Gene

KWMTBOMO15199

Pre Gene Modal

BGIBMGA004946

Annotation

PREDICTED:_cyclin-dependent_kinase_20_[Papilio_xuthus]

Location

Bomo_Chr25(+):6618439-6619924      View in EpiBrowser

Full name

Cyclin-dependent kinase 20      

Alternative Name

Cell cycle-related kinase
Cell division protein kinase 20
CDK-activating kinase p42
CDK-related protein kinase PNQLARE
Cyclin-dependent protein kinase H
Cyclin-kinase-activating kinase p42

Location in the cell

Cytoplasmic   Reliability : 1.509 Mitochondrial   Reliability : 2.048

CDS

ATGGATTATGATGTTAATAATTATACAGTCGTTGGTCGAATCGGTGAAGGAGCCCACGGGCTTGTTTTCAAAGCCAAACACAACACAACAGGTCGCGAGGTGGCCTTAAAGAAAATTCTGATAAAGAATCTTGAAGATGGAATACCGGTCCATGTCATGAGAGAGATCAAGGCTTTACAACTACTAAGATGTAAATACATTATTAAACTATACGATATGTTCCCGCGCGGCATGAGTCTTGTTCTCGTGCTAGAATATATGTACTCCGGATTATGGGAAATGTTGCACCAATGCGAGCATGAACTGACAATAGCTAGAGTCAAAACTTATGCAGAAATGTTATTAAAGGGAATGCGTTACATGCATGCTCATTACGTCATGCATAGGGATCTGAAACCAGCAAACCTGTTAATAAATCATGAGGGAATATTGAAAATAGCAGATCTAGGATTAGCGCGACTATACTGGCCTGAGGGTGGTAGGCCCTATTCACATCAAGTGGCCACAAGGTTAATACGCACTATATTATTTAATTAA

Protein

MDYDVNNYTVVGRIGEGAHGLVFKAKHNTTGREVALKKILIKNLEDGIPVHVMREIKALQLLRCKYIIKLYDMFPRGMSLVLVLEYMYSGLWEMLHQCEHELTIARVKTYAEMLLKGMRYMHAHYVMHRDLKPANLLINHEGILKIADLGLARLYWPEGGRPYSHQVATRLIRTILFN

Description

Involved in cell growth. Activates cdk2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with tbc1d32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling.
Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling.
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Subunit

Monomer. Interacts with tbc1d32.
Monomer (By similarity). Interacts with MAK (By similarity). Interacts with TBC1D32.
Monomer. Interacts with TBC1D32 and MAK.

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Keywords

ATP-binding   Cell cycle   Cell division   Cell projection   Cilium   Complete proteome   Cytoplasm   Developmental protein   Kinase   Nucleotide-binding   Nucleus   Reference proteome   Transferase   Alternative splicing  

Feature

chain  Cyclin-dependent kinase 20
splice variant  In isoform 2.

Uniprot

A0A2H1VQQ9   A0A2A4JFC8   A0A3S2LRP2   A0A194RLI1   A0A212F736   H9J605   + More
A0A0L7KWI8   A0A2P8XZC4   A0A067QIA3   A0A2J7QLN6   E2C0C0   A0A0C9R231   K7IUI8   A0A232EX67   F4X6L5   A0A0C9PLU0   A0A195E7E4   A0A195F2F8   A0A158NLD3   A0A151XCJ8   A0A1B6BWK7   A0A1B6D7T3   A0A195CZN9   T1HNR4   E2ATA2   A0A026WJG0   A0A146MD59   A0A0A9WHZ5   A0A2Y9FL45   A0A1Y7VIW8   A0A341ACZ7   A0A2Y9MGK8   A0A340W849   A0A3Q3WV06   A0A3Q3CA41   A0A224XFJ1   W5LCM0   A8WIP6   A0A1W4WYD6   Q9JHU3-2   A0A3B4EIE8   A0A0V0JA06   A0A0X3PDD3   A0A340WDN7   A0A0P7WR33   A0A2D0R103   A0A3Q1J361   A0A3Q3K091   V8PAH0   A0A3B1JHK7   A8K6P8   A0A3Q0R3Q9   A0A3Q3LY45   G1KH48   A0A340WB01   A0A3B4EIG4   A0A3N0YRV9   A0A3Q3G5K9   A0A2K6F9B7   A0A2K6RYN7   A0A0L8FIL7   A0A2K5ECB0   W5NC09   A0A2G9SDB4   A0A2Y9FJ01   A0A1S3W275   A0A3Q4GZ80   A0A3B4F134   A0A3P8PQR0   A0A3P9DCQ6   Q9JHU3   A0A337S3C2   A0A341AF79   A0A3Q1JDT8   A0A341AF74   Q4KM34   A0A2K6F997   A0A2D0R1Q6   A0A2J8WNX6   A0A3Q3KB96   B4DFP8   A0A3B4WTA6   A0A3B4VC32   G3ICC3   A0A2K5KXN7   A0A091CP52   A0A3P9P7Q4   H0VCP1   A0A3P9ADU3   A0A2K5RK67   A0A1S3AT12   A0A3Q3M5W3   A0A1S3ASH7   A0A3B5PWL5   A0A0X3P0U7   D3K5N0   A0A2K6K5C0   A0A2K6NYZ6   A0A2Y9FJ58   A0A2Y9K4U7  

EC Number

2.7.11.22

Pubmed

26354079    22118469    19121390    26227816    29403074    24845553    + More
20798317    20075255    28648823    21719571    21347285    24508170    30249741    26823975    25401762    19468303    25329095    23594743    20159594    15489334    24297900    11181995    25186727    17975172    21804562    29704459    21993624    25069045    23542700    25362486   

EMBL

ODYU01003861    SOQ43150.1    NWSH01001593    PCG70767.1    RSAL01000022    RVE52388.1    + More
KQ460045    KPJ18175.1    AGBW02009936    OWR49543.1    BABH01029894    BABH01029895    JTDY01005048    KOB67431.1    PYGN01001128    PSN37361.1    KK853567    KDR06664.1    NEVH01013243    PNF29500.1    GL451770    EFN78579.1    GBYB01002060    JAG71827.1    AAZX01004049    NNAY01001765    OXU22976.1    GL888818    EGI57797.1    GBYB01002058    JAG71825.1    KQ979568    KYN20777.1    KQ981864    KYN34362.1    ADTU01019320    KQ982314    KYQ58018.1    GEDC01031632    GEDC01003575    JAS05666.1    JAS33723.1    GEDC01015566    GEDC01003859    JAS21732.1    JAS33439.1    KQ977115    KYN05604.1    ACPB03018039    GL442545    EFN63347.1    KK107185    QOIP01000012    EZA55816.1    RLU15907.1    GDHC01000955    JAQ17674.1    GBHO01039114    GBHO01039113    GBRD01015897    GBRD01015896    JAG04490.1    JAG04491.1    JAG49929.1    CT025616    GFTR01005191    JAW11235.1    BX571687    BC086697    AY005133    AY904369    BC031907    GEEE01021526    GEEE01012963    GEEE01001148    JAP62077.1    GEEE01013497    JAP49728.1    JARO02005892    KPP66074.1    AZIM01000454    ETE70966.1    AK291713    CH471089    BAF84402.1    EAW62747.1    RJVU01030786    ROL48408.1    KQ430924    KOF63485.1    AHAT01006438    AHAT01006439    KV924701    PIO38092.1    AANG04003916    BC098838    NDHI03003383    PNJ71459.1    AK294193    BAG57509.1    JH001908    RAZU01000141    EGW11400.1    RLQ69609.1    KN124574    KFO20774.1    AAKN02038453    GEEE01021643    GEEE01013999    JAP41582.1    GU373708    ADC38908.1   

Proteomes

UP000218220    UP000283053    UP000053240    UP000007151    UP000005204    UP000037510    + More
UP000245037    UP000027135    UP000235965    UP000008237    UP000002358    UP000215335    UP000007755    UP000078492    UP000078541    UP000005205    UP000075809    UP000078542    UP000015103    UP000000311    UP000053097    UP000279307    UP000248484    UP000000589    UP000252040    UP000248483    UP000265300    UP000261620    UP000264840    UP000018467    UP000000437    UP000192223    UP000261440    UP000034805    UP000221080    UP000265040    UP000261600    UP000261340    UP000261640    UP000001646    UP000261660    UP000233160    UP000233220    UP000053454    UP000233020    UP000018468    UP000079721    UP000261580    UP000261460    UP000265100    UP000265160    UP000011712    UP000002494    UP000261360    UP000261420    UP000001075    UP000273346    UP000233060    UP000028990    UP000242638    UP000005447    UP000265140    UP000233040    UP000002852    UP000233180    UP000233200    UP000248482   

PRIDE

H9J605    A8WIP6    Q9JHU3    Q4KM34    B4DFP8    G3ICC3    + More
D3K5N0   

Pfam

PF00069   Pkinase        + More
PF00320   GATA

Interpro

IPR000719   Prot_kinase_dom        + More
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR039355   Transcription_factor_GATA       
IPR000679   Znf_GATA       
IPR013088   Znf_NHR/GATA       

SUPFAM

SSF56112   SSF56112       

Gene 3D

3.30.50.10    

CDD

cd00202  ZnF_GATA

ProteinModelPortal

A0A2H1VQQ9   A0A2A4JFC8   A0A3S2LRP2   A0A194RLI1   A0A212F736   H9J605   + More
A0A0L7KWI8   A0A2P8XZC4   A0A067QIA3   A0A2J7QLN6   E2C0C0   A0A0C9R231   K7IUI8   A0A232EX67   F4X6L5   A0A0C9PLU0   A0A195E7E4   A0A195F2F8   A0A158NLD3   A0A151XCJ8   A0A1B6BWK7   A0A1B6D7T3   A0A195CZN9   T1HNR4   E2ATA2   A0A026WJG0   A0A146MD59   A0A0A9WHZ5   A0A2Y9FL45   A0A1Y7VIW8   A0A341ACZ7   A0A2Y9MGK8   A0A340W849   A0A3Q3WV06   A0A3Q3CA41   A0A224XFJ1   W5LCM0   A8WIP6   A0A1W4WYD6   Q9JHU3-2   A0A3B4EIE8   A0A0V0JA06   A0A0X3PDD3   A0A340WDN7   A0A0P7WR33   A0A2D0R103   A0A3Q1J361   A0A3Q3K091   V8PAH0   A0A3B1JHK7   A8K6P8   A0A3Q0R3Q9   A0A3Q3LY45   G1KH48   A0A340WB01   A0A3B4EIG4   A0A3N0YRV9   A0A3Q3G5K9   A0A2K6F9B7   A0A2K6RYN7   A0A0L8FIL7   A0A2K5ECB0   W5NC09   A0A2G9SDB4   A0A2Y9FJ01   A0A1S3W275   A0A3Q4GZ80   A0A3B4F134   A0A3P8PQR0   A0A3P9DCQ6   Q9JHU3   A0A337S3C2   A0A341AF79   A0A3Q1JDT8   A0A341AF74   Q4KM34   A0A2K6F997   A0A2D0R1Q6   A0A2J8WNX6   A0A3Q3KB96   B4DFP8   A0A3B4WTA6   A0A3B4VC32   G3ICC3   A0A2K5KXN7   A0A091CP52   A0A3P9P7Q4   H0VCP1   A0A3P9ADU3   A0A2K5RK67   A0A1S3AT12   A0A3Q3M5W3   A0A1S3ASH7   A0A3B5PWL5   A0A0X3P0U7   D3K5N0   A0A2K6K5C0   A0A2K6NYZ6   A0A2Y9FJ58   A0A2Y9K4U7  

PDB

1V0O     E-value=5.07879e-29,     Score=314

KEGG

101743926    K08817 cell cycle related kinase [EC:2.7.11.22] | (RefSeq) cyclin-dependent kinase 20-like

GO

GO:0070985   GO:0005524   GO:0008353   GO:0004674   GO:0051301   GO:0007049   GO:0004693   GO:0005929   GO:0060271   GO:0005634   GO:0006468   GO:0007275   GO:0005737   GO:0005654   GO:0016301   GO:0046872   GO:0004672   GO:0017183   GO:0006391   GO:0031167   GO:0003677   GO:0008408   GO:0005112   GO:0015930  

PANTHER

PTHR10071  

Subcellular location

Nucleus  
Cytoplasm  
Cell projection  
Cilium  

Length:

178

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.66476

Exp number, first 60 AAs:

0.00719999999999999

Total prob of N-in:

0.40752

outside

1  -  178

 

 

Pi

289.722229

Theta

162.90995

Tajima's D

1.735876

CLR

0.125084

CSRT

0.83650817459127

Interpretation

Uncertain