Gene

KWMTBOMO15157

Pre Gene Modal

BGIBMGA004931

Annotation

PREDICTED:_dimethyladenosine_transferase_2?_mitochondrial_[Bombyx_mori]

Location

Bomo_Chr25(+):5918134-5922777      View in EpiBrowser

Full name

rRNA adenine N(6)-methyltransferase       + More
Dimethyladenosine transferase 2, mitochondrial      
Pyruvate kinase      

Alternative Name

Mitochondrial 12S rRNA dimethylase 2
Mitochondrial transcription factor B2
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
d-mtTFB2

Location in the cell

Cytoplasmic   Reliability : 1.018 Mitochondrial   Reliability : 1.267 Nuclear   Reliability : 1.33

CDS

ATGCGTCACAAATTAAATAAACTGAGTGAAAAACAGCCGAAATTGGCCGAAGATGTTCTCAAGTTTTTAAATAGTTCACCAGAATACAATGGTTTGAAAGAACAACTTCCTACGTCATTACTTAGAAAATATAAAGCACCTGAAAGTTCACCATTGATTGAGGTTAACCCTGGCTTGGGTATTCTTACTGAAAATATTCTAAAATGTCAAAATAACAAGATATACTTATTTGAACAGTCTAATCATTTTTCTCCATACTTGGATGACTTACAACAAAAATACCCAGGCAGGATCTCATTCAAAATAGCAGATTTTTTTGGAATGTGGAAATTAGCATTCAAAGATAAAATGGATGATGGAAACAGAATTCAGGAATTGCTAGGAGATTTATCTACTACTGACAAAAATAGGACTGTCAAGATACTGGGATCAATGCCAGGACTATCTTTCATGAAACATTTGATTTACAATGTATTATTCCATAACACTACAAATCAGCTCGGTAGACCTGATCTGTTTATAACAATGCCTGTACATCATTATGAGTTTCTTACAGATAAGGAGGTTCAGCAATCAAAACAGAAATCTGTGCCAACCTTATTCCAGCTTTTGTTTGATTGCAAAACATTAACAACGGTTACAAAAGCCCATTTTCTGCCATGGACATTGAGTAATAGCAAACACCATTCTGTGCTGAATGAACACAACCTGTATTTGGTAAATATAACACAAAAGGAAAAACTACCATGTCCAGCAGAATATTTGCCATTGTTATGGTATTTTTTCAAACCACAAATGTTCTCGAAATCGACGAGAGTTATTCCGATGTTGGAGCAATGGATACCAGGGTGCGGAGTGTGGCTTATAACTGGACAGGATCCACCGGACAGCAATAAATTATTATCCCCAGGAAAAGATGACGCGTCACTGCCACATATGACCATATTTACAGAGTTTGGTGATCTTAATTTACAACAAAAAATTACTGTTTTCAAAAGGTACATTTTCTATATATCATAA

Protein

MRHKLNKLSEKQPKLAEDVLKFLNSSPEYNGLKEQLPTSLLRKYKAPESSPLIEVNPGLGILTENILKCQNNKIYLFEQSNHFSPYLDDLQQKYPGRISFKIADFFGMWKLAFKDKMDDGNRIQELLGDLSTTDKNRTVKILGSMPGLSFMKHLIYNVLFHNTTNQLGRPDLFITMPVHHYEFLTDKEVQQSKQKSVPTLFQLLFDCKTLTTVTKAHFLPWTLSNSKHHSVLNEHNLYLVNITQKEKLPCPAEYLPLLWYFFKPQMFSKSTRVIPMLEQWIPGCGVWLITGQDPPDSNKLLSPGKDDASLPHMTIFTEFGDLNLQQKITVFKRYIFYIS

Description

Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA. Also regulates mitochondrial DNA copy number. Stimulates transcription independently of the methyltransferase activity.

Catalytic Activity

ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
Belongs to the pyruvate kinase family.

Keywords

Complete proteome   Methyltransferase   Mitochondrion   Reference proteome   RNA-binding   rRNA processing   S-adenosyl-L-methionine   Transcription   Transcription regulation   Transferase   Transit peptide  

Feature

chain  Dimethyladenosine transferase 2, mitochondrial

Uniprot

A0A2H1WV65   A0A1E1WHZ5   A0A1E1W153   A0A194PMD7   A0A194RKZ2   A0A212FE22   + More
A0A034V410   A0A0A1X1H7   A0A034V534   A0A0K8VXA9   B4JSL0   A0A1I8QD22   W8AS10   B4KCG3   A0A1A9XNN1   A0A1B0DNZ7   B4NFL8   A0A1L8E141   B4M688   A0A2J7QNZ3   A0A0K8VKI4   B3P4M6   A0A1B0BK93   A0A1A9ZQ04   B4GZ09   A0A1A9VZA8   A0A067QQU3   A0A1I8MMU9   B4QVV5   A0A3B0K392   A0A1J1HU80   A0A1B0FHF6   Q9VH38   B4HJA9   Q29B70   B3M1F0   A0A2J7QNZ6   B4PVI5   A0A1B3PDF8   A0A0M5J4W3   A0A0L0BKZ3   A0A1W4W0K1   A0A1A9VNU8   A0A1B3PDB3   A0A023EYN0   A0A1Q3F632   A0A182H1Q2   A0A0K8U2I3   A0A336MXX8   J9JY26   A0A1B6D0A2   A0A1B6E0S9   A0A2S2QM08   A0A1S4FWI2   Q16LP3   A0A224XS25   A0A182QP86   A0A182TAI1   A0A182Y3T3   A0A026W748   E2BCN1   A0A0J7NQY4   Q16F37   A0A2H8TWS3   A0A182NRT5   A0A139WEP0   A0A2M4AWE9   A0A2M4AW36   A0A182JG70   W5JWF5   A0A182MR20   A0A182FP48   E2AVH6   N6SSI5   A0A182VZM2   A0A1Y1KCK8   A0A195C9S0   A0A1B6IKN4   A0A182TXU5   A0A182LA32   Q7PY27   A0A182PSI6   A0A182UTL6   A0A182HLN8   A0A182JU81   A0A1B6L546   A0A151IXH4   A0A0L7R1J5   A0A2M4BSH0   A0A2R7W7F0   A0A2M4BTB2   A0A2M4CNV7   A0A293N6V4   A0A084VLC0   A0A088A0E7   A0A182WST4   A0A0M8ZUN4   A0A0A9W2A9  

EC Number

2.1.1.-
2.7.1.40

Pubmed

26354079    22118469    25348373    25830018    17994087    24495485    + More
24845553    25315136    15060065    10731132    12537572    12537569    15632085    17550304    26108605    25474469    26483478    17510324    25244985    24508170    30249741    20798317    18362917    19820115    20920257    23761445    23537049    28004739    20966253    12364791    14747013    17210077    24438588    25401762    26823975   

EMBL

ODYU01011303    SOQ56953.1    GDQN01004517    JAT86537.1    GDQN01010392    JAT80662.1    + More
KQ459604    KPI92280.1    KQ460045    KPJ18212.1    AGBW02008977    OWR52015.1    GAKP01022065    JAC36887.1    GBXI01009789    JAD04503.1    GAKP01022067    JAC36885.1    GDHF01008798    JAI43516.1    CH916373    EDV94750.1    GAMC01017704    GAMC01017701    GAMC01017698    GAMC01017694    JAB88857.1    CH933806    EDW14782.1    AJVK01017930    AJVK01017931    CH964251    EDW83085.1    GFDF01001700    JAV12384.1    CH940652    EDW59164.1    NEVH01012098    PNF30306.1    GDHF01012923    JAI39391.1    CH954181    EDV49679.1    JXJN01015848    CH479198    EDW28027.1    KK853074    KDR11763.1    CM000364    EDX13535.1    OUUW01000005    SPP80429.1    CVRI01000015    CRK90054.1    CCAG010006669    AY508412    AE014297    AY060616    CH480815    EDW42781.1    CM000070    EAL27128.2    CH902617    EDV42177.1    PNF30309.1    CM000160    EDW96758.1    KU659969    AOG17767.1    CP012526    ALC46461.1    JRES01001712    KNC20603.1    KU659916    AOG17715.1    GBBI01004470    JAC14242.1    GFDL01012117    JAV22928.1    JXUM01023189    JXUM01023190    KQ560654    KXJ81422.1    GDHF01031603    JAI20711.1    UFQS01003764    UFQT01003764    SSX15920.1    SSX35262.1    ABLF02022843    GEDC01018166    JAS19132.1    GEDC01005774    JAS31524.1    GGMS01008989    MBY78192.1    CH477898    EAT35245.1    GFTR01005483    JAW10943.1    AXCN02001148    KK107364    QOIP01000007    EZA51932.1    RLU20370.1    GL447336    EFN86541.1    LBMM01002400    KMQ94875.1    CH478516    EAT32847.1    GFXV01006902    MBW18707.1    KQ971354    KYB26311.1    GGFK01011597    MBW44918.1    GGFK01011654    MBW44975.1    ADMH02000156    ETN67550.1    AXCM01000026    GL443112    EFN62571.1    APGK01058767    KB741291    KB631759    ENN70609.1    ERL85851.1    GEZM01088526    JAV58131.1    KQ978068    KYM97609.1    GECU01020227    JAS87479.1    AAAB01008987    EAA00845.4    APCN01000909    GEBQ01021124    JAT18853.1    KQ980832    KYN12397.1    KQ414667    KOC64740.1    GGFJ01006868    MBW56009.1    KK854345    PTY14910.1    GGFJ01006867    MBW56008.1    GGFL01002771    MBW66949.1    GFWV01023211    MAA47938.1    ATLV01014443    KE524972    KFB38764.1    KQ435863    KOX70356.1    GBHO01042053    GBRD01012169    GDHC01010996    JAG01551.1    JAG53655.1    JAQ07633.1   

Proteomes

UP000053268    UP000053240    UP000007151    UP000001070    UP000095300    UP000009192    + More
UP000092443    UP000092462    UP000007798    UP000008792    UP000235965    UP000008711    UP000092460    UP000092445    UP000008744    UP000091820    UP000027135    UP000095301    UP000000304    UP000268350    UP000183832    UP000092444    UP000000803    UP000001292    UP000001819    UP000007801    UP000002282    UP000092553    UP000037069    UP000192221    UP000078200    UP000069940    UP000249989    UP000007819    UP000008820    UP000075886    UP000075901    UP000076408    UP000053097    UP000279307    UP000008237    UP000036403    UP000075884    UP000007266    UP000075880    UP000000673    UP000075883    UP000069272    UP000000311    UP000019118    UP000030742    UP000075920    UP000078542    UP000075902    UP000075882    UP000007062    UP000075885    UP000075903    UP000075840    UP000075881    UP000078492    UP000053825    UP000030765    UP000005203    UP000076407    UP000053105   

PRIDE

Q9VH38   

Pfam

PF00398   RrnaAD        + More
PF02887   PK_C
PF00224   PK
PF16033   DUF4789
PF00018   SH3_1
PF02218   HS1_rep

Interpro

IPR029063   SAM-dependent_MTases        + More
IPR001737   KsgA/Erm       
IPR016861   TFB2M       
IPR020598   rRNA_Ade_methylase_Trfase_N       
IPR011037   Pyrv_Knase-like_insert_dom_sf       
IPR036918   Pyrv_Knase_C_sf       
IPR015806   Pyrv_Knase_insert_dom_sf       
IPR015813   Pyrv/PenolPyrv_Kinase-like_dom       
IPR040442   Pyrv_Kinase-like_dom_sf       
IPR015793   Pyrv_Knase_brl       
IPR001697   Pyr_Knase       
IPR015795   Pyrv_Knase_C       
IPR018209   Pyrv_Knase_AS       
IPR031993   DUF4789       
IPR035716   Cortactin_SH3       
IPR003134   Hs1_Cortactin       
IPR001452   SH3_domain       
IPR036028   SH3-like_dom_sf       

SUPFAM

SSF53335   SSF53335        + More
SSF50800   SSF50800       
SSF51621   SSF51621       
SSF52935   SSF52935       
SSF50044   SSF50044       

Gene 3D

2.40.33.10     3.20.20.60     3.40.1380.20    

CDD

cd00288  Pyruvate_Kinase
cd11959  SH3_Cortactin

ProteinModelPortal

A0A2H1WV65   A0A1E1WHZ5   A0A1E1W153   A0A194PMD7   A0A194RKZ2   A0A212FE22   + More
A0A034V410   A0A0A1X1H7   A0A034V534   A0A0K8VXA9   B4JSL0   A0A1I8QD22   W8AS10   B4KCG3   A0A1A9XNN1   A0A1B0DNZ7   B4NFL8   A0A1L8E141   B4M688   A0A2J7QNZ3   A0A0K8VKI4   B3P4M6   A0A1B0BK93   A0A1A9ZQ04   B4GZ09   A0A1A9VZA8   A0A067QQU3   A0A1I8MMU9   B4QVV5   A0A3B0K392   A0A1J1HU80   A0A1B0FHF6   Q9VH38   B4HJA9   Q29B70   B3M1F0   A0A2J7QNZ6   B4PVI5   A0A1B3PDF8   A0A0M5J4W3   A0A0L0BKZ3   A0A1W4W0K1   A0A1A9VNU8   A0A1B3PDB3   A0A023EYN0   A0A1Q3F632   A0A182H1Q2   A0A0K8U2I3   A0A336MXX8   J9JY26   A0A1B6D0A2   A0A1B6E0S9   A0A2S2QM08   A0A1S4FWI2   Q16LP3   A0A224XS25   A0A182QP86   A0A182TAI1   A0A182Y3T3   A0A026W748   E2BCN1   A0A0J7NQY4   Q16F37   A0A2H8TWS3   A0A182NRT5   A0A139WEP0   A0A2M4AWE9   A0A2M4AW36   A0A182JG70   W5JWF5   A0A182MR20   A0A182FP48   E2AVH6   N6SSI5   A0A182VZM2   A0A1Y1KCK8   A0A195C9S0   A0A1B6IKN4   A0A182TXU5   A0A182LA32   Q7PY27   A0A182PSI6   A0A182UTL6   A0A182HLN8   A0A182JU81   A0A1B6L546   A0A151IXH4   A0A0L7R1J5   A0A2M4BSH0   A0A2R7W7F0   A0A2M4BTB2   A0A2M4CNV7   A0A293N6V4   A0A084VLC0   A0A088A0E7   A0A182WST4   A0A0M8ZUN4   A0A0A9W2A9  

PDB

6ERO     E-value=0.0127687,     Score=90

KEGG

101736704    K17653 dimethyladenosine transferase 2, mitochondrial [EC:2.1.1.-] | (RefSeq) dimethyladenosine tran

GO

GO:0006355   GO:0003712   GO:0006391   GO:0005739   GO:0000179   GO:0003723   GO:0006390   GO:0005759   GO:0004743   GO:0000287   GO:0016301   GO:0030955   GO:0031167   GO:0003677   GO:0008408   GO:0005112   GO:0015930  

PANTHER

PTHR11727   PTHR11727:SF13   PTHR11817  

Subcellular location

Mitochondrion  

Length:

339

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.12087

Exp number, first 60 AAs:

0.00011

Total prob of N-in:

0.04133

outside

1  -  339

 

 

Pi

231.278613

Theta

219.126892

Tajima's D

0.437823

CLR

62.56809

CSRT

0.498575071246438

Interpretation

Uncertain