACGTGCTGTAAATTCCCTCCTCCTGAATGTATGGAGGAGGGCGAACGCTACCTTTTCGAGTTCTTCGATGACGACGAAAACGTTAACAAACTGGTCTCGTTCCTGACCGTCGAGGAGAAAAAGGGCAAGGACAAGTTCAGCGGCGTTCGATTCTTGTTCTTCAAGTTTCTGTTCGCTCATTACGGACCTCGTATAGCGGACAAGTTCACGGCGCACGCGCTGCGGTGTGCGGCGGAGACGCGCGAGGCGCCGCAGCGGTTCGCGGCGGAGGTCGCGTCCGCCGCGCTGCGGGCCGCGCGCTACTGGACCAGAGACGACGCTCTGAAGATGCACAGCGACACACTAGAGATATTTAAAGCGGGTCTAACATCAGTGACTCCAGAGACGATGAATGATTGGGGCACGGCTTTGGCGACCGGTATGGAGAAGATGGATCCGCTGCGGGGCGCCACTGTGGTGCAGGGGATCGTGGACCTCGCCATTCCGCCACCAGCGCCAGCTAATGCTGACCCTGATCAGAAGGCATCCTTCGTTGTGTGTGCCCGATTGCACGCATTACAGGGAGCCATCGGGTCACTGAAATGGCGAACTGCACCGCTGTCCCAGATCCTGCTGAAGAAACTCGATGCTGCGAACTTTATACAGCATCCTTACCAGAATGTGCGGGAAAGTGTCGGAAGTTTGCTAGCGACAATGTTCGACACGGAAGTGTTGTTCCCCGGCGGGCCGACTGGTTACTCCCTGTCTCTTGGCGACTTCATAGAATCGATTCAGCCAAGACTGGCCCCGTTATATGATGAGAATGGAGACATTGTAATATCCCTGACGTCGACTACGTCACCCCTACAAGCGACGGCCGCCGAGGAGGCTCCGCAGTCGGCCGCTTCCACGTCCAGAACTAGGAACTCGTTAAGCGGACAGATACCGGTGCGCGTCGCCAGACTGTCGCCCGACTCCGCTGAAGCTTCCGTGAGCGAAGACGCAGCGCAGTCTGAAGCGGTTGAAGGTGAAGAAGAATCGATAGGCCGTAGTCGTTTAGAGAAGCAGCTGGTGGATCGGCTCGACGCGGCCCTCAGTCTGTCCGGGGACGCGCCTGTCGTCGCGCCCCAACCCAAGGATCACGCCCGGGCTCTGAGTCTACTCACTACCGTGATCCGCGCGAGCACGGGCGTGTGCGTGCGCGGCGTGAGCGCGGGCGGCGTGGGCGGCGGCGTGGTGCGCGCGGCGTGTCGGTGCGCGGCGCGCGGCCCCACGCAGCCGCACGACGAGCTGCCGCGCGCCGCCGCTGCGCTGCTTGCCGCGCTCGCCGTGCAGACGCGCACCGCCGCCGGCTTCGACCGCACCTGCGACGAACTAGACTTGCTCGCCACAGGTAACTCGTGGTGGGCTCGACTGGCGTGCTTGGACTTTGCTCAGCCGTTCCTGTTTTACGGGCTCCCGTTTCTGTGCGATAGTCCGGACAGAGCTGTTCGAGCCGAACAGTTCGCTTTGAAACTCATGCGTGACTCGCGACTCGAGGTTCGACAGTCGGCTGCTAAGCTGTTGACAGGATTGATGCACTGTCGCGCTCTACCCGACGAACAGAGGACGTTGCGTTTGTTGATACGCAGCGCTCGATCGAAGCAACTGGTGGAGAGACACTTCGGGGTGCTCGGCATGTGCGCCTACCTGTCCTCTCGACCGTACAGCATCGGGTCCAAGTTCGGCGACGTGCTGTCCGAGCTGTCCCGGCACACGAACGCGCCGGACCCGGTCCCCGCGACCATACGACGCGCACTAGCCGACTTCAGGAGGACCCACCAAGACGACTGGCCGAAACATAGAGATCAACTCTCCGAAGACGAACTGGACATGTTGGCGGATCTCACTTCCCCCCCTTCGTACTTCGCCTAG
Protein
MIQDDEYELLVTTPERIKALGFKPQKEFLTNHLLPYASELDEESTRFLGQVKINLAKSVMLREMKPACGVWLSRLMKYIRIYGLKFSKADHIDLIKLAYELIIIPDLEPSKVHKFSTMFIMLTKKRQLISPEELKLPWRPLYDLGQRIFDKNALHVGMFHYISSLESSYVALVKCARPYFELSATKEILDLLLPRINPWTADSYVLSQLVVFLPVALHPRNSALGHELWFEKLMVLWDTCYNAQCGVWDLMIIFTGLAKRNPGVINWSQYAPRIFSRFLHALNLPVSYKDMQINNHYTLDTKHMASWIVWSICPDGVVLKHLRCFMGGVESYLHSANSGRWSYKLRDFLKKLTKEFLNRYRRETEHKFKESWENQVPEHYKLREEDITEFINIVLEPTLQALYNRVDSLEVSFALQNLATLRPAIVIPPLLEKFKTSLNSLTEPHRVTAAMSGLAAVARPMVRGPDAGYLEGPTHIVHILMAVLPGLDPNDIKKTLVSLHFILFFSWMVPLIDCSSAHEYWPDLTEEELLTCESTAQIEDFVLVFFEKIFSIVESSVLEHVRLDTKESDGMRSKADAVMEAALSSATTAVLMQCSPKIFKEALRKFKSFATQTTFETNVSGSMVGVLLRVFARVDPESTLAAFLPLLCDELDELLASDDALKEENPPRDLMYRLVLLMHLVECDGTVLLKYVPRIIPVLDRALKIQTYYALNRASEILAHMLISFNCIELKEWKSSTKDYSAAPQTWLPVREWGHGCKLKDLSFKWHVPCKEEAECAQMLLDRYMKPEISKLKQWVNGDCEMSREERCRCFYVLVAVLSCGNFLPQPNEEPVLLLETQVPSTSIPYTNGVKFSITLDGENVRVAVTRLLVRVQERMLADKSDDTRGLELLTKVWERVVVMKGSRVGPSLEERLISYGALDRVLDGRAGPTNRFGGAGTSRLRMLTAEAARIHDESRVNLVCEAGITPIALKALHALAELSVNTYTSVRMLSQIRLYWMLNHYPYSYRTLVPKLAELLIKGGEGDEWHARHKGTLYMMLGPRNAPLIAKQDWEVARTLWPAILKAPLSEKPSILKLEQAFGDTIHRNFPAVNTRLVIPQSAIDAAARLLTEEQLNDAEFVEMLKKAKQNETAFSDRNERLYNELILELVDLAETPNIPWRRLELAFNMAVYCPSLQTAYPARAVRLAARGLLHDDVAVRRSAQRLAHYALKQRKRPLHKIHVDPYELAGLPRPAQHIPGYRKDVEWVMWSEDRIPKNDEEWDRPWLRSPSFGFYQWPEKLVVAAPISQQTCCKFPPPECMEEGERYLFEFFDDDENVNKLVSFLTVEEKKGKDKFSGVRFLFFKFLFAHYGPRIADKFTAHALRCAAETREAPQRFAAEVASAALRAARYWTRDDALKMHSDTLEIFKAGLTSVTPETMNDWGTALATGMEKMDPLRGATVVQGIVDLAIPPPAPANADPDQKASFVVCARLHALQGAIGSLKWRTAPLSQILLKKLDAANFIQHPYQNVRESVGSLLATMFDTEVLFPGGPTGYSLSLGDFIESIQPRLAPLYDENGDIVISLTSTTSPLQATAAEEAPQSAASTSRTRNSLSGQIPVRVARLSPDSAEASVSEDAAQSEAVEGEEESIGRSRLEKQLVDRLDAALSLSGDAPVVAPQPKDHARALSLLTTVIRASTGVCVRGVSAGGVGGGVVRAACRCAARGPTQPHDELPRAAAALLAALAVQTRTAAGFDRTCDELDLLATGNSWWARLACLDFAQPFLFYGLPFLCDSPDRAVRAEQFALKLMRDSRLEVRQSAAKLLTGLMHCRALPDEQRTLRLLIRSARSKQLVERHFGVLGMCAYLSSRPYSIGSKFGDVLSELSRHTNAPDPVPATIRRALADFRRTHQDDWPKHRDQLSEDELDMLADLTSPPSYFA

Summary

Description
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved in DNA damage response in somatic cells: binds to acetylated histones and promotes degradation of histones (By similarity).
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks (By similarity).
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
Subunit
Homodimer. Interacts with the 20S and 26S proteasomes (By similarity).
Homodimer. Component of the spermatoproteasome, a form of the proteasome specifically found in testis (By similarity). Interacts with the 20S and 26S proteasomes.
Homodimer. Interacts with the 20S and 26S proteasomes. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
Similarity
Belongs to the BLM10 family.
Keywords
Cytoplasm   DNA damage   DNA repair   Nucleus   Proteasome   Repeat   Complete proteome   Developmental protein   Differentiation   Phosphoprotein   Reference proteome   Spermatogenesis   Alternative splicing   Polymorphism  
Feature
chain  Proteasome activator complex subunit 4
splice variant  In isoform 4.
sequence variant  In dbSNP:rs2302878.
EMBL
BABH01019970    BABH01019971    BABH01019972    BABH01019973    BABH01019974    ODYU01003230    + More
SOQ41719.1    NWSH01000977    PCG73297.1    RSAL01000102    RVE47470.1    PCG73298.1    AGBW02010802    OWR47698.1    KQ460045    KPJ18140.1    KQ459604    KPI92359.1    KK853153    KDR10575.1    NEVH01006756    PNF36516.1    KQ971352    KYB26764.1    GALX01003625    JAB64841.1    DS235366    EEB15344.1    UFQS01000380    UFQT01000380    SSX03385.1    SSX23750.1    GDIP01045732    JAM57983.1    GDIQ01231075    JAK20650.1    EFA07261.2    GDIQ01208981    JAK42744.1    GDIP01096276    JAM07439.1    GL732605    EFX71935.1    GEZM01009726    JAV94355.1    GL446481    EFN87710.1    GDIP01008472    JAM95243.1    GDIQ01011101    JAN83636.1    GEBQ01026638    JAT13339.1    GDIQ01071737    JAN23000.1    GDIQ01055638    JAN39099.1    GDIQ01174388    JAK77337.1    GDRN01073104    JAI63443.1    KQ434905    KZC11232.1    GDIQ01215382    JAK36343.1    GDIQ01110118    JAL41608.1    GDIQ01110119    JAL41607.1    GDRN01073103    JAI63444.1    GANO01001113    JAB58758.1    CM004474    OCT79288.1    ACTA01064234    ACTA01072234    ACTA01080234    ACTA01088234    ACTA01096234    ACTA01104234    ACTA01112234    BC070702    GAMR01001617    JAB32315.1    GAMT01004919    GAMT01004918    GAMT01004917    GAMS01006887    GAMP01008991    JAB06942.1    JAB16249.1    JAB43764.1    GL192376    EFB28562.1    AEMK02000021    DQIR01222549    HDB78026.1    KQ980322    KYN16591.1    GFFV01000177    JAV39768.1    AGTP01023557    AGTP01023558    AGTP01023559    AGTP01023560    AGTP01023561    AGTP01023562    AGTP01023563    DAAA02030893    DAAA02030894    AANG04002548    ADTU01025099    ADTU01025100    ADTU01025101    ADTU01025102    AQIA01018066    JSUE03010883    JSUE03010884    JSUE03010885    JU321762    JU474861    JV043865    AFE65518.1    AFH31665.1    AFI33936.1    ABGA01330917    ABGA01330918    ABGA01330919    ABGA01330920    ABGA01330921    ABGA01330922    ABGA01330923    ABGA01330924    ABGA01330925    ABGA01330926    NDHI03003368    PNJ79875.1    CABD030012798    CABD030012799    CABD030012800    CABD030012801    CABD030012802    GABD01003546    JAA29554.1    AACZ04001898    GABF01004847    GABD01003547    GABE01003218    NBAG03000238    JAA17298.1    JAA29553.1    JAA41521.1    PNI66216.1    AJFE02079189    AJFE02079190    AJFE02079191    AJFE02079192    AJFE02079193    AJFE02079194    GL887898    EGI69587.1    HAAF01011048    CCP82872.1    KQ976723    KYM76663.1    AQIB01040366    AQIB01040367    AQIB01040368    AQIB01040369    AQIB01040370    AQIB01040371    AQIB01040372    AQIB01040373    AQIB01040374    AQIB01040375    AAKN02055083    AAKN02055084    AAKN02055085    AAKN02055086    AY894754    AY894755    AY894756    BC043602    BC071768    BC112169    BC113668    D38521    HAEH01021759    SBS12841.1    HADY01015408    HAEJ01008088    SBP53893.1    HAED01000155    SBQ86000.1    HAEB01018856    HAEC01004939    SBQ65383.1    HADZ01015863    SBP79804.1   
Pfam
PF11919   DUF3437        + More
PF16507   BLM10_mid
Interpro
IPR016024   ARM-type_fold        + More
IPR035309   PSME4       
IPR021843   PSME4_C       
IPR032430   Blm10_mid       
IPR011989   ARM-like       
SUPFAM
SSF48371   SSF48371       
Gene 3D

Ontologies

Topology

Subcellular location
Cytoplasm  
Cytosol  
Nucleus  
Nucleus speckle  
Length:
1918
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.05493
Exp number, first 60 AAs:
3e-05
Total prob of N-in:
0.00051
outside
1  -  1918
 
 

Population Genetic Test Statistics

Pi
29.883885
Theta
202.649999
Tajima's D
1.333026
CLR
0.575867
CSRT
0.752262386880656
Interpretation
Uncertain
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