Gene

KWMTBOMO15063  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004822

Annotation

eukaryotic_initiation_factor_4A-III_[Bombyx_mori]

Location

Bomo_Chr25(+):3871793-3875353      View in EpiBrowser

Full name

Eukaryotic initiation factor 4A-III      

Location in the cell

Nuclear   Reliability : 3.172

CDS

ATGACATCGTCTGAAGTATCGTCCAATAGAAAAATATTGTCGGAAGATTTGTCGAATGTTGAGTTCGACACGAGTGAAGATGTCGAAGTTATTCCCACTTTTGACTCCATGGGACTTCGAGATGAGTTATTGCGAGGAATATACACATATGGTTTCGAAAAACCTTCAGCAATTCAGCAGAGAAGCATCTTGCCTATAGTCAAAGGCAGAGATGTAATAGCTCAAGCACAATCTGGTACAGGAAAGACTGCGACATTCTCAATTTCAATACTACAGACTTTAGACACGACTCTGCGTGAAACTCAAGTACTTATTCTTTCACCGACCCGTGAACTGGCTACTCAGATTCAGAAAGTGATATTAGCTCTTGGAGATTTCATGAACGTTCAATGTCATGCTTGTATTGGAGGTACCAATCTTGGAGAAGATATAAGGAAATTGGATTACGGACAGCATGTTGTGTCTGGCACACCTGGCAGAGTTTTTGATATGATCAGAAGGCGTGTGTTGAGAACCCGGTCAATAAAGATGCTGGTTCTTGATGAGGCTGATGAGATGTTGAACAAAGGTTTCAAAGAGCAAATTTATGATGTATACCGCTATCTGCCTCCTGCAACTCAGGTTGTGCTAATATCAGCAACACTACCCCATGAGATATTGGAAATGACATCAAAGTTTATGACTGATCCAATAAGGATATTAGTAAAACGTGATGAGTTGACACTGGAGGGTATCAAACAGTTCTTCGTGGCAGTTGAACGAGAAGAATGGAAGTTTGACACACTTTGTGACCTCTATGATACACTGACAATTACCCAAGCAGTAATATTTTGTAATACAAAGAGGAAGGTTGACTGGCTCACACAGAAGATGCAAGAGGCAAACTTCACTGTCAGTTCAATGCATGGTGACATGCCACAGAAAGAGAGAGACAACATTATGAAGGAATTTCGTTCTGGTCAAAGCCGTGTGCTCATTACAACTGACGTCTGGGCACGAGGCATTGATGTCCAACAAGTATCCTTGGTTATAAACTATGACTTGCCCAACAATCGTGAGTTATACATTCACAGAATTGGTAGATCGGGTCGATTCGGTCGTAAGGGTGTCGCCATCAACTTCGTTAAATCAGATGACATCAGGATCTTGAGAGACATTGAACAGTACTACTCTACTCAAATAGATGAAATGCCAATGAATGTGGCTGACTTAATATAA

Protein

MTSSEVSSNRKILSEDLSNVEFDTSEDVEVIPTFDSMGLRDELLRGIYTYGFEKPSAIQQRSILPIVKGRDVIAQAQSGTGKTATFSISILQTLDTTLRETQVLILSPTRELATQIQKVILALGDFMNVQCHACIGGTNLGEDIRKLDYGQHVVSGTPGRVFDMIRRRVLRTRSIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTSKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTQKMQEANFTVSSMHGDMPQKERDNIMKEFRSGQSRVLITTDVWARGIDVQQVSLVINYDLPNNRELYIHRIGRSGRFGRKGVAINFVKSDDIRILRDIEQYYSTQIDEMPMNVADLI

Description

ATP-dependent RNA helicase (PubMed:22961380). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:22961380). Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983). Has a role in oskar mRNA localization at the posterior pole of the developing oocyte (PubMed:14973490).

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Subunit

Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains btz/CASC3, eIF4AIII, mago and tsu/RBM8A (PubMed:14973490, PubMed:22961380). Interacts with btz/CASC3 and mago (PubMed:14973490). Interacts with ncm/CWC22 (PubMed:22961380).

Similarity

Belongs to the DEAD box helicase family.

Keywords

ATP-binding   Complete proteome   Developmental protein   Helicase   Hydrolase   mRNA processing   mRNA splicing   mRNA transport   Nucleotide-binding   Nucleus   Reference proteome   RNA-binding   Transport  

Feature

chain  Eukaryotic initiation factor 4A-III

Uniprot

Q0PZE7   A0A212FLI2   A0A2W1BRX8   A0A2A4JP97   A0A3S2PKD7   A0A2H1WTH0   + More
I4DME1   I4DJR8   A0A194PFX7   A0A0N1PHX3   S4PWN2   A0A1Q3FV91   A0A2J7QNB4   A0A0M8ZSQ6   A0A067RMC6   A0A1B0CXD4   A0A154P503   A0A182J1G5   A0A2A3ERN3   A0A087ZZS7   A0A0L7R1R2   E2BEH0   A0A182QXS5   A0A182N6M7   A0A084W917   Q16GE2   A0A182VJT6   A0A1B0DM43   A0A182P301   A0A182MFM2   A0A182SNI4   A0A182UES5   A0A182X8D7   Q7PQQ2   A0A182RXB9   A0A182HIZ1   A0A1L8DGW1   A0A0J7KKY9   E9IZK2   A0A2M3Z6Y1   A0A2M4AH50   A0A2M4BQA4   W5JLN7   A0A151J4R6   A0A182XVP1   A0A151JVP6   A0A182JWR5   A0A026WX81   A0A195CSB2   A0A158NIN0   E2AWS1   A0A0K8TMU1   A0A1L8DGS9   A0A1B6L3M7   A0A232ELK5   W8BID8   A0A1B6FKM8   A0A1B6IUQ3   B4NGN0   A0A1W4VH90   B4LYN9   B4K8T2   B4PT42   A0A0M3QX77   B3M0D8   B4JV86   B3NZU1   Q9VHS8   A0A0K8UBI3   A0A034VAP8   A0A1B6C2G1   A0A0L0CBE0   B4HLL9   A0A3B0JQK9   T1PG03   Q298G7   B4G3R2   A0A1I8Q8H2   A0A1A9WML1   A0A1B0FFV4   A0A1A9YQ17   A0A1A9UFH7   A0A1B0B4Y7   A0A1A9ZT23   E0W2V0   A0A3S3SQE4   A0A1S3J3P5   T1K100   A0A2S1TJI0   A0A0K2T8I3   G3MPX6   A0A023GJK7   A0A0P5URV6   A0A0P6BGL6   T1E1I3   L7M7P7   A0A131XB35   A0A0P5CLK1   A0A0P5VWE4   C1C2L4  

EC Number

3.6.4.13

Pubmed

19121390    22118469    28756777    22651552    26354079    23622113    + More
24845553    20798317    24438588    17510324    12364791    14747013    17210077    21282665    20920257    23761445    25244985    24508170    30249741    21347285    26369729    28648823    24495485    17994087    17550304    10731132    12537572    14973490    20946982    20946983    22961380    25348373    26108605    25315136    15632085    20566863    22216098    24330624    25576852    28049606   

EMBL

BABH01025034    DQ667967    ABG73410.1    AGBW02007763    OWR54603.1    KZ149918    + More
PZC77842.1    NWSH01000949    PCG73414.1    RSAL01000008    RVE53942.1    ODYU01010900    SOQ56297.1    AK402459    BAM19081.1    AK401536    BAM18158.1    KQ459604    KPI92197.1    KQ460594    KPJ13926.1    GAIX01006493    JAA86067.1    GFDL01003531    JAV31514.1    NEVH01013196    PNF30072.1    KQ435863    KOX70370.1    KK852425    KDR24148.1    AJWK01033613    KQ434809    KZC06210.1    KZ288194    PBC33932.1    KQ414667    KOC64731.1    GL447812    EFN85902.1    AXCN02000299    ATLV01021572    KE525320    KFB46711.1    CH478287    EAT33304.1    AJVK01016664    AXCM01000558    AAAB01008879    EAA08469.4    APCN01002105    GFDF01008423    JAV05661.1    LBMM01006135    KMQ90891.1    GL767232    EFZ14001.1    GGFM01003447    MBW24198.1    GGFK01006721    MBW40042.1    GGFJ01006061    MBW55202.1    ADMH02001068    ETN64218.1    KQ980102    KYN17746.1    KQ981702    KYN37460.1    KK107072    QOIP01000007    EZA60660.1    RLU20877.1    KQ977306    KYN03623.1    ADTU01017000    GL443424    EFN62107.1    GDAI01001931    JAI15672.1    GFDF01008422    JAV05662.1    GEBQ01021736    JAT18241.1    NNAY01003564    OXU19192.1    GAMC01005535    JAC01021.1    GECZ01019216    JAS50553.1    GECU01017032    JAS90674.1    CH964272    EDW84377.2    CH940650    EDW68059.1    CH933806    EDW15501.1    CM000160    EDW96503.1    CP012526    ALC45453.1    CH902617    EDV43144.1    CH916374    EDV91406.1    CH954181    EDV49939.1    AE014297    AY089635    BT133445    AAF54221.1    AAL90373.1    AFH89818.1    GDHF01028310    JAI24004.1    GAKP01019785    JAC39167.1    GEDC01029878    JAS07420.1    JRES01000634    KNC29728.1    CH480815    EDW43046.1    OUUW01000007    SPP82662.1    KA647075    AFP61704.1    CM000070    EAL27988.1    CH479179    EDW24383.1    CCAG010004727    JXJN01008574    DS235879    EEB19956.1    NCKU01000061    RWS17558.1    CAEY01001145    CAEY01001146    KY982623    AWI47734.1    HACA01005023    CDW22384.1    JO843927    AEO35544.1    GBBM01001292    GBBM01001291    JAC34127.1    GDIP01111056    JAL92658.1    GDIP01198200    GDIP01197293    GDIP01181843    GDIP01029558    JAM74157.1    GALA01001639    JAA93213.1    GACK01004708    JAA60326.1    GEFH01004268    JAP64313.1    GDIP01168739    JAJ54663.1    GDIP01200627    GDIP01198199    GDIP01196289    GDIP01195089    GDIP01183393    GDIP01181842    GDIP01111055    GDIP01094302    GDIP01094301    GDIP01086556    GDIP01052356    JAM09413.1    BT081093    ACO15517.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000283053    UP000053268    UP000053240    + More
UP000235965    UP000053105    UP000027135    UP000092461    UP000076502    UP000075880    UP000242457    UP000005203    UP000053825    UP000008237    UP000075886    UP000075884    UP000030765    UP000008820    UP000075903    UP000092462    UP000075885    UP000075883    UP000075901    UP000075902    UP000076407    UP000007062    UP000075900    UP000075840    UP000036403    UP000000673    UP000078492    UP000076408    UP000078541    UP000075881    UP000053097    UP000279307    UP000078542    UP000005205    UP000000311    UP000215335    UP000007798    UP000192221    UP000008792    UP000009192    UP000002282    UP000092553    UP000007801    UP000001070    UP000008711    UP000000803    UP000037069    UP000001292    UP000268350    UP000095301    UP000001819    UP000008744    UP000095300    UP000091820    UP000092444    UP000092443    UP000078200    UP000092460    UP000092445    UP000009046    UP000285301    UP000085678    UP000015104   

PRIDE

Q0PZE7    Q9VHS8    G3MPX6    L7M7P7   

Pfam

PF00270   DEAD        + More
PF00271   Helicase_C

Interpro

IPR027417   P-loop_NTPase        + More
IPR000629   RNA-helicase_DEAD-box_CS       
IPR014001   Helicase_ATP-bd       
IPR001650   Helicase_C       
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR014014   RNA_helicase_DEAD_Q_motif       

SUPFAM

SSF52540   SSF52540       

CDD

cd00079  HELICc

ProteinModelPortal

Q0PZE7   A0A212FLI2   A0A2W1BRX8   A0A2A4JP97   A0A3S2PKD7   A0A2H1WTH0   + More
I4DME1   I4DJR8   A0A194PFX7   A0A0N1PHX3   S4PWN2   A0A1Q3FV91   A0A2J7QNB4   A0A0M8ZSQ6   A0A067RMC6   A0A1B0CXD4   A0A154P503   A0A182J1G5   A0A2A3ERN3   A0A087ZZS7   A0A0L7R1R2   E2BEH0   A0A182QXS5   A0A182N6M7   A0A084W917   Q16GE2   A0A182VJT6   A0A1B0DM43   A0A182P301   A0A182MFM2   A0A182SNI4   A0A182UES5   A0A182X8D7   Q7PQQ2   A0A182RXB9   A0A182HIZ1   A0A1L8DGW1   A0A0J7KKY9   E9IZK2   A0A2M3Z6Y1   A0A2M4AH50   A0A2M4BQA4   W5JLN7   A0A151J4R6   A0A182XVP1   A0A151JVP6   A0A182JWR5   A0A026WX81   A0A195CSB2   A0A158NIN0   E2AWS1   A0A0K8TMU1   A0A1L8DGS9   A0A1B6L3M7   A0A232ELK5   W8BID8   A0A1B6FKM8   A0A1B6IUQ3   B4NGN0   A0A1W4VH90   B4LYN9   B4K8T2   B4PT42   A0A0M3QX77   B3M0D8   B4JV86   B3NZU1   Q9VHS8   A0A0K8UBI3   A0A034VAP8   A0A1B6C2G1   A0A0L0CBE0   B4HLL9   A0A3B0JQK9   T1PG03   Q298G7   B4G3R2   A0A1I8Q8H2   A0A1A9WML1   A0A1B0FFV4   A0A1A9YQ17   A0A1A9UFH7   A0A1B0B4Y7   A0A1A9ZT23   E0W2V0   A0A3S3SQE4   A0A1S3J3P5   T1K100   A0A2S1TJI0   A0A0K2T8I3   G3MPX6   A0A023GJK7   A0A0P5URV6   A0A0P6BGL6   T1E1I3   L7M7P7   A0A131XB35   A0A0P5CLK1   A0A0P5VWE4   C1C2L4  

PDB

2J0S     E-value=0,     Score=1834

KEGG

692360    K13025 ATP-dependent RNA helicase [EC:3.6.4.13] | (RefSeq) eIF4AIII; eukaryotic initiation factor 4A

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)
03015    mRNA surveillance pathway - Bombyx mori (domestic silkworm)
03040    Spliceosome - Bombyx mori (domestic silkworm)

GO

GO:0004386   GO:0005524   GO:0003676   GO:0003743   GO:0045451   GO:0005634   GO:0008380   GO:0045495   GO:0010628   GO:0006325   GO:1903040   GO:0071013   GO:0003723   GO:0071011   GO:0051028   GO:0000398   GO:0003682   GO:0003677   GO:0003700   GO:0006355   GO:0008270   GO:0043565   GO:0005112   GO:0015930  

Subcellular location

Nucleus  

Length:

405

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0630099999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01725

outside

1  -  405

 

 

Pi

254.378964

Theta

174.591154

Tajima's D

1.33245

CLR

0.031631

CSRT

0.752712364381781

Interpretation

Uncertain