Gene

KWMTBOMO15118  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004993

Annotation

hypothetical_protein_KGM_16296_[Danaus_plexippus]

Location

Bomo_Chr25(-):5481856-5486714      View in EpiBrowser

Full name

Probable pterin-4-alpha-carbinolamine dehydratase       + More
Pterin-4-alpha-carbinolamine dehydratase      

Alternative Name

4-alpha-hydroxy-tetrahydropterin dehydratase
Pterin carbinolamine dehydratase

Location in the cell

Cytoplasmic   Reliability : 1.352 Nuclear   Reliability : 1.828

CDS

ATGGCTGATAAACTTAATCAAGAGGAGCGCACAACTGAGCTCAAACCTCTACTGGAATCTGGTTGGAAAATTCAGAGCAACAGAGACGCAATAGAAAAGGAATTTCAGTTCAAAAATTTTAATGAAGCTTTTGGATTCATGACCAGGGTCGCGCTGCTAGCTGAGAAAATGGATCATCATCCTGAGTGGTTCAATGTATACAACAAGTTGCAAGTGACACTTTCTTCACATGACGTAAATGGATTGAGCAAAAGGGATATCAAAATGGCCAGTTTTATGGATAAAAATTATAATTAA

Protein

MADKLNQEERTTELKPLLESGWKIQSNRDAIEKEFQFKNFNEAFGFMTRVALLAEKMDHHPEWFNVYNKLQVTLSSHDVNGLSKRDIKMASFMDKNYN

Description

Involved in tetrahydrobiopterin biosynthesis.

Catalytic Activity

(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O

Similarity

Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

Keywords

Lyase   Tetrahydrobiopterin biosynthesis  

Feature

chain  Probable pterin-4-alpha-carbinolamine dehydratase

Uniprot

A0A2H1W3E9   A0A212FKX8   A0A1E1WEZ9   A0A3S2LMS3   A0A194RLQ8   I4DJ38   + More
A0A194PG24   S4PDT3   A0A0L7KSR2   D6WSN1   E9J8L2   A0A151IET1   A0A0J7NF19   Q0PXW3   A0A0M9A2A9   E2BIN1   A0A195DMN3   A0A0L7R9Q1   F4W696   A0A1W4XLJ6   A0A2P8XPX6   A0A158NWP0   A0A2J7QUJ4   A0A067RQQ6   A0A1Y1MD96   K7J1K5   A0A154P0E2   A0A1J1IQF5   A0A1W0WCQ8   P0C8L6   A0A087TT03   A0A088A3V1   A0A2H4MCS2   E0W0B4   A0A1B6DMD8   E2ACR2   A0A026WCW7   A0A2A3EKB4   A0A2L2YCR0   A0A367KFP1   A0A0C7B9U7   A0A1D1VAU2   A0A0B2VHE3   A0A151WHQ1   A0A2G4SFG0   A0A1X0R650   A0A0K0G1W5   T1D5J4   A0A182MWS8   H9J652   A0A182RMW7   T1EZ60   A0A0C7CHN1   A0A2C9JM84   N6SYA3   A0A2G4T1X9   A0A1X0RB64   A0A183H5D5   A0A1S4F318   T1J3D0   A0A1D2NAS6   Q17GS3   U4UNN7   A0A1S3H7L4   A0A023EJL2   A0A195AW62   A0A023EJN6   V5IA76   A0A1X0S1K0   A0A367JQZ5   A0A0M3HUM5   F1L9R7   A0A182G557   A0A023EKG5   H3F4J3   A0A1B6J5D6   A0A3M6V4E1   A0A1V9XT71   A0A0N4ZUP2   A0A0P5ZI94   A0A0K8RRF0   A0A0P5YMW9   A0A131Y9F5   S4RZI4   A0A2B4SAN6   A0A367JTB6   A0A0N8EJX8   A0A0R3RW82   A0A023G9I6   A0A023FRB9   A0A023G6T6   G3MMY8   A0A210PVD7   A0A0P6BIV2   A0A1B6LTL2   B7P7V8   E9GGR8   P58249   A0A2R7X2N6   A0A023FG19  

EC Number

4.2.1.96

Pubmed

22118469    26354079    22651552    23622113    26227816    18362917    + More
19820115    21282665    20798317    21719571    29403074    21347285    24845553    28004739    20075255    20566863    24508170    30249741    26561354    29674435    27956601    27649274    24330624    19121390    23254933    15562597    23537049    27289101    17510324    24945155    21685128    26483478    18806794    30382153    28327890    22216098    28812685    21292972    11710527   

EMBL

ODYU01005792    SOQ47024.1    AGBW02007949    OWR54394.1    GDQN01005490    JAT85564.1    + More
RSAL01000053    RVE50060.1    KQ460045    KPJ18250.1    AK401306    BAM17928.1    KQ459604    KPI92247.1    GAIX01003521    JAA89039.1    JTDY01006327    KOB66101.1    KQ971354    EFA07130.1    GL769036    EFZ10827.1    KQ977858    KYM99323.1    LBMM01005909    KMQ91105.1    DQ673423    ABG81996.1    KQ435759    KOX75737.1    GL448516    EFN84478.1    KQ980724    KYN14091.1    KQ414621    KOC67600.1    GL887707    EGI70231.1    PYGN01001559    PSN34053.1    ADTU01028278    NEVH01010578    PNF32247.1    KK852478    KDR22975.1    GEZM01037936    JAV81836.1    KQ434787    KZC05311.1    CVRI01000057    CRL02447.1    MTYJ01000133    OQV12970.1    CK326948    KK116615    KFM68242.1    KX898002    ATI15031.1    DS235858    EEB19070.1    GEDC01010471    JAS26827.1    GL438568    EFN68806.1    KK107262    QOIP01000010    EZA53907.1    RLU17706.1    KZ288225    PBC31934.1    IAAA01010135    IAAA01010136    LAA05150.1    PJQL01000029    RCI00999.1    CCYT01000008    CCYT01000333    KV921302    CEG67846.1    CEG82113.1    ORE19922.1    BDGG01000005    GAU98756.1    JPKZ01001747    UYWY01020014    KHN80385.1    VDM40177.1    KQ983112    KYQ47366.1    KZ303875    PHZ07497.1    KV921903    ORE07487.1    GALA01000478    JAA94374.1    AXCM01004309    BABH01030005    BABH01030006    BABH01030007    BABH01030008    AMQM01002737    KB095858    ESO10741.1    CCYT01000424    CEG82969.1    APGK01052220    KB741211    ENN72774.1    KZ303845    PHZ15030.1    KV921879    ORE09118.1    KZ269977    UZAJ01001605    OZC12686.1    VDO33899.1    JH431823    LJIJ01000115    ODN02362.1    CH477256    EAT45864.1    KI207581    ERL95699.1    GAPW01004377    JAC09221.1    KQ976731    KYM76270.1    GAPW01004378    JAC09220.1    GALX01001670    JAB66796.1    KV921339    ORE18089.1    PJQL01000838    RCH92372.1    JI174827    ADY46871.1    JXUM01043026    KQ561347    KXJ78872.1    GAPW01003945    JAC09653.1    GECU01013313    JAS94393.1    RCHS01000120    RMX60775.1    MNPL01004580    OQR76643.1    GDIP01043177    LRGB01000725    JAM60538.1    KZS16236.1    GADI01000609    JAA73199.1    GDIP01056427    JAM47288.1    GEFM01000716    JAP75080.1    LSMT01000140    PFX25880.1    PJQL01000734    RCH93156.1    GDIQ01019444    JAN75293.1    GBBM01005880    JAC29538.1    GBBK01001312    JAC23170.1    GBBM01005879    JAC29539.1    JO843239    AEO34856.1    NEDP02005462    OWF40457.1    GDIP01015202    JAM88513.1    GEBQ01014037    GEBQ01012951    JAT25940.1    JAT27026.1    ABJB010347675    DS653761    EEC02680.1    GL732543    EFX81435.1    AF382144    KK856590    PTY26064.1    GBBK01004814    JAC19668.1   

Proteomes

UP000007151    UP000283053    UP000053240    UP000053268    UP000037510    UP000007266    + More
UP000078542    UP000036403    UP000079169    UP000053105    UP000008237    UP000078492    UP000053825    UP000007755    UP000192223    UP000245037    UP000005205    UP000235965    UP000027135    UP000002358    UP000076502    UP000183832    UP000054359    UP000005203    UP000009046    UP000000311    UP000053097    UP000279307    UP000242457    UP000252139    UP000054919    UP000242381    UP000186922    UP000031036    UP000050794    UP000267007    UP000075809    UP000242254    UP000242414    UP000035680    UP000075883    UP000005204    UP000075900    UP000015101    UP000076420    UP000019118    UP000050787    UP000094527    UP000008820    UP000030742    UP000085678    UP000078540    UP000036681    UP000069940    UP000249989    UP000005239    UP000275408    UP000192247    UP000038045    UP000076858    UP000245300    UP000225706    UP000050640    UP000242188    UP000001555    UP000000305   

PRIDE

H9J652    B7P7V8   

Pfam

PF01329   Pterin_4a        + More
PF08423   Rad51
PF12627   PolyA_pol_RNAbd
PF01743   PolyA_pol
PF02978   SRP_SPB
PF06870   RNA_pol_I_A49
PF02881   SRP54_N
PF00448   SRP54

Interpro

IPR036428   PCD_sf        + More
IPR001533   Pterin_deHydtase       
IPR036891   Signal_recog_part_SRP54_M_sf       
IPR004125   Signal_recog_particle_SRP54_M       
IPR002646   PolA_pol_head_dom       
IPR020588   RecA_ATP-bd       
IPR013632   DNA_recomb/repair_Rad51_C       
IPR032828   PolyA_RNA-bd       
IPR027417   P-loop_NTPase       
IPR009668   RNA_pol-assoc_fac_A49-like       
IPR036225   SRP/SRP_N       
IPR022941   SRP54       
IPR003593   AAA+_ATPase       
IPR000897   SRP54_GTPase_dom       
IPR042101   SRP54_N_sf       
IPR006325   SRP54_euk       
IPR013822   Signal_recog_particl_SRP54_hlx       

SUPFAM

SSF55248   SSF55248        + More
SSF47446   SSF47446       
SSF52540   SSF52540       
SSF47364   SSF47364       

Gene 3D

3.30.1360.20     1.10.260.30     1.20.120.140    

CDD

cd05398  NT_ClassII-CCAase

ProteinModelPortal

A0A2H1W3E9   A0A212FKX8   A0A1E1WEZ9   A0A3S2LMS3   A0A194RLQ8   I4DJ38   + More
A0A194PG24   S4PDT3   A0A0L7KSR2   D6WSN1   E9J8L2   A0A151IET1   A0A0J7NF19   Q0PXW3   A0A0M9A2A9   E2BIN1   A0A195DMN3   A0A0L7R9Q1   F4W696   A0A1W4XLJ6   A0A2P8XPX6   A0A158NWP0   A0A2J7QUJ4   A0A067RQQ6   A0A1Y1MD96   K7J1K5   A0A154P0E2   A0A1J1IQF5   A0A1W0WCQ8   P0C8L6   A0A087TT03   A0A088A3V1   A0A2H4MCS2   E0W0B4   A0A1B6DMD8   E2ACR2   A0A026WCW7   A0A2A3EKB4   A0A2L2YCR0   A0A367KFP1   A0A0C7B9U7   A0A1D1VAU2   A0A0B2VHE3   A0A151WHQ1   A0A2G4SFG0   A0A1X0R650   A0A0K0G1W5   T1D5J4   A0A182MWS8   H9J652   A0A182RMW7   T1EZ60   A0A0C7CHN1   A0A2C9JM84   N6SYA3   A0A2G4T1X9   A0A1X0RB64   A0A183H5D5   A0A1S4F318   T1J3D0   A0A1D2NAS6   Q17GS3   U4UNN7   A0A1S3H7L4   A0A023EJL2   A0A195AW62   A0A023EJN6   V5IA76   A0A1X0S1K0   A0A367JQZ5   A0A0M3HUM5   F1L9R7   A0A182G557   A0A023EKG5   H3F4J3   A0A1B6J5D6   A0A3M6V4E1   A0A1V9XT71   A0A0N4ZUP2   A0A0P5ZI94   A0A0K8RRF0   A0A0P5YMW9   A0A131Y9F5   S4RZI4   A0A2B4SAN6   A0A367JTB6   A0A0N8EJX8   A0A0R3RW82   A0A023G9I6   A0A023FRB9   A0A023G6T6   G3MMY8   A0A210PVD7   A0A0P6BIV2   A0A1B6LTL2   B7P7V8   E9GGR8   P58249   A0A2R7X2N6   A0A023FG19  

PDB

4WIL     E-value=8.89756e-29,     Score=309

KEGG

101741518    K01724 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96] | (RefSeq) probable pterin-4-alpha-ca

PATHWAY

00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008124   GO:0006729   GO:0003677   GO:0016779   GO:0006396   GO:0048500   GO:0008094   GO:0005524   GO:0006614   GO:0006281   GO:0008312   GO:0006351   GO:0003899   GO:0005634   GO:0005525   GO:0003924   GO:0046983   GO:0005515   GO:0000166   GO:0008408   GO:0005112   GO:0015930  

PANTHER

PTHR12599   PTHR14440   PTHR11564  

Length:

98

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00417999999999999

Exp number, first 60 AAs:

0.00399

Total prob of N-in:

0.54738

inside

1  -  98

 

 

Pi

210.368292

Theta

182.416624

Tajima's D

0.398594

CLR

1.938909

CSRT

0.489575521223939

Interpretation

Uncertain