Gene

KWMTBOMO15124  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004909

Annotation

presenilin_isoform_A_[Bombyx_mori]

Location

Bomo_Chr25(+):5519465-5529244      View in EpiBrowser

Full name

Presenilin       + More
Presenilin homolog      

Alternative Name

dPS

Location in the cell

PlasmaMembrane   Reliability : 4.662

CDS

ATGAGTGAGTCAGGCAGTGACTTAGACGCAACCGAGCACACTGCACTCATGGACGGCCACATCGCAGAAGCTCGTCCTGACAGGGAGTTAGCTGAAAGGATAGCTAGGAAACGAAAGACTAAATCCGATAATCAGCGCTCCTATGGCAGTGTAGAACAGATTGAAGGTGGCCCATCGGGGGCTTCTATTGCCCAGCAACCTCGAGTTCCAGCAGCACCAGTGGAACCACAGATTGAGGAGCTGGAGTTGAAGTATGGGGCTCGCCATGTCATCAAACTGTTTGTGCCTGTCACATTGTGCATGCTCGTAGTTGTTGCAACAATATCATCTATAAATTTTTACTCCGTTAAAGATGTATATTTGGCATATACACCGTTTCATGAAGAGAGTCCATACGCATCAACAAAAGTGTGGAATGCATTGGCCAATTCGATGATCTTGTTGTGTGTGATTGCATTAATGACGGTGTTACTTATTGTGCTTTACAAGAAAAAATGCTACAAGACTATTCATGGATGGTTGATTCTATCATCATTAATCTTGCTGTTTCTATTCTCTTACTTGTATATTGAGGAAGCACTCATTGCCTATAATATACCAATGGATTATATAACTTTAGGCTTTGTGTTGTGGAATTTTGGAGTCATGGGCATGATTGTCATACATTGGAAGGGTCCGCTGAGGCTACAACAAGCTTACTTGATCTTCATTGCAGCCCTTATGGCACTTGTGTTCATCAAGTATTTGCCGGAATGGACAACATGGGCCGTTCTTGCAGTGATATCTATTTGGGATTTGGTGGCTGTATTAACACCGAAGGGACCTTTGAGAATATTGGTTGAAACAGCACAGGAACGCAATGAGCCTATATTTCCAGCTCTCATTTATTCATCGACAGTGATGTACTGCATGGCGGCAGCGAGCCCCGCGCCCGGCGCCGCAGGTGAGCGCGAGCTGCGCCCGCTGCAACCGCACGGAACTGTCGAGGGCGAAGGTCGCGACGGCACGGAGGCGGGGGGCGGGGAGGCGGGGTTCGACGCGGCGTGGAGGGAGAGACGCGACGAGGGTGCGGCGCCGCGCCGGCTGCGGGTCGACTCTGCGCCGCCGCGCTACGTCACGCGCCTCGACCCGCCGCACGCGCCCCACGCGCCGCCGCACGCGCCCGACCTCGACGAGGAGAAAGGCGTAAAACTTGGTCTAGGTGATTTCATATTCTATAGTGTCCTCGTAGGAAAAGCAAGTTCATACGGCGATTGGAATACAACATTAGCCTGTTTTGTAGCTATACTTATAGGTTTATGTCTAACACTCCTGCTGCTCGCCATATTAAAGAAGGCTCTTCCGGCGCTCCCTATATCGATAACATTCGGACTTATATTCTATTTCGCAACGCGATCGGTCGTGAAGCCATTTGCGGACGCTTTGGCGGCGGAACAGGTGTTCATTTAG

Protein

MSESGSDLDATEHTALMDGHIAEARPDRELAERIARKRKTKSDNQRSYGSVEQIEGGPSGASIAQQPRVPAAPVEPQIEELELKYGARHVIKLFVPVTLCMLVVVATISSINFYSVKDVYLAYTPFHEESPYASTKVWNALANSMILLCVIALMTVLLIVLYKKKCYKTIHGWLILSSLILLFLFSYLYIEEALIAYNIPMDYITLGFVLWNFGVMGMIVIHWKGPLRLQQAYLIFIAALMALVFIKYLPEWTTWAVLAVISIWDLVAVLTPKGPLRILVETAQERNEPIFPALIYSSTVMYCMAAASPAPGAAGERELRPLQPHGTVEGEGRDGTEAGGGEAGFDAAWRERRDEGAAPRRLRVDSAPPRYVTRLDPPHAPHAPPHAPDLDEEKGVKLGLGDFIFYSVLVGKASSYGDWNTTLACFVAILIGLCLTLLLLAILKKALPALPISITFGLIFYFATRSVVKPFADALAAEQVFI

Description

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes.

Subunit

Homodimer.
Homodimer (By similarity). Component of the gamma-secretase complex, a complex composed of a presenilin (Psn) homodimer, nicastrin (Nct), Aph-1 and Pen-2. Interacts with Metl. Isoform 2 shows a better interaction with Metl than isoform 1.

Similarity

Belongs to the peptidase A22A family.

Keywords

Alternative splicing   Complete proteome   Endoplasmic reticulum   Glycoprotein   Golgi apparatus   Hydrolase   Membrane   Notch signaling pathway   Protease   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Presenilin homolog
splice variant  In isoform 3.

Uniprot

I6TQW0   H9J5W9   I6SI17   A0A194PGT5   A0A212F6K6   A0A2H1W1S6   + More
A0A3S2LBK5   A0A194RLE8   A0A2A4JJ37   E2AIY0   A0A026WL78   D6WT91   A0A151JTA9   A0A1Y1MTP2   A0A151X1I3   A0A158NMP8   N6TTS6   F4X309   A0A195C5U0   A0A158NMP7   E9IN62   A0A195DBK4   E0VJ41   A0A1B6G2R2   A0A1L8DJX2   A0A087ZT87   A0A232EWS9   A0A1B6IMH8   A0A0J7NRQ2   A0A0L7QMG0   K7J3W8   A0A0K8TN21   A0A2A3EBM3   A0A224XFU1   A0A0V0G3M5   A0A023FA90   A0A034VM22   A0A182MVX8   A0A0K8UTF6   A0A1B6E1I8   A0A1B6E8G8   A0A0P4VV44   A0A182VYK5   W8BBE9   A0A182P6M5   A0A1W4WQW1   A0A151I5D9   A0A0A9XDD3   W5JK58   A0A1B6LC92   E2BSL4   A0A182IKB1   A0A034VGZ4   A0A1B6LQP3   V5GYH1   A0A1A9WH55   A0A0K8U1K6   A0A1J1HVM3   A0A0P8YHE3   A0A226E6I0   A0A1J1HTT8   A0A2S2R2L9   T1HN85   A0A0A1XHD2   A0A084VEG5   A0A0R1EF33   O02194-3   B7Z090   T1JMG4   A0A0J9RYT6   A0A1A9YCK9   A0A0R3P963   A0A0A1WKY9   A0A1A9V551   A0A0P6EKX4   A0A1D2NKD9   A0A0P6DWS1   A0A0P5LFQ4   A0A0P5P8L2   A0A0N8EP47   A0A0P6FYS7   A0A0P6DNF4   A0A0P6EYM6   A0A0P5IIM6   E9FSB0   A0A0P6DLS7   A0A0P6FJ95   A0A1E1X9G2   A0A1E1XQK9   A0A2R7WNQ8   A0A1I8PAT7   A0A1I8PAY2   R4WSJ8   A0A0P6BFJ8   A0A131XDX4   A0A1I8MUS4   A0A224Z6H3   T1P9B8   A0A0P5RUF1  

EC Number

3.4.23.-

Pubmed

19121390    26354079    22118469    20798317    24508170    30249741    + More
18362917    19820115    28004739    21347285    23537049    21719571    21282665    20566863    28648823    20075255    26369729    25474469    25348373    27129103    24495485    25401762    26823975    20920257    23761445    17994087    25830018    24438588    17550304    9141085    9106743    10349633    10206647    9666900    10493744    10731132    12537572    12537569    10662508    10206646    11738826    12660785    12537568    12537573    12537574    16110336    17569856    17569867    22936249    15632085    27289101    21292972    28503490    29209593    23691247    28049606    25315136    28797301   

EMBL

JQ993471    AFM77431.1    BABH01030000    BABH01030001    BABH01030002    JQ993472    + More
AFM77432.1    KQ459604    KPI92253.1    AGBW02010001    OWR49367.1    ODYU01005792    SOQ47029.1    RSAL01000053    RVE50067.1    KQ460045    KPJ18244.1    NWSH01001392    PCG71412.1    GL439921    EFN66569.1    KK107159    QOIP01000001    EZA56693.1    RLU27020.1    KQ971354    EFA07178.2    KQ981936    KYN32775.1    GEZM01021500    JAV88971.1    KQ982588    KYQ54133.1    ADTU01020664    APGK01054774    KB741253    ENN71791.1    GL888604    EGI59167.1    KQ978231    KYM96212.1    GL764276    EFZ17997.1    KQ981010    KYN10305.1    DS235219    EEB13397.1    GECZ01013041    JAS56728.1    GFDF01007316    JAV06768.1    NNAY01001825    OXU22798.1    GECU01019576    JAS88130.1    LBMM01002226    KMQ95110.1    KQ414894    KOC59729.1    AAZX01006133    GDAI01002072    JAI15531.1    KZ288292    PBC29118.1    GFTR01006522    JAW09904.1    GECL01003454    JAP02670.1    GBBI01000311    JAC18401.1    GAKP01016364    GAKP01016362    JAC42588.1    AXCM01012076    GDHF01022335    JAI29979.1    GEDC01005541    JAS31757.1    GEDC01003079    JAS34219.1    GDKW01000148    JAI56447.1    GAMC01012207    GAMC01012205    JAB94348.1    KQ976431    KYM87618.1    GBHO01025595    GBRD01013164    GDHC01009376    GDHC01006931    JAG18009.1    JAG52662.1    JAQ09253.1    JAQ11698.1    ADMH02001205    ETN63698.1    GEBQ01018670    JAT21307.1    GL450241    EFN81260.1    GAKP01016371    JAC42581.1    GEBQ01013967    JAT26010.1    GALX01003023    JAB65443.1    GDHF01031722    JAI20592.1    CVRI01000020    CRK91412.1    CH902618    KPU78360.1    LNIX01000006    OXA53039.1    CRK91411.1    GGMS01015084    MBY84287.1    ACPB03010082    GBXI01003930    JAD10362.1    ATLV01012277    KE524778    KFB36359.1    CH891902    KRK05351.1    U77934    U78084    AF084184    AF017024    AF017025    AF017026    AF093402    AE014296    AY061316    ACL83343.1    JH432007    CM002912    KMZ00789.1    CH379070    KRT08995.1    GBXI01015219    JAC99072.1    GDIQ01061120    JAN33617.1    LJIJ01000018    ODN05697.1    GDIQ01071662    JAN23075.1    GDIQ01191662    GDIQ01171860    GDIQ01091951    GDIQ01081002    JAK60063.1    JAK79865.1    GDIQ01138334    JAL13392.1    GDIQ01007692    JAN87045.1    GDIQ01041176    JAN53561.1    GDIQ01074456    JAN20281.1    GDIQ01056219    JAN38518.1    GDIQ01213807    JAK37918.1    GL732523    EFX90351.1    GDIQ01079139    JAN15598.1    GDIQ01058920    JAN35817.1    GFAC01003299    JAT95889.1    GFAA01002125    JAU01310.1    KK855171    PTY21268.1    AK417682    BAN20897.1    GDIP01015416    JAM88299.1    GEFH01004261    JAP64320.1    GFPF01010774    MAA21920.1    KA644755    AFP59384.1    GDIQ01096102    JAL55624.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000283053    UP000053240    UP000218220    + More
UP000000311    UP000053097    UP000279307    UP000007266    UP000078541    UP000075809    UP000005205    UP000019118    UP000007755    UP000078542    UP000078492    UP000009046    UP000005203    UP000215335    UP000036403    UP000053825    UP000002358    UP000242457    UP000075883    UP000075920    UP000075885    UP000192223    UP000078540    UP000000673    UP000008237    UP000075880    UP000091820    UP000183832    UP000007801    UP000198287    UP000015103    UP000030765    UP000002282    UP000000803    UP000092443    UP000001819    UP000078200    UP000094527    UP000000305    UP000095300    UP000095301   

PRIDE

I6TQW0    H9J5W9    I6SI17    O02194    B7Z090   

Pfam

PF01080   Presenilin

Interpro

IPR006639   Preselin/SPP        + More
IPR001108   Peptidase_A22A       

ProteinModelPortal

I6TQW0   H9J5W9   I6SI17   A0A194PGT5   A0A212F6K6   A0A2H1W1S6   + More
A0A3S2LBK5   A0A194RLE8   A0A2A4JJ37   E2AIY0   A0A026WL78   D6WT91   A0A151JTA9   A0A1Y1MTP2   A0A151X1I3   A0A158NMP8   N6TTS6   F4X309   A0A195C5U0   A0A158NMP7   E9IN62   A0A195DBK4   E0VJ41   A0A1B6G2R2   A0A1L8DJX2   A0A087ZT87   A0A232EWS9   A0A1B6IMH8   A0A0J7NRQ2   A0A0L7QMG0   K7J3W8   A0A0K8TN21   A0A2A3EBM3   A0A224XFU1   A0A0V0G3M5   A0A023FA90   A0A034VM22   A0A182MVX8   A0A0K8UTF6   A0A1B6E1I8   A0A1B6E8G8   A0A0P4VV44   A0A182VYK5   W8BBE9   A0A182P6M5   A0A1W4WQW1   A0A151I5D9   A0A0A9XDD3   W5JK58   A0A1B6LC92   E2BSL4   A0A182IKB1   A0A034VGZ4   A0A1B6LQP3   V5GYH1   A0A1A9WH55   A0A0K8U1K6   A0A1J1HVM3   A0A0P8YHE3   A0A226E6I0   A0A1J1HTT8   A0A2S2R2L9   T1HN85   A0A0A1XHD2   A0A084VEG5   A0A0R1EF33   O02194-3   B7Z090   T1JMG4   A0A0J9RYT6   A0A1A9YCK9   A0A0R3P963   A0A0A1WKY9   A0A1A9V551   A0A0P6EKX4   A0A1D2NKD9   A0A0P6DWS1   A0A0P5LFQ4   A0A0P5P8L2   A0A0N8EP47   A0A0P6FYS7   A0A0P6DNF4   A0A0P6EYM6   A0A0P5IIM6   E9FSB0   A0A0P6DLS7   A0A0P6FJ95   A0A1E1X9G2   A0A1E1XQK9   A0A2R7WNQ8   A0A1I8PAT7   A0A1I8PAY2   R4WSJ8   A0A0P6BFJ8   A0A131XDX4   A0A1I8MUS4   A0A224Z6H3   T1P9B8   A0A0P5RUF1  

PDB

5FN5     E-value=3.97221e-100,     Score=932

KEGG

101739954    K04505 presenilin 1 [EC:3.4.23.-] | (RefSeq) presenilin-1

PATHWAY

04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)
04330    Notch signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0007219   GO:0004190   GO:0000139   GO:0005789   GO:0016021   GO:0016485   GO:0043025   GO:0005634   GO:0050435   GO:0030018   GO:0016324   GO:0006816   GO:0006509   GO:0004175   GO:0005887   GO:0007220   GO:0048471   GO:0006508   GO:0035333   GO:0006915   GO:0034205   GO:0007614   GO:0008593   GO:0048190   GO:0055037   GO:0008306   GO:0005770   GO:0070765   GO:0015677   GO:0042803   GO:0002027   GO:0030163   GO:0005525   GO:0000166   GO:0003677   GO:0008408   GO:0005112   GO:0015930  

PANTHER

PTHR10202  

Subcellular location

Endoplasmic reticulum membrane  
Golgi apparatus membrane  

Length:

482

Number of predicted TMHs:

8

Exp number of AAs in TMHs:

175.50606

Exp number, first 60 AAs:

0

Total prob of N-in:

0.96067

inside

1  -  92

TMhelix

93  -  115

outside

116  -  139

TMhelix

140  -  162

inside

163  -  168

TMhelix

169  -  191

outside

192  -  200

TMhelix

201  -  223

inside

224  -  231

TMhelix

232  -  249

outside

250  -  252

TMhelix

253  -  270

inside

271  -  420

TMhelix

421  -  443

outside

444  -  446

TMhelix

447  -  464

inside

465  -  482

 

 

Pi

154.985849

Theta

167.258973

Tajima's D

-0.411656

CLR

1.218658

CSRT

0.271486425678716

Interpretation

Uncertain