Gene

KWMTBOMO15078

Annotation

reverse_transcriptase_[Bombyx_mori]

Location

Bomo_Chr25(+):4295842-4297726      View in EpiBrowser

Full name

RNA-directed DNA polymerase from mobile element jockey      

Alternative Name

Reverse transcriptase

Location in the cell

Nuclear   Reliability : 3.287

CDS

ATGTTCACGATTTACTTCCACGGCAAAGGAATAACATCGGGTAATAAAAAACAAACCCGCAAAAAGCAAACTCGCAAAATTATAATTTGCGTACTTAGTGGTGAAAGGACGTCTTGTAACTGCCATCGCACGAATGTGAACGGTAGGCGTCTCGACGCGTTCATAGACGACCTCACATTCGAAATATTCAACCCCCCGACCCCCACGTGCTATCCGTATAACGCCGCGCGTCGTCCGAGCACAATAGATCTGGCACTGCTGAGGAACGTAACTCTGCGCTTACGCTCCATCGAGGCAATGTCAGAACTCGACTCAGACCACCGACCTGTCGTCATGCAGCTCGGTCGCCCACTCAATCGCGAACCAGATACGAGGACCATGGTGGATTGGAAGAAGCTGGGCACGTGCTTAGCTGACACCGCTCCACCAATCCTCCCTTGCGGCCCGGATTCAACTCCATCCCCCGAGGATACCGTCGAATCCATAAACATCTTCACTGATCACGTCTCGACGGCGATCATAAGATCCTCGAAACAAGTCGATGTGGAGGACTGCTTCCACCGCATCAGACTTTCCCCCGATCTTAGGGACCTCGTTAGAATTAGAAACGCGGCAATCCGGGCCTACGATCGATATCCCACGGATTTAAACCGGACTTGGATGCGTCGCTTACAGCGGGAGGTCAAATCCCGCTTAAGCGACGCCCGAAACGAAAACTGGGATAGTTATTTAGAAGAACTCGCGCCCACTCACCAAGCATACTGGCAACTAGCTAGGACCCTCAAGTCCGAAACTATAGCCACTATGCCGCCTCTCGTACGCCCCTCAGGCCAATCACCGGCTTACGATGACGATGACAAGGCAGAGTTGCTGGCCGATGCACTGCAAGAACAGTGCACCACCAGCACTCAACACGCGGACCGCGAACACACCGAGTTCGTCGCCAGGGAGGTCGAGCGCAGAGCTTCCCTGCCGCCCTCGGACGCGTTACCCCCCATTACCACTTCCGAGGTTAAGGAGGCGATCGATAGCCTACAACCACGGAAAGCTCCCGGCTCCGACGGCATCCGCAACCGCGCGCTTAAATTGTTACCAGCCCAACTGATAACGATGTTGGCCACCATATTAAATGCTGCTATGACGAACTGCATCTTTCCCGCGGCGTGGAAAGAAGCGGACGTTATCGGCATACACAAGCCGGGCAAACCGAAGAACGAAACCGCGAGTTACCGCCCCATCAGTCTCCTCCCGGCGATAGGCAAACTATACGAACGGCTCCTTCGTAAACGCCTCTGGGACTTCGTATCCGCGAATAAAATTCTTATAGACGAGCAGTTTGGATTCCGCGCCAGACACTCGTGCGTCCATCAAGTGCACCGCCTCACGGAGCACATCTTACTAGGGCTGAACAGGCGGAAACCCATTCCGACAGGAGCCCTCTTCTTCGATATAGCGAAGGCGTTCGACAAAGTCTAG

Protein

MFTIYFHGKGITSGNKKQTRKKQTRKIIICVLSGERTSCNCHRTNVNGRRLDAFIDDLTFEIFNPPTPTCYPYNAARRPSTIDLALLRNVTLRLRSIEAMSELDSDHRPVVMQLGRPLNREPDTRTMVDWKKLGTCLADTAPPILPCGPDSTPSPEDTVESINIFTDHVSTAIIRSSKQVDVEDCFHRIRLSPDLRDLVRIRNAAIRAYDRYPTDLNRTWMRRLQREVKSRLSDARNENWDSYLEELAPTHQAYWQLARTLKSETIATMPPLVRPSGQSPAYDDDDKAELLADALQEQCTTSTQHADREHTEFVAREVERRASLPPSDALPPITTSEVKEAIDSLQPRKAPGSDGIRNRALKLLPAQLITMLATILNAAMTNCIFPAAWKEADVIGIHKPGKPKNETASYRPISLLPAIGKLYERLLRKRLWDFVSANKILIDEQFGFRARHSCVHQVHRLTEHILLGLNRRKPIPTGALFFDIAKAFDKV

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Cofactor

Mg(2+)
Mn(2+)

Miscellaneous

Prefers poly(rC) and poly(rA) as template and activated DNA is not effective.

Keywords

Nucleotidyltransferase   RNA-directed DNA polymerase   Transferase   Transposable element  

Feature

chain  RNA-directed DNA polymerase from mobile element jockey

Uniprot

Q93137   Q9XXW0   Q9BPQ0   O96546   A0A0N1PFV1   A0A139W8G9   + More
A0A1Y1NA23   A0A139WA11   A0A2S2QEE0   A0A023EYS8   A0A1B0CHA5   V5GNJ2   X1WVL6   D7EM17   Q07995   A0A023EZE6   A0A2S2PPK8   D7GYA5   A0A087UCW3   A0A2S2NCK2   A0A2S2PA10   A0A2J7R7D0   A0A2S2Q383   A0A2M4CV42   K7IN67   V9H092   A0A2S2NPT6   A0A2M4BEF4   A0A2M4BEZ9   A0A2M4BD66   A0A2M4BDA5   A0A2M4CV52   A0A2M4BD62   J9M522   J9LC21   J9KLB1   A0A2S2NPG3   A0A2S2PJ52   J9MAC6   A0A224XB44   A0A3N5Z7I3   A0A2S2Q352   A0A0H3UA66   A0A1Y1LKN6   X1WXE6   A0A224X724   A0A087UB64   A0A1Y1KFT3   A0A224XF24   A0A2S2NGV8   A0A2S2P698   A0A0L0CBP5   A0A1Y1KFR3   A0A1B6C2V8   A0A224X6Q4   P21329   A0A087THU2   A0A224X6T4   A0A224XK92   X1WZH0   A0A232ENU1   A0A2J7Q0S7   A0A2A4IUM2   J9M0H4   A0A2S2R4B7   A0A1Y1K0C8   A0A2S2R9D4   A0A0J7K503   A0A2S2N6Q7   A0A224XJI0   A0A2S2NJB5   V5GNF3   A0A023F069   A0A146KV64   A0A2S2PBB4   A0A2S2P6S3   J9KSK5   J9LYS0   A0A224X6S1  

EC Number

2.7.7.49

Pubmed

10333566    10380107    26354079    18362917    19820115    28004739    + More
25474469    8387152    20075255    9061921    30086797    26812285    26108605    1701254    28648823    26823975   

EMBL

U07847    AAA17752.1    AB018558    BAA76304.1    AB055391    BAB21761.1    + More
AF081103    AAC72921.1    KQ459265    KPJ02064.1    KQ973342    KXZ75569.1    GEZM01008457    JAV94772.1    KQ971729    KYB24751.1    GGMS01006359    MBY75562.1    GBBI01004395    JAC14317.1    AJWK01012157    GALX01005299    JAB63167.1    ABLF02042385    KQ973412    EFA12510.2    S59870    AAB26437.2    GBBI01004571    JAC14141.1    GGMR01018716    MBY31335.1    KQ973363    EFA13335.2    KK119261    KFM75202.1    GGMR01002322    MBY14941.1    GGMR01013409    MBY26028.1    NEVH01006736    PNF36716.1    GGMS01002992    MBY72195.1    GGFL01005012    MBW69190.1    L79944    AAB04627.1    GGMR01006581    MBY19200.1    GGFJ01002256    MBW51397.1    GGFJ01002257    MBW51398.1    GGFJ01001844    MBW50985.1    GGFJ01001842    MBW50983.1    GGFL01004957    MBW69135.1    GGFJ01001843    MBW50984.1    ABLF02024246    ABLF02036316    ABLF02036319    ABLF02048663    ABLF02066977    ABLF02040174    ABLF02040183    ABLF02055266    GGMR01006408    MBY19027.1    GGMR01016297    MBY28916.1    ABLF02007779    ABLF02007782    ABLF02050375    GFTR01008262    JAW08164.1    RPOV01000134    RPJ78669.1    GGMS01002955    MBY72158.1    KF280391    AIE77315.1    GEZM01053022    JAV74219.1    ABLF02016634    GFTR01008169    JAW08257.1    KK119069    KFM74603.1    GEZM01084970    JAV60359.1    GFTR01008038    JAW08388.1    GGMR01003407    MBY16026.1    GGMR01012305    MBY24924.1    JRES01000644    KNC29657.1    GEZM01084969    JAV60363.1    GEDC01029594    JAS07704.1    GFTR01008279    JAW08147.1    M38437    KK115285    KFM64681.1    GFTR01008261    JAW08165.1    GFTR01007997    JAW08429.1    ABLF02034467    NNAY01003095    OXU19992.1    NEVH01019963    PNF22185.1    NWSH01007753    PCG62823.1    ABLF02034460    GGMS01015632    MBY84835.1    GEZM01099921    GEZM01099920    GEZM01099918    GEZM01099906    JAV53125.1    GGMS01017365    MBY86568.1    LBMM01014024    KMQ85369.1    GGMR01000226    MBY12845.1    GFTR01008257    JAW08169.1    GGMR01004661    MBY17280.1    GALX01005359    JAB63107.1    GBBI01003810    JAC14902.1    GDHC01018248    JAQ00381.1    GGMR01014053    MBY26672.1    GGMR01012443    MBY25062.1    ABLF02014118    ABLF02014121    ABLF02054790    ABLF02041861    GFTR01008271    JAW08155.1   

Proteomes

UP000053268    UP000007266    UP000092461    UP000007819    UP000054359    UP000235965    + More
UP000002358    UP000037069    UP000215335    UP000218220    UP000036403   

PRIDE

Q93137    Q9XXW0    Q9BPQ0    P21329   

Pfam

PF00078   RVT_1        + More
PF14529   Exo_endo_phos_2
PF07530   PRE_C2HC
PF07727   RVT_2
PF10551   MULE
PF03564   DUF1759
PF18701   DUF5641
PF00665   rve
PF05380   Peptidase_A17
PF17921   Integrase_H2C2
PF05585   DUF1758
PF03372   Exo_endo_phos

Interpro

IPR036691   Endo/exonu/phosph_ase_sf        + More
IPR005135   Endo/exonuclease/phosphatase       
IPR000477   RT_dom       
IPR006579   Pre_C2HC_dom       
IPR013103   RVT_2       
IPR013083   Znf_RING/FYVE/PHD       
IPR018289   MULE_transposase_dom       
IPR041588   Integrase_H2C2       
IPR036397   RNaseH_sf       
IPR005312   DUF1759       
IPR040676   DUF5641       
IPR008737   Peptidase_asp_put       
IPR008042   Retrotrans_Pao       
IPR012337   RNaseH-like_sf       
IPR001584   Integrase_cat-core       

SUPFAM

SSF56219   SSF56219        + More
SSF53098   SSF53098       

Gene 3D

3.60.10.10     3.30.40.10     3.30.420.10    

ProteinModelPortal

Q93137   Q9XXW0   Q9BPQ0   O96546   A0A0N1PFV1   A0A139W8G9   + More
A0A1Y1NA23   A0A139WA11   A0A2S2QEE0   A0A023EYS8   A0A1B0CHA5   V5GNJ2   X1WVL6   D7EM17   Q07995   A0A023EZE6   A0A2S2PPK8   D7GYA5   A0A087UCW3   A0A2S2NCK2   A0A2S2PA10   A0A2J7R7D0   A0A2S2Q383   A0A2M4CV42   K7IN67   V9H092   A0A2S2NPT6   A0A2M4BEF4   A0A2M4BEZ9   A0A2M4BD66   A0A2M4BDA5   A0A2M4CV52   A0A2M4BD62   J9M522   J9LC21   J9KLB1   A0A2S2NPG3   A0A2S2PJ52   J9MAC6   A0A224XB44   A0A3N5Z7I3   A0A2S2Q352   A0A0H3UA66   A0A1Y1LKN6   X1WXE6   A0A224X724   A0A087UB64   A0A1Y1KFT3   A0A224XF24   A0A2S2NGV8   A0A2S2P698   A0A0L0CBP5   A0A1Y1KFR3   A0A1B6C2V8   A0A224X6Q4   P21329   A0A087THU2   A0A224X6T4   A0A224XK92   X1WZH0   A0A232ENU1   A0A2J7Q0S7   A0A2A4IUM2   J9M0H4   A0A2S2R4B7   A0A1Y1K0C8   A0A2S2R9D4   A0A0J7K503   A0A2S2N6Q7   A0A224XJI0   A0A2S2NJB5   V5GNF3   A0A023F069   A0A146KV64   A0A2S2PBB4   A0A2S2P6S3   J9KSK5   J9LYS0   A0A224X6S1  

KEGG

105841429    no KO assigned | (RefSeq) uncharacterized LOC105841429

GO

GO:0003964   GO:0004519   GO:0003676   GO:0015074  

Length:

491

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.07345

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00266

outside

1  -  491

 

 

Pi

27.113755

Theta

22.597912

Tajima's D

0.400592

CLR

0

CSRT

0.490075496225189

Interpretation

Uncertain