Gene

KWMTBOMO15207  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004963

Annotation

PREDICTED:_intron-binding_protein_aquarius_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr25(-):6751728-6791498      View in EpiBrowser

Full name

RNA helicase aquarius      

Location in the cell

Cytoplasmic   Reliability : 1.469 Mitochondrial   Reliability : 1.194 Nuclear   Reliability : 1.61

CDS

ATGCTGAAGTTTTACGCAAGATTTGAGATTAGCGATCAGACCGGAGATCCTATGACCGACCGTGACATGACATTACAGCACTACTCAAAAATCACCTCACTACAGAAAGCCGCATTTTCCAAGTTTCCTGATCTTCGTTTATTTGCCCTCGCGAATGTAGCGAGTGTCGACACCAGAGAAACGTTGCAGAAGCACTTCAAGAATTTGAGTGACAAAGCTTTAAGAGCAATCGCCACGTACCTGAACCTGGTTCCTCCTGAAGGAAAAGAAGACGAGACGCCTTGGCACCGACTCGACAAAGATTTCCTCAGAGAGCTATTGATCTCGCGTCACGAGAGGCGAATTTCACAATTGGAAGAATTGAACTTAATGCCCCTGTATCCTACAGAAGAGATTATCTGGGACGAGAATGTAGTGCCCACAGAGATATACAGCGGAGAGAATTGCCTAGCCCTGCCTAAGCTGAATCTACAATTTTTAACATTACACGACTATCTGTTACGAAACTTCAATTTGTTCCGCTTGGAGAGCACATACGAGATAAGACAAGACATTGAAGACGCCGTATACAGATTGGCGCCGTGGAATTCAGAAGACGGAAGCGTTTATTTTGGGGGCTGGGCGCGGATGGCGCATCCTATAAAGAGCTTCGCAGTTGTCGAAGTGGCCAAACCGAACATCGGCGAGAAGGCCCCGTCGAGGGTCCGAGCCGATGTCACCGTCACGTTGAGCCTCAGAAACGAGATAAAACACGAATGGGAAAACCTCAGGAAGCATGACGTTTGCTTCCTGGTAACCGTCAGACCTACACAAGGCATAGGTACAAAGTATGACTACAGAAAGAGTATGGTGGATCAGGCGGGGATAGTGTACGTGAGGGGTTGCGAAGTTGAAGGTATGCTGGACGCATCCGGCAGAGTCATTGAGGACGGGCCGGAACCGCGGCCGGAGTTAGAGGGAGATTCCAGGACCTTCAGGCTCTTACTCGATCCTAACCAATACAGACTTGACTTGGACAGAGCTAGTAAAGGGAATGAGGACGTGTACGAGACTTTCAATATAGTTATGCGTCGTAAACCGAAAGAGAACAACTTCAAGGCCGTATTGGAAACGATACGAGAATTAATGAACACCGAATGCGTTGTACCGGACTGGCTTCACGATATAGTCTTGGGCTACGGAGATCCCGGTCAAGCTCATTACACGAGGATGCCGAACGAGATAGCTACTCTGGACTTCAACGATACATTCCTGAACATGGATCATCTGCGGAACAGCTTCCCGGGGTACGAAATCAAGGTGCAGACCAACGACCCAAGGAAGCTCGTCAGGCCGTTCAAGTTGACTTTCGAAAACGTCGTACGGAAGCAGCAGGTCGGGGACGCAGCTATGGACGAAGACGAACCCCGCAAAGCGATCATTGTCGAACCCCACGTACAACCGAAGAGGGGACCGTATTTGTACAACGAACCAAAGAAGAATAATATACTATTCACTCCGACACAAGTGGAAGCTATACGTTCTGGAATGCAACCTGGACTCACATTGGTCGTCGGTCCACCTGGAACTGGTAAAACGGACGTGGCAGTTCAAATAATTTCGAACATATACCACAACTTCCCGTGGCAACGTACCCTGGTCGTAACGCACAGCAACCAGGCCCTGAATCAGCTATTCGAGAAGGTCGCCGAGCTGGATGTAGACGAAAGGCATCTACTGCGTCTCGGTCACGGCGAGGAAGCTCTTCAGACAGACAAAGACTTCTCCAGATACGGCCGCGTGAACTATGTGTTGGCAAAGCGTCTGGAGCTGCTCGAGCTGGTGTCGCGGCTGCAGCGAACGTTGGACGCGGGCTCGGACGCCGGCGCTACGTGCGAGCTGGCGCACCACTTCCACGTCTACCACGTGCGGCCGCGCTGGCGAGCCTTCCTCGAGAACTGCCAGCAACAGACAAACTCGATTGAGATAGTCAGCAAGGAGTTTCCGTTCCACGAATTCTTCGATGATGCCCCGAAACCCTTGTTCCTGAGGAAGTCTCACGAAGAGGACATGGAAATAGCCAAAAGCTGTTACAGGTATATTGATCACATATTCGAGGAATTGGAAGAGTTCCGAGCCTTCGAACTACTGAGGTCCGGACTGGATCGGTCCAAGTACCTGTTGGTCAAAGAAGCGAAAATAATCGCGATGACGTGCACGCACGCCGCCCTCAAACGTTCCGAATTAGTGCAAATGGGTTTCAAATACGACAACATACTGATGGAGGAATCAGCTCAAATCCTCGAGATCGAGACGTTCATACCGCTGCTCCTGCAGAACCCGCAGGACGGCAGGTCCCGGCTGAAGCGTTGGATCATGATCGGCGACCACCACCAGCTGCCCCCGGTCGTCAAGAACATGGCGTTCCAGAAGTACTGCAACATGGAACAGAGCCTGTTCACCAGAATGGTCAGACTGGGTGTTCCGTACGTGGAACTGGACGCACAAGGTCGAGCTAGACCCAGCATCTGCAACCTGTACCGCTGGCGCTACCGGGCGCTGGGCGACCTGTGCCACGTGACGCAGCTCCCGGAGTACCGCGCCGCCAACGCGGGCCTGCGACACGACTTCCAGCTCGTCAACGTGGACGACTTCAACGGCGTCGGCGAGACCGAGCCCAGCCCTTACTTCTATCAGAATTTAGCGGAAGCAGAATACGTTGTAGCGGTTTTCATGTACATGCGCCTGATCGGATGGCCTGCAGAGCGCATCTCCATACTGACCACATATAACGGGCAGAAACATCTCATCAGGGACGTCATAGATAAGCGATGTGCCGATAATCCACTCATCGGTCGACCTCACAAGGTGACGACGGTAGACAAGTACCAGGGCCAGCAGAACGACATAGCTCTAGTGTCGCTGGTCCGTACGAAGGCGGTGGGTCACGTGCGCGACCTGCGGAGACTCATCGTCGCCGCCTCAAGAGCCCGTCTCGGCCTATACATATTCGCGAGGGCCAACCTCTTCAGGAACTGCTACGAGCTACAGCCTACATTCAATCAGCTCGTGGAGCGTCCACTGCAGCTTGAACTAGTCCCGGGCGAGCGGTACCCGGCGCAGCGCGCGGCGGGCGTGGCCGTGCCGCCGGAGCTGCTGCTGTCCGTCCGGGACATGCCGCACATGGCGCGCTACGTCTACGACATGTACCTGCACATTGTCAACGACGCACCCGACGCTCGACAGAGTGAATAG

Protein

MLKFYARFEISDQTGDPMTDRDMTLQHYSKITSLQKAAFSKFPDLRLFALANVASVDTRETLQKHFKNLSDKALRAIATYLNLVPPEGKEDETPWHRLDKDFLRELLISRHERRISQLEELNLMPLYPTEEIIWDENVVPTEIYSGENCLALPKLNLQFLTLHDYLLRNFNLFRLESTYEIRQDIEDAVYRLAPWNSEDGSVYFGGWARMAHPIKSFAVVEVAKPNIGEKAPSRVRADVTVTLSLRNEIKHEWENLRKHDVCFLVTVRPTQGIGTKYDYRKSMVDQAGIVYVRGCEVEGMLDASGRVIEDGPEPRPELEGDSRTFRLLLDPNQYRLDLDRASKGNEDVYETFNIVMRRKPKENNFKAVLETIRELMNTECVVPDWLHDIVLGYGDPGQAHYTRMPNEIATLDFNDTFLNMDHLRNSFPGYEIKVQTNDPRKLVRPFKLTFENVVRKQQVGDAAMDEDEPRKAIIVEPHVQPKRGPYLYNEPKKNNILFTPTQVEAIRSGMQPGLTLVVGPPGTGKTDVAVQIISNIYHNFPWQRTLVVTHSNQALNQLFEKVAELDVDERHLLRLGHGEEALQTDKDFSRYGRVNYVLAKRLELLELVSRLQRTLDAGSDAGATCELAHHFHVYHVRPRWRAFLENCQQQTNSIEIVSKEFPFHEFFDDAPKPLFLRKSHEEDMEIAKSCYRYIDHIFEELEEFRAFELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRSELVQMGFKYDNILMEESAQILEIETFIPLLLQNPQDGRSRLKRWIMIGDHHQLPPVVKNMAFQKYCNMEQSLFTRMVRLGVPYVELDAQGRARPSICNLYRWRYRALGDLCHVTQLPEYRAANAGLRHDFQLVNVDDFNGVGETEPSPYFYQNLAEAEYVVAVFMYMRLIGWPAERISILTTYNGQKHLIRDVIDKRCADNPLIGRPHKVTTVDKYQGQQNDIALVSLVRTKAVGHVRDLRRLIVAASRARLGLYIFARANLFRNCYELQPTFNQLVERPLQLELVPGERYPAQRAAGVAVPPELLLSVRDMPHMARYVYDMYLHIVNDAPDARQSE

Description

Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.

Subunit

Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.

Similarity

Belongs to the CWF11 family.

Uniprot

H9J622   A0A2A4JLC6   A0A194PHX3   A0A194RLH7   A0A2W1BNZ4   A0A2J7PR08   + More
A0A067R9P9   A0A232EXP4   K7IQG0   A0A087ZT71   A0A2A3EDJ5   A0A0M9A6N3   E2BAW2   A0A0L7QMC6   A0A0C9QLK7   A0A158NCM0   A0A151X614   F4WFE7   A0A195F9R1   A0A195EMU4   A0A195BXI1   E2AK68   E0VSM8   E9IMC2   A0A0J7KW62   A0A1W4XP01   A0A026WA84   A0A3L8DKL5   A0A154PHF7   A0A139WFX9   A0A195CQN9   A0A1B6KBV0   A0A1S4G0D7   A0A1Y1LXY0   Q16IB0   A0A0P6J137   A0A182G802   A0A034VGH3   A0A182LS08   A0A0K8VLN3   A0A182P429   A0A0A1WJY7   A0A182QEI5   A0A182VWZ5   A0A2M4A8F1   A0A2M4A9Q0   A0A182YG12   A0A2M4A8E8   A0A0L0CC12   B0W925   A0A182RFJ9   A0A182FA37   A0A182SJS1   A0A182NDY0   W5JKE2   A0A087Z6K8   A0A2M4CVB5   A0A182K5H0   A0A182U8A4   A0A182I870   W8AM97   F5HM53   A0A384D0C3   A0A3Q7UI82   A0A3Q2H0V9   L5K2K4   A0A286ZI68   A0A182XKI2   A0A2Y9HN94   A0A2K6S0F9   Q7Q257   A0A0N8ETY7   D2H7R7   W5QFI2   A0A2R9AK31   A0A096NTB7   A0A2K6RM46   M3WK08   F7H585   A0A091DR01   A0A096NTB5   A0A2U3XFX8   A0A2U3WJR2   A0A2K6S0G9   A0A3Q0D6E4   A0A2K5URQ7   L8IU75   A0A2K6AGR0   A0A0D9R489   A0A3Q7T2L7   A5D7E4   H9ZFS7   H3AVK7   A0A2U4BC65   A0A2R9AEP9   A0A2R9ADM6   A0A2K5NC12   A0A2J8JB32   A0A3Q7SDH2   A0A2K5KC27  

Pubmed

19121390    26354079    28756777    24845553    28648823    20075255    + More
20798317    21347285    21719571    20566863    21282665    24508170    30249741    18362917    19820115    17510324    28004739    26999592    26483478    25348373    25830018    25244985    26108605    20920257    24495485    12364791    14747013    17210077    24813606    19892987    23258410    20010809    20809919    22722832    25362486    17975172    22751099    25319552    9215903   

EMBL

BABH01029882    BABH01029883    BABH01029884    BABH01029885    NWSH01001119    PCG72508.1    + More
KQ459604    KPI92324.1    KQ460045    KPJ18170.1    KZ150014    PZC74997.1    NEVH01022633    PNF18773.1    KK852653    KDR19357.1    NNAY01001737    OXU23077.1    KZ288292    PBC29091.1    KQ435736    KOX77023.1    GL446861    EFN87169.1    KQ414894    KOC59704.1    GBYB01001520    GBYB01001521    GBYB01001522    GBYB01001523    GBYB01007951    GBYB01011553    JAG71287.1    JAG71288.1    JAG71289.1    JAG71290.1    JAG77718.1    JAG81320.1    ADTU01011962    ADTU01011963    ADTU01011964    KQ982490    KYQ55807.1    GL888115    EGI67198.1    KQ981727    KYN36952.1    KQ978691    KYN29222.1    KQ976396    KYM93005.1    GL440194    EFN66172.1    AAZO01005147    DS235751    EEB16384.1    GL764129    EFZ18539.1    LBMM01002673    KMQ94494.1    KK107364    EZA51939.1    QOIP01000007    RLU20378.1    KQ434905    KZC11291.1    KQ971351    KYB26824.1    KQ977408    KYN02960.1    GEBQ01031049    JAT08928.1    GEZM01046474    JAV77210.1    CH478091    EAT33999.1    GDUN01000236    JAN95683.1    JXUM01047201    KQ561510    KXJ78338.1    GAKP01018067    JAC40885.1    AXCM01002744    GDHF01012829    JAI39485.1    GBXI01015291    JAC99000.1    AXCN02002211    GGFK01003762    MBW37083.1    GGFK01004202    MBW37523.1    GGFK01003689    MBW37010.1    JRES01000630    KNC29790.1    DS231861    EDS39463.1    ADMH02001261    ETN63350.1    GGFL01004600    MBW68778.1    APCN01002659    GAMC01016635    JAB89920.1    AAAB01008978    EGK97364.1    KB031042    ELK05567.1    AEMK02000004    EAA13627.5    GEBF01003067    JAO00566.1    GL192565    EFB17996.1    AMGL01102452    AMGL01102453    AMGL01102454    AJFE02038412    AJFE02038413    AJFE02038414    AJFE02038415    AJFE02038416    AJFE02038417    AJFE02038418    AJFE02038419    AHZZ02030743    AHZZ02030744    AHZZ02030745    AANG04001761    KN122106    KFO32908.1    AQIA01062161    AQIA01062162    AQIA01062163    AQIA01062164    AQIA01062165    AQIA01062166    AQIA01062167    JH880809    ELR58707.1    AQIB01116411    AQIB01116412    AQIB01116413    BC140525    AAI40526.1    JU477989    AFH34793.1    AFYH01147097    AFYH01147098    AFYH01147099    AFYH01147100    AFYH01147101    AFYH01147102    AFYH01147103    AFYH01147104    AFYH01147105    NBAG03000488    PNI19963.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000235965    UP000027135    + More
UP000215335    UP000002358    UP000005203    UP000242457    UP000053105    UP000008237    UP000053825    UP000005205    UP000075809    UP000007755    UP000078541    UP000078492    UP000078540    UP000000311    UP000009046    UP000036403    UP000192223    UP000053097    UP000279307    UP000076502    UP000007266    UP000078542    UP000008820    UP000069940    UP000249989    UP000075883    UP000075885    UP000075886    UP000075920    UP000076408    UP000037069    UP000002320    UP000075900    UP000069272    UP000075901    UP000075884    UP000000673    UP000075881    UP000075902    UP000075840    UP000007062    UP000261680    UP000291021    UP000286642    UP000002281    UP000010552    UP000008227    UP000076407    UP000248481    UP000233220    UP000002356    UP000240080    UP000028761    UP000233200    UP000011712    UP000008225    UP000028990    UP000245341    UP000245340    UP000189706    UP000233100    UP000233140    UP000029965    UP000286640    UP000008672    UP000245320    UP000233060    UP000233080   

PRIDE

H9J622   

Pfam

PF13087   AAA_12        + More
PF16399   Aquarius_N
PF13086   AAA_11

Interpro

IPR041677   DNA2/NAM7_AAA_11        + More
IPR027417   P-loop_NTPase       
IPR032174   Aquarius_N       
IPR041679   DNA2/NAM7-like_AAA       
IPR026300   CWF11_fam       

SUPFAM

SSF52540   SSF52540       

ProteinModelPortal

H9J622   A0A2A4JLC6   A0A194PHX3   A0A194RLH7   A0A2W1BNZ4   A0A2J7PR08   + More
A0A067R9P9   A0A232EXP4   K7IQG0   A0A087ZT71   A0A2A3EDJ5   A0A0M9A6N3   E2BAW2   A0A0L7QMC6   A0A0C9QLK7   A0A158NCM0   A0A151X614   F4WFE7   A0A195F9R1   A0A195EMU4   A0A195BXI1   E2AK68   E0VSM8   E9IMC2   A0A0J7KW62   A0A1W4XP01   A0A026WA84   A0A3L8DKL5   A0A154PHF7   A0A139WFX9   A0A195CQN9   A0A1B6KBV0   A0A1S4G0D7   A0A1Y1LXY0   Q16IB0   A0A0P6J137   A0A182G802   A0A034VGH3   A0A182LS08   A0A0K8VLN3   A0A182P429   A0A0A1WJY7   A0A182QEI5   A0A182VWZ5   A0A2M4A8F1   A0A2M4A9Q0   A0A182YG12   A0A2M4A8E8   A0A0L0CC12   B0W925   A0A182RFJ9   A0A182FA37   A0A182SJS1   A0A182NDY0   W5JKE2   A0A087Z6K8   A0A2M4CVB5   A0A182K5H0   A0A182U8A4   A0A182I870   W8AM97   F5HM53   A0A384D0C3   A0A3Q7UI82   A0A3Q2H0V9   L5K2K4   A0A286ZI68   A0A182XKI2   A0A2Y9HN94   A0A2K6S0F9   Q7Q257   A0A0N8ETY7   D2H7R7   W5QFI2   A0A2R9AK31   A0A096NTB7   A0A2K6RM46   M3WK08   F7H585   A0A091DR01   A0A096NTB5   A0A2U3XFX8   A0A2U3WJR2   A0A2K6S0G9   A0A3Q0D6E4   A0A2K5URQ7   L8IU75   A0A2K6AGR0   A0A0D9R489   A0A3Q7T2L7   A5D7E4   H9ZFS7   H3AVK7   A0A2U4BC65   A0A2R9AEP9   A0A2R9ADM6   A0A2K5NC12   A0A2J8JB32   A0A3Q7SDH2   A0A2K5KC27  

PDB

6QDV     E-value=0,     Score=3970

KEGG

101743352    K12874 intron-binding protein aquarius | (RefSeq) intron-binding protein aquarius

GO

GO:0000398   GO:0005681   GO:0008380   GO:0006397   GO:0005634   GO:0071013   GO:0003729   GO:0003723   GO:0071007   GO:0005654   GO:0004386  

PANTHER

PTHR10887:SF5  

Subcellular location

Nucleus  

Length:

1077

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02149

Exp number, first 60 AAs:

0.00019

Total prob of N-in:

0.00002

outside

1  -  1077

 

 

Pi

264.891636

Theta

163.306382

Tajima's D

2.221545

CLR

0.38135

CSRT

0.91730413479326

Interpretation

Uncertain