Gene

KWMTBOMO15234  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005010

Annotation

PREDICTED:_ubiquinone_biosynthesis_monooxygenase_COQ6?_mitochondrial_[Bombyx_mori]

Location

Bomo_Chr25(+):7185324-7194615      View in EpiBrowser

Full name

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial      

Alternative Name

Coenzyme Q10 monooxygenase 6

Location in the cell

Mitochondrial   Reliability : 1.634

CDS

ATGGGTGTGGTGGCCACCTTGTACTTAGCCGAGGAAACGGATAACACAACTGCCTGGCAAAGATGGCTGCCCTCAGGTCCAATAGCCATCCTGCCTTTGGACTCGCAGCGTAGCTCACTCGTCTGGTCGACGTGGGAGGACAACGCGAAACGACTCTTGAAACTACCCGAGGAACAATTCGTCGATGAACTCAACGATGCCCTTTGGAAGCAGTATCCTCGGAGCGGCGCAGTGGAGGGCTGCATGTCGTGGGTGAGCGGCTGCCTGCGTCGGGCCGGACTACCGGACGGTGCGGCGCGCCAGCTCCCGCCTTCCGTGCAAGGAGTAGCGTCCTCCTCCCGCGCCGCTTTCCCCCTCGCCTTCGGGCACAGTACACGATACGTCGCTAACGGAGTAGCTCTAGTCGGAGATGCGGCCCACAGAGTCCATCCGCTGGCTGGACAGGGCGTTAACCTCGGATTTGGCGACGTAAAGGAACTCACGGAACTGCTAGCCGACGCCACATACGGCGGCTTCGATATTAACGATCCGAGCTACCTGCAGAGATACGAGAGTAACCGTCAGAGGCATAACGTGCCGACTCAGCTCGCTATAGAGGCCCTCCACCGGCTCTACACGGTCGACCTGCCTCCGGTCGTGCTGCTGAGGAGTGTCGGCCTCCAACTGACAAACGCTCTACATCCTGTCAAGAAATTATTAATGTCTCACGCTGCAACGTAG

Protein

MGVVATLYLAEETDNTTAWQRWLPSGPIAILPLDSQRSSLVWSTWEDNAKRLLKLPEEQFVDELNDALWKQYPRSGAVEGCMSWVSGCLRRAGLPDGAARQLPPSVQGVASSSRAAFPLAFGHSTRYVANGVALVGDAAHRVHPLAGQGVNLGFGDVKELTELLADATYGGFDINDPSYLQRYESNRQRHNVPTQLAIEALHRLYTVDLPPVVLLRSVGLQLTNALHPVKKLLMSHAAT

Description

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Cofactor

FAD

Subunit

Component of a multi-subunit COQ enzyme complex.
Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.
Component of a multi-subunit COQ enzyme complex, composed of at least coq3, coq4, coq5, coq6, coq7 and coq9. Interacts with coq8b and coq7.

Similarity

Belongs to the UbiH/COQ6 family.

Keywords

Cell projection   Complete proteome   FAD   Flavoprotein   Golgi apparatus   Membrane   Mitochondrion   Mitochondrion inner membrane   Monooxygenase   Oxidoreductase   Reference proteome   Transit peptide   Ubiquinone biosynthesis  

Feature

chain  Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

Uniprot

H9J669   A0A3S2LZA8   A0A194PGC2   A0A2A4J127   A0A2W1BIY2   S4PSV2   + More
A0A2H1W860   A0A194RLF2   K7JED2   A0A026WIN1   A0A3L8D7B0   A0A232ESL8   A0A2J7Q225   A0A151WR83   A0A154P3J3   A0A195BY98   A0A088A361   A0A195EG56   A0A158NI89   A0A195AWK6   A0A0N0U755   A0A2A3E8X6   E2C8K8   A0A0C9Q6W0   U5EJF9   A0A0C9R8M6   A0A0C9R127   J3JWE3   A0A182GUL0   A0A1Y1KQA6   A0A067QHI4   A0A2L2YHY1   Q1DGZ9   A0A310SI00   E2APB4   A0A195FEZ9   A0A182HIK4   A0A139WF39   A0A182KY78   A0A182JWI7   A0A182PFC4   A0A182R6D3   W4Y3Y9   A0A182STQ3   A0A182W410   E0W075   W5MYN5   Q0IFQ5   A0A182M1J0   A0A212FEZ1   A0A2C9H898   F1RAX8   A0A034W8T8   A0A182UCM3   V9KLF4   A0A0A1X366   A0A182UN08   A0A1Q3G445   A0A087T878   R7V989   W8BQT3   C3XS22   A0A151NKA4   S4RFM1   S4RFM3   A0A2R8Q6S9   A0A182IW11   B4JAF7   A0A0L0BZ71   B0WV09   K7G9A7   Q7QER0   A0A182YQW7   B4LU17   A0A2H6NMH8   A0A3Q0GC79   A0A2D0RRD1   A0A3B4E2Q0   T1P9T1   A0A1I8MBS7   I3KWA8   V8NPZ8   H3DJ31   A0A1J1J3R1   Q6DF46   W4YG09   A0A091IBM0   A0A1L8F969   G3UUV4   Q4QQX3   A0A3B5A032   A0A1L8F0Q6   F1NBR7   E9JB46   A0A3B4ZX06   M4AL43   T1DCP6   A0A218VEU9   A0A093R5Y9  

EC Number

1.14.13.-

Pubmed

19121390    26354079    28756777    23622113    20075255    24508170    + More
30249741    28648823    21347285    20798317    22516182    26483478    28004739    24845553    26561354    17510324    18362917    19820115    20966253    20566863    22118469    23594743    25348373    24402279    25830018    23254933    24495485    18563158    22293439    17994087    26108605    17381049    12364791    14747013    17210077    25244985    25315136    25186727    24297900    15496914    20431018    27762356    20838655    15592404    21282665    23542700    23758969   

EMBL

BABH01019983    BABH01019984    RSAL01000102    RVE47474.1    KQ459604    KPI92352.1    + More
NWSH01004460    PCG65083.1    KZ150014    PZC75019.1    GAIX01013143    JAA79417.1    ODYU01006958    SOQ49279.1    KQ460045    KPJ18145.1    AAZX01007490    KK107185    EZA55833.1    QOIP01000012    RLU16365.1    NNAY01002421    OXU21307.1    NEVH01019373    PNF22636.1    KQ982813    KYQ50311.1    KQ434809    KZC06392.1    KQ978501    KYM93567.1    KQ978957    KYN27223.1    ADTU01016099    ADTU01016100    KQ976725    KYM76556.1    KQ435719    KOX78758.1    KZ288322    PBC28175.1    GL453666    EFN75738.1    GBYB01009843    JAG79610.1    GANO01002249    JAB57622.1    GBYB01012719    JAG82486.1    GBYB01009844    JAG79611.1    BT127561    AEE62523.1    JXUM01089336    KQ563763    KXJ73353.1    GEZM01079905    GEZM01079904    JAV62350.1    KK853628    KDR03814.1    IAAA01021616    LAA07743.1    CH899941    EAT32429.1    KQ761039    OAD58343.1    GL441504    EFN64713.1    KQ981636    KYN38797.1    APCN01003992    KQ971353    KYB26590.1    AAGJ04124569    AAGJ04124570    AAZO01006645    DS235857    EEB19031.1    AHAT01003744    CH477294    EAT44481.1    AXCM01004049    AGBW02008891    OWR52290.1    BX936443    BC122260    GAKP01007828    JAC51124.1    JW866370    AFO98887.1    GBXI01008720    JAD05572.1    GFDL01000474    JAV34571.1    KK113905    KFM61317.1    AMQN01000789    KB295623    ELU12926.1    GAMC01005133    JAC01423.1    GG666456    EEN69490.1    AKHW03002792    KYO37217.1    CH916368    EDW03828.1    JRES01001119    KNC25362.1    DS232115    EDS35337.1    AGCU01050015    AGCU01050016    AAAB01008846    EAA06342.5    CH940649    EDW65070.1    IACI01120289    IACI01120290    LAA35763.1    KA645511    AFP60140.1    AERX01030277    AZIM01002372    ETE64145.1    CVRI01000069    CRL07024.1    CR761032    AAMC01082860    BC076897    KL217612    KFO97160.1    CM004480    OCT68139.1    BC097912    AAH97912.1    CM004481    OCT65145.1    AADN05000303    GL770938    EFZ09924.1    GAAZ01000574    JAA97369.1    MUZQ01000005    OWK64102.1    KL430757    KFW91567.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000218220    UP000053240    UP000002358    + More
UP000053097    UP000279307    UP000215335    UP000235965    UP000075809    UP000076502    UP000078542    UP000005203    UP000078492    UP000005205    UP000078540    UP000053105    UP000242457    UP000008237    UP000069940    UP000249989    UP000027135    UP000008820    UP000000311    UP000078541    UP000075840    UP000007266    UP000075882    UP000075881    UP000075885    UP000075900    UP000007110    UP000075901    UP000075920    UP000009046    UP000018468    UP000075883    UP000007151    UP000076407    UP000000437    UP000075902    UP000075903    UP000054359    UP000014760    UP000001554    UP000050525    UP000245300    UP000075880    UP000001070    UP000037069    UP000002320    UP000007267    UP000007062    UP000076408    UP000008792    UP000189705    UP000221080    UP000261440    UP000095301    UP000005207    UP000007303    UP000183832    UP000008143    UP000054308    UP000186698    UP000001645    UP000261400    UP000000539    UP000002852    UP000197619   

PRIDE

H9J669    F1RAX8    Q6DF46   

Pfam

PF01494   FAD_binding_3        + More
PF03109   ABC1
PF10545   MADF_DNA_bdg

Interpro

IPR010971   UbiH/COQ6        + More
IPR002938   FAD-bd       
IPR018168   Ubi_Hdrlase_CS       
IPR036188   FAD/NAD-bd_sf       
IPR000689   UbQ_mOase_COQ6       
IPR000719   Prot_kinase_dom       
IPR004147   UbiB_dom       
IPR011009   Kinase-like_dom_sf       
IPR006578   MADF-dom       

SUPFAM

SSF51905   SSF51905        + More
SSF56112   SSF56112       

Gene 3D

3.50.50.60    

ProteinModelPortal

H9J669   A0A3S2LZA8   A0A194PGC2   A0A2A4J127   A0A2W1BIY2   S4PSV2   + More
A0A2H1W860   A0A194RLF2   K7JED2   A0A026WIN1   A0A3L8D7B0   A0A232ESL8   A0A2J7Q225   A0A151WR83   A0A154P3J3   A0A195BY98   A0A088A361   A0A195EG56   A0A158NI89   A0A195AWK6   A0A0N0U755   A0A2A3E8X6   E2C8K8   A0A0C9Q6W0   U5EJF9   A0A0C9R8M6   A0A0C9R127   J3JWE3   A0A182GUL0   A0A1Y1KQA6   A0A067QHI4   A0A2L2YHY1   Q1DGZ9   A0A310SI00   E2APB4   A0A195FEZ9   A0A182HIK4   A0A139WF39   A0A182KY78   A0A182JWI7   A0A182PFC4   A0A182R6D3   W4Y3Y9   A0A182STQ3   A0A182W410   E0W075   W5MYN5   Q0IFQ5   A0A182M1J0   A0A212FEZ1   A0A2C9H898   F1RAX8   A0A034W8T8   A0A182UCM3   V9KLF4   A0A0A1X366   A0A182UN08   A0A1Q3G445   A0A087T878   R7V989   W8BQT3   C3XS22   A0A151NKA4   S4RFM1   S4RFM3   A0A2R8Q6S9   A0A182IW11   B4JAF7   A0A0L0BZ71   B0WV09   K7G9A7   Q7QER0   A0A182YQW7   B4LU17   A0A2H6NMH8   A0A3Q0GC79   A0A2D0RRD1   A0A3B4E2Q0   T1P9T1   A0A1I8MBS7   I3KWA8   V8NPZ8   H3DJ31   A0A1J1J3R1   Q6DF46   W4YG09   A0A091IBM0   A0A1L8F969   G3UUV4   Q4QQX3   A0A3B5A032   A0A1L8F0Q6   F1NBR7   E9JB46   A0A3B4ZX06   M4AL43   T1DCP6   A0A218VEU9   A0A093R5Y9  

PDB

4K22     E-value=1.04594e-16,     Score=209

KEGG

101746083    K06126 ubiquinone biosynthesis monooxygenase Coq6 [EC:1.14.13.-] | (RefSeq) ubiquinone biosynthesis

PATHWAY

00130    Ubiquinone and other terpenoid-quinone biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0071949   GO:0006744   GO:0016709   GO:0031314   GO:0016712   GO:0004672   GO:0005524   GO:0016491   GO:0005739   GO:0005794   GO:0042995   GO:0050660   GO:0043874   GO:0016020   GO:0003677   GO:0008408   GO:0005112   GO:0015930   GO:0055114  

Subcellular location

Mitochondrion inner membrane  
Golgi apparatus   Localizes to cell processes and Golgi apparatus in podocytes.   With evidence from 1 publications.
Cell projection   Localizes to cell processes and Golgi apparatus in podocytes.   With evidence from 1 publications.

Length:

239

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00741

Exp number, first 60 AAs:

0.00019

Total prob of N-in:

0.02533

outside

1  -  239

 

 

Pi

4.94979

Theta

204.624869

Tajima's D

2.391667

CLR

0.967113

CSRT

0.934903254837258

Interpretation

Uncertain