Gene

KWMTBOMO15242

Pre Gene Modal

BGIBMGA005169

Annotation

transcription_initiation_factor_IIA_gamma_chain_[Bombyx_mori]

Location

Bomo_Chr25(-):7258568-7263423      View in EpiBrowser

Full name

Transcription initiation factor IIA subunit 2      

Alternative Name

General transcription factor IIA subunit 2
TFIIA p14 subunit
Transcription initiation factor IIA gamma chain
dTFIIA-S

Location in the cell

Nuclear   Reliability : 3.715

CDS

ATGTCATATCAATTATACAGAAATACCACTATTGGTAATACACTTCAAGAAAGCCTAGACGAGCTGATCCAATATGGACAAATAACACCAGCACTAGCAGTAAAAGTTTTGCTGCAATTCGACAAATCTATAAATCAAGCTCTGTCCAATAGAGTAAAGTCTAGGCTAACCTTTAAAGCAGGAAAACTGAACACATACAGGTTTTGTGATAATGTATGGACTTTTATGTTGAATGATGTTGAATTTCGAGAAGTACAAGAATTGGCCAAGGTGGAAAAAGTTAAAATAGTAGCATGTGATGGTAAAAATGTTGACGACCGCAGATAA

Protein

MSYQLYRNTTIGNTLQESLDELIQYGQITPALAVKVLLQFDKSINQALSNRVKSRLTFKAGKLNTYRFCDNVWTFMLNDVEFREVQELAKVEKVKIVACDGKNVDDRR

Description

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation (PubMed:7958898). TFIIA in a complex with TBP mediates transcriptional activity (PubMed:7958898). Part of a rhi-dependent transcription machinery that enables the generation of piRNA precursors from heterochromatin while maintaining the suppression of transposon-encoded promoters and enhancers (PubMed:28847004). Forms a complex with Moonshiner/CG12721 and Trf2 which recruit transcriptional machinery to heterochromatin to initiate the bidirectional transcription of piRNA clusters, by interacting with the RDC (rhi, del and cuff) complex that binds to repressive H3K9me3 marks in the chromatin (PubMed:28847004). This mechanism allows transcription to occur in piRNA clusters despite the lack of proper promoter elements and in the presence of the repressive H3K9me3 mark (PubMed:28847004).

Subunit

TFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma (PubMed:7958898). It was originally believed to be a heterotrimer of an alpha (p30), a beta (p20) and a gamma (p14) subunit (PubMed:7958898). Forms a complex with Moonshiner/CG12721 and Trf2 (PubMed:28847004).

Similarity

Belongs to the TFIIA subunit 2 family.

Keywords

Complete proteome   Direct protein sequencing   Nucleus   Reference proteome   Transcription   Transcription regulation  

Feature

chain  Transcription initiation factor IIA subunit 2

Uniprot

Q1HPQ3   A0A2W1BMK6   A0A2H1VLL1   A0A2A4JNA2   A0A1E1WL83   A0A212F1T3   + More
S4PTT6   H9J6M7   A0A194RQ43   A0A194PH33   A0A1B6CI72   A0A026W3N7   V5FWB1   A0A195CMA0   A0A195CRM4   F4WS91   V9IKI4   A0A087ZWY8   A0A158NIM0   A0A310SRI4   A0A151XDU4   E1ZWR8   A0A1B6LJW3   A0A232ERF6   A0A2J7R2U2   A0A1W4WRZ3   A0A1B6FLB4   A0A1B6I0Y3   A0A2P8ZF93   A0A023EEX3   A0A0L7RG16   K7IUJ4   T1E3A2   Q17J10   A0A154P6E8   U5EK68   A0A1Y1N5J6   A0A182QLP1   J3JUB6   E2BFC2   A0A1Q3FWM1   A0A0T6B231   Q17J11   A0A2A3EU00   A0A182PLE1   A0A182KG68   A0A182XF36   Q7QA87   A2I432   D6WU86   A0A0A9Y581   A0A1B0ESI8   A0A0J7KWF4   A0A182W351   A0A182LZU4   A0A182RI55   A0A182SN83   A0A1L8DGN8   B0WJG2   B4M071   A0A1S4EQY7   A0A182HVK4   A0A2H8TGQ2   C4WSL4   B4KDS5   B4N825   A0A2S2R874   B4JTB0   A0A1B2AK92   P52656   A0A0M3QYG7   Q299B6   B4G4Z7   A0A1W4U8J5   B4R261   A0A3B0JL68   B4PNZ0   B4HFZ6   B3P8D1   A0A1J1J259   A0A023FAP4   A0A224XXI6   A0A0V0GBQ3   A0A0P4VKG8   R4FMM2   B3LXP8   A0A1B0G018   A0A1A9XVL4   A0A1A9VGD9   A0A1B0BKZ1   A0A1A9ZWW1   A0A1A9WNH4   E0VX10   T1P8P6   A0A2S2P363   A0A336L2C9   A0A023GH03   G3MSJ9   A0A224Z1M2   A0A131YVL8  

Pubmed

28756777    22118469    23622113    19121390    26354079    24508170    + More
30249741    21719571    21347285    20798317    28648823    29403074    24945155    26483478    20075255    24330624    17510324    28004739    22516182    23537049    12364791    14747013    17210077    18362917    19820115    25401762    26823975    17994087    7958898    10731132    12537572    12537569    28847004    15632085    17550304    25474469    27129103    20566863    25315136    22216098    28797301    26830274   

EMBL

DQ443349    ABF51438.1    KZ150046    PZC74507.1    ODYU01003230    SOQ41720.1    + More
NWSH01000977    PCG73299.1    GDQN01003292    JAT87762.1    AGBW02010802    OWR47697.1    GAIX01011473    JAA81087.1    BABH01019974    KQ460045    KPJ18141.1    KQ459604    KPI92358.1    GEDC01024159    JAS13139.1    KK107503    QOIP01000006    EZA49659.1    RLU22101.1    GALX01006531    JAB61935.1    KQ977634    KYN01209.1    KQ977372    KYN03285.1    GL888307    EGI62927.1    JR052162    AEY61633.1    ADTU01016949    KQ759888    OAD62119.1    KQ982254    KYQ58542.1    GL434901    EFN74357.1    GEBQ01015974    JAT24003.1    NNAY01002610    OXU20953.1    NEVH01007825    PNF35158.1    GECZ01018787    JAS50982.1    GECU01027099    JAS80607.1    PYGN01000075    PSN55171.1    JXUM01135077    GAPW01006194    GAPW01006193    GAPW01006192    GAPW01006191    KQ568218    JAC07406.1    KXJ69091.1    KQ414597    KOC69887.1    AAZX01002625    GALA01000024    JAA94828.1    CH477235    EAT46701.1    KQ434827    KZC07516.1    GANO01001925    JAB57946.1    GEZM01014336    JAV92140.1    AXCN02000338    APGK01028609    BT126829    KB740694    KB631600    AEE61791.1    ENN79448.1    ERL84526.1    GL448009    EFN85582.1    GFDL01003179    JAV31866.1    LJIG01016137    KRT81503.1    EAT46700.1    KZ288189    PBC34619.1    AAAB01008898    EAA09250.4    EF070535    ABM55601.1    KQ971352    EFA06253.1    GBHO01016808    GBRD01007295    GDHC01000929    JAG26796.1    JAG58526.1    JAQ17700.1    AJWK01004372    LBMM01002408    KMQ94867.1    AXCM01000063    GFDF01008580    JAV05504.1    DS231959    EDS29136.1    CH940650    EDW68321.2    APCN01005796    GFXV01000653    MBW12458.1    ABLF02038565    AK340239    BAH70884.1    CH933806    EDW14922.1    CH964232    EDW81276.1    GGMS01016920    MBY86123.1    CH916373    EDV95000.1    KX531771    ANY27581.1    X83271    AE014297    AY113478    BT044069    CP012526    ALC47589.1    CM000070    EAL27787.2    CH479179    EDW24663.1    CM000364    EDX14118.1    OUUW01000007    SPP83064.1    CM000160    EDW98200.1    CH480815    EDW43389.1    CH954182    EDV53955.1    CVRI01000066    CRL05852.1    GBBI01000603    JAC18109.1    GFTR01001778    JAW14648.1    GECL01001351    JAP04773.1    GDKW01001023    JAI55572.1    ACPB03031360    GAHY01000928    JAA76582.1    CH902617    EDV43942.1    CCAG010000726    JXJN01016126    DS235824    EEB17916.1    KA644490    AFP59119.1    GGMR01011251    MBY23870.1    UFQS01001369    UFQT01001369    SSX10543.1    SSX30229.1    GBBM01003150    JAC32268.1    JO844850    AEO36467.1    GFPF01012602    MAA23748.1    GEDV01006351    JAP82206.1   

Proteomes

UP000218220    UP000007151    UP000005204    UP000053240    UP000053268    UP000053097    + More
UP000279307    UP000078542    UP000007755    UP000005203    UP000005205    UP000075809    UP000000311    UP000215335    UP000235965    UP000192223    UP000245037    UP000069940    UP000249989    UP000053825    UP000002358    UP000008820    UP000076502    UP000075886    UP000019118    UP000030742    UP000008237    UP000242457    UP000075885    UP000075881    UP000076407    UP000007062    UP000007266    UP000092461    UP000036403    UP000075920    UP000075883    UP000075900    UP000075901    UP000002320    UP000008792    UP000079169    UP000075840    UP000007819    UP000009192    UP000007798    UP000001070    UP000000803    UP000092553    UP000001819    UP000008744    UP000192221    UP000000304    UP000268350    UP000002282    UP000001292    UP000008711    UP000183832    UP000015103    UP000007801    UP000092444    UP000092443    UP000078200    UP000092460    UP000092445    UP000091820    UP000009046    UP000095301   

PRIDE

Q1HPQ3    H9J6M7    P52656   

Pfam

PF02268   TFIIA_gamma_N        + More
PF02751   TFIIA_gamma_C

Interpro

IPR015871   TFIIA_gsu_C        + More
IPR015872   TFIIA_gsu_N       
IPR003194   TFIIA_gsu       
IPR009083   TFIIA_a-hlx       
IPR009088   TFIIA_b-brl       

SUPFAM

SSF50784   SSF50784       

Gene 3D

1.10.287.190     2.30.18.10    

CDD

cd10145  TFIIA_gamma_N
cd10014  TFIIA_gamma_C

ProteinModelPortal

Q1HPQ3   A0A2W1BMK6   A0A2H1VLL1   A0A2A4JNA2   A0A1E1WL83   A0A212F1T3   + More
S4PTT6   H9J6M7   A0A194RQ43   A0A194PH33   A0A1B6CI72   A0A026W3N7   V5FWB1   A0A195CMA0   A0A195CRM4   F4WS91   V9IKI4   A0A087ZWY8   A0A158NIM0   A0A310SRI4   A0A151XDU4   E1ZWR8   A0A1B6LJW3   A0A232ERF6   A0A2J7R2U2   A0A1W4WRZ3   A0A1B6FLB4   A0A1B6I0Y3   A0A2P8ZF93   A0A023EEX3   A0A0L7RG16   K7IUJ4   T1E3A2   Q17J10   A0A154P6E8   U5EK68   A0A1Y1N5J6   A0A182QLP1   J3JUB6   E2BFC2   A0A1Q3FWM1   A0A0T6B231   Q17J11   A0A2A3EU00   A0A182PLE1   A0A182KG68   A0A182XF36   Q7QA87   A2I432   D6WU86   A0A0A9Y581   A0A1B0ESI8   A0A0J7KWF4   A0A182W351   A0A182LZU4   A0A182RI55   A0A182SN83   A0A1L8DGN8   B0WJG2   B4M071   A0A1S4EQY7   A0A182HVK4   A0A2H8TGQ2   C4WSL4   B4KDS5   B4N825   A0A2S2R874   B4JTB0   A0A1B2AK92   P52656   A0A0M3QYG7   Q299B6   B4G4Z7   A0A1W4U8J5   B4R261   A0A3B0JL68   B4PNZ0   B4HFZ6   B3P8D1   A0A1J1J259   A0A023FAP4   A0A224XXI6   A0A0V0GBQ3   A0A0P4VKG8   R4FMM2   B3LXP8   A0A1B0G018   A0A1A9XVL4   A0A1A9VGD9   A0A1B0BKZ1   A0A1A9ZWW1   A0A1A9WNH4   E0VX10   T1P8P6   A0A2S2P363   A0A336L2C9   A0A023GH03   G3MSJ9   A0A224Z1M2   A0A131YVL8  

PDB

6O9L     E-value=1.42535e-37,     Score=385

KEGG

733002    K03123 transcription initiation factor TFIIA small subunit | (RefSeq) transcription initiation facto

PATHWAY

03022    Basal transcription factors - Bombyx mori (domestic silkworm)

GO

GO:0005672   GO:0006367   GO:0003743   GO:0016021   GO:0051123   GO:0045944   GO:0003713   GO:0017025   GO:0051091   GO:0006366   GO:0005634   GO:0016251   GO:0016709   GO:0050660   GO:0043874   GO:0016020   GO:0003677   GO:0008408   GO:0005112   GO:0015930  

PANTHER

PTHR10966  

Subcellular location

Nucleus  

Length:

108

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00953

Exp number, first 60 AAs:

0.00883

Total prob of N-in:

0.64880

inside

1  -  108

 

 

Pi

200.265781

Theta

187.312152

Tajima's D

0.798508

CLR

0.005517

CSRT

0.595870206489675

Interpretation

Uncertain