Gene

KWMTBOMO15232

Annotation

transient_receptor_potential_channel_pyrexia_[Bombyx_mori]

Location

Bomo_Chr25(-):7172938-7177193      View in EpiBrowser

Full name

Transient receptor potential channel pyrexia      

Location in the cell

PlasmaMembrane   Reliability : 4.15

CDS

ATGTTTACTACAGTTACGGTTAATTTTGCCACATTCCTCCTGGCGTACAGTTGTCTCCTCATTGCTTTTGGTCTAGCTTTTAGCGTGCTGTTCAGCAACTACCCCGCATTCCATTTACCGGCTGGTTTAGTCAAAACGGTCATGATGATGTCAGGAGAGCTTGAATACGAGGATATATTCTACAACAACTGCACAAATTCCGAGATTTACTATCCTCTGACGGCACACATTATGTTCCTGATATTTGTACTACTTGTTACCGTTATATTGACAAACCTACTAGTTGGTTTGGCTGTTAGTGATATCCAGGCGTTACAAGAGGGTGCTGGATTGGATCGGTTGGTGCGTCAAACACAATTGATAGCTCATCTCGAGGGAATGCTGTTCAGCTCACTGTTATCATGTGCGCCTCAGCAGTTGCTGACTGTTTTACGTTGGGGAGCATTACTGACGGCGACGCACATGCGCACAATTAATATTAGACCGAACGATCCAAGAGAGAATAGAATACCGAAGGAATTCATATCAGCTATCTACAAGATGGTGGCAAGTCGAAAGAATACGAAAAGAAGTGTACGAAAAAATAACAATTACGAATTTAGAATAAGGAGATGCCCGGAAGAGGAAACAATATCAAAACCAGAAATCGTTAAACGAAAAAGCAATTTATATGACAGATTCTCGTTTGATAGTCAACAGGTGGAAAGAAGGAAGCGACCTACTTCAGGATCAAATACTGACAGCAGGAACAGACCCCCTTCATTGACGATCAACGCTATACAGGAAATATGTATGGTTGATATAAAAACCCAACTTCTTGAACTAACAAAGAAAGTTAATAAATTACTTGAAGGTACAGAAGCAAGATTAAATCAAATCGAAAGCAAAGTAAACGGACAACTGCCGTAA

Protein

MFTTVTVNFATFLLAYSCLLIAFGLAFSVLFSNYPAFHLPAGLVKTVMMMSGELEYEDIFYNNCTNSEIYYPLTAHIMFLIFVLLVTVILTNLLVGLAVSDIQALQEGAGLDRLVRQTQLIAHLEGMLFSSLLSCAPQQLLTVLRWGALLTATHMRTINIRPNDPRENRIPKEFISAIYKMVASRKNTKRSVRKNNNYEFRIRRCPEEETISKPEIVKRKSNLYDRFSFDSQQVERRKRPTSGSNTDSRNRPPSLTINAIQEICMVDIKTQLLELTKKVNKLLEGTEARLNQIESKVNGQLP

Description

Receptor-activated non-selective cation channel involved in protection or tolerance from high temperature stress. Activated by temperatures above 40 degrees Celsius. More permeable to K(+) than to Na(+). May act in stress protection allow flies to survive in natural environments.

Subunit

Homooligomer; between isoform A and isoform B.

Similarity

Belongs to the transient receptor (TC 1.A.4) family.
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.

Keywords

Alternative splicing   ANK repeat   Complete proteome   Glycoprotein   Ion channel   Ion transport   Membrane   Reference proteome   Repeat   Sensory transduction   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Transient receptor potential channel pyrexia
splice variant  In isoform B.

Uniprot

W8VMI8   A0A212FEW5   A0A0L7KRD5   A0A194PG37   A0A194RQ48   A0A2W1BQK8   + More
A0A2A4IZ93   A0A2A4J0Z3   A0A3S2NSL9   H9J6M8   A0A2J7Q265   A0A067QSF9   A0A1B0A764   A0A182GUK9   A0A1A9UH95   A0A1J1J7Z5   U4UZS4   N6T3C1   U4UZM9   A0A0L0BVP7   A0A1I8NAZ6   Q9W0T5-2   A0A0Q5UCQ4   U4UN02   A0A1Y1LNQ8   A0A0R1DTZ0   A0A1W4VP01   A0A0J9UBA1   Q9W0T5   B3NEM1   A0A1W4VP94   B4HVD0   B4PC33   A0A1W4W1C3   B4QKU8   B3M8Z5   A0A3B0JY03   A0A195EG32   B4LS35  

Pubmed

24639527    22118469    26227816    26354079    28756777    19121390    + More
24845553    26483478    23537049    26108605    25315136    10731132    12537572    12537569    15731759    17994087    28004739    17550304    22936249    18057021   

EMBL

AB437368    BAO53209.1    AGBW02008891    OWR52289.1    JTDY01006890    KOB65611.1    + More
KQ459604    KPI92351.1    KQ460045    KPJ18146.1    KZ150014    PZC75020.1    NWSH01004460    PCG65081.1    PCG65082.1    RSAL01000102    RVE47475.1    BABH01019984    BABH01019985    NEVH01019373    PNF22682.1    KK853628    KDR03815.1    JXUM01089330    JXUM01089331    KQ563763    KXJ73352.1    CVRI01000069    CRL07025.1    KI208385    ERL95850.1    APGK01054163    KB741247    ENN72053.1    KI208426    ERL95861.1    JRES01001267    KNC24063.1    AE014296    BT001363    BT010317    CH954178    KQS43009.1    KB632281    ERL91380.1    GEZM01050962    GEZM01050961    JAV75259.1    CM000159    KRK00656.1    CM002912    KMY96600.1    EDV50016.1    CH480817    EDW49895.1    EDW92688.1    CM000363    EDX08694.1    CH902618    EDV38939.1    OUUW01000012    SPP86934.1    KQ978957    KYN27225.1    CH940649    EDW64721.1    KRF81817.1   

Proteomes

UP000007151    UP000037510    UP000053268    UP000053240    UP000218220    UP000283053    + More
UP000005204    UP000235965    UP000027135    UP000092445    UP000069940    UP000249989    UP000078200    UP000183832    UP000030742    UP000019118    UP000037069    UP000095301    UP000000803    UP000008711    UP000002282    UP000192221    UP000001292    UP000000304    UP000007801    UP000268350    UP000078492    UP000008792   

PRIDE

W8VMI8    H9J6M8    Q9W0T5   

Pfam

PF00023   Ank        + More
PF12796   Ank_2
PF00520   Ion_trans

Interpro

IPR020683   Ankyrin_rpt-contain_dom        + More
IPR036770   Ankyrin_rpt-contain_sf       
IPR005821   Ion_trans_dom       
IPR002110   Ankyrin_rpt       

SUPFAM

SSF48403   SSF48403       

Gene 3D

1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

W8VMI8   A0A212FEW5   A0A0L7KRD5   A0A194PG37   A0A194RQ48   A0A2W1BQK8   + More
A0A2A4IZ93   A0A2A4J0Z3   A0A3S2NSL9   H9J6M8   A0A2J7Q265   A0A067QSF9   A0A1B0A764   A0A182GUK9   A0A1A9UH95   A0A1J1J7Z5   U4UZS4   N6T3C1   U4UZM9   A0A0L0BVP7   A0A1I8NAZ6   Q9W0T5-2   A0A0Q5UCQ4   U4UN02   A0A1Y1LNQ8   A0A0R1DTZ0   A0A1W4VP01   A0A0J9UBA1   Q9W0T5   B3NEM1   A0A1W4VP94   B4HVD0   B4PC33   A0A1W4W1C3   B4QKU8   B3M8Z5   A0A3B0JY03   A0A195EG32   B4LS35  

PDB

3J9P     E-value=5.51438e-05,     Score=110

KEGG

101746226    no KO assigned | (RefSeq) BmPyrexia; transient receptor potential channel pyrexia

GO

GO:0016021   GO:0005216   GO:0006811   GO:0048060   GO:0006812   GO:0005261   GO:0051290   GO:0009408   GO:0034703   GO:0006813   GO:0005262   GO:0006816   GO:0016020   GO:0000287   GO:0043874   GO:0003677   GO:0008408   GO:0005112   GO:0015930   GO:0055085  

Subcellular location

Membrane  

Length:

302

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

51.1282000000001

Exp number, first 60 AAs:

22.66232

Total prob of N-in:

0.96590

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  29

outside

30  -  76

TMhelix

77  -  99

inside

100  -  302

 

 

Pi

241.451917

Theta

177.442913

Tajima's D

1.702914

CLR

0.170602

CSRT

0.828208589570521

Interpretation

Uncertain