SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO15204
Pre Gene Modal
BGIBMGA004949
Annotation
PREDICTED:_probable_ATP-dependent_RNA_helicase_spindle-E_[Bombyx_mori]
Full name
Probable ATP-dependent RNA helicase spindle-E      
Alternative Name
Homeless
Location in the cell
Nuclear   Reliability : 2.501
 

Sequence

CDS
ATGGATGAATTAAAAGCATTCTTCAATTCCCCATGTCCATCGAGTAATCAAGTTACAAAATTGCGCGGTCCCCTAACAGGTGGTTTTCGTATTCCCAAAGAAGATACAATGAACGATATGAATAGAAAAGAGGCACATCGGCATATGGTGGTGCCTAGTGGTACGGATTACGCTCGAGAAGTGAAAGATCGAGAAACAGAACTGTATTTAAAGAATGAAATTGAGCGGAAACAATATGAAAGCATGTCGGCCGGCTTGGAGTCTTTGGAGCAACTCTCATTAATTGGTGCGTCGGTACAGAACATTGGGGAGCTCAATGATGAAGCAATGACAGAAGTGTATAGTAAATATTCTTTCCAAAAGAAAGAAGATGCTAATAATCTAGCAATCAATTCATATAAACAACAGATATTAGATCGAATTAGAGGCTTCCCAGTTGTCATCATTGAAGGTCCAACAGGTTGCGGCAAAACAACTCAGGTCCCACAATGGTTATTAGATGATTGTTACCATAACCGAAGACCGTGTAAAATTATTGTGACACAGCCAAGGAGGATTGCAGCTATATCTATAACAAGGCGAGTTGCTCAGGAGAGGGGCTGGGATGTTGGGGGATTAGTTGGATATCAGGTCGGCCTAGACAATCGGACATCAACAGACACTCGTATACATTATGTTACCACAGGAGTTCTGCTTCAGAAACTAGTTTCTGCCAAAACAATGAATGAATACACCCATGTTATTCTTGATGAAGTTCACGAAAGAGGACAAGAGATGGATTTTCTACTCTTAGTTGTGAAAAAACTTTTATACACCATGTCCCCAGCTGTAAAAGTTGTCCTGATGTCAGCTACATTTAATAGTAAAGCTTTTGCTGATTATTTCATGATACCAACGCCTCGTGGACTGCAGATGTCAACTTGCATCAAAGTCGAGAAGAGGGAACATATGTTCACTGTCAAAACATTTTATCTGAATCATTTAAATAAGTTTGGTTCGGTTCTTCAAAACTCAATGCCAAAAAATGGAGAACCCGGAATAAATCCAGAAATGCATCACCTAGTCATCAAACTGTTGAACGCATTTGAGCAAATTGACAAGCAAGAAGACAATTATATGGACAGATCAGAAGCTGACTTGCCGTCTGTGTTAATATTTTTGCCCGGTATCAATGAGATTGAAGATTTGTATTCCAGTCTTACTGATCATGATTTAAGGACAAAAGTAGCAGATTTGGAATGCGCAAACTACAAATGGTGGGTGCTTCCTCTGCACTCTACCATCACAGCTGATGAACAAGTACGTGTGTTCCAACGCGCGCCGCTCGGGCACCGCAAGATCATTCTTTCCACTAACATCGCCGAAAGCTCCATCACTGTACCCGACATCAAATATGTGGTGGACTTCTGTCTAATGAAAGTATTAGAAGCAGACGCGATCACAAACTTCACATCACTGAAGTTATGTTGGGCCTCGAAGACAAACTGCGAGCAGCGGGCCGGTCGCGCGGGCCGCGTGCGTGACGGACGCGTATATCGCTTAGTCACAGATAAGTTTTACGATAGCCTGAGAGATGAATGTCCTCCTGAGATAGTGCGGTGTCCACTAGAAAGGCTAGCATTACTTGCTAAGATGCTGGATATGGGTCCGCCCAGTGATATCCTGGCGTTGGCCATGGACCCACCTGATATGTCTAACATACATCGAACTGTACTTGTATTAAAAGAAATTGGAGCTTTAAAAAAGACTTTAGACAACGAGTGGAGTTCCTCGGATGGTGACCTCACTTATATGGGGCGTATTATGGCAAAATTGCCCATTGATGTACGAGCATCTAAGCTGATAGTGCTCGGCTATGTCTACGGATGTCTGGACGAGTGTGTCATAATGGCCGCTGCAATGTCTGTGAAAAACGTGTTCAACAGTCCGTTCCGTGAGCGTCTAAATGCGTACAACTCTAAGTTGACTTGGGCGGACGGCTCAACCAGTGACTGTATTGCTCTACTCAATGTCTATAAGGTGTGGAACCACTTGAGACAGCAGCAGCAGTTCAAGCAGCAAGGCAGCGAGGTGCAGTGGTCGCGCCGGTTCTTCGTGCAGGTCCGAGCGCTGCGGGAGCTCGACGACATGGTCCGCGAGCTGCGGCTGCGGCTGTCCCGAGAGGGATTGGAATCGGAGGGAAACGCATCGCCCTGGGCCAGGAACGAACTCCCTCTCGCTTTGAAGGTAATAATGGCGGGCGCATTCTACCCACAATACTTCATACAAGTGTCACAAGACGAAGAACGAGAACGTGAGGCTTTGCGGACGCTCAGCGGGTTCGACCCCAGGAACACGGTTTATTTGAGGAACTTTCCGGATCACCAGCCCGGGGAGGTGTATGCGTCTCTCATCAAAAAAGTAGTAAAACAACAAATAGGAGACGAACCCTGCGTCTCATTTGATAAAAACGGGAGAAAGGTGTTCTTGACCTTCAATGACGGGAGCTACCTGTCGAGAAGTGAAAAAGAAAATAGTGGCGATCCAACGATTCCCGGTCAAGTGGCACTACCTGTTTACAAATGTATCAAAGCTCGACAACTTCGGTTGGATATCAGGATACCTTTACTGCCCCTGGAAAAAGCAAATGCTTTGGCAAGCGCAATGCAAATAAACAACAAGGATATCAGCATGGAAAGGACAGTGCCGCGCCTTCCGGAGATCGATGACACTCATTTCCCACTCAAAATTACCCACGAGGTGAACGTTGGGAAGTTTTGGGTGCAATATGACGATGAATCAACCGCAGCCGAACTCCGCCTTATCCAGTACGCGCTGAACCACGGGCCCCTGCTGACCCACACTGGGGACGTGTCCGCGGACGAGATATACGCCGCCCCCTACGCGGACGCCTCGGGGACCGTCATGTGCCGAGTGCGGGTGCTTAAATTGTTGCCCATGGACATGGTCGAGGTGGCGTACATGGACTACGGCGGCACGGGGCGCGTGAGCACGTGCAACCTGCACGCGCTGCCGGCGGGCGCGAGCCGCACGTGCCCGCCGCTGGGCGTGCCGTGCGCGCTGGCCGGTGTAGCGCCCGCGCGGCGCCTGCACGACCGGCCCGCCTGGTCGCCGCAGGCCTACAGCTGCTTCCGGGAGCTCATCTCGCGTCCGCGTCTTATAGCCAAGGTTTATTCTGTAGTACATGGCGTCGTAGCTATCGAACTGCTCACAGATGGCGGCCATGTAAGCGTTAATGAAATACTAATTAAAAAAGGATTTGCTGTTCCGTGTGAAGAGAGTTACGAATCTAAGCTGAACCATGACCTGAGACAGACTGCGAACGAACTGAACCTCGCGCAGAAGCGAGCTTATAACAAGGAGCAGACGGAAGCCGCGTTCTACCAGCTAGGGGACGCGGCGCCGCCTAATTACAGGGAATGTGTTGCGGATGTTTGCCTCAAAGGACCCTACAGCCCGCTGGAGTCGTCGTTGCACAACTTGATGTACTCGAGCCGCGACAAGCCCGTGCAGATCGACAGCAGCTCCGTCAACTCGGTCCTGCTCGACACCGAGCCCCAGATTACGTACGAAAGGTTGCTGGTCGCGGCAGAGGTCGGACAGAATGAGAGCTTTAGCAAGCTGACCCTGCGACTCTCGACGTTGATGCCGAACATTCCGGCTCTGCCCGCCATCATCGCGCTGCTGTTCTGTCCCACGGCGGAGCTCCGACGGGACAGCTCGGCCACCCGCTACGTGAGCGCGCTGTGCGGGCTGGGGGCCGCGCCCGACGCCGCGCCGCGCTTCCCCGAGCACGACCTGCTCGTCAACATCGACGCCGACCTCGACGTCGAGGACATCGGATGGATAAATCACAATCGTTACCTGACGGACTACATGCTGTACTGCGGCGAGGGGCAGGACATGCCGACTGCGGATGATGAATTCCGACCTCAGATTCCCGGCATCATTCGAAAGAATCTCATGCAGTTGATAAAGAAACGTCGCAAGCTCCGCCCGACCGAGGCGGTGCCGACCGCGTGGGAGTGGAAGAGCGTGCCCGAGGACGAGCTCATGGAGATCACCGTGCCCGACATGGTGGAGCGCGCCGTGCTGTACGAGCTGCACGTGCCGCTAGAGCTGCACCCCGTCTCGCGCGACCACCTGCTGGCACTCAAGCGGGACAACGACCAACTCAAGCTGCTCGTCAGCAGGACTCCGATATCGTCAAGCGCCGAATTGTCGTGTAAGCTGTGCGGCACCGGACCGATGCCGCCTCACGCCATGAGGCTGCATCTCTACTCCAACATTCACAAAGAAAAGGAAGAAGATTTTCAGATGTTCCAAACATAA
Protein
MDELKAFFNSPCPSSNQVTKLRGPLTGGFRIPKEDTMNDMNRKEAHRHMVVPSGTDYAREVKDRETELYLKNEIERKQYESMSAGLESLEQLSLIGASVQNIGELNDEAMTEVYSKYSFQKKEDANNLAINSYKQQILDRIRGFPVVIIEGPTGCGKTTQVPQWLLDDCYHNRRPCKIIVTQPRRIAAISITRRVAQERGWDVGGLVGYQVGLDNRTSTDTRIHYVTTGVLLQKLVSAKTMNEYTHVILDEVHERGQEMDFLLLVVKKLLYTMSPAVKVVLMSATFNSKAFADYFMIPTPRGLQMSTCIKVEKREHMFTVKTFYLNHLNKFGSVLQNSMPKNGEPGINPEMHHLVIKLLNAFEQIDKQEDNYMDRSEADLPSVLIFLPGINEIEDLYSSLTDHDLRTKVADLECANYKWWVLPLHSTITADEQVRVFQRAPLGHRKIILSTNIAESSITVPDIKYVVDFCLMKVLEADAITNFTSLKLCWASKTNCEQRAGRAGRVRDGRVYRLVTDKFYDSLRDECPPEIVRCPLERLALLAKMLDMGPPSDILALAMDPPDMSNIHRTVLVLKEIGALKKTLDNEWSSSDGDLTYMGRIMAKLPIDVRASKLIVLGYVYGCLDECVIMAAAMSVKNVFNSPFRERLNAYNSKLTWADGSTSDCIALLNVYKVWNHLRQQQQFKQQGSEVQWSRRFFVQVRALRELDDMVRELRLRLSREGLESEGNASPWARNELPLALKVIMAGAFYPQYFIQVSQDEEREREALRTLSGFDPRNTVYLRNFPDHQPGEVYASLIKKVVKQQIGDEPCVSFDKNGRKVFLTFNDGSYLSRSEKENSGDPTIPGQVALPVYKCIKARQLRLDIRIPLLPLEKANALASAMQINNKDISMERTVPRLPEIDDTHFPLKITHEVNVGKFWVQYDDESTAAELRLIQYALNHGPLLTHTGDVSADEIYAAPYADASGTVMCRVRVLKLLPMDMVEVAYMDYGGTGRVSTCNLHALPAGASRTCPPLGVPCALAGVAPARRLHDRPAWSPQAYSCFRELISRPRLIAKVYSVVHGVVAIELLTDGGHVSVNEILIKKGFAVPCEESYESKLNHDLRQTANELNLAQKRAYNKEQTEAAFYQLGDAAPPNYRECVADVCLKGPYSPLESSLHNLMYSSRDKPVQIDSSSVNSVLLDTEPQITYERLLVAAEVGQNESFSKLTLRLSTLMPNIPALPAIIALLFCPTAELRRDSSATRYVSALCGLGAAPDAAPRFPEHDLLVNIDADLDVEDIGWINHNRYLTDYMLYCGEGQDMPTADDEFRPQIPGIIRKNLMQLIKKRRKLRPTEAVPTAWEWKSVPEDELMEITVPDMVERAVLYELHVPLELHPVSRDHLLALKRDNDQLKLLVSRTPISSSAELSCKLCGTGPMPPHAMRLHLYSNIHKEKEEDFQMFQT

Summary

Description
Probable ATP-binding RNA helicase which plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity).
Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of testis-expressed Stellate genes by the homologous Su(Ste) repeats. Required for anteroposterior and dorsoventral axis formation during oogenesis (By similarity).
Catalytic Activity
ATP + H2O = ADP + H(+) + phosphate
Similarity
Belongs to the DEAD box helicase family. DEAH subfamily.
Keywords
ATP-binding   Complete proteome   Cytoplasm   Developmental protein   Differentiation   Helicase   Hydrolase   Meiosis   Nucleotide-binding   Reference proteome   RNA-mediated gene silencing   Spermatogenesis   Oogenesis  
Feature
chain  Probable ATP-dependent RNA helicase spindle-E
EC Number
3.6.4.13
EMBL
BABH01029887    AGBW02009936    OWR49546.1    KQ460045    KPJ18172.1    KQ459604    + More
KPI92320.1    NEVH01027057    PNF14099.1    KK853465    KDR07426.1    KZ288194    PBC33845.1    KQ434809    KZC06335.1    KQ435848    KOX71058.1    GBGD01000100    JAC88789.1    GBBI01004055    JAC14657.1    GECL01002988    JAP03136.1    NNAY01001084    OXU25207.1    GECU01033630    JAS74076.1    GEBQ01029726    JAT10251.1    KQ414741    KOC61958.1    GDHF01006053    JAI46261.1    GBYB01005186    JAG74953.1    GFDL01014282    JAV20763.1    GBXI01015875    GBXI01014554    GBXI01005285    JAC98416.1    JAC99737.1    JAD09007.1    GEDC01008806    JAS28492.1    GAMC01011377    JAB95178.1    KQ982684    KYQ52375.1    DS235824    EEB17885.1    GECZ01009166    JAS60603.1    GECZ01009752    JAS60017.1    CH477994    GEZM01013503    JAV92520.1    ADTU01003779    ADTU01003780    ADTU01003781    KQ980055    KYN17992.1    ACPB03022493    GEZM01013501    JAV92523.1    KQ977004    KYN06454.1    GL771866    EFZ09194.1    GFAA01002220    JAU01215.1    GEFM01004569    JAP71227.1    JRES01000032    KNC34771.1    KQ971352    EFA07562.1    APGK01025902    APGK01025903    APGK01025904    KB740605    ENN80053.1    KB632095    ERL88744.1    AXCN02001814    AAGJ04014119    GFAC01000552    JAT98636.1    GDIP01083524    JAM20191.1    GDIQ01235681    JAK16044.1    KK107419    EZA51074.1    GDIP01088683    GDIP01063585    JAM15032.1    GDIP01220566    JAJ02836.1    GDIQ01004971    JAN89766.1    GDIP01113924    GDIP01112331    JAL91383.1    GDIQ01157102    JAK94623.1    GDIP01159219    JAJ64183.1    GDIP01053186    JAM50529.1    GDIP01177110    JAJ46292.1    GDIP01051632    JAM52083.1    GDIQ01182694    JAK69031.1    GDIQ01127169    JAL24557.1    UFQS01000092    UFQT01000092    SSW99192.1    SSX19572.1    GDIP01208809    JAJ14593.1    GDHC01013706    JAQ04923.1    GDIQ01182695    JAK69030.1    GDIP01122120    JAL81594.1    CCAG010018631    GL732540    EFX82068.1    GDIP01122121    JAL81593.1    GDIQ01115820    JAL35906.1    GDIP01159218    JAJ64184.1    GEGO01005511    JAR89893.1    GDIP01229316    JAI94085.1    CH933806    GDIP01046986    JAM56729.1    GBIH01001649    JAC93061.1    GDIP01219307    JAJ04095.1    GDIP01157166    JAJ66236.1    GDIP01196208    JAJ27194.1    GDIQ01199137    GDIQ01197785    JAK52588.1    ADMH02000186    ETN67440.1    AXCM01002203    GDIQ01097976    JAL53750.1    GDIP01085125    JAM18590.1    GDIQ01079238    JAN15499.1    GDIP01229315    JAI94086.1    GDIQ01235680    JAK16045.1   
Pfam
PF00567   TUDOR        + More
PF00270   DEAD
PF00271   Helicase_C
PF04408   HA2
PF02784   Orn_Arg_deC_N
PF16060   DUF4802
PF00133   tRNA-synt_1
PF08264   Anticodon_1
PF16059   DUF4801
Interpro
IPR001650   Helicase_C        + More
IPR014001   Helicase_ATP-bd       
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR035437   SNase_OB-fold_sf       
IPR007502   Helicase-assoc_dom       
IPR027417   P-loop_NTPase       
IPR002999   Tudor       
IPR022644   De-COase2_N       
IPR009006   Ala_racemase/Decarboxylase_C       
IPR029066   PLP-binding_barrel       
IPR013087   Znf_C2H2_type       
IPR003604   Matrin/U1-like-C_Znf_C2H2       
IPR036236   Znf_C2H2_sf       
IPR032061   DUF4802       
IPR013155   M/V/L/I-tRNA-synth_anticd-bd       
IPR009080   tRNAsynth_Ia_anticodon-bd       
IPR001412   aa-tRNA-synth_I_CS       
IPR002303   Valyl-tRNA_ligase       
IPR033705   Anticodon_Ia_Val       
IPR009008   Val/Leu/Ile-tRNA-synth_edit       
IPR002300   aa-tRNA-synth_Ia       
IPR014729   Rossmann-like_a/b/a_fold       
IPR032060   DUF4801       
IPR002464   DNA/RNA_helicase_DEAH_CS       
SUPFAM
SSF52540   SSF52540        + More
SSF50621   SSF50621       
SSF57667   SSF57667       
SSF50677   SSF50677       
SSF47323   SSF47323       
PDB
5AOR     E-value=2.11768e-71,     Score=689

Ontologies

Topology

Subcellular location
Cytoplasm   Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis.   With evidence from 1 publications.
Length:
1443
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.60907
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00091
outside
1  -  1443
 
 

Population Genetic Test Statistics

Pi
271.90051
Theta
184.831134
Tajima's D
1.385123
CLR
0.174566
CSRT
0.75991200439978
Interpretation
Uncertain
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