Gene

KWMTBOMO15224  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA005173

Annotation

BzArgOEtase_precursor_[Bombyx_mori]

Location

Bomo_Chr25(-):7119011-7129623      View in EpiBrowser

Full name

CLIP domain-containing serine protease 2       + More
Serine protease easter      
Eukaryotic translation initiation factor 3 subunit D      

Alternative Name

BzArgOEtase
Eukaryotic translation initiation factor 3 subunit 7

Location in the cell

Extracellular   Reliability : 2.8

CDS

ATGAGAATCCCGTTCGAGAAGATACGAATCATCAGCTGTATACTTGTGGTCGTGTCGTCCAATGTAGTCGGACAGAAATGCAACGGCGGTGCCAACTGTATACCTTTAGAAGAATGCACAGACTTGTTCCAGCAACTAAAACAAGGAAATTCGCCTCAGTTAACGAGGTTGCTGCGAGGCCTTCATTGTGGCTTCGAAGATTTGAATTCCCCAAAGATTTGCTGCCCGCCAGAATTCTTGGCACGGAGGAGTGCTTTCAGCAGTGCCGGCACTAACTCGAATCCTACGTCAATATTACCGAACGAAAAAGTCTGTGGTATCCAAAATAATGACAGAATATTTGGAGGTATACAAACTGAAATCGACGAGCATCCGTGGATGGCGTTATTGAGATACGATAAACCTCTTGGCTGGGGTTTCTACTGCGGAGGTGTGCTGATCGCCCCGATGTACGTTTTGACTGCCGCACACTGCGTCAAGGGATCGGATCTACCTTCGAGCTGGCAATTATCACAGGTTCGATTGGGCGAATGGAACACGTCTACCGAGACGGACTGCGTGGAGGGCGACTGTAGCGGCCCCGTCCAGGATATACCCGTACAACAAATAATTGCACATGAAAATTATGATCCAAACGACAAAGACCAGCAGAACGATATTGCCCTCTTGAGACTCTCAAGGAATGCGCAGTTCAATGATTTCGTAAGTCCCATTTGCCTACCGACAAGCAACGAGTTGAGGCAGAATGAATTTGAAAGTGACTATATGGAAGTAGCCGGATGGGGAAAAACTGAAACACGATCCGAATCTGATGTGAAACTAAAGGTTCGAGTGCCTATAGTGAACAGAGAGGAGTGTGCTAACGTATATAGCAACGTGGATCGGCGCGTGACTAATAAACAAATATGCGCTGGCGGCTTGGCGGGCAGAGACTCCTGCCGAGGAGACTCAGGAGGCGCGCTAATGGGCCAATCGCCTAAGGCCAATAATTGGTACGTTTTCGGGGTGGTTTCCTACGGACCTTCGCCCTGTGGCACCGAAGGCTGGCCAGGTGTCTACACCAGAGTCGGATCTTTTATGGATTGGATTCTTTCCAAACTCGAACAGTAA

Protein

MRIPFEKIRIISCILVVVSSNVVGQKCNGGANCIPLEECTDLFQQLKQGNSPQLTRLLRGLHCGFEDLNSPKICCPPEFLARRSAFSSAGTNSNPTSILPNEKVCGIQNNDRIFGGIQTEIDEHPWMALLRYDKPLGWGFYCGGVLIAPMYVLTAAHCVKGSDLPSSWQLSQVRLGEWNTSTETDCVEGDCSGPVQDIPVQQIIAHENYDPNDKDQQNDIALLRLSRNAQFNDFVSPICLPTSNELRQNEFESDYMEVAGWGKTETRSESDVKLKVRVPIVNREECANVYSNVDRRVTNKQICAGGLAGRDSCRGDSGGALMGQSPKANNWYVFGVVSYGPSPCGTEGWPGVYTRVGSFMDWILSKLEQ

Description

Endopeptidase with selective post-Arg cleavage site (PubMed:16399077, PubMed:7737188). Might play a role in innate immunity in response to fungal and Gram-positive bacterial infections (PubMed:16399077).
Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo (PubMed:9477324, PubMed:2107028, PubMed:12493753). Three proteases; ndl, gd and snk process easter to create active easter (PubMed:9477324). Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo (PubMed:9477324).
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

Subunit

In the active form, heterodimer of a light chain and a heavy chain; disulfide-linked.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.

Similarity

Belongs to the peptidase S1 family. CLIP subfamily.
Belongs to the peptidase S1 family.
Belongs to the eIF-3 subunit D family.

Keywords

Calcium   Cleavage on pair of basic residues   Complete proteome   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Metal-binding   Protease   Reference proteome   Secreted   Serine protease   Signal   Zymogen   Developmental protein  

Feature

chain  CLIP domain-containing serine protease 2 light chain
propeptide  Activation peptide

Uniprot

Q2VG86   Q5MPC6   A0A290U621   A0A2H1VCQ7   A0A2A4IX69   A0A2A4IVR3   + More
A0A212F949   I4DND8   A0A194RQ53   S4PKY1   A0A1W4XI92   A0A336LMT0   B1B5K1   A0A1Y1L107   D6WUF6   A0A1Y1KZL1   N6TWW7   J3JYT9   U4U606   A0A212ER24   A0A1J1J5N3   K7J980   A0A0C9QZC0   A0A1Q3FHX1   A0A182G580   E2C8L2   A0A023EQV6   A0A2M4AVL9   Q17B76   T1DQ97   A0A182G5Z0   W5J726   B0WQE7   A0A1Y1K3W7   A0A1I8N439   A0A1B0DG63   A0A1A9UVH0   A0A0J7NWE6   B4JV72   A0A1A9ZZ96   A0A1W4VIJ6   A0A034V0K7   A0A182WQM1   A0A084WTM6   A0A182JMK2   A0A182IIR9   A0A0K8VF53   B4QYJ5   A0A182SX76   A0A154P5I7   B3P0U7   P13582   B4HDX9   A0A023EPR7   B4PS51   B4LYW9   A0A182R142   A0A1B0CC54   Q7QB73   W8BBZ8   A0A195C079   A0A195EG37   A0A0A1WU83   B4N7Z2   B3MSM9   A0A2C9GW66   A0A2A3EA55   B4K8U6   A0A182MC19   A0A0L0CQ15   A0A0K8WKM9   A0A034VLF9   A0A1L8DQG0   A0A1L8DQR9   A0A0K8U524   A0A0K8VUA4   A0A182FPJ1   A0A151WR74   E2AV85   A0A0A1X7H3   A0A088A359   A0A026WIN7   A0A1A9WYR0   A0A2Y9D4S9   A0A2M4BS32   Q299G4   B4G551   A0A182JPR1   A0A1A9YT44   D6WUF7   A0A0M9A7E2   D3TMC5   A0A195FEH3   A0A2M4BS51   A0A1B0FFU3   A0A1A9UFJ1   A0A182S527   F4WPR9   A0A2Y9D4R4   A0A2M4BS19  

EC Number

3.4.21.-

Pubmed

16399077    19121390    7737188    15944088    28756777    28953952    + More
22118469    22651552    26354079    23622113    18195005    28004739    18362917    19820115    23537049    22516182    20075255    26483478    20798317    24945155    17510324    20920257    23761445    25315136    17994087    25348373    24438588    2492450    10731132    12537572    9477324    9533958    2107028    12493753    17550304    12364791    14747013    17210077    24495485    25830018    26108605    24508170    15632085    20353571    21719571   

EMBL

AB035418    AY061936    DQ157441    BABH01019990    AAL31707.1    ABB58762.1    + More
BAE73254.1    AY672784    AAV91006.1    KY680242    KZ150014    ATD13323.1    PZC75014.1    ODYU01001850    SOQ38623.1    NWSH01005677    PCG64066.1    PCG64067.1    AGBW02009640    OWR50264.1    AK402861    KQ459604    BAM19428.1    KPI92345.1    KQ460045    KPJ18151.1    GAIX01004295    JAA88265.1    UFQT01000091    SSX19534.1    AB363980    BAG14262.2    GEZM01073843    JAV64787.1    KQ971352    EFA07558.1    GEZM01073844    JAV64786.1    APGK01057809    KB741282    ENN70807.1    BT128420    AEE63377.1    KB631684    ERL85365.1    AGBW02013167    OWR43919.1    CVRI01000070    CRL07282.1    AAZX01002213    GBYB01001065    JAG70832.1    GFDL01007911    JAV27134.1    JXUM01042955    JXUM01042956    KQ561344    KXJ78893.1    GL453666    EFN75742.1    GAPW01002093    JAC11505.1    GGFK01011500    MBW44821.1    CH477325    EAT43491.1    GAMD01001290    JAB00301.1    JXUM01044209    JXUM01044210    KQ561391    KXJ78725.1    ADMH02002100    ETN59198.1    DS232039    EDS32818.1    GEZM01097973    JAV54026.1    AJVK01059305    LBMM01001207    KMQ96720.1    CH916374    EDV91392.1    GAKP01022176    JAC36776.1    ATLV01026902    KE525420    KFB53570.1    APCN01002556    GDHF01015149    JAI37165.1    CM000364    EDX12840.1    KQ434809    KZC06390.1    CH954181    EDV48995.1    J03154    AE014297    BT009978    CH480815    EDW42071.1    GAPW01002593    JAC11005.1    CM000160    EDW97471.1    CH940650    EDW68072.2    AXCN02001158    AJWK01006155    AJWK01006156    AAAB01008880    EAA08507.4    GAMC01007780    JAB98775.1    KQ978501    KYM93571.1    KQ978957    KYN27230.1    GBXI01012101    JAD02191.1    CH964232    EDW81243.1    CH902623    EDV30269.1    AXCN02000165    KZ288322    PBC28172.1    CH933806    EDW15515.2    AXCM01000330    JRES01000065    KNC34443.1    GDHF01000894    JAI51420.1    GAKP01015995    JAC42957.1    GFDF01005388    JAV08696.1    GFDF01005389    JAV08695.1    GDHF01030580    JAI21734.1    GDHF01009855    JAI42459.1    KQ982813    KYQ50307.1    GL443059    EFN62639.1    GBXI01007200    JAD07092.1    KK107185    EZA55838.1    GGFJ01006673    MBW55814.1    CM000070    EAL27739.2    CH479179    EDW24717.1    EFA07559.2    KQ435719    KOX78755.1    EZ422577    ADD18853.1    KQ981636    KYN38803.1    GGFJ01006672    MBW55813.1    CCAG010004727    GL888255    EGI63810.1    GGFJ01006671    MBW55812.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000192223    + More
UP000007266    UP000019118    UP000030742    UP000183832    UP000002358    UP000069940    UP000249989    UP000008237    UP000008820    UP000000673    UP000002320    UP000095301    UP000092462    UP000078200    UP000036403    UP000001070    UP000092445    UP000192221    UP000075920    UP000030765    UP000075880    UP000075840    UP000000304    UP000075901    UP000076502    UP000008711    UP000000803    UP000001292    UP000002282    UP000008792    UP000075886    UP000092461    UP000007062    UP000078542    UP000078492    UP000007798    UP000007801    UP000242457    UP000009192    UP000075883    UP000037069    UP000069272    UP000075809    UP000000311    UP000005203    UP000053097    UP000091820    UP000095300    UP000001819    UP000008744    UP000075881    UP000092443    UP000053105    UP000078541    UP000092444    UP000075900    UP000007755   

PRIDE

Q2VG86    P13582   

Pfam

PF00089   Trypsin        + More
PF12032   CLIP
PF13019   Sde2_N_Ubi
PF05091   eIF-3_zeta

Interpro

IPR022700   CLIP        + More
IPR033116   TRYPSIN_SER       
IPR038565   CLIP_sf       
IPR001314   Peptidase_S1A       
IPR009003   Peptidase_S1_PA       
IPR018114   TRYPSIN_HIS       
IPR001254   Trypsin_dom       
IPR029071   Ubiquitin-like_domsf       
IPR024974   Sde2_N       
IPR007783   eIF3d       

SUPFAM

SSF50494   SSF50494        + More
SSF54236   SSF54236       

Gene 3D

2.20.20.90    

CDD

cd00190  Tryp_SPc

ProteinModelPortal

Q2VG86   Q5MPC6   A0A290U621   A0A2H1VCQ7   A0A2A4IX69   A0A2A4IVR3   + More
A0A212F949   I4DND8   A0A194RQ53   S4PKY1   A0A1W4XI92   A0A336LMT0   B1B5K1   A0A1Y1L107   D6WUF6   A0A1Y1KZL1   N6TWW7   J3JYT9   U4U606   A0A212ER24   A0A1J1J5N3   K7J980   A0A0C9QZC0   A0A1Q3FHX1   A0A182G580   E2C8L2   A0A023EQV6   A0A2M4AVL9   Q17B76   T1DQ97   A0A182G5Z0   W5J726   B0WQE7   A0A1Y1K3W7   A0A1I8N439   A0A1B0DG63   A0A1A9UVH0   A0A0J7NWE6   B4JV72   A0A1A9ZZ96   A0A1W4VIJ6   A0A034V0K7   A0A182WQM1   A0A084WTM6   A0A182JMK2   A0A182IIR9   A0A0K8VF53   B4QYJ5   A0A182SX76   A0A154P5I7   B3P0U7   P13582   B4HDX9   A0A023EPR7   B4PS51   B4LYW9   A0A182R142   A0A1B0CC54   Q7QB73   W8BBZ8   A0A195C079   A0A195EG37   A0A0A1WU83   B4N7Z2   B3MSM9   A0A2C9GW66   A0A2A3EA55   B4K8U6   A0A182MC19   A0A0L0CQ15   A0A0K8WKM9   A0A034VLF9   A0A1L8DQG0   A0A1L8DQR9   A0A0K8U524   A0A0K8VUA4   A0A182FPJ1   A0A151WR74   E2AV85   A0A0A1X7H3   A0A088A359   A0A026WIN7   A0A1A9WYR0   A0A2Y9D4S9   A0A2M4BS32   Q299G4   B4G551   A0A182JPR1   A0A1A9YT44   D6WUF7   A0A0M9A7E2   D3TMC5   A0A195FEH3   A0A2M4BS51   A0A1B0FFU3   A0A1A9UFJ1   A0A182S527   F4WPR9   A0A2Y9D4R4   A0A2M4BS19  

PDB

2OLG     E-value=1.82102e-55,     Score=546

KEGG

692384    no KO assigned | (RefSeq) BAEE, BmCLIP2, CLIP2, PPAE-3, pro-BAEEase; BzArgOEtase

GO

GO:0004175   GO:0005576   GO:0004252   GO:0046872   GO:0005615   GO:0006508   GO:0016021   GO:0009950   GO:0007370   GO:0045752   GO:0009953   GO:0007311   GO:0098595   GO:0008063   GO:0001732   GO:0003743   GO:0005852   GO:0016282   GO:0002191   GO:0098808   GO:0033290   GO:0046873   GO:0000287   GO:0043874   GO:0016020   GO:0003677   GO:0008408   GO:0005112   GO:0015930  

PANTHER

PTHR12399  

Subcellular location

Secreted   Secreted in the hemolymph.   With evidence from 6 publications.
Cytoplasm  

SignalP

Position:   1 - 24,         Likelihood:  0.900765

 

 

Length:

369

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

13.50531

Exp number, first 60 AAs:

0.05926

Total prob of N-in:

0.54643

outside

1  -  369

 

 

Pi

219.951741

Theta

169.724079

Tajima's D

0.99526

CLR

0.000995

CSRT

0.657667116644168

Interpretation

Uncertain