Gene

KWMTBOMO15173

Pre Gene Modal

BGIBMGA004978

Annotation

PREDICTED:_uncharacterized_protein_LOC106129259_[Amyelois_transitella]

Location

Bomo_Chr25(-):6103397-6104163      View in EpiBrowser

Full name

Presenilin      

Location in the cell

Mitochondrial   Reliability : 2.311

CDS

ATGATTTATAAATGGTGGCATGCGTTCGTTCGTAAGCGGACAAAACCTATTCCCGAAGACAAAGCTATTCTATGGAAACGACGATTGAGTTTTGCCTATGCTCTATTTGCCTGGAATGCTTTTGGTTTAGTAGTTTATAGTGCTTATAAAGGAAAGGCTGATTGGGCTCACTACTATGGAATTAAAAGTGACGAAGAAAAATCCATACCTCCAGGTTATGCCTGGGCTAATACTCTTGGTATAAAAAATGCTAAAGTTTATAGAATATCTGGATTCAAGAAGGTTGATGAATATGATATTGTAGACGGGGAGATGGTTACTAAAGATAAAGTTGAAACAAATACATAG

Protein

MIYKWWHAFVRKRTKPIPEDKAILWKRRLSFAYALFAWNAFGLVVYSAYKGKADWAHYYGIKSDEEKSIPPGYAWANTLGIKNAKVYRISGFKKVDEYDIVDGEMVTKDKVETNT

Description

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Subunit

Homodimer.

Similarity

Belongs to the peptidase A22A family.

Uniprot

H9J637   A0A2H1WYP1   A0A2A4JLD0   A0A1E1VXB4   A0A194PHU6   A0A3S2NR75   + More
A0A194RKX7   S4PEJ0   A0A0L7KR41   V5I7Y4   A0A0T6B3Y8   A0A1I8MJU3   W5JEK4   A0A336LQA4   A0A1I8NRL7   A0A034WQU4   A0A084W7X1   W8CAP0   T1E7B5   A0A182FQ16   A0A2M3ZD42   A0A2M4C4K8   A0A2M4AXG6   A0A1A9ZGL2   A0A0A1XEL7   A0A0L0BYS0   A0A1A9X8T5   A0A067RWB8   B4JMI2   D6WT01   A0A182RE99   A0A1W4X5B6   A0A0M3QYZ1   B4L4S5   B3MYA8   Q9W5E7   B4M2D7   A0A2R7W7A6   B4R7F6   Q29I52   B4HAA2   B4I936   A0A1W4V7Z6   B3P980   B4PX12   A0A0P4VQ32   R4FN50   A0A1B6ERQ1   B4N263   A0A182U875   Q7Q7Q2   A0A182YES1   A0A182G2P6   A0A182VPS1   A0A182NE01   A0A182HCT0   A0A182JVX3   A0A182Q0Q8   A0A2R7WXL5   B0WGQ1   A0A1S4FUV6   A0A170UEP5   A6YPG9   A0A023FAX8   A0A1L8DC66   A0A069DNZ6   Q16NH2   A0A224XQC7   A0A1Q3FH88   U5EUS4   A0A1Q3FIA3   A0A1Y1MRN5   A0A1J1I509   A0A0A9X6F2   A0A0A9WH98   A0A1B0CHZ0   A0A146LC02   A0A182M5A2   A0A1B0D4U0   A0A1B6C8U8   A0A1D2MXU5   A0A0K8TQ00   K7JZ97   E9GEL2   A0A232F0L7   A0A0P6CWE1   A0A0P5TAM7   A0A0P6AQS2   A0A1W0WTK2   A0A151JSH6  

EC Number

3.4.23.-

Pubmed

19121390    26354079    23622113    26227816    25315136    20920257    + More
23761445    25348373    24438588    24495485    25830018    26108605    24845553    17994087    18362917    19820115    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    15632085    17550304    27129103    12364791    14747013    17210077    25244985    26483478    18207082    25474469    26334808    17510324    28004739    25401762    26823975    27289101    26369729    20075255    21292972    28648823   

EMBL

BABH01029933    ODYU01012080    SOQ58190.1    NWSH01001069    PCG72781.1    GDQN01011688    + More
JAT79366.1    KQ459604    KPI92294.1    RSAL01000329    RVE42500.1    KQ460045    KPJ18197.1    GAIX01004482    JAA88078.1    JTDY01006730    KOB65743.1    GALX01005630    JAB62836.1    LJIG01009914    KRT82128.1    ADMH02001712    ETN61325.1    UFQT01000045    SSX18813.1    GAKP01001938    JAC57014.1    ATLV01021318    KE525316    KFB46315.1    GAMC01001139    JAC05417.1    GAMD01003187    JAA98403.1    GGFM01005662    MBW26413.1    GGFJ01010767    MBW59908.1    GGFK01011967    MBW45288.1    GBXI01004468    JAD09824.1    JRES01001143    KNC25193.1    KK852425    KDR24169.1    CH916371    EDV91925.1    KQ971352    EFA06680.1    CP012528    ALC48459.1    CH933810    EDW07553.1    CH902632    EDV32602.1    AE014298    AY119061    AAF45524.1    AAM50921.1    CH940651    EDW65841.1    KK854343    PTY14870.1    CM000366    EDX16767.1    CH379064    EAL31554.1    CH479239    EDW37496.1    CH480825    EDW43717.1    CH954183    EDV45376.1    CM000162    EDX00798.1    GDKW01001481    JAI55114.1    ACPB03010888    GAHY01001449    JAA76061.1    GECZ01029157    GECZ01021796    JAS40612.1    JAS47973.1    CH963925    EDW78452.1    AAAB01008952    EAA10573.3    JXUM01139844    KQ568963    KXJ68820.1    JXUM01128047    KQ567268    KXJ69507.1    AXCN02002212    KK855891    PTY24278.1    DS231928    EDS27127.1    GEMB01007613    JAR95822.1    EF638980    ABR27865.1    GBBI01000080    JAC18632.1    GFDF01010021    JAV04063.1    GBGD01003567    JAC85322.1    CH477824    EAT35891.1    GFTR01001720    JAW14706.1    GFDL01008141    JAV26904.1    GANO01003739    JAB56132.1    GFDL01007771    JAV27274.1    GEZM01026168    GEZM01026167    JAV87190.1    CVRI01000041    CRK95368.1    GBHO01028045    JAG15559.1    GBHO01036485    GBHO01028047    GBHO01028046    GBRD01009107    JAG07119.1    JAG15557.1    JAG15558.1    JAG56714.1    AJWK01012911    AJWK01012912    GDHC01012828    GDHC01000048    JAQ05801.1    JAQ18581.1    AXCM01000238    AJVK01024876    GEDC01027444    JAS09854.1    LJIJ01000401    ODM97859.1    GDAI01001154    JAI16449.1    GL732540    EFX82292.1    NNAY01001358    OXU24245.1    GDIQ01089261    JAN05476.1    GDIQ01190832    GDIP01134913    JAK60893.1    JAL68801.1    GDIP01025730    JAM77985.1    MTYJ01000048    OQV18521.1    KQ978530    KYN30307.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000283053    UP000053240    UP000037510    + More
UP000095301    UP000000673    UP000095300    UP000030765    UP000069272    UP000092445    UP000037069    UP000092443    UP000027135    UP000001070    UP000007266    UP000075900    UP000192223    UP000092553    UP000009192    UP000007801    UP000000803    UP000008792    UP000000304    UP000001819    UP000008744    UP000001292    UP000192221    UP000008711    UP000002282    UP000015103    UP000007798    UP000075902    UP000007062    UP000076408    UP000069940    UP000249989    UP000075920    UP000075884    UP000075881    UP000075886    UP000002320    UP000008820    UP000183832    UP000092461    UP000075883    UP000092462    UP000094527    UP000002358    UP000000305    UP000215335    UP000078492   

PRIDE

H9J637    Q9W5E7   

Pfam

PF00018   SH3_1        + More
PF02218   HS1_rep
PF01080   Presenilin
PF00076   RRM_1

Interpro

IPR036028   SH3-like_dom_sf        + More
IPR001452   SH3_domain       
IPR003134   Hs1_Cortactin       
IPR011992   EF-hand-dom_pair       
IPR002048   EF_hand_dom       
IPR001108   Peptidase_A22A       
IPR006639   Preselin/SPP       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR000504   RRM_dom       
IPR035979   RBD_domain_sf       
IPR033568   Srek1       

SUPFAM

SSF50044   SSF50044        + More
SSF47473   SSF47473       
SSF54928   SSF54928       

Gene 3D

3.30.70.330    

CDD

cd00051  EFh

ProteinModelPortal

H9J637   A0A2H1WYP1   A0A2A4JLD0   A0A1E1VXB4   A0A194PHU6   A0A3S2NR75   + More
A0A194RKX7   S4PEJ0   A0A0L7KR41   V5I7Y4   A0A0T6B3Y8   A0A1I8MJU3   W5JEK4   A0A336LQA4   A0A1I8NRL7   A0A034WQU4   A0A084W7X1   W8CAP0   T1E7B5   A0A182FQ16   A0A2M3ZD42   A0A2M4C4K8   A0A2M4AXG6   A0A1A9ZGL2   A0A0A1XEL7   A0A0L0BYS0   A0A1A9X8T5   A0A067RWB8   B4JMI2   D6WT01   A0A182RE99   A0A1W4X5B6   A0A0M3QYZ1   B4L4S5   B3MYA8   Q9W5E7   B4M2D7   A0A2R7W7A6   B4R7F6   Q29I52   B4HAA2   B4I936   A0A1W4V7Z6   B3P980   B4PX12   A0A0P4VQ32   R4FN50   A0A1B6ERQ1   B4N263   A0A182U875   Q7Q7Q2   A0A182YES1   A0A182G2P6   A0A182VPS1   A0A182NE01   A0A182HCT0   A0A182JVX3   A0A182Q0Q8   A0A2R7WXL5   B0WGQ1   A0A1S4FUV6   A0A170UEP5   A6YPG9   A0A023FAX8   A0A1L8DC66   A0A069DNZ6   Q16NH2   A0A224XQC7   A0A1Q3FH88   U5EUS4   A0A1Q3FIA3   A0A1Y1MRN5   A0A1J1I509   A0A0A9X6F2   A0A0A9WH98   A0A1B0CHZ0   A0A146LC02   A0A182M5A2   A0A1B0D4U0   A0A1B6C8U8   A0A1D2MXU5   A0A0K8TQ00   K7JZ97   E9GEL2   A0A232F0L7   A0A0P6CWE1   A0A0P5TAM7   A0A0P6AQS2   A0A1W0WTK2   A0A151JSH6  

KEGG

101746420    no KO assigned | (RefSeq) uncharacterized LOC101746420

GO

GO:0016021   GO:0005509   GO:0016485   GO:0005789   GO:0000139   GO:0004190   GO:0007219   GO:0003723  

PANTHER

PTHR10202   PTHR32343:SF7  

Subcellular location

Endoplasmic reticulum membrane  
Golgi apparatus membrane  

Length:

115

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

19.59886

Exp number, first 60 AAs:

19.53603

Total prob of N-in:

0.55373

POSSIBLE N-term signal

sequence

outside

1  -  29

TMhelix

30  -  49

inside

50  -  115

 

 

Pi

184.883404

Theta

164.325037

Tajima's D

0.393462

CLR

0

CSRT

0.483525823708815

Interpretation

Uncertain