Gene

KWMTBOMO15165  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000065

Annotation

hypothetical_protein_KGM_18427_[Danaus_plexippus]

Location

Bomo_Chr25(+):6013354-6020278      View in EpiBrowser

Full name

Cystathionine beta-synthase      

Location in the cell

Cytoplasmic   Reliability : 2.417

CDS

ATGTCCAATTCAAGAAGTTTTACTCGCAACAGAATTTATAATAACATACTAGAAACTATCGGTGATACACCGCTTGTTAGACTCAATCGAATTCCAAAAGACTATGGCTTGGAATGTGAAATGTTTGCAAAATGCGAATTCGTGAATCCCGGTGGTTCGATTAAAGATCGTATTTCATATACAATGGTACTGGAAGCACAAAAATCAGGAATTGCGAAATCGGGCACAAGATTCATTGAACCGACATCAGGAAATACTGGTATAGGTGTTGCTTTAGCTACGGCTGTCTGTGGATTTGGATGCACCATAGTAACTCCTGACAAGAATTCAGATGAAAAAATGAGCACGATAAGCTTACTAGGGGCGGAAGTGGTTCAGACTCCAGCCATGGCACCTTGGGAGAGCTCTGAGCATTTCTTGTCAGTAGCTAAAAGAAGACTACTCGAAGATCCGAACGCAATATCTTGCGATCAGTACAAGAACGATGTTAATCCTAGAACTCATTACGAATACACTGCTGAAGAAATATTAGCCTTGGTTCCTGATGTGGATATGATCGTGATGGGTTCAGGGACCGGTGGAACGGTGACAGGTGTCGCACAAAAAGTGAAAGAGAAATGCCCAAAATGCATAATTGTGACGGTTGATCCTCAGGGCTCTCTCATATTTGGCGAAGGGCCTGCCGATCTCTACTTCGTTGAAGGAATCGGAGGAGATTTCGTTCCAGATGTGCTGGATAAAAGCGTGATCGATAAAGTTGAAAAACCAAATGATTATGACGCGTTTAATATGTCCAGGGAAATAATTAAAAAGGAAGGATTATTATGCGGCGGTAGTAGCGGAGCGGCCATGATTTCTGCTATAAGGGCTGCAAAAAAACTCAACTTTGGAGCTGGGAAACGTGTTGTTGTCATTCTGCCTGACGGTATTCGGAATTATATGACTAAATTTGTATGCGACCAATGGATGGAAGCGCATCTCTTCAAAGAGCCACCAGAACGTGAATTTTTGTGGTGGAACAGATGTATATCAAACTTGACCTTAAATAGAACAGTGCCTCGATTACTAGAAAACAGTACATGTATAGAGGCACTGGCCGCAATGGGATCTGAAAATAATGTTGCTTTAGTGGTAAACGACGAAGGGTTCTTTAAAGGCGTCCTTACAAAGGATAGTTTGAGATCCGAAGCCACAAATCCAAAGAAAGCGGGCCGTATCGATTTTAATGAGCCCGTGAATCGACACCTTATCAAGACGTATTATAAAATAGTGGAAAACCGAGGAAACCCAACTGTGGGGTTAGCTTCGAGAATATTAGACATTGCTCCGTTTGTTATAATCGTTGAAGCCTATTATGAAAACAGTAATAAAAAACAGTTTAAAGGATATATACCAAAGGGAATCGTAACAACAGAGCATGTGATGGAATATATACTGGAACACCAGGACAAACTATAA

Protein

MSNSRSFTRNRIYNNILETIGDTPLVRLNRIPKDYGLECEMFAKCEFVNPGGSIKDRISYTMVLEAQKSGIAKSGTRFIEPTSGNTGIGVALATAVCGFGCTIVTPDKNSDEKMSTISLLGAEVVQTPAMAPWESSEHFLSVAKRRLLEDPNAISCDQYKNDVNPRTHYEYTAEEILALVPDVDMIVMGSGTGGTVTGVAQKVKEKCPKCIIVTVDPQGSLIFGEGPADLYFVEGIGGDFVPDVLDKSVIDKVEKPNDYDAFNMSREIIKKEGLLCGGSSGAAMISAIRAAKKLNFGAGKRVVVILPDGIRNYMTKFVCDQWMEAHLFKEPPEREFLWWNRCISNLTLNRTVPRLLENSTCIEALAAMGSENNVALVVNDEGFFKGVLTKDSLRSEATNPKKAGRIDFNEPVNRHLIKTYYKIVENRGNPTVGLASRILDIAPFVIIVEAYYENSNKKQFKGYIPKGIVTTEHVMEYILEHQDKL

Catalytic Activity

L-homocysteine + L-serine = H2O + L,L-cystathionine

Cofactor

pyridoxal 5'-phosphate

Similarity

Belongs to the cysteine synthase/cystathionine beta-synthase family.

Feature

chain  Cystathionine beta-synthase

Uniprot

H9IS39   A0A2A4JLE0   A0A2H1WSU3   A0A2A4J564   A0A212EZ66   A0A2A4J585   + More
A0A3S2LMU4   A0A220K8K7   A0A3S2PFP7   S4P7L6   A0A2H1WR14   A0A2A4JN07   A0A194RLL3   A0A310SQV6   A0A1B0EV47   A0A3R7PF73   A0A0L7QR91   A0A1L8DZD1   A0A2J7Q1E7   A0A2J7Q1E8   K7J973   A0A1J1IAM8   A0A154PQ00   V5HE91   A0A0L8H496   U5EX28   A0A1Y1NCB2   A0A2P6KYR5   A0A023FM23   A0A2A3EPJ2   B4M0J8   A7RYI9   A0A1I8MNS0   T1PE52   A0A026WL31   A0A091R074   T2MGI5   Q640V0   A0A0P5M2Z9   A0A0N8CHE3   A0A093H0G9   A0A0P5IC46   A0A0P5NNR3   A0A0P5K0K0   A0A0P5WHT4   A0A091G2H8   A0A0P5MKC5   A0A0P4WR60   A0A0P5KK63   A0A067QHU9   Q2V0C9   A0A0K8TND8   A0A0P5WEY2   A0A0J7KYD6   A0A0D2UJA4   A0A0P5QX77   A0A0P4ZWP2   A0A091JXW5   V9KFT8   A0A023GL79   A0A0P4YBY2   A0A091UFT0   A0A0P5UT36   A0A0P5NTC2   A0A1A8M3U6   A0A1A8QSQ8   A0A1A8KLA6   A0A1A8EGU4   A0A1A8VLJ1   A0A0P6ETM4   A0A1A8J909   A0A293N1E9   A0A1A8EN37   A0A093P0J6   A0A224YMJ3   A0A1S3PPT8   A0A023GNS9   A0A1A8QQW5   A0A131YFI4   A0A1E1X3K5   H2TMC5   A0A131XMA2   M4ACD3   A0A0P5IGF5   A0A0S7GEW1   A0A087X5D8   A0A131Z728   A0A093FPS7   A0A0P6GF51   A0A315W7M7   A0A091QS08   A0A2P8YZZ4   A0A087Y704   A0A1A7Y6J9   A0A087R995   A0A091JB33   A0A1A7XGM1   A0A091RID3   A0A3B3VL57   W8BEL3  

EC Number

4.2.1.22

Pubmed

19121390    22118469    28630352    23622113    26354079    20075255    + More
25765539    28004739    17994087    17615350    25315136    24508170    24065732    24845553    29275181    26369729    24402279    28797301    26830274    28503490    21551351    28049606    23542700    29703783    29403074    24495485   

EMBL

BABH01043931    NWSH01001069    PCG72791.1    ODYU01010411    SOQ55494.1    NWSH01003327    + More
PCG66553.1    AGBW02011379    OWR46747.1    PCG66552.1    RSAL01000053    RVE50096.1    MF319703    ASJ26417.1    RVE50097.1    GAIX01004534    JAA88026.1    SOQ55493.1    PCG72792.1    KQ460045    KPJ18205.1    KQ761546    OAD57403.1    AJWK01013647    QCYY01000469    ROT84926.1    KQ414784    KOC61145.1    GFDF01002263    JAV11821.1    NEVH01019415    PNF22396.1    PNF22397.1    AAZX01002215    CVRI01000044    CRK96786.1    KQ435028    KZC13973.1    GANP01010961    JAB73507.1    KQ419271    KOF84116.1    GANO01002712    JAB57159.1    GEZM01006923    GEZM01006920    JAV95562.1    MWRG01003551    PRD31464.1    GBBK01002248    JAC22234.1    KZ288206    PBC33039.1    CH940650    EDW68377.1    DS469553    EDO43469.1    KA647006    AFP61635.1    KK107185    EZA55814.1    KK687076    KFQ15019.1    HAAD01004825    CDG71057.1    BC082489    CR942417    AAH82489.1    CAJ83236.1    GDIQ01185753    JAK65972.1    GDIP01131503    JAL72211.1    KK615018    KFV48193.1    GDIQ01239605    JAK12120.1    GDIQ01142433    JAL09293.1    GDIQ01196468    JAK55257.1    GDIP01086307    JAM17408.1    KL447686    KFO76148.1    GDIQ01162480    GDIQ01051777    GDIQ01051776    JAK89245.1    GDIP01251875    JAI71526.1    GDIQ01190061    JAK61664.1    KK853386    KDR07977.1    AB244761    BAE66603.1    GDAI01001982    JAI15621.1    GDIP01087349    JAM16366.1    LBMM01001916    KMQ95547.1    KE346368    KJE95166.1    GDIQ01128693    JAL23033.1    GDIP01208683    JAJ14719.1    KK533780    KFP28818.1    JW864662    AFO97179.1    GBBM01000834    JAC34584.1    GDIP01229688    JAI93713.1    KK450093    KFQ73077.1    GDIP01125851    LRGB01002490    JAL77863.1    KZS07300.1    GDIQ01159522    JAK92203.1    HAEF01011141    HAEG01005535    SBR51740.1    HAEI01006214    SBR96616.1    HAEE01013003    SBR33053.1    HADZ01017264    HAEA01016907    SBQ45388.1    HADY01020953    HAEJ01019441    SBS59898.1    GDIQ01065562    JAN29175.1    HAED01019672    HAEE01007783    SBR06150.1    GFWV01021300    MAA46028.1    HAEB01001334    HAEC01014473    SBQ47809.1    KL225241    KFW69936.1    GFPF01007019    MAA18165.1    GBBM01000748    JAC34670.1    HAEH01012872    SBR95931.1    GEDV01010870    JAP77687.1    GFAC01005364    JAT93824.1    GEFH01001745    JAP66836.1    GDIQ01221656    JAK30069.1    GBYX01453904    GBYX01453903    GBYX01453902    JAO27612.1    AYCK01026850    GEDV01001935    JAP86622.1    KK394244    KFV56351.1    GDIQ01036850    JAN57887.1    NHOQ01000204    PWA32084.1    KK704493    KFQ29371.1    PYGN01000261    PSN49836.1    AYCK01006150    HADX01003691    SBP25923.1    KL226222    KFM10049.1    KK501770    KFP17807.1    HADW01015812    SBP17212.1    KK819839    KFQ39633.1    GAMC01011137    JAB95418.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000053240    UP000092461    + More
UP000283509    UP000053825    UP000235965    UP000002358    UP000183832    UP000076502    UP000053454    UP000242457    UP000008792    UP000001593    UP000095301    UP000053097    UP000053760    UP000027135    UP000036403    UP000008743    UP000076858    UP000054081    UP000087266    UP000005226    UP000002852    UP000028760    UP000245037    UP000053286    UP000053119    UP000261500   

PRIDE

H9IS39   

Pfam

PF00291   PALP        + More
PF00571   CBS

Interpro

IPR001216   P-phosphate_BS        + More
IPR036052   Trypto_synt_PLP_dependent       
IPR001926   PLP-dep       
IPR000644   CBS_dom       
IPR005857   Cysta_beta_synth       

SUPFAM

SSF53686   SSF53686       

ProteinModelPortal

H9IS39   A0A2A4JLE0   A0A2H1WSU3   A0A2A4J564   A0A212EZ66   A0A2A4J585   + More
A0A3S2LMU4   A0A220K8K7   A0A3S2PFP7   S4P7L6   A0A2H1WR14   A0A2A4JN07   A0A194RLL3   A0A310SQV6   A0A1B0EV47   A0A3R7PF73   A0A0L7QR91   A0A1L8DZD1   A0A2J7Q1E7   A0A2J7Q1E8   K7J973   A0A1J1IAM8   A0A154PQ00   V5HE91   A0A0L8H496   U5EX28   A0A1Y1NCB2   A0A2P6KYR5   A0A023FM23   A0A2A3EPJ2   B4M0J8   A7RYI9   A0A1I8MNS0   T1PE52   A0A026WL31   A0A091R074   T2MGI5   Q640V0   A0A0P5M2Z9   A0A0N8CHE3   A0A093H0G9   A0A0P5IC46   A0A0P5NNR3   A0A0P5K0K0   A0A0P5WHT4   A0A091G2H8   A0A0P5MKC5   A0A0P4WR60   A0A0P5KK63   A0A067QHU9   Q2V0C9   A0A0K8TND8   A0A0P5WEY2   A0A0J7KYD6   A0A0D2UJA4   A0A0P5QX77   A0A0P4ZWP2   A0A091JXW5   V9KFT8   A0A023GL79   A0A0P4YBY2   A0A091UFT0   A0A0P5UT36   A0A0P5NTC2   A0A1A8M3U6   A0A1A8QSQ8   A0A1A8KLA6   A0A1A8EGU4   A0A1A8VLJ1   A0A0P6ETM4   A0A1A8J909   A0A293N1E9   A0A1A8EN37   A0A093P0J6   A0A224YMJ3   A0A1S3PPT8   A0A023GNS9   A0A1A8QQW5   A0A131YFI4   A0A1E1X3K5   H2TMC5   A0A131XMA2   M4ACD3   A0A0P5IGF5   A0A0S7GEW1   A0A087X5D8   A0A131Z728   A0A093FPS7   A0A0P6GF51   A0A315W7M7   A0A091QS08   A0A2P8YZZ4   A0A087Y704   A0A1A7Y6J9   A0A087R995   A0A091JB33   A0A1A7XGM1   A0A091RID3   A0A3B3VL57   W8BEL3  

PDB

5OHX     E-value=4.8572e-96,     Score=897

KEGG

101742616    K01697 cystathionine beta-synthase [EC:4.2.1.22] | (RefSeq) cystathionine beta-synthase-like

PATHWAY

00260    Glycine, serine and threonine metabolism - Bombyx mori (domestic silkworm)
00270    Cysteine and methionine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0006535   GO:0004122   GO:0019343   GO:0005737   GO:0070814   GO:0004124   GO:0050667   GO:0030170   GO:0019346   GO:0050666   GO:0003401   GO:0016787   GO:0005739   GO:0006355   GO:0006391   GO:0031167   GO:0003677   GO:0008408   GO:0005112   GO:0015930  

Length:

485

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.90436

Exp number, first 60 AAs:

0.00338

Total prob of N-in:

0.17528

outside

1  -  485

 

 

Pi

298.629591

Theta

210.397532

Tajima's D

1.485417

CLR

0.385791

CSRT

0.785410729463527

Interpretation

Uncertain