Gene

KWMTBOMO15154

Annotation

ML-domain_containing_secreted_protein_precursor_[Bombyx_mori]

Location

Bomo_Chr25(-):5865695-5877423      View in EpiBrowser

Location in the cell

Extracellular   Reliability : 2.731

CDS

ATGTTTGAAACGAGCGCTTTTGTTTGTTTGGCCCTCGCAGCTGTCGTCTCAGCCACAAACGTGAGACAATGTCCAGGAAAATCAGTCCCCGAGTTGAGTAAGGCGGTCCAGTTACATGAATGCATTAAACTACCTTGCGTTCTAAAGAAAAATACAGATCAACATATTGTAATTAAATTTACACCAGAAAAAGATGTCTTGGATTTAAAAAACAGTGTGAGTGCGAAATTATTTGAAATAGACCTACCTTTTATTGGTGTAGACGGAACGTCTGTCTGCGACAAGATACATACAGAAGATGATCAGAAATCAGGATGTCCGCTCAAAGCGGGGACCAACTACATCTATAAAGACACCTTTCCTATTCTCAGTATTTACCCATCAATTCAAGCGGAAGTAACATGGGCTTTAAAAGCTGAAGATAAGGATGTGATTTGTTTTAGAGTACCTGTTAAGATTTCTTAA

Protein

MFETSAFVCLALAAVVSATNVRQCPGKSVPELSKAVQLHECIKLPCVLKKNTDQHIVIKFTPEKDVLDLKNSVSAKLFEIDLPFIGVDGTSVCDKIHTEDDQKSGCPLKAGTNYIYKDTFPILSIYPSIQAEVTWALKAEDKDVICFRVPVKIS

Uniprot

Q1HPS1   I7EG48   A0A212EM89   A0A2H1X1J9   A0A2A4JM23   I4DJC1   + More
A0A1B0CC70   E2AC22   E9IBI6   A0A232ESL1   A0A151I4K1   K7J6M8   E0VBV8   A0A158NI14   A0A1Y1LLV0   A0A026WYP5   E2BSK8   A0A023EG39   A0A3B0K1F2   B4G4T0   A0A023EHE2   Q16N77   A0A023EGZ7   A0A023EHI2   A0A023EFX6   A0A1L8DZ83   Q298W8   A0A1L8DZ62   A0A023EHH7   A0A023EHE1   T1GD78   F4X114   N6SSZ9   A0A023EJM0   A0A1Q1NPD3   B4JTD3   E2BSK9   B3LYS4   A0A194RLM3   A0A195CLD6   A0A0C9QLR3   A0A0L0C9V5   B4M031   A0A195F7A2   A0A1W4UTA8   A0A0A1WUA7   A0A034V8C0   B4R0I6   A0A1B6KTE6   I4DL62   A0A0K8UAN9   B4N9H4   A0A0M4ENN7   A0A310SH36   B4HF63   Q9VFN7   B0WFD2   B4KDX4   A0A1L8DQH3   R4G3F2   A0A195EH12   A0A1B6GY04   A0A026VRZ6   T1PFI7   B3P0K8   A0A195F7N4   B4PTD2   A0A1I8NGZ9   A0A1J1J5T6   W8B8D8   A0A1I8PL47   A0A151WJV0   A0A2A3E4G3   V9IJT2   A0A2A4JNN6   A0A1B6CSB2   A0A088A045   A0A195EFX3   A0A224XZQ1   A0A2R7W2K4   A0A154P3L1   D6WPC4   A0A1A9YLE2   A0A1A9ZK38   A0A1Q3FNK9   A0A1Q3FN38   U5EPT8   A0A151WJU0   D3TQM1   A0A1Y1KS17   A0A2M4C1H8   A0A2M4C164   A0A0A9XL67   A0A2M4C006   A0A1A9UDJ1   A0A219T7T7   A0A146L724   A0A346RVH7   A0A182FR11  

Pubmed

22118469    22651552    26354079    20798317    21282665    28648823    + More
20075255    20566863    21347285    28004739    24508170    30249741    24945155    17994087    17510324    15632085    23185243    26483478    21719571    23537049    28130397    18057021    26108605    25830018    25348373    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    25315136    24495485    18362917    19820115    20353571    25401762    26823975   

EMBL

DQ443331    MF405488    ABF51420.1    AWL83211.1    JX046918    AFO83994.1    + More
AGBW02013885    OWR42589.1    ODYU01012743    SOQ59205.1    NWSH01001030    PCG73031.1    AK401389    KQ459604    BAM18011.1    KPI92279.1    AJWK01006215    GL438389    EFN69040.1    GL762111    EFZ22042.1    NNAY01002406    OXU21348.1    KQ976456    KYM84866.1    AAZX01003989    DS235042    EEB10864.1    ADTU01016177    ADTU01016178    GEZM01055872    JAV72905.1    KK107078    QOIP01000011    EZA60264.1    RLU16463.1    GL450240    EFN81341.1    GAPW01005286    JAC08312.1    OUUW01000013    SPP88097.1    CH479179    EDW24596.1    GAPW01005287    JAC08311.1    CH477835    EAT35799.1    GAPW01005482    JAC08116.1    GAPW01005284    JAC08314.1    GAPW01005285    JAC08313.1    GFDF01002330    JAV11754.1    CM000070    EAL27837.1    KRT00305.1    GFDF01002331    JAV11753.1    GAPW01005290    GAPW01005289    JAC08309.1    JXUM01057822    JXUM01057823    GAPW01005288    KQ561973    JAC08310.1    KXJ77021.1    CAQQ02110627    CAQQ02110628    CAQQ02110629    CAQQ02110630    CAQQ02110631    CAQQ02110632    GL888520    EGI59874.1    APGK01057844    APGK01057845    APGK01057846    APGK01057847    KB741282    KB632233    ENN70819.1    ERL90397.1    GAPW01004362    JAC09236.1    KX459618    AQM58369.1    CH916786    CH916373    EDV90459.1    EDV95023.1    EFN81342.1    CH902617    EDV44040.1    KQ460045    KPJ18215.1    KQ977622    KYN01277.1    GBYB01001582    JAG71349.1    JRES01000809    KNC28229.1    CH940650    EDW68281.1    KQ981763    KYN36062.1    GBXI01012284    JAD02008.1    GAKP01020591    GAKP01020590    JAC38362.1    CM000364    EDX13001.1    GEBQ01025251    JAT14726.1    AK402030    BAM18652.1    KPI92278.1    GDHF01029952    GDHF01028663    JAI22362.1    JAI23651.1    CH964232    EDW81650.1    CP012526    ALC45560.1    KQ764717    OAD54443.1    CH480815    EDW42237.1    AE014297    AY084159    KX531562    AAF55013.1    AAL89897.1    AAN13595.1    ANY27372.1    DS231916    EDS26149.1    CH933806    EDW14971.1    KRG01302.1    GFDF01005494    JAV08590.1    ACPB03009184    GAHY01001731    JAA75779.1    KQ978957    KYN27159.1    GECZ01002463    JAS67306.1    KK110791    EZA46533.1    KA647562    AFP62191.1    CH954181    EDV48834.1    KYN36074.1    CM000160    EDW97631.1    KRK03865.1    KRK03866.1    CVRI01000070    CRL07140.1    GAMC01009080    GAMC01009079    GAMC01009078    JAB97475.1    KQ983039    KYQ48080.1    KZ288379    PBC26578.1    JR050663    AEY61325.1    PCG73030.1    GEDC01020974    JAS16324.1    KYN27170.1    GFTR01002673    JAW13753.1    KK854246    PTY13658.1    KQ434809    KZC06461.1    KQ971354    EFA07578.1    GFDL01005979    JAV29066.1    GFDL01006050    JAV28995.1    GANO01003580    JAB56291.1    KYQ48070.1    CCAG010009592    EZ423723    ADD19999.1    GEZM01075219    JAV64202.1    GGFJ01010021    MBW59162.1    GGFJ01009919    MBW59060.1    GBHO01022132    JAG21472.1    GGFJ01009471    MBW58612.1    KU342586    ANT46053.1    GDHC01015030    GDHC01009311    JAQ03599.1    JAQ09318.1    MG191334    AXS78217.1   

Proteomes

UP000007151    UP000218220    UP000053268    UP000092461    UP000000311    UP000215335    + More
UP000078540    UP000002358    UP000009046    UP000005205    UP000053097    UP000279307    UP000008237    UP000268350    UP000008744    UP000008820    UP000001819    UP000069940    UP000249989    UP000015102    UP000007755    UP000019118    UP000030742    UP000001070    UP000007801    UP000053240    UP000078542    UP000037069    UP000008792    UP000078541    UP000192221    UP000000304    UP000007798    UP000092553    UP000001292    UP000000803    UP000002320    UP000009192    UP000015103    UP000078492    UP000008711    UP000002282    UP000095301    UP000183832    UP000095300    UP000075809    UP000242457    UP000005203    UP000076502    UP000007266    UP000092443    UP000092445    UP000092444    UP000078200    UP000069272   

PRIDE

Q1HPS1    Q9VFN7   

Pfam

PF02221   E1_DerP2_DerF2

Interpro

IPR014756   Ig_E-set        + More
IPR003172   ML_dom       
IPR039670   NPC2-like       
IPR033916   ML_Npc2-like       

SUPFAM

SSF81296   SSF81296       

CDD

cd00916  Npc2_like

ProteinModelPortal

Q1HPS1   I7EG48   A0A212EM89   A0A2H1X1J9   A0A2A4JM23   I4DJC1   + More
A0A1B0CC70   E2AC22   E9IBI6   A0A232ESL1   A0A151I4K1   K7J6M8   E0VBV8   A0A158NI14   A0A1Y1LLV0   A0A026WYP5   E2BSK8   A0A023EG39   A0A3B0K1F2   B4G4T0   A0A023EHE2   Q16N77   A0A023EGZ7   A0A023EHI2   A0A023EFX6   A0A1L8DZ83   Q298W8   A0A1L8DZ62   A0A023EHH7   A0A023EHE1   T1GD78   F4X114   N6SSZ9   A0A023EJM0   A0A1Q1NPD3   B4JTD3   E2BSK9   B3LYS4   A0A194RLM3   A0A195CLD6   A0A0C9QLR3   A0A0L0C9V5   B4M031   A0A195F7A2   A0A1W4UTA8   A0A0A1WUA7   A0A034V8C0   B4R0I6   A0A1B6KTE6   I4DL62   A0A0K8UAN9   B4N9H4   A0A0M4ENN7   A0A310SH36   B4HF63   Q9VFN7   B0WFD2   B4KDX4   A0A1L8DQH3   R4G3F2   A0A195EH12   A0A1B6GY04   A0A026VRZ6   T1PFI7   B3P0K8   A0A195F7N4   B4PTD2   A0A1I8NGZ9   A0A1J1J5T6   W8B8D8   A0A1I8PL47   A0A151WJV0   A0A2A3E4G3   V9IJT2   A0A2A4JNN6   A0A1B6CSB2   A0A088A045   A0A195EFX3   A0A224XZQ1   A0A2R7W2K4   A0A154P3L1   D6WPC4   A0A1A9YLE2   A0A1A9ZK38   A0A1Q3FNK9   A0A1Q3FN38   U5EPT8   A0A151WJU0   D3TQM1   A0A1Y1KS17   A0A2M4C1H8   A0A2M4C164   A0A0A9XL67   A0A2M4C006   A0A1A9UDJ1   A0A219T7T7   A0A146L724   A0A346RVH7   A0A182FR11  

PDB

5KWY     E-value=1.97924e-06,     Score=117

KEGG

732993    K13443 Niemann-Pick C2 protein | (RefSeq) ML-domain containing secreted protein

PATHWAY

04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0032367   GO:0005623   GO:0045456   GO:0005615   GO:0032934   GO:0032504   GO:0015918   GO:0016021  

PANTHER

PTHR11306  

SignalP

Position:   1 - 18,         Likelihood:  0.981084

 

 

Length:

154

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.31472

Exp number, first 60 AAs:

0.3112

Total prob of N-in:

0.05070

outside

1  -  154

 

 

Pi

223.783333

Theta

178.420133

Tajima's D

-1.085403

CLR

0.328188

CSRT

0.12134393280336

Interpretation

Uncertain