SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO15166
Pre Gene Modal
BGIBMGA004935
Annotation
PREDICTED:_cystathionine_beta-synthase-like_[Bombyx_mori]
Full name
Cystathionine beta-synthase      
Alternative Name
Beta-thionase
Hemoprotein H-450
Serine sulfhydrase
Location in the cell
Cytoplasmic   Reliability : 2.579
 

Sequence

CDS
ATGCCTCACATTGTAAGGGCACTGGATCGAAATCAGAAGGTACATTCAGATATTTTGAATGTAATCGGAAATACACCACTGGTGAAGCTATCCAAATTACCTAAAGATGAAGGATTGAAATGTGAAATGTATGCAAAATGCGAGTTCCTCAACCCTGGAGGATCCGTCAAAGACCGCATAGCTTACCGCATGTTTCTGGATGCAGAACAGAAGGGTATTTTGAAGCCTGGCAAGTCAGTCATAGTAGAACCCACATCTGGTAACACAGGAATCGGACTGGCACTTGCCGCTGCTGTCAGAGGGTACAGGTGCATTATAGTGTTGCCTGAGAAAATGTCAGATGAAAAAGTAAACACACTTGTCGCATTGGGTGCTGAAATAATCCGCACGCCAACTGAAGCTGCCTGGGACTCACCAGAGAGCAACATCATGGTTGCGCATCGACTCGCTAAAGAGATACCGCACGCTATTATTCTCGATCAATACAACAACCCTTGCAATCCATTGGCTCATTACGACGGCACCGCGGAGGAGATCCTGTGGGCGCTGGACGACGCCGTGGACATGGTGGTGATCGGCGCTGGAACCAGCGGCACCATCTCCGGCGTCGGGCACAAGATCAAAGAGCGCTGTCCCGACTGCGTTATTGTTGGGGTCGACCCTTACGGATCCATACTCGCCGAGCCTGAAGTATTGAATGAATCCGACGTACAAGTTTATGAGGTTGAAGGTATTGGTTACGATTTCTTGCCGGGCACACTCGACAGAACCGTCGTCGACAAATGGGTGAAAAGTGATGACCAAAACTCTTTGGAAATTGCTCGCAGACTCATCAAAGATGAAGGGCTTCTATGCGGTGGCAGCAGCGGCGCGGCGATGTGGGGCGCCATACAAGCCGCCAAATCCCTTAAAGAAGGACAGAAGTGTGTGGTGCTATTACCGGACAGCATTCGAAACTATATGACCAAATTCATATCAGATCAATGGATGGAAGCCCGTAACTTCAAACCTTTGATTAAAAACGATAAATTATTATGGTGGGATAAACATTTAACGCAAGATATGGTTCGACCAACAAAAAGTATATCGCATTATAGCACGACTGCGTATGCAATTGCAACACTGAAAGAAAATCCTACACCACTACTAAATGTCACAGGTGATAATGGGTCATTAGTTGGTCTATTAACTGCTGACAATGTACGCAAGAAGTTATCAAATATGCTTGCCAAAACATCAGATCCGTTGGACAAATTTTTAGTGAAAAAGTATTACAAGGTAGACTTATCGAACAAACCCAGCTTAGGGCTTGTATCTCGAATGCTCGACATCTCCCCCTACGTTGTAGTCGTCAGATCAGTTTCCTCTGCTGTCCTACCTGTTGGAATAATCACATCTGAAGATTTACTCTCAGGTATTCATTAG
Protein
MPHIVRALDRNQKVHSDILNVIGNTPLVKLSKLPKDEGLKCEMYAKCEFLNPGGSVKDRIAYRMFLDAEQKGILKPGKSVIVEPTSGNTGIGLALAAAVRGYRCIIVLPEKMSDEKVNTLVALGAEIIRTPTEAAWDSPESNIMVAHRLAKEIPHAIILDQYNNPCNPLAHYDGTAEEILWALDDAVDMVVIGAGTSGTISGVGHKIKERCPDCVIVGVDPYGSILAEPEVLNESDVQVYEVEGIGYDFLPGTLDRTVVDKWVKSDDQNSLEIARRLIKDEGLLCGGSSGAAMWGAIQAAKSLKEGQKCVVLLPDSIRNYMTKFISDQWMEARNFKPLIKNDKLLWWDKHLTQDMVRPTKSISHYSTTAYAIATLKENPTPLLNVTGDNGSLVGLLTADNVRKKLSNMLAKTSDPLDKFLVKKYYKVDLSNKPSLGLVSRMLDISPYVVVVRSVSSAVLPVGIITSEDLLSGIH

Summary

Description
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (PubMed:20149843, PubMed:8558235).
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).
Catalytic Activity
L-homocysteine + L-serine = H2O + L,L-cystathionine
Cofactor
pyridoxal 5'-phosphate
Subunit
Homotetramer.
Similarity
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Keywords
Alternative splicing   Amino-acid biosynthesis   CBS domain   Complete proteome   Cysteine biosynthesis   Cytoplasm   Direct protein sequencing   Heme   Iron   Isopeptide bond   Lyase   Metal-binding   Nucleus   Phosphoprotein   Pyridoxal phosphate   Reference proteome   Ubl conjugation  
Feature
chain  Cystathionine beta-synthase
splice variant  In isoform IV.
EC Number
4.2.1.22
EMBL
ODYU01010411    SOQ55493.1    NWSH01001069    PCG72792.1    RSAL01000053    RVE50097.1    + More
KQ460045    KPJ18205.1    GAIX01004534    JAA88026.1    AGBW02011379    OWR46747.1    CVRI01000044    CRK96786.1    GDHF01033006    GDHF01032171    GDHF01029992    JAI19308.1    JAI20143.1    JAI22322.1    GAKP01011212    JAC47740.1    GBXI01011149    JAD03143.1    CH940650    EDW68377.1    KA647006    AFP61635.1    GANO01002712    JAB57159.1    JRES01001642    KNC21255.1    AJWK01013647    GAMC01011137    JAB95418.1    GALX01003051    JAB65415.1    GDAI01001982    JAI15621.1    KK853386    KDR07977.1    CH933806    EDW15070.1    GFDL01015632    JAV19413.1    JXJN01001850    CM000162    EDX03060.2    GG666475    EEN66712.1    DS232229    EDS37947.1    CH964239    EDW82625.1    CH954180    EDV47583.1    BBXB01000079    GAX98120.1    CH480823    EDW56340.1    EZ422640    ADD18916.1    GFDF01002263    JAV11821.1    AE014298    AY058508    AAF50862.1    AAL13737.1    QCYY01000469    ROT84926.1    HAAD01004825    CDG71057.1    JXUM01087496    JXUM01087497    JXUM01087498    JXUM01087499    JH817182    EKC27927.1    CH916378    EDV98592.1    CP012526    ALC45748.1    CH902640    EDV38395.1    GEZM01006923    GEZM01006920    JAV95562.1    OUUW01000003    SPP78054.1    M88344    M88346    D01098    AK077669    BC013472    BC013480    BC026595    CH379065    EAL31478.1    CH477512    EAT39750.1    NEDP02004672    OWF44800.1    CM000366    EDX18496.1    GL832976    EGD77032.1    KE346368    KJE95166.1    KL225241    KFW69936.1    KQ435028    KZC13973.1    KK501770    KFP17807.1    EAT39751.1    NEVH01019415    PNF22397.1    PNF22396.1    KQ419271    KOF84116.1    UFQS01000843    UFQT01000843    SSX07228.1    SSX27571.1    AAZX01002215    PYGN01000261    PSN49836.1    UFQT01000749    SSX26936.1    KB202685    ESO88456.1    NBNE01002866    OWZ09226.1    DS469553    EDO43469.1    AXCN02001298    JW864662    AFO97179.1    KK450093    KFQ73077.1    ADOS01001567    AEFK01104237    AEFK01104238    KK718745    KFO58497.1    JH159154    EGZ16685.1    DS028145    EEY60543.1    HAEE01013003    SBR33053.1    HAED01019672    HAEE01007783    SBR06150.1    HADZ01017264    HAEA01016907    SBQ45388.1    HADY01020953    HAEJ01019441    SBS59898.1    HAEF01011141    HAEG01005535    SBR51740.1    HAEB01001334    HAEC01014473    SBQ47809.1    HAEH01012872    SBR95931.1    ABQF01021003    ATLV01015189    KE525003    KFB40177.1    HADW01015812    SBP17212.1    HAEI01006214    SBR96616.1    AKHW03002379    KYO39072.1   
Pfam
PF00291   PALP        + More
PF00571   CBS
Interpro
IPR001926   PLP-dep        + More
IPR036052   Trypto_synt_PLP_dependent       
IPR000644   CBS_dom       
IPR001216   P-phosphate_BS       
IPR005857   Cysta_beta_synth       
SUPFAM
SSF53686   SSF53686       
PDB
3PC4     E-value=8.64222e-135,     Score=1231

Ontologies

Topology

Subcellular location
Cytoplasm  
Nucleus  
Length:
474
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.16604
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00709
outside
1  -  474
 
 

Population Genetic Test Statistics

Pi
284.935298
Theta
189.387452
Tajima's D
1.547929
CLR
0.058194
CSRT
0.797710114494275
Interpretation
Uncertain
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