Gene

KWMTBOMO15123  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004908

Annotation

PREDICTED:_26S_protease_regulatory_subunit_4_[Bombyx_mori]

Location

Bomo_Chr25(+):5512845-5516994      View in EpiBrowser

Full name

26S proteasome regulatory subunit 4      

Location in the cell

Cytoplasmic   Reliability : 3.012

CDS

ATGGGTCAAAATCAATCAGGTGGAGGTGGTGACAAAAAAGATGACAAAGACAAGAAGAAGAAGTATGAGCCTCCGATCCCTACACGAGTTGGTAAAAAGAAAAGGAAAGCTAAGGGACCAGATGCGGCTCTCAAGCTTCCGCAAGTCACGCCTCATACAAGATGTCGACTCAAGTTGTTAAAACTCGAAAGAATAAAAGACTATTTGTTGATGGAAGAGGAGTTCATCCGTAATCAAGAACGCTTGAAGCCACAGGAAGAGAAAATTGAAGAAGAAAGGTCTAAGGTTGATGACCTAAGAGGAACTCCAATGTCAGTTGGTAATCTTGAGGAAATCATAGATGACAATCATGCAATAGTGTCAACTTCAGTTGGCAGTGAACATTATGTTAGCATTCTCTCCTTTGTTGACAAGGATCAGCTTGAACCTGGATGCTCTGTGTTACTGAATCATAAGGTGCACGCAGTTGTTGGTGTTTTGGGTGATGACACGGATCCCATGGTGTCAGTCATGAAGCTTGAAAAGGCTCCACAGGAAACCTATGCTGACATTGGTGGCCTGGACACCCAGATCCAGGAAATCAAGGAATCTGTGGAGTTGCCTCTAACACATCCGGAATACTATGAAGAAATGGGAATCAAACCTCCCAAAGGAGTCATCTTGTACGGTCCTCCGGGCACTGGTAAAACACTCCTGGCCAAGGCTGTTGCAAATCAGACATCTGCTACCTTCCTACGTGTAGTTGGATCTGAACTTATACAAAAATATTTGGGTGATGGTCCCAAGTTGGTTCGTGAACTGTTCCGTGTTGCTGAGGAACATGCACCTTCAATTGTTTTCATTGATGAAATTGATGCAGTGGGCACTAAACGTTATGATTCAAACTCTGGTGGTGAAAGGGAAATTCAAAGGACCATGTTGGAATTATTGAATCAACTTGATGGTTTTGATTCAAGAGGAGATGTGAAGGTGATCATGGCCACAAACCGTATAGAAACTTTAGACCCGGCACTTATCCGACCAGGTCGTATTGATAGGAAGATTGAATTCCCCTTGCCTGACGAGAAAACCAAGAGAAGGATTTTCACCATTCATACATCAAGAATGACATTAGCTGATGATGTGAACTTGTCTGAACTTATTATGTCAAAAGATGATCTTTCTGGTGCTGATATTAAGGCAATATGTACTGAAGCTGGTCTCATGGCACTTAGAGAGCGCCGTATGAAAGTAACAAATGAGGACTTCAAGAAATCAAAGGAAAGTGTCCTATACCGCAAGAAGGAAGGCACACCAGAAGGACTTTATTTATAA

Protein

MGQNQSGGGGDKKDDKDKKKKYEPPIPTRVGKKKRKAKGPDAALKLPQVTPHTRCRLKLLKLERIKDYLLMEEEFIRNQERLKPQEEKIEEERSKVDDLRGTPMSVGNLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNHKVHAVVGVLGDDTDPMVSVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFTIHTSRMTLADDVNLSELIMSKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKESVLYRKKEGTPEGLYL

Description

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).

Subunit

Interacts with PSMD5.

Similarity

Belongs to the AAA ATPase family.
Belongs to the UDP-glycosyltransferase family.

Keywords

ATP-binding   Complete proteome   Cytoplasm   Nucleotide-binding   Nucleus   Proteasome   Reference proteome  

Feature

chain  26S proteasome regulatory subunit 4

Uniprot

A0A2A4JHF8   A0A3S2NVS4   A0A2H1W1T9   A0A194PG29   S4PC80   A0A182FSK9   + More
I4DND5   A0A1J1HPP4   A0A182QB88   T1E2M9   A0A2M3Z2A7   A0A2M4A938   A0A2M4BNF7   A0A182PE42   E3WN61   A0A182N5B1   B0WWV3   A0A182TUL9   A0A182XE26   A0A182LCH1   A0T4G5   A0A182HJ96   Q1HQY1   A0A023ES93   A0A1W4UK15   B4QSD0   A0A1Q3FDQ6   A0A0B4LIJ0   B4PL52   B3M322   B4NBQ9   B4HG06   B3P8C1   P48601   A0A182G9P6   A0A1L8DT25   A0A0L0BMZ9   B4JRP6   B4M0C9   A0A3B0KCN1   A0A084WSL1   D3TMJ5   A0A1A9UQ60   A0A1B0BZ88   Q298N1   A0A1L8EHU8   A0A1B0A8W2   A0A1A9W6H4   U5EX60   A0A182XUX0   A0A067RGZ7   A0A336LG10   B4K736   A0A1I8QEI4   W8B0V2   E2BWH6   T1P826   A0A069DUE0   R4FNS2   A0A1W4X6M8   A0A0M4EK14   J3JXA9   A0A0K8UH06   A0A034W729   A0A2J7R280   R4WD80   A0A0B4J2L7   A0A182V0H7   A0A224XNL3   A0A0L7R1J4   V9IG44   A0A1B6HWI1   D6WTT2   A0A2A3EQB0   A0A0C9RQW5   A0A2R7VYI9   A0A026W6M8   A0A0A9WW95   A0A1B6MFA0   A0A1B6DDK7   A0A1Y1KB25   F4W4Q7   A0A0J7L139   E2ALJ9   A0A232ETH9   A0A0P4VME7   T1JN31   V5G8R3   E0W054   K7J1D7   A0A0P4WS62   A0A0P5GTX9   A0A2P6KDC2   A0A226ESC3   A0A3S1BJS8   A0A1D2MMR6   A0A1B0FHF8   A0A0K8TN88   A0A0B7BB55   C3XS01  

Pubmed

26354079    23622113    22651552    24330624    20920257    23761445    + More
20966253    12364791    14747013    17210077    17204158    17510324    24945155    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17550304    8808288    12537569    23622245    26483478    26108605    24438588    20353571    15632085    25244985    24845553    24495485    20798317    25315136    26334808    22516182    23537049    25348373    23691247    18362917    19820115    24508170    25401762    26823975    28004739    21719571    28648823    27129103    20566863    20075255    27289101    26369729    18563158   

EMBL

NWSH01001392    PCG71411.1    RSAL01000053    RVE50066.1    ODYU01005792    SOQ47028.1    + More
KQ459604    KPI92252.1    GAIX01005582    JAA86978.1    AK402858    BAM19425.1    CVRI01000008    CRK88438.1    AXCN02000148    GALA01001135    JAA93717.1    GGFM01001908    MBW22659.1    GGFK01003964    MBW37285.1    GGFJ01005444    MBW54585.1    ADMH02002074    ETN59541.1    ETN59542.1    DS232152    EDS36214.1    AAAB01008879    EAA08386.4    EAA08387.4    APCN01002133    DQ440313    CH477841    ABF18346.1    EAT35749.1    GAPW01001486    JAC12112.1    CM000364    EDX14129.1    GFDL01009344    JAV25701.1    AE014297    AHN57492.1    CM000160    EDW99037.1    CH902617    EDV42422.2    CH964232    EDW81223.1    CH480815    EDW43399.1    CH954182    EDV53945.1    U39303    AY058759    JXUM01049616    KQ561613    KXJ78005.1    GFDF01004560    JAV09524.1    JRES01001623    KNC21396.1    CH916373    EDV94436.1    CH940650    EDW67291.2    OUUW01000007    SPP82771.1    ATLV01026615    KE525415    KFB53205.1    EZ422647    ADD18923.1    JXJN01023016    CM000070    EAL27924.1    GFDG01000575    JAV18224.1    GANO01001108    JAB58763.1    KK852643    KDR19574.1    UFQS01003326    UFQT01003326    SSX15505.1    SSX34871.1    CH933806    EDW16349.1    GAMC01019655    GAMC01019649    GAMC01019644    GAMC01019640    JAB86911.1    GL451131    EFN79932.1    KA644699    AFP59328.1    GBGD01001493    JAC87396.1    ACPB03013520    GAHY01000463    JAA77047.1    CP012526    ALC47421.1    APGK01051054    BT127878    KB741181    AEE62840.1    ENN73080.1    GDHF01026468    JAI25846.1    GAKP01007581    GAKP01007576    GAKP01007575    GAKP01007572    JAC51376.1    NEVH01008200    PNF34943.1    AK417299    BAN20514.1    GFTR01006254    JAW10172.1    KQ414667    KOC64717.1    JR040801    AEY59304.1    GECU01028683    JAS79023.1    KQ971352    EFA06741.1    KZ288194    PBC33918.1    GBYB01010915    GBYB01010916    JAG80682.1    JAG80683.1    KK854173    PTY12573.1    KK107405    EZA51286.1    GBHO01030862    GBRD01016386    GDHC01001057    JAG12742.1    JAG49440.1    JAQ17572.1    GEBQ01005374    JAT34603.1    GEDC01013539    JAS23759.1    GEZM01089123    JAV57678.1    GL887547    EGI70823.1    LBMM01001445    KMQ96298.1    GL440609    EFN65701.1    NNAY01002276    OXU21652.1    GDKW01000889    JAI55706.1    JH431265    GALX01001961    JAB66505.1    DS235857    EEB19010.1    GDRN01035851    JAI67379.1    GDIQ01239804    JAK11921.1    MWRG01015336    PRD24323.1    LNIX01000002    OXA59486.1    RQTK01000172    RUS85375.1    LJIJ01000839    ODM94222.1    CCAG010022398    GDAI01002203    JAI15400.1    HACG01042636    CEK89501.1    GG666456    EEN69469.1   

Proteomes

UP000218220    UP000283053    UP000053268    UP000069272    UP000183832    UP000075886    + More
UP000075885    UP000000673    UP000075884    UP000002320    UP000075902    UP000076407    UP000075882    UP000007062    UP000075840    UP000008820    UP000192221    UP000000304    UP000000803    UP000002282    UP000007801    UP000007798    UP000001292    UP000008711    UP000069940    UP000249989    UP000037069    UP000001070    UP000008792    UP000268350    UP000030765    UP000078200    UP000092460    UP000001819    UP000092445    UP000091820    UP000076408    UP000027135    UP000009192    UP000095300    UP000008237    UP000095301    UP000015103    UP000192223    UP000092553    UP000019118    UP000235965    UP000005203    UP000075903    UP000053825    UP000007266    UP000242457    UP000053097    UP000007755    UP000036403    UP000000311    UP000215335    UP000009046    UP000002358    UP000198287    UP000271974    UP000094527    UP000092444    UP000001554   

PRIDE

P48601    A0A0B4J2L7   

Pfam

PF17862   AAA_lid_3        + More
PF16450   Prot_ATP_ID_OB
PF00004   AAA
PF04931   DNA_pol_phi
PF05158   RNA_pol_Rpc34
PF01740   STAS
PF00916   Sulfate_transp
PF00201   UDPGT

Interpro

IPR003959   ATPase_AAA_core        + More
IPR027417   P-loop_NTPase       
IPR003960   ATPase_AAA_CS       
IPR041569   AAA_lid_3       
IPR003593   AAA+_ATPase       
IPR032501   Prot_ATP_ID_OB       
IPR035244   26S_subunit_4       
IPR005937   26S_Psome_P45-like       
IPR016024   ARM-type_fold       
IPR007015   DNA_pol_V/MYBBP1A       
IPR011547   SLC26A/SulP_dom       
IPR036513   STAS_dom_sf       
IPR001902   SLC26A/SulP_fam       
IPR036390   WH_DNA-bd_sf       
IPR036388   WH-like_DNA-bd_sf       
IPR007832   RNA_pol_Rpc34       
IPR002645   STAS_dom       
IPR035595   UDP_glycos_trans_CS       
IPR002213   UDP_glucos_trans       
IPR013083   Znf_RING/FYVE/PHD       
IPR001841   Znf_RING       

SUPFAM

SSF52540   SSF52540        + More
SSF48371   SSF48371       
SSF46785   SSF46785       
SSF52091   SSF52091       

Gene 3D

1.10.10.10     3.30.750.24     3.30.40.10    

ProteinModelPortal

A0A2A4JHF8   A0A3S2NVS4   A0A2H1W1T9   A0A194PG29   S4PC80   A0A182FSK9   + More
I4DND5   A0A1J1HPP4   A0A182QB88   T1E2M9   A0A2M3Z2A7   A0A2M4A938   A0A2M4BNF7   A0A182PE42   E3WN61   A0A182N5B1   B0WWV3   A0A182TUL9   A0A182XE26   A0A182LCH1   A0T4G5   A0A182HJ96   Q1HQY1   A0A023ES93   A0A1W4UK15   B4QSD0   A0A1Q3FDQ6   A0A0B4LIJ0   B4PL52   B3M322   B4NBQ9   B4HG06   B3P8C1   P48601   A0A182G9P6   A0A1L8DT25   A0A0L0BMZ9   B4JRP6   B4M0C9   A0A3B0KCN1   A0A084WSL1   D3TMJ5   A0A1A9UQ60   A0A1B0BZ88   Q298N1   A0A1L8EHU8   A0A1B0A8W2   A0A1A9W6H4   U5EX60   A0A182XUX0   A0A067RGZ7   A0A336LG10   B4K736   A0A1I8QEI4   W8B0V2   E2BWH6   T1P826   A0A069DUE0   R4FNS2   A0A1W4X6M8   A0A0M4EK14   J3JXA9   A0A0K8UH06   A0A034W729   A0A2J7R280   R4WD80   A0A0B4J2L7   A0A182V0H7   A0A224XNL3   A0A0L7R1J4   V9IG44   A0A1B6HWI1   D6WTT2   A0A2A3EQB0   A0A0C9RQW5   A0A2R7VYI9   A0A026W6M8   A0A0A9WW95   A0A1B6MFA0   A0A1B6DDK7   A0A1Y1KB25   F4W4Q7   A0A0J7L139   E2ALJ9   A0A232ETH9   A0A0P4VME7   T1JN31   V5G8R3   E0W054   K7J1D7   A0A0P4WS62   A0A0P5GTX9   A0A2P6KDC2   A0A226ESC3   A0A3S1BJS8   A0A1D2MMR6   A0A1B0FHF8   A0A0K8TN88   A0A0B7BB55   C3XS01  

PDB

6MSK     E-value=0,     Score=1887

KEGG

101740447    K03062 26S proteasome regulatory subunit T2 | (RefSeq) 26S protease regulatory subunit 4

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0036402   GO:0030163   GO:0005737   GO:0005524   GO:0008233   GO:0003677   GO:0005730   GO:0006355   GO:0008134   GO:0000502   GO:0006383   GO:0005666   GO:0016021   GO:0008271   GO:0017025   GO:0008540   GO:0043161   GO:0005838   GO:0008063   GO:0005654   GO:0005829   GO:0007623   GO:0016887   GO:0008568   GO:0016758   GO:0016787   GO:0005525   GO:0000166   GO:0008408   GO:0005112   GO:0015930  

PANTHER

PTHR23073:SF77  

Subcellular location

Cytoplasm  
Nucleus  

Length:

437

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00094

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00208

outside

1  -  437

 

 

Pi

257.569066

Theta

221.666626

Tajima's D

0.632663

CLR

0

CSRT

0.550222488875556

Interpretation

Uncertain