Gene

KWMTBOMO15099

Pre Gene Modal

BGIBMGA004897

Annotation

PREDICTED:_CAAX_prenyl_protease_2_[Papilio_machaon]

Location

Bomo_Chr25(+):4824567-4829839      View in EpiBrowser

Full name

CAAX prenyl protease 2      

Alternative Name

Farnesylated proteins-converting enzyme 2
Prenyl protein-specific endoprotease 2
Protein severas

Location in the cell

PlasmaMembrane   Reliability : 4.954

CDS

ATGGAATTACTTGCAATTTTCGATCATAGTACATGTATATTTTCAATATTAGCCTGTATTTTACTCACAATTTCATATGTTGCCAGTTTATATATTTGGAGGACAAATTTAAGCAGAGATCATCCATCTACAATTAAGAGAAGGTTCTTTAGTGTATCTTGTATGATGTTACTTGCGCCATTTTTCATGAAATACTTCCTTACCAAGGAAACTCTAAGTAAAGGAGAACTGTTGGAACATTTGGGCTTAAGAACTTCAGGATGGATACAGGCAACACTGTTACCTCTATTTTTAACTGCTATTTTATTTTTGGGACCATTGACAATGCAATTTTTGTCTGGAATTTGGAAGCTGTACACTAAACCACTATACTGGCTTGCCAGTTGGCAGGATTTGGTCTGGCTGAGAAATCATATTATGGCTCCATTGAGCGAGGAGTGGGTATTTCGAGCTTGCATGATGCCTTTACTACTCCAATGTCTCAAGGCTGAAGTGGCAATATTTACTGGACCATTACTTTTTGGAACTGCTCACTTTCATCACATGTTTGAACAAATGAAGTCTGGTTATGACTTTAAAACAGCTTTGATGGTTTCATCATTCCAATTCACGTATACTAGTCTATTTGGTGCTTACTCTGCATATCTCTTTTTAAGGACAGGACACTTTGTTGCTCCACTGGTCGCACACATTTTCTGCAATCATATGGGATTTCCGAATTTTGGAGAGATACCTCAATTTCAGCCCTTGCAGAGAATTTTAATTATTTGCAATTTCATAATCGGTTTTATACTTTGGTGTTTGTTGTTGACACCTTTAACAACACCGGGAATTTATGACAACAGATTATATTGGGAAACTTGA

Protein

MELLAIFDHSTCIFSILACILLTISYVASLYIWRTNLSRDHPSTIKRRFFSVSCMMLLAPFFMKYFLTKETLSKGELLEHLGLRTSGWIQATLLPLFLTAILFLGPLTMQFLSGIWKLYTKPLYWLASWQDLVWLRNHIMAPLSEEWVFRACMMPLLLQCLKAEVAIFTGPLLFGTAHFHHMFEQMKSGYDFKTALMVSSFQFTYTSLFGAYSAYLFLRTGHFVAPLVAHIFCNHMGFPNFGEIPQFQPLQRILIICNFIIGFILWCLLLTPLTTPGIYDNRLYWET

Description

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins.

Similarity

Belongs to the peptidase U48 family.

Keywords

Complete proteome   Endoplasmic reticulum   Hydrolase   Membrane   Protease   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  CAAX prenyl protease 2

Uniprot

A0A2A4JKC1   A0A3S2NLY8   A0A2H1VRI8   A0A194RQG4   A0A194PFR9   A0A212ERA3   + More
A0A2J7Q3B0   A0A067QX36   A0A158NTH8   F4WG37   A0A195EGF7   A0A151XBR9   A0A195C8Q0   A0A1B6GH78   A0A195BG82   A0A1B6HVQ7   E2AL00   A0A195F0I7   K7IQE2   A0A1B6E5A9   T1I4Y7   A0A026WKX8   E2BN50   E9IBF3   A0A1B0D3S2   A0A0V0G7V6   A0A088A0I3   A0A1W4X6E8   A0A182QIB4   A0A182T0X0   A0A2M4BUP8   A0A182N5J1   A0A1L8D8R1   W5J597   A0A1J1ITT1   A0A182XFI3   A0A182U5K0   A0A182JR17   Q7QH53   A0A182Y769   A0A2M3ZB92   A0A1S4G3P5   A0A182W2V7   A0A182URS6   A0A1D2N3B4   A0A182RYF0   A0A293LPR0   A0A0K8UGS7   W8BU42   A0A1S3I1M6   A0A1B0CDH4   A0A034V769   A0A2M4AW07   B0W6D9   A0A2A3ERX8   A0A1Z5L8J5   A0A069DQZ1   A0A182I815   A0A182JDV5   A0A182FPR9   A0A3L8D639   L7LYL0   A0A023EP44   A0A232FG03   A0A1Q3F1V6   A0A131YAG8   V5GME5   A0A0A9ZHB9   V5H045   A0A0A9VUY6   A0A182MDD1   A0A131YWC6   A0A336M742   B4KVB0   A0A2P8Z2N5   B4QRL4   A0A1A9XRQ6   A0A226EU80   A0A1B0ADV2   A0A1W4VSA9   B4HUG4   D3TP37   A0A1I8MMS9   B4PIU5   B4IXS0   A0A1A9VLD9   L7LRV6   Q9U1H8   A0A1I8PTV6   B3NGC2   J3JUN2   A0A0L7R1F8   B3M3P6   A0A0L0C4B1   A0A146MHY1   V5H061   R7T615   A0A1B0G079   V5HVF9  

EC Number

3.4.22.-

Pubmed

26354079    22118469    24845553    21347285    21719571    20798317    + More
20075255    24508170    21282665    20920257    23761445    12364791    14747013    17210077    25244985    27289101    24495485    25348373    28528879    26334808    30249741    25576852    24945155    28648823    25765539    25401762    26830274    17994087    29403074    22936249    20353571    25315136    17550304    10731132    12537572    12537569    22516182    18057021    26108605    26823975    23254933   

EMBL

NWSH01001225    PCG72044.1    RSAL01000006    RVE54325.1    ODYU01004018    SOQ43463.1    + More
KQ460045    KPJ18266.1    KQ459604    KPI92226.1    AGBW02013098    OWR43981.1    NEVH01019069    PNF23073.1    KK853256    KDR09270.1    ADTU01025965    GL888128    EGI66804.1    KQ978957    KYN26987.1    KQ982320    KYQ57804.1    KQ978205    KYM96493.1    GECZ01007975    JAS61794.1    KQ976488    KYM83602.1    GECU01028986    JAS78720.1    GL440425    EFN65917.1    KQ981897    KYN33672.1    GEDC01004187    JAS33111.1    ACPB03002489    KK107185    EZA55759.1    GL449385    EFN82812.1    GL762111    EFZ22158.1    AJVK01023686    GECL01001905    JAP04219.1    AXCN02001165    GGFJ01007669    MBW56810.1    GFDF01011218    JAV02866.1    ADMH02002178    ETN58040.1    CVRI01000057    CRL02518.1    AAAB01008817    EAA05370.5    GGFM01005063    MBW25814.1    LJIJ01000257    ODM99758.1    GFWV01005078    MAA29808.1    GDHF01026445    JAI25869.1    GAMC01001675    JAC04881.1    AJWK01007832    AJWK01007833    GAKP01021564    JAC37388.1    GGFK01011656    MBW44977.1    DS231848    EDS36613.1    KZ288194    PBC33879.1    GFJQ02003227    JAW03743.1    GBGD01002401    JAC86488.1    APCN01002607    QOIP01000012    RLU15696.1    GACK01008149    JAA56885.1    GAPW01002858    JAC10740.1    NNAY01000255    OXU29684.1    GFDL01013528    JAV21517.1    GEFM01000356    JAP75440.1    GANP01012983    JAB71485.1    GBHO01002019    JAG41585.1    GANP01008158    JAB76310.1    GBHO01045561    JAF98042.1    AXCM01000405    GEDV01005054    JAP83503.1    UFQT01000217    SSX21848.1    CH933809    EDW18353.1    PYGN01000223    PSN50774.1    CM000363    CM002912    EDX09325.1    KMY97753.1    LNIX01000002    OXA60780.1    CH480817    EDW50585.1    EZ423189    ADD19465.1    CM000159    EDW93515.1    CH916366    EDV96441.1    GACK01010579    JAA54455.1    AJ252068    AE014296    AY069692    CH954178    EDV51023.1    BT126947    AEE61909.1    KQ414667    KOC64679.1    CH902618    EDV40339.1    KPU78510.1    JRES01000996    KNC26304.1    GDHC01000975    GDHC01000339    JAQ17654.1    JAQ18290.1    GANP01014299    JAB70169.1    AMQN01003396    KB311733    ELT88683.1    CCAG010016737    GANP01001939    JAB82529.1   

Proteomes

UP000218220    UP000283053    UP000053240    UP000053268    UP000007151    UP000235965    + More
UP000027135    UP000005205    UP000007755    UP000078492    UP000075809    UP000078542    UP000078540    UP000000311    UP000078541    UP000002358    UP000015103    UP000053097    UP000008237    UP000092462    UP000005203    UP000192223    UP000075886    UP000075901    UP000075884    UP000000673    UP000183832    UP000076407    UP000075902    UP000075881    UP000007062    UP000076408    UP000075920    UP000075903    UP000094527    UP000075900    UP000085678    UP000092461    UP000002320    UP000242457    UP000075840    UP000075880    UP000069272    UP000279307    UP000215335    UP000075883    UP000009192    UP000245037    UP000000304    UP000092443    UP000198287    UP000092445    UP000192221    UP000001292    UP000095301    UP000002282    UP000001070    UP000078200    UP000000803    UP000095300    UP000008711    UP000053825    UP000007801    UP000037069    UP000014760    UP000092444   

PRIDE

V5GME5    V5H045    Q9U1H8    V5H061    V5HVF9   

Pfam

PF02517   CPBP        + More
PF06585   JHBP
PF12767   SAGA-Tad1

Interpro

IPR039731   Rce1        + More
IPR003675   CAAX_protease_2       
IPR010562   Haemolymph_juvenile_hormone-bd       
IPR038606   To_sf       
IPR011146   HIT-like       
IPR036265   HIT-like_sf       
IPR024738   Hfi1/Tada1       

SUPFAM

SSF54197   SSF54197       

Gene 3D

3.15.10.30     3.30.428.10    

ProteinModelPortal

A0A2A4JKC1   A0A3S2NLY8   A0A2H1VRI8   A0A194RQG4   A0A194PFR9   A0A212ERA3   + More
A0A2J7Q3B0   A0A067QX36   A0A158NTH8   F4WG37   A0A195EGF7   A0A151XBR9   A0A195C8Q0   A0A1B6GH78   A0A195BG82   A0A1B6HVQ7   E2AL00   A0A195F0I7   K7IQE2   A0A1B6E5A9   T1I4Y7   A0A026WKX8   E2BN50   E9IBF3   A0A1B0D3S2   A0A0V0G7V6   A0A088A0I3   A0A1W4X6E8   A0A182QIB4   A0A182T0X0   A0A2M4BUP8   A0A182N5J1   A0A1L8D8R1   W5J597   A0A1J1ITT1   A0A182XFI3   A0A182U5K0   A0A182JR17   Q7QH53   A0A182Y769   A0A2M3ZB92   A0A1S4G3P5   A0A182W2V7   A0A182URS6   A0A1D2N3B4   A0A182RYF0   A0A293LPR0   A0A0K8UGS7   W8BU42   A0A1S3I1M6   A0A1B0CDH4   A0A034V769   A0A2M4AW07   B0W6D9   A0A2A3ERX8   A0A1Z5L8J5   A0A069DQZ1   A0A182I815   A0A182JDV5   A0A182FPR9   A0A3L8D639   L7LYL0   A0A023EP44   A0A232FG03   A0A1Q3F1V6   A0A131YAG8   V5GME5   A0A0A9ZHB9   V5H045   A0A0A9VUY6   A0A182MDD1   A0A131YWC6   A0A336M742   B4KVB0   A0A2P8Z2N5   B4QRL4   A0A1A9XRQ6   A0A226EU80   A0A1B0ADV2   A0A1W4VSA9   B4HUG4   D3TP37   A0A1I8MMS9   B4PIU5   B4IXS0   A0A1A9VLD9   L7LRV6   Q9U1H8   A0A1I8PTV6   B3NGC2   J3JUN2   A0A0L7R1F8   B3M3P6   A0A0L0C4B1   A0A146MHY1   V5H061   R7T615   A0A1B0G079   V5HVF9  

KEGG

101735415    K08658 prenyl protein peptidase [EC:3.4.22.-] | (RefSeq) CAAX prenyl protease 2

PATHWAY

00900    Terpenoid backbone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0071586   GO:0004222   GO:0030176   GO:0016021   GO:0004197   GO:0070461   GO:0016020   GO:0008270   GO:0005840   GO:0006412   GO:0005515   GO:0000166   GO:0003677   GO:0008408   GO:0005112   GO:0015930  

PANTHER

PTHR13046  

Subcellular location

Endoplasmic reticulum membrane  

Length:

287

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

130.52181

Exp number, first 60 AAs:

34.72237

Total prob of N-in:

0.15001

POSSIBLE N-term signal

sequence

outside

1  -  9

TMhelix

10  -  32

inside

33  -  48

TMhelix

49  -  68

outside

69  -  87

TMhelix

88  -  107

inside

108  -  156

TMhelix

157  -  179

outside

180  -  193

TMhelix

194  -  216

inside

217  -  252

TMhelix

253  -  275

outside

276  -  287

 

 

Pi

226.609251

Theta

164.216011

Tajima's D

1.281296

CLR

0.817363

CSRT

0.731763411829409

Interpretation

Uncertain