Gene

KWMTBOMO15198  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004965

Annotation

uridine_diphosphate_glucosyltransferase_precursor_[Bombyx_mori]

Location

Bomo_Chr25(-):6614608-6617418      View in EpiBrowser

Full name

UDP-glucuronosyltransferase       + More
Ecdysteroid UDP-glucosyltransferase      

Location in the cell

PlasmaMembrane   Reliability : 2.628

CDS

ATGTGGTTAAAGTTTTTCTACTTCTTTAGTTTAGTTTTATGTCCGTGTTATGCGGCTCAAGGCGCTTCGATATTAGCAGTCTTCTCTTCACTTTCCTATTCAGATCATCTGGTTTTTCGGGGCTATGTGTCTCTCCTCGCTCAAAGAGGACATTCCGTTGTGGTCATGACTCCTTATCCAGGCGAGTTTCAATATCCGGAGGTAGAAAACATAATCGAGCTAGATGTTAGTCAAGAATCAGCACCGTTTTGGGAGGAGTACAAAAGGCTGATGACCAATACGGACGATTACTATCCGCGGCTTAAAGCACTGAACGAGCTCTCACTAAAAATTGCCATAGCGCAGCTGAAGTCCAAGCAAATGACGGCGCTGCTCATTAATCCTAATGTAAAATTCGACTTGGTAATAACTGAAGCAGATGTACCATTACTTTACGCTTTAGCTGACAAATACCAGACTCCACATATAACGATAAGTACATTTAATGGAAAAATTCACCAGTACGAAGCTAAAGGCAATCCCATTCACCCTATTTTGTATCCCGACGTGAACTCACTGAACTACGGTAATTTGACTCGTTGGCAGAAAATTATCGAATTCTACAGACACATACAAACGAAAACAGAGTTTTACAACAACTATTTGCCGTTATGCGATGTTGCCGCCAAAAAGATACTAGGATTGAAAAGAGATTTACAAGAAGTTGAATATGACATCGATATGTTGTTCATTGCCAGTAATCCGCTGTTAATCGGGAATAGACCGGTTGTACCTGCCATACAATTTGTGGATCGGATGCATATTAAACCAAGGATGAGTCTTCCGCAGAATTTACAATCATTGTTAGACTCTCAAACGAAGGGAGTAATTTACTTTAGCTTGGGAACTCTACAAGAGGCGGAGAAATTATCTGTTAAAACACTTCAAGTTTTCGCGGATGCTTTTAGAGAATTACCTTTCACAGTTTTGTGGAAGATTGGTAAAATGAGCACGTTAAAGCTATCTGATAACGTTATCACAGACGTATGGTTTCCGCAACAACAATTATTGGCACACAAAAACGTAAGGGCATTTATAACTCACGGCGGACCTAGATCTTTGGAAGAAGCACTATTTTATGAAGTACCAATCATAGGTTTTCCTCTTATCACATCTAGAAAGATATTTATAAGAGAGCTTACCAAGTACGGCGCTGGTGAAATCTTGGACCCCTTACACATTGACAAACAAACATTGAAACAGGTCATATCCACAGTGGCCACTGATGAAAAGTACAAAAAAGCGATAATTAAGCTTAAAGGTATGGTTGTCGATCCGTTGATTTCGGGTCCCGACAACGCTGTCTGGTGGACTGAATACGTTCTTCGTAACCGCGGCGCACAACATCTACGTTCACCAGTTGTTGGCGTTACCTTCATCAAATATTACATGTTGGACATTCTTACTTATATACTTGCAGTCGTTCTATTTCTGCTATATTTAACTTTTCTTGTGCTGAAATGTATTTACAGACGTTTACGAGCACGATTTGTGCTGAGAACTGGTCAAGGACCAGAAGGAAAATTCAAGGCTTTGTAA

Protein

MWLKFFYFFSLVLCPCYAAQGASILAVFSSLSYSDHLVFRGYVSLLAQRGHSVVVMTPYPGEFQYPEVENIIELDVSQESAPFWEEYKRLMTNTDDYYPRLKALNELSLKIAIAQLKSKQMTALLINPNVKFDLVITEADVPLLYALADKYQTPHITISTFNGKIHQYEAKGNPIHPILYPDVNSLNYGNLTRWQKIIEFYRHIQTKTEFYNNYLPLCDVAAKKILGLKRDLQEVEYDIDMLFIASNPLLIGNRPVVPAIQFVDRMHIKPRMSLPQNLQSLLDSQTKGVIYFSLGTLQEAEKLSVKTLQVFADAFRELPFTVLWKIGKMSTLKLSDNVITDVWFPQQQLLAHKNVRAFITHGGPRSLEEALFYEVPIIGFPLITSRKIFIRELTKYGAGEILDPLHIDKQTLKQVISTVATDEKYKKAIIKLKGMVVDPLISGPDNAVWWTEYVLRNRGAQHLRSPVVGVTFIKYYMLDILTYILAVVLFLLYLTFLVLKCIYRRLRARFVLRTGQGPEGKFKAL

Description

Catalyzes the transfer of glucose from UDP-glucose to ecdysteroids which are insect molting hormones.

Catalytic Activity

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP

Similarity

Belongs to the UDP-glycosyltransferase family.
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Feature

chain  UDP-glucuronosyltransferase

Uniprot

B5AU20   C0JKP8   A0A3G1T1A4   A0A2A4JG63   G9LPP8   A0A1E1WQJ5   + More
A0A2H1VQM8   A0A0L7KWD8   A0A194RQ77   D2JLK9   A0A2H4WB71   A0A194PG03   A0A1L8D6G4   A0A212F721   A0A212EW38   A0A0N1I2R8   A0A1Y1M2S7   A0A0N0PE43   A0A2A4JXE4   V5GJ31   M4M1W9   A0A2W1BAD4   G9LPP6   A0A2H4WB54   A0A191T2J5   A0A1Y1M828   A0A1L8D6H9   A0A2H4WB68   A0A1Y1MKU1   A0A1W4XHT9   A0A024AGL3   A0A2I6RJL8   G9LPT6   A0A346TPQ3   A0A3S2NVG0   A0A191T1N0   A0A191T2J2   A0A2W1BL20   A0A139WAV2   G9LPP3   A0A191T2G3   A0A2H1WTF5   A0A024AG00   A0A2R4FXG6   A0A2H1VUS4   A0A2H4WB70   A0A2H4WB73   A0A2W1BQP4   D2A215   A0A191T1L3   G9LPP7   A0A2R4FXJ6   H9JWC0   A0A2H1VUM4   A0A1W4XIA4   A0A191T1K8   I4DM75   A0A024AH14   A0A0N1IMZ0   A0A2W1B3V4   A0A2W1BEA5   G9LPP5   A0A1Y1LVX9   B7TZA3   G9LPS9   A0A2H1VU94   A0A2A4JWQ0   A0A191T1K4   G9LPS5   A0A2H4WB72   A0A1Y1MFU9   A0A2H1WSA7   A0A1Y1KEF7   G9LPN5   A0A2W1BA70   A0A140EA35   A0A191T1L2   Q1HPX7   A0A1L8D6H2   G9LPS6   A0A0N0P9C8   A0A1L8D6T8   V5GKI9   G9LPN8   A0A2W1BE55   A0A2W1B475   A0A2W1B9W6   G9LPT1   G9LPN6   A0A1L8D6G1   A0A191T1L8   A0A1Y1LUT9   G9LPN9   A0A2H4WB83   A0A191T1M4   A0A1Y1NHT4   A0A2W1BBH1   A0A2W1B8G2   A0A2W1B8D3  

EC Number

2.4.1.17
2.4.1.-

Pubmed

19121390    22155036    26227816    26354079    19954531    29027758    + More
22118469    28004739    28756777    24698447    18362917    19820115    22651552    26873292   

EMBL

BABH01029895    EU873318    JQ070244    ACF57674.1    AEW43160.1    FJ237534    + More
ACN39598.1    MG846900    AXY94752.1    NWSH01001593    PCG70766.1    JQ070205    AEW43121.1    GDQN01001867    JAT89187.1    ODYU01003861    SOQ43151.1    JTDY01005048    KOB67430.1    KQ460045    KPJ18176.1    GQ915325    ACZ97419.2    KY202940    AUC64284.1    KQ459604    KPI92316.1    GEYN01000080    JAV02049.1    AGBW02009936    OWR49542.1    AGBW02012096    OWR45677.1    KQ459547    KPJ00048.1    GEZM01042572    JAV79781.1    KQ459937    KPJ19195.1    NWSH01000435    PCG76446.1    GALX01004392    JAB64074.1    JQ747500    AGG36457.1    KZ150193    PZC72372.1    JQ070203    AEW43119.1    KY202924    AUC64268.1    KU680289    ANI21995.1    GEZM01037675    JAV81989.1    GEYN01000078    JAV02051.1    KY202939    AUC64283.1    GEZM01030332    GEZM01030328    JAV85628.1    KF777112    AHY99683.1    KY304474    AUN86405.1    JQ070243    AEW43159.1    MH124167    AXU41563.1    RSAL01000157    RVE45575.1    KU680291    ANI21997.1    KU680284    ANI21990.1    PZC72373.1    KQ971380    KYB25037.1    JQ070200    AEW43116.1    KU680290    ANI21996.1    ODYU01010933    SOQ56350.1    KF777109    AHY99680.1    MF034854    AVT42220.1    ODYU01004546    SOQ44548.1    KY202938    AUC64282.1    KY202933    AUC64277.1    KZ149974    PZC75964.1    KQ971338    EFA01500.1    KU680288    ANI21994.1    JQ070204    AEW43120.1    MF034855    AVT42221.1    BABH01029259    SOQ44549.1    KU680282    ANI21988.1    AK402393    BAM19015.1    KF777111    AHY99682.1    KPJ00054.1    KZ150360    PZC71192.1    PZC71190.1    JQ070202    AEW43118.1    GEZM01049908    JAV75766.1    FJ418685    ACJ48963.1    BABH01029271    JQ070236    AEW43152.1    ODYU01004485    SOQ44409.1    PCG76447.1    KU680283    ANI21989.1    JQ070232    AEW43148.1    KY202941    AUC64285.1    GEZM01032416    JAV84594.1    ODYU01010294    SOQ55304.1    GEZM01086036    JAV59829.1    JQ070192    AEW43108.1    PZC71195.1    KU214506    AMK97472.1    KU680287    ANI21993.1    DQ443275    ABF51364.1    GEYN01000077    JAV02052.1    JQ070233    AEW43149.1    KPJ00042.1    GEYN01000079    JAV02050.1    GALX01003882    JAB64584.1    JQ070195    AEW43111.1    PZC71196.1    PZC71189.1    PZC72369.1    JQ070238    AEW43154.1    JQ070193    AEW43109.1    GEYN01000091    JAV02038.1    KU680281    ANI21987.1    GEZM01049909    JAV75765.1    JQ070196    AEW43112.1    KY202943    AUC64287.1    KU680286    ANI21992.1    GEZM01006626    JAV95676.1    PZC71194.1    PZC71201.1    PZC71191.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053240    UP000053268    UP000007151    + More
UP000192223    UP000283053    UP000007266   

PRIDE

B5AU20    C0JKP8    G9LPT6    H9JWC0    B7TZA3    G9LPS9    + More
G9LPS5    Q1HPX7    G9LPS6    G9LPT1   

Pfam

PF00201   UDPGT        + More
PF05571   JAMP
PF00208   ELFV_dehydrog
PF02812   ELFV_dehydrog_N

Interpro

IPR002213   UDP_glucos_trans        + More
IPR035595   UDP_glycos_trans_CS       
IPR008485   JAMP       
IPR006326   UDPGT_MGT       
IPR016224   Ecdysteroid_UDP-Glc_Trfase       
IPR036291   NAD(P)-bd_dom_sf       
IPR033524   Glu/Leu/Phe/Val_DH_AS       
IPR006096   Glu/Leu/Phe/Val_DH_C       
IPR006095   Glu/Leu/Phe/Val_DH       
IPR006097   Glu/Leu/Phe/Val_DH_dimer_dom       
IPR033922   NAD_bind_Glu_DH       

SUPFAM

SSF51735   SSF51735       

CDD

cd01076  NAD_bind_1_Glu_DH

ProteinModelPortal

B5AU20   C0JKP8   A0A3G1T1A4   A0A2A4JG63   G9LPP8   A0A1E1WQJ5   + More
A0A2H1VQM8   A0A0L7KWD8   A0A194RQ77   D2JLK9   A0A2H4WB71   A0A194PG03   A0A1L8D6G4   A0A212F721   A0A212EW38   A0A0N1I2R8   A0A1Y1M2S7   A0A0N0PE43   A0A2A4JXE4   V5GJ31   M4M1W9   A0A2W1BAD4   G9LPP6   A0A2H4WB54   A0A191T2J5   A0A1Y1M828   A0A1L8D6H9   A0A2H4WB68   A0A1Y1MKU1   A0A1W4XHT9   A0A024AGL3   A0A2I6RJL8   G9LPT6   A0A346TPQ3   A0A3S2NVG0   A0A191T1N0   A0A191T2J2   A0A2W1BL20   A0A139WAV2   G9LPP3   A0A191T2G3   A0A2H1WTF5   A0A024AG00   A0A2R4FXG6   A0A2H1VUS4   A0A2H4WB70   A0A2H4WB73   A0A2W1BQP4   D2A215   A0A191T1L3   G9LPP7   A0A2R4FXJ6   H9JWC0   A0A2H1VUM4   A0A1W4XIA4   A0A191T1K8   I4DM75   A0A024AH14   A0A0N1IMZ0   A0A2W1B3V4   A0A2W1BEA5   G9LPP5   A0A1Y1LVX9   B7TZA3   G9LPS9   A0A2H1VU94   A0A2A4JWQ0   A0A191T1K4   G9LPS5   A0A2H4WB72   A0A1Y1MFU9   A0A2H1WSA7   A0A1Y1KEF7   G9LPN5   A0A2W1BA70   A0A140EA35   A0A191T1L2   Q1HPX7   A0A1L8D6H2   G9LPS6   A0A0N0P9C8   A0A1L8D6T8   V5GKI9   G9LPN8   A0A2W1BE55   A0A2W1B475   A0A2W1B9W6   G9LPT1   G9LPN6   A0A1L8D6G1   A0A191T1L8   A0A1Y1LUT9   G9LPN9   A0A2H4WB83   A0A191T1M4   A0A1Y1NHT4   A0A2W1BBH1   A0A2W1B8G2   A0A2W1B8D3  

PDB

2O6L     E-value=7.54592e-17,     Score=215

KEGG

100174975    K00699 glucuronosyltransferase [EC:2.4.1.17] | (RefSeq) Ugt2, UGT34A2, ugt; uridine diphosphate gluc

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00830    Retinol metabolism - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
00980    Metabolism of xenobiotics by cytochrome P450 - Bombyx mori (domestic silkworm)
00982    Drug metabolism - cytochrome P450 - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0015020   GO:0016021   GO:0006986   GO:0016758   GO:0016999   GO:0016639   GO:0006520   GO:0008194   GO:0043231   GO:0008152   GO:0006468   GO:0017183   GO:0006391   GO:0031167   GO:0003677   GO:0008408   GO:0005112   GO:0015930  

PANTHER

PTHR12740  

Subcellular location

Membrane  

SignalP

Position:   1 - 18,         Likelihood:  0.932664

 

 

Length:

525

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

40.91694

Exp number, first 60 AAs:

18.84436

Total prob of N-in:

0.82575

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  27

outside

28  -  480

TMhelix

481  -  503

inside

504  -  525

 

 

Pi

218.657884

Theta

177.48336

Tajima's D

0.699852

CLR

0.157634

CSRT

0.574971251437428

Interpretation

Uncertain