Gene

KWMTBOMO15119

Annotation

PREDICTED:_uncharacterized_protein_LOC106130647_[Amyelois_transitella]

Location

Bomo_Chr25(+):5490765-5493619      View in EpiBrowser

Full name

Abscission/NoCut checkpoint regulator      

Alternative Name

MLL partner containing FYVE domain
Zinc finger FYVE domain-containing protein 19

Location in the cell

Nuclear   Reliability : 4.194

CDS

ATGGCGTGTAATACTTGTGCGAAACCTTTCAATTTACTGCGGAAAGAAAAGGGATGTCCAGGTTGTGGATTTAGTTATTGTTCAAAATGTCTTGACCACAAAATGTTTTTGGAGAAACTGAATGCTGAAGCAAAGGTATGTGTACAATGTAAAAAAAAATCTAATTATGATAAAAAAATAGAGCCTCCATCTGCTTACTTCAAAAGATTAGCTACTGTTCAACCACCAGATCCAAATGATAGCAATACAAACTATGCTGGAGCAAGTTCAAAAGACAATGAGATTTTAAAACGATTACAGAACCTAAAGCAAGAACAAGTTCACAAGAAAGTTTCCACAGATGACGAGATTGCTCAGAGGCTTAAAAATATAAAAGGTGACCTTCCATCAGCAAGTGTCAGTGAAATTGAAGCACGACTGGCTAATTTAAGAGGTGTACCTGTACAATCACATTGTAAGCCCATATTACCCACTCCAGATTTAAGAACGGAACAGGAGCAGGCAGATGATTTGATGAAACAGTATTTGGAGCAAGTTAATATAGACACAAAATATAAAGATGATTTTAATGATATAATAGACAGTATTGAATCTAGAGTGCAAAAATTGAAATCATCAAGTACCGAGATATCAGAAGATAAAAGTAAATTATTGTCAAATAATAATACAGAATTAGATGAAGAAGAAACAGTGAATAAAATAATTGAAAAGATAAAGGCTGATCCTTCACTTGATGAAACAGTAGATTCACCTACAAAAAATGATGAGTTGCCTTTTTGTGAGATATGTAATGAAGATGCAGTATTGCGGTGTTTGGGATGTCGATATTTGTTTTGTAAGCTTTGCTTCATGGAACACAAAGATGATGATGATGGCTGTGATAGATACGAAAATTATCAACCTCCAACAAATTAA

Protein

MACNTCAKPFNLLRKEKGCPGCGFSYCSKCLDHKMFLEKLNAEAKVCVQCKKKSNYDKKIEPPSAYFKRLATVQPPDPNDSNTNYAGASSKDNEILKRLQNLKQEQVHKKVSTDDEIAQRLKNIKGDLPSASVSEIEARLANLRGVPVQSHCKPILPTPDLRTEQEQADDLMKQYLEQVNIDTKYKDDFNDIIDSIESRVQKLKSSSTEISEDKSKLLSNNNTELDEEETVNKIIEKIKADPSLDETVDSPTKNDELPFCEICNEDAVLRCLGCRYLFCKLCFMEHKDDDDGCDRYENYQPPTN

Description

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission (By similarity).

Subunit

Interacts (via MIM1-B) with VPS4A; interaction takes place at the midbody ring following cytokinesis checkpoint activation.

Keywords

Alternative splicing   Cell cycle   Cell division   Chromosomal rearrangement   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Isopeptide bond   Lipid-binding   Metal-binding   Phosphoprotein   Polymorphism   Proto-oncogene   Reference proteome   Ubl conjugation   Zinc   Zinc-finger   3D-structure  

Feature

chain  Abscission/NoCut checkpoint regulator
splice variant  In isoform 4.
sequence variant  In dbSNP:rs34819163.

Uniprot

A0A2H1W1Q7   A0A212FKX2   A0A0L7KS53   A0A194PMA6   S4PHU8   A0A194RL26   + More
A0A1I8MPZ9   A0A2I3SR96   A0A2R9BSX9   A0A2I2ZHW8   A0A0K8TS31   Q96K21-3   Q9DAZ9   Q96K21   H3BRF9   A0A2K5VEY2   F7ISY7   A0A2K6UBD3   A0A2R8P4A1   H2Q970   A0A2R9BPE8   G3QCV4   A0A2R9BQ49   A0A2I3SJ48   F7FW77   A0A2K6NQZ0   A0A2K5XF75   A0A2K5LEC3   A0A2K5XF77   A0A2K6KW02   A0A2K5H9S4   A0A1J1J0V0   A0A2K6NQY4   A0A2K6NQY7   A0A1I8Q5D5   A0A2K5LE63   A0A2K5XF74   A0A2K5H9R4   A0A2K6KVZ8   Q499R6   G3RN38   A0A2K5VER2   A0A2K5H9Q0   A0A2K5VEZ4   A0A2K6NQY2   A0A2K6B434   A0A2K5LE58   A0A2K6KVZ0   F7ISZ0   A0A2J8S5Z7   A0A1D5Q4G3   G1Q682   A0A1D5QCI0   A0A1D5QII7   B4PX72   S7P8D9   A0A2J8S600   H0VQA1   A0A2K6B424   A0A2K6B426   A0A1Q3F6V8   A0A3B0JWM5   G3TDS0   K7G4H8   A0A0D9R5F0   H2NMV4   A0A1A6H4T0   A0A1A9W8I6   G3HYR7   A0A0L0C248   G1SP94   A0A1Q3F6N2   B3NXJ7   A0A2K5S8L5   A0A2K6UBF1   A0A2K6UBD0   A0A2K5S8N7   A0A2K6GMT9   A0A2K5S8P9   A0A384D135   A0A182I006   A0A182V6Q1   A0A2K5EVE8   A0A3B3RJK4   A0A1S3AN04   A0A3Q0DIK3   A0A3B3RKC4   A0A0A1WPM9   B4MGD7   A0A2K5S8N3   Q7PUI4   A0A182X0B6   Q4QQ70   A0A1L8DWA1   T1DH90   A0A1W7RBF4   K7G4F6   F1QWA6   A8E531  

Pubmed

22118469    26227816    26354079    23622113    25315136    16136131    + More
22722832    22398555    26369729    12618766    14702039    16572171    15489334    19367720    18669648    18318008    19690332    20068231    21406692    23186163    24275569    24814515    25218447    28112733    16141072    19468303    17242355    18630941    19144319    19131326    21183079    17431167    25362486    15057822    15632090    22673903    21993624    17994087    17550304    17381049    21804562    26108605    24813606    29240929    25830018    12364791    14747013    17210077    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    23758969    26358130    23594743    12477932   

EMBL

ODYU01005792    SOQ47025.1    AGBW02007949    OWR54393.1    JTDY01006327    KOB66103.1    + More
KQ459604    KPI92250.1    GAIX01000354    JAA92206.1    KQ460045    KPJ18247.1    AACZ04038081    NBAG03000046    PNI94386.1    AJFE02093133    CABD030095576    GDAI01000645    JAI16958.1    AF445414    AK027746    AK122779    AC012476    CH471125    BC021092    AK005386    AL772264    AL929318    BC018420    AQIA01062298    PNI94383.1    PNI94381.1    JSUE03038066    CVRI01000066    CRL06023.1    AC111293    BC099795    CH473949    AAH99795.1    EDL79896.1    NDHI03003606    PNJ16193.1    AAPE02025705    CM000162    EDX01835.2    KE161462    EPQ03977.1    PNJ16195.1    AAKN02015886    GFDL01011744    JAV23301.1    OUUW01000011    SPP86487.1    AGCU01123730    AGCU01123731    AQIB01116308    ABGA01056823    PNJ16191.1    LZPO01047449    OBS73331.1    JH000944    EGW09307.1    JRES01000996    KNC26322.1    AAGW02024521    GFDL01011872    JAV23173.1    CH954180    EDV46956.2    APCN01002028    GBXI01013939    JAD00353.1    CH940672    EDW57460.1    AAAB01008987    EAA01452.3    AE014298    BT023531    BT023546    AAF48518.2    AAY84931.1    AAY84946.1    GFDF01003376    JAV10708.1    GAAZ01003003    JAA94940.1    GDAY02002991    JAV48476.1    CABZ01043842    CABZ01052589    CABZ01052590    BC153443    AAI53444.1   

Proteomes

UP000007151    UP000037510    UP000053268    UP000053240    UP000095301    UP000002277    + More
UP000240080    UP000001519    UP000005640    UP000000589    UP000233100    UP000008225    UP000233220    UP000006718    UP000233200    UP000233140    UP000233060    UP000233180    UP000233080    UP000183832    UP000095300    UP000002494    UP000233120    UP000001074    UP000002282    UP000005447    UP000268350    UP000007646    UP000007267    UP000029965    UP000001595    UP000092124    UP000091820    UP000001075    UP000037069    UP000001811    UP000008711    UP000233040    UP000233160    UP000261680    UP000291021    UP000075840    UP000075903    UP000233020    UP000261540    UP000079721    UP000189704    UP000008792    UP000007062    UP000076407    UP000000803    UP000000437   

PRIDE

Q96K21    Q9DAZ9    H3BRF9    G3HYR7    Q4QQ70    F1QWA6    + More

Pfam

PF01363   FYVE        + More
PF00643   zf-B_box

Interpro

IPR000306   Znf_FYVE        + More
IPR013083   Znf_RING/FYVE/PHD       
IPR017455   Znf_FYVE-rel       
IPR011011   Znf_FYVE_PHD       
IPR000315   Znf_B-box       

SUPFAM

SSF57903   SSF57903       

Gene 3D

3.30.40.10    

ProteinModelPortal

A0A2H1W1Q7   A0A212FKX2   A0A0L7KS53   A0A194PMA6   S4PHU8   A0A194RL26   + More
A0A1I8MPZ9   A0A2I3SR96   A0A2R9BSX9   A0A2I2ZHW8   A0A0K8TS31   Q96K21-3   Q9DAZ9   Q96K21   H3BRF9   A0A2K5VEY2   F7ISY7   A0A2K6UBD3   A0A2R8P4A1   H2Q970   A0A2R9BPE8   G3QCV4   A0A2R9BQ49   A0A2I3SJ48   F7FW77   A0A2K6NQZ0   A0A2K5XF75   A0A2K5LEC3   A0A2K5XF77   A0A2K6KW02   A0A2K5H9S4   A0A1J1J0V0   A0A2K6NQY4   A0A2K6NQY7   A0A1I8Q5D5   A0A2K5LE63   A0A2K5XF74   A0A2K5H9R4   A0A2K6KVZ8   Q499R6   G3RN38   A0A2K5VER2   A0A2K5H9Q0   A0A2K5VEZ4   A0A2K6NQY2   A0A2K6B434   A0A2K5LE58   A0A2K6KVZ0   F7ISZ0   A0A2J8S5Z7   A0A1D5Q4G3   G1Q682   A0A1D5QCI0   A0A1D5QII7   B4PX72   S7P8D9   A0A2J8S600   H0VQA1   A0A2K6B424   A0A2K6B426   A0A1Q3F6V8   A0A3B0JWM5   G3TDS0   K7G4H8   A0A0D9R5F0   H2NMV4   A0A1A6H4T0   A0A1A9W8I6   G3HYR7   A0A0L0C248   G1SP94   A0A1Q3F6N2   B3NXJ7   A0A2K5S8L5   A0A2K6UBF1   A0A2K6UBD0   A0A2K5S8N7   A0A2K6GMT9   A0A2K5S8P9   A0A384D135   A0A182I006   A0A182V6Q1   A0A2K5EVE8   A0A3B3RJK4   A0A1S3AN04   A0A3Q0DIK3   A0A3B3RKC4   A0A0A1WPM9   B4MGD7   A0A2K5S8N3   Q7PUI4   A0A182X0B6   Q4QQ70   A0A1L8DWA1   T1DH90   A0A1W7RBF4   K7G4F6   F1QWA6   A8E531  

PDB

1WFK     E-value=7.71389e-05,     Score=108

KEGG

101746517    no KO assigned | (RefSeq) abscission/NoCut checkpoint regulator

GO

GO:0046872   GO:0051301   GO:0009838   GO:0005813   GO:0005737   GO:0044878   GO:0032154   GO:0030496   GO:0090543   GO:0032466   GO:0032266   GO:0008270   GO:0016740   GO:0008124   GO:0046983   GO:0003677   GO:0005515   GO:0000166   GO:0008408   GO:0005112   GO:0015930  

Subcellular location

Cytoplasm   Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis.   With evidence from 16 publications.
Cytoskeleton   Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis.   With evidence from 16 publications.
Microtubule organizing center   Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis.   With evidence from 16 publications.
Centrosome   Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis.   With evidence from 16 publications.
Cleavage furrow   Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis.   With evidence from 16 publications.
Midbody   Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis.   With evidence from 16 publications.
Midbody ring   Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis.   With evidence from 16 publications.

Length:

304

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04787

outside

1  -  304

 

 

Pi

303.454399

Theta

232.226877

Tajima's D

1.116643

CLR

0.116201

CSRT

0.690615469226539

Interpretation

Uncertain