Gene

KWMTBOMO15231

Pre Gene Modal

BGIBMGA005009

Annotation

putative_ubiquinone_biosynthesis_monooxygenase_COQ6?_partial_[Operophtera_brumata]

Location

Bomo_Chr25(+):7168774-7172836      View in EpiBrowser

Full name

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial      

Alternative Name

Coenzyme Q10 monooxygenase 6

Location in the cell

Extracellular   Reliability : 1.995

CDS

ATGGTTGGCTGCACCTTGGCTTGTGCCTTAGCTAAAAACTCACTATTTTCCACTTTCAAAATATTACTATTGGAAAGCAGCCCTTACAAGCAATTTGAACTGAGAAAAGAATACAGCAATAGAGTTGTGGCACTTAGTCAAAATACCAAATCATTAATGTCATCTTTGAATGTTTGGAAACATATTGAAGATATGAGACTGCAACCTGTAAAACATATGCAAGTTTGGGATGCTTGTTCAGATGCTTTAATATCATTCAACAGTGCCGACAACTACAATGATGATGTTGCCTACATTGTCGAAAATGATGTATTGCTGCACGCTGTCAATACAGAACTAAATAATACAGACAATAAAAACTTTAATATTGTCTATGAAGCAAAGATTGCAGATTATACACTGCCAAATTCTGAAGAAATAAATCCAAAGAGTTTAGTTAAAATGAACAATGGTGACACATATTCATGCCAACTGCTGATTGAAATTAGTATGTTGGATTAG

Protein

MVGCTLACALAKNSLFSTFKILLLESSPYKQFELRKEYSNRVVALSQNTKSLMSSLNVWKHIEDMRLQPVKHMQVWDACSDALISFNSADNYNDDVAYIVENDVLLHAVNTELNNTDNKNFNIVYEAKIADYTLPNSEEINPKSLVKMNNGDTYSCQLLIEISMLD

Description

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Cofactor

FAD

Subunit

Component of a multi-subunit COQ enzyme complex.
Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.

Similarity

Belongs to the UbiH/COQ6 family.

Keywords

Complete proteome   FAD   Flavoprotein   Membrane   Mitochondrion   Mitochondrion inner membrane   Monooxygenase   Oxidoreductase   Reference proteome   Transit peptide   Ubiquinone biosynthesis  

Feature

chain  Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

Uniprot

A0A0L7KQN6   A0A2H1VL88   A0A2W1BIY2   A0A2A4IZL9   A0A194RLF2   A0A212FEZ2   + More
S4P958   A0A194PMK8   A0A026WIJ2   K7JED1   A0A232ESL8   V9IIU2   A0A2A3E8X6   E2C8K8   A0A088A361   A0A154P3J3   A0A3L8D6P3   A0A0N0U755   A0A158NI87   A0A310SI00   A0A195FFJ8   A0A195AWD4   A0A195BY98   A0A0C9R127   A0A1S3IS81   A0A151WR83   A0A0L7QXE3   A0A195EGE9   A0A139WFD9   A0A182FJL6   E2APB4   W5JRB1   A0A182N043   B4JAF7   A0A067QHI4   A0A182R6D5   A0A0P4WEC7   A0A2M3Z7R3   A0A2M3YXK0   A0A182MID6   A0A2M4AN04   A0A2M4BMD5   A0A2M4BMG8   A0A2M4CMM9   E0W075   A0A2M4CV75   A0A182JWI9   V4CJ86   A0A182U5L8   A0A182HIK6   Q0IFQ5   A0A182VIR1   A0A0L8GWX2   A0A2M4CWL9   A0A182TCB2   A0A1I8MBS7   V9KLF4   B4KF33   A0A084WFL1   T1P9T1   A0A182YQW7   B4LU17   A0A182GUK8   A0A1W4UIH1   Q7QER0   A0A2C9H898   A0A182QHV1   A0A1B6EMM7   A0A336KKH4   B4MWC8   A0A1Q3G445   H2VBJ8   U5EJF9   A0A023ETR5   A0A3P9LXR2   A0A3Q2EKU4   H3DJ31   A0A3P9KCV8   Q4RLY4   A0A3Q3VJP4   A0A2J7Q269   A0A3Q1ECR3   A0A3Q1GWD2   A0A1Y1KQA6   B5X2C0   A0A1B6KZM5   A0A3B5JZF5   A0A1S2ZMU0   A0A1I8Q2L8   A0A182PFC6   A0A3Q3ESC1   A0A2D0RRD1   A0A3Q1C556   A0A3Q0RFW6   B3N4W9   Q9VMQ5   A0A1B0FH47   D3TNK7   A0A1A9UQZ6  

EC Number

1.14.13.-

Pubmed

26227816    28756777    26354079    22118469    23622113    24508170    + More
20075255    28648823    20798317    30249741    21347285    18362917    19820115    20920257    23761445    17994087    24845553    20566863    23254933    17510324    25315136    24402279    24438588    25244985    26483478    12364791    14747013    17210077    21551351    24945155    17554307    15496914    28004739    20433749    10731132    12537572    12537569    20353571   

EMBL

JTDY01006890    KOB65613.1    ODYU01003165    SOQ41566.1    KZ150014    PZC75019.1    + More
NWSH01004460    PCG65079.1    KQ460045    KPJ18145.1    AGBW02008891    OWR52288.1    GAIX01005666    JAA86894.1    KQ459604    KPI92350.1    KK107185    EZA55835.1    AAZX01007490    NNAY01002421    OXU21307.1    JR047411    AEY60411.1    KZ288322    PBC28175.1    GL453666    EFN75738.1    KQ434809    KZC06392.1    QOIP01000012    RLU15929.1    KQ435719    KOX78758.1    ADTU01016098    KQ761039    OAD58343.1    KQ981636    KYN38799.1    KQ976725    KYM76558.1    KQ978501    KYM93567.1    GBYB01009844    JAG79611.1    KQ982813    KYQ50311.1    KQ414704    KOC63288.1    KQ978957    KYN27226.1    KQ971353    KYB26591.1    GL441504    EFN64713.1    ADMH02000338    ETN66912.1    CH916368    EDW03828.1    KK853628    KDR03814.1    GDRN01069811    JAI63990.1    GGFM01003794    MBW24545.1    GGFM01000242    MBW20993.1    AXCM01004049    GGFK01008854    MBW42175.1    GGFJ01005013    MBW54154.1    GGFJ01005012    MBW54153.1    GGFL01001970    MBW66148.1    AAZO01006645    DS235857    EEB19031.1    GGFL01005069    MBW69247.1    KB200294    ESP02270.1    APCN01003993    CH477294    EAT44481.1    KQ420065    KOF81417.1    GGFL01005070    MBW69248.1    JW866370    AFO98887.1    CH933807    EDW13016.1    ATLV01023372    KE525342    KFB49005.1    KA645511    AFP60140.1    CH940649    EDW65070.1    JXUM01089328    KQ563763    KXJ73351.1    AAAB01008846    EAA06342.5    AXCN02002023    GECZ01030618    JAS39151.1    UFQS01000499    UFQT01000499    SSX04418.1    SSX24782.1    CH963857    EDW75998.1    GFDL01000474    JAV34571.1    GANO01002249    JAB57622.1    GAPW01001789    JAC11809.1    CAAE01015019    CAG10598.1    NEVH01019373    PNF22683.1    GEZM01079905    GEZM01079904    JAV62350.1    BT045189    ACI33451.1    GEBQ01023075    JAT16902.1    CH954177    EDV57871.1    AE014134    AY058443    CCAG010021907    EZ423009    ADD19285.1   

Proteomes

UP000037510    UP000218220    UP000053240    UP000007151    UP000053268    UP000053097    + More
UP000002358    UP000215335    UP000242457    UP000008237    UP000005203    UP000076502    UP000279307    UP000053105    UP000005205    UP000078541    UP000078540    UP000078542    UP000085678    UP000075809    UP000053825    UP000078492    UP000007266    UP000069272    UP000000311    UP000000673    UP000075884    UP000001070    UP000027135    UP000075900    UP000075883    UP000009046    UP000075881    UP000030746    UP000075902    UP000075840    UP000008820    UP000075903    UP000053454    UP000075901    UP000095301    UP000009192    UP000030765    UP000076408    UP000008792    UP000069940    UP000249989    UP000192221    UP000007062    UP000076407    UP000075886    UP000007798    UP000005226    UP000265180    UP000265020    UP000007303    UP000261620    UP000235965    UP000257200    UP000265040    UP000087266    UP000079721    UP000095300    UP000075885    UP000264800    UP000221080    UP000257160    UP000261340    UP000008711    UP000000803    UP000092444    UP000078200   

PRIDE

Q9VMQ5   

Pfam

PF01494   FAD_binding_3        + More
PF03109   ABC1

Interpro

IPR036188   FAD/NAD-bd_sf        + More
IPR000689   UbQ_mOase_COQ6       
IPR018168   Ubi_Hdrlase_CS       
IPR002938   FAD-bd       
IPR010971   UbiH/COQ6       
IPR000719   Prot_kinase_dom       
IPR004147   UbiB_dom       
IPR011009   Kinase-like_dom_sf       

SUPFAM

SSF51905   SSF51905        + More
SSF56112   SSF56112       

Gene 3D

3.50.50.60    

ProteinModelPortal

A0A0L7KQN6   A0A2H1VL88   A0A2W1BIY2   A0A2A4IZL9   A0A194RLF2   A0A212FEZ2   + More
S4P958   A0A194PMK8   A0A026WIJ2   K7JED1   A0A232ESL8   V9IIU2   A0A2A3E8X6   E2C8K8   A0A088A361   A0A154P3J3   A0A3L8D6P3   A0A0N0U755   A0A158NI87   A0A310SI00   A0A195FFJ8   A0A195AWD4   A0A195BY98   A0A0C9R127   A0A1S3IS81   A0A151WR83   A0A0L7QXE3   A0A195EGE9   A0A139WFD9   A0A182FJL6   E2APB4   W5JRB1   A0A182N043   B4JAF7   A0A067QHI4   A0A182R6D5   A0A0P4WEC7   A0A2M3Z7R3   A0A2M3YXK0   A0A182MID6   A0A2M4AN04   A0A2M4BMD5   A0A2M4BMG8   A0A2M4CMM9   E0W075   A0A2M4CV75   A0A182JWI9   V4CJ86   A0A182U5L8   A0A182HIK6   Q0IFQ5   A0A182VIR1   A0A0L8GWX2   A0A2M4CWL9   A0A182TCB2   A0A1I8MBS7   V9KLF4   B4KF33   A0A084WFL1   T1P9T1   A0A182YQW7   B4LU17   A0A182GUK8   A0A1W4UIH1   Q7QER0   A0A2C9H898   A0A182QHV1   A0A1B6EMM7   A0A336KKH4   B4MWC8   A0A1Q3G445   H2VBJ8   U5EJF9   A0A023ETR5   A0A3P9LXR2   A0A3Q2EKU4   H3DJ31   A0A3P9KCV8   Q4RLY4   A0A3Q3VJP4   A0A2J7Q269   A0A3Q1ECR3   A0A3Q1GWD2   A0A1Y1KQA6   B5X2C0   A0A1B6KZM5   A0A3B5JZF5   A0A1S2ZMU0   A0A1I8Q2L8   A0A182PFC6   A0A3Q3ESC1   A0A2D0RRD1   A0A3Q1C556   A0A3Q0RFW6   B3N4W9   Q9VMQ5   A0A1B0FH47   D3TNK7   A0A1A9UQZ6  

PDB

4N9X     E-value=1.07632e-08,     Score=138

KEGG

101746083    K06126 ubiquinone biosynthesis monooxygenase Coq6 [EC:1.14.13.-] | (RefSeq) ubiquinone biosynthesis

GO

GO:0004497   GO:0031314   GO:0071949   GO:0006744   GO:0016709   GO:0016712   GO:0016491   GO:0005739   GO:0004672   GO:0005524   GO:0005794   GO:0042995   GO:0016021   GO:0006508   GO:0046873   GO:0000287   GO:0043874   GO:0016020   GO:0003677   GO:0008408   GO:0005112   GO:0015930  

Subcellular location

Mitochondrion inner membrane  
Golgi apparatus   Localizes to cell processes and Golgi apparatus in podocytes.   With evidence from 1 publications.
Cell projection   Localizes to cell processes and Golgi apparatus in podocytes.   With evidence from 1 publications.

Length:

166

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05208

Exp number, first 60 AAs:

0.05208

Total prob of N-in:

0.07762

outside

1  -  166

 

 

Pi

190.263006

Theta

167.157883

Tajima's D

0.44389

CLR

0

CSRT

0.502774861256937

Interpretation

Uncertain