Gene

KWMTBOMO15051  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004857

Annotation

PREDICTED:_adenylosuccinate_synthetase-like_[Bombyx_mori]

Location

Bomo_Chr25(-):3495019-3513087      View in EpiBrowser

Full name

Adenylosuccinate synthetase       + More
Adenylosuccinate synthetase isozyme 1      

Alternative Name

IMP--aspartate ligase
Adenylosuccinate synthetase, basic isozyme
Adenylosuccinate synthetase, muscle isozyme
IMP--aspartate ligase 1

Location in the cell

Cytoplasmic   Reliability : 2.327

CDS

ATGGTTACAACAGTGAATTCGATTAATACAGAAATTAACGGTGAATTGTCGCGTTCGTGCCCATCAAAGAAAACCAAAATGGAAAACAAAGTAACTGTTGTTTTGGGTGCTCAGTGGGGCGATGAGGGCAAAGGAAAAGTTGTAGATTTACTTGCGGTGGATTCCGACATTGTTTGCCGTTGTCAGGGCGGGAACAACGCTGGACACACAGTGGTAGTTGACGGCAAAGAATTTGACTTCCATCTGTTGCCAAGTGGCATCATCAACCAGAAGTGCACGTCTGTCATAGGTAATGGCGTGGTGATCCACCTGCCCGGACTGTTTGAGGAGCTGAAGAAGAACGAGCTGAAAGGCATGAAGGGTTGCGAAGGCAGACTCGTGATCTCGGACAGGGCTCATCTTGTTTTCGATATACATCAACAGGTATAG

Protein

MVTTVNSINTEINGELSRSCPSKKTKMENKVTVVLGAQWGDEGKGKVVDLLAVDSDIVCRCQGGNNAGHTVVVDGKEFDFHLLPSGIINQKCTSVIGNGVVIHLPGLFEELKKNELKGMKGCEGRLVISDRAHLVFDIHQQV

Description

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.
Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

Catalytic Activity

GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate

Cofactor

Mg(2+)

Subunit

Homodimer.

Similarity

Belongs to the adenylosuccinate synthetase family.

Keywords

Complete proteome   Cytoplasm   GTP-binding   Ligase   Magnesium   Metal-binding   Nucleotide-binding   Purine biosynthesis   Reference proteome   Phosphoprotein  

Feature

chain  Adenylosuccinate synthetase

Uniprot

A0A2H1W6Y8   A0A220K8N8   A0A3S2PKC8   A0A194PGM4   S4PBN4   A0A212ETE7   + More
V9ICX8   E2BWT4   A0A026WH21   A0A0J7KG59   A0A087ZXT6   A0A2A3EAG2   E2A7N5   A0A1B6DNJ2   A0A154PDF2   A0A195CK02   A0A2D0RLL9   A0A3Q1GDU1   A0A2P8XV56   A0A3B4WWZ8   A0A3Q1EYT2   A0A067QMR7   A0A3Q0S1J8   A0A151I0Q4   A0A151X5C1   A0A158NAF0   F4WMJ2   A0A182PS43   E9I9P3   A0A195EVK5   A0A2J7R6L9   A0A151J0F6   A0A2M4CV48   A0A1A8V891   A0A2M4CUQ0   H2ZYA8   A0A2M4AA55   A0A2M4BML8   A0A0S7GLR8   A0A2D4L0B1   A0A3B3RGB3   A0A3Q2QGT3   A0A2S2NLH3   Q17G75   A0A3Q3AWN5   A0A060WG10   A0A2M4CUS8   A0A1A7WDA1   A0A182FA55   A0A3B4CTF0   A0A3N0XLU3   A0A3Q3GN41   A0A3Q1HML1   A0A182GDW5   A0A023ETL6   A0A2I4BI08   G3NSJ9   A0A3Q1F0S9   A0A3B1K2H3   F6TXD9   A0A3Q0S1A6   T1D2C0   A0A3Q1GBA2   A0A2M3Z1E3   A0A336LYM2   A0A3Q0J6D1   A0A3Q2P5T9   A0A182JBY9   A0A182NKU2   V9KKL2   W5KYJ9   A0A182R802   A0A0P7VU47   T1D2A9   A0A336KE12   A0A1W4Y2Z2   A0A3S2P4I4   U5EUC9   A0A060VPG7   A0A2M3ZG43   A0A3P9IBG6   B9EL12   A0A084VZC5   A0A1Y1JWT5   A0A3P9K396   H2MR87   A0A2M3Z1D7   Q6NSN5   A0A0K8TT85   A0A3Q0S720   A0A0C9Q2C0   A0A3Q0S6F6   I3K2F0   A0A2R7WE21   H3DJA4   Q4RLN9   A0A1S6KZC4   A0A3P8UCN4   A0A3Q1B364   A0A3P8RK35  

EC Number

6.3.4.4

Pubmed

28630352    26354079    23622113    22118469    20798317    24508170    + More
30249741    29403074    24845553    21347285    21719571    21282665    9215903    29240929    17510324    24755649    26483478    24945155    25329095    17495919    24330624    24402279    17554307    20433749    24438588    28004739    18307296    26506222    26369729    25186727    15496914    24330026    24487278   

EMBL

ODYU01006731    SOQ48840.1    MF319738    ASJ26452.1    RSAL01000008    RVE53928.1    + More
KQ459604    KPI92183.1    GAIX01005822    JAA86738.1    AGBW02012595    OWR44749.1    JR038558    AEY58316.1    GL451188    EFN79798.1    KK107231    QOIP01000009    EZA54971.1    RLU18603.1    LBMM01008054    KMQ89186.1    KZ288308    PBC28708.1    GL437365    EFN70556.1    GEDC01020859    GEDC01010052    JAS16439.1    JAS27246.1    KQ434869    KZC09288.1    KQ977642    KYN01043.1    PYGN01001299    PSN35890.1    KK853153    KDR10573.1    KQ976600    KYM79472.1    KQ982519    KYQ55489.1    ADTU01010272    GL888217    EGI64603.1    GL761846    EFZ22633.1    KQ981954    KYN32176.1    NEVH01006756    PNF36482.1    KQ980629    KYN14996.1    GGFL01004893    MBW69071.1    HAEJ01015325    SBS55782.1    GGFL01004894    MBW69072.1    AFYH01002014    AFYH01002015    AFYH01002016    AFYH01002017    AFYH01002018    AFYH01002019    AFYH01002020    AFYH01002021    GGFK01004301    MBW37622.1    GGFJ01005179    MBW54320.1    GBYX01451398    JAO30108.1    IACL01112146    LAB14404.1    GGMR01005414    MBY18033.1    CH477265    FR904523    CDQ65951.1    GGFL01004895    MBW69073.1    HADW01002305    SBP03705.1    RJVU01069573    ROI68631.1    JXUM01056782    JXUM01056783    JXUM01056784    KQ561925    KXJ77138.1    GAPW01001382    JAC12216.1    GALA01001673    JAA93179.1    GGFM01001582    MBW22333.1    UFQS01000309    UFQT01000309    SSX02708.1    SSX23082.1    JW866046    AFO98563.1    JARO02000699    KPP77688.1    GALA01001688    JAA93164.1    SSX02707.1    SSX23081.1    CM012458    RVE57099.1    GANO01001537    JAB58334.1    FR904269    CDQ56828.1    GGFM01006751    MBW27502.1    BT056337    ACM08209.1    ATLV01018738    ATLV01018739    ATLV01018740    KE525248    KFB43319.1    GEZM01098728    JAV53784.1    GGFM01001591    MBW22342.1    BC070009    GDAI01000242    JAI17361.1    GBYB01008148    JAG77915.1    AERX01018666    KK854669    PTY17759.1    CAAE01015019    CAG10693.1    KC223176    AQT27079.1   

Proteomes

UP000283053    UP000053268    UP000007151    UP000008237    UP000053097    UP000279307    + More
UP000036403    UP000005203    UP000242457    UP000000311    UP000076502    UP000078542    UP000221080    UP000257200    UP000245037    UP000261360    UP000027135    UP000261340    UP000078540    UP000075809    UP000005205    UP000007755    UP000075885    UP000078541    UP000235965    UP000078492    UP000008672    UP000261540    UP000265000    UP000008820    UP000264800    UP000193380    UP000069272    UP000261440    UP000261660    UP000265040    UP000069940    UP000249989    UP000192220    UP000007635    UP000018467    UP000002280    UP000079169    UP000075880    UP000075884    UP000075900    UP000034805    UP000192224    UP000265200    UP000030765    UP000265180    UP000001038    UP000000437    UP000005207    UP000007303    UP000265120    UP000257160    UP000265080   

PRIDE

A0A087ZXT6    Q17G75   

Pfam

PF00709   Adenylsucc_synt

Interpro

IPR042109   Adenylosuccinate_synth_dom1        + More
IPR001114   Adenylosuccinate_synthetase       
IPR042110   Adenylosuccinate_synth_dom2       
IPR033128   Adenylosuccin_syn_Lys_AS       
IPR018220   Adenylosuccin_syn_GTP-bd       
IPR042111   Adenylosuccinate_synth_dom3       
IPR027417   P-loop_NTPase       
IPR027509   AdSS_1_vert       

SUPFAM

SSF52540   SSF52540       

Gene 3D

1.10.300.10     3.40.440.10     3.90.170.10    

CDD

cd03108  AdSS

ProteinModelPortal

A0A2H1W6Y8   A0A220K8N8   A0A3S2PKC8   A0A194PGM4   S4PBN4   A0A212ETE7   + More
V9ICX8   E2BWT4   A0A026WH21   A0A0J7KG59   A0A087ZXT6   A0A2A3EAG2   E2A7N5   A0A1B6DNJ2   A0A154PDF2   A0A195CK02   A0A2D0RLL9   A0A3Q1GDU1   A0A2P8XV56   A0A3B4WWZ8   A0A3Q1EYT2   A0A067QMR7   A0A3Q0S1J8   A0A151I0Q4   A0A151X5C1   A0A158NAF0   F4WMJ2   A0A182PS43   E9I9P3   A0A195EVK5   A0A2J7R6L9   A0A151J0F6   A0A2M4CV48   A0A1A8V891   A0A2M4CUQ0   H2ZYA8   A0A2M4AA55   A0A2M4BML8   A0A0S7GLR8   A0A2D4L0B1   A0A3B3RGB3   A0A3Q2QGT3   A0A2S2NLH3   Q17G75   A0A3Q3AWN5   A0A060WG10   A0A2M4CUS8   A0A1A7WDA1   A0A182FA55   A0A3B4CTF0   A0A3N0XLU3   A0A3Q3GN41   A0A3Q1HML1   A0A182GDW5   A0A023ETL6   A0A2I4BI08   G3NSJ9   A0A3Q1F0S9   A0A3B1K2H3   F6TXD9   A0A3Q0S1A6   T1D2C0   A0A3Q1GBA2   A0A2M3Z1E3   A0A336LYM2   A0A3Q0J6D1   A0A3Q2P5T9   A0A182JBY9   A0A182NKU2   V9KKL2   W5KYJ9   A0A182R802   A0A0P7VU47   T1D2A9   A0A336KE12   A0A1W4Y2Z2   A0A3S2P4I4   U5EUC9   A0A060VPG7   A0A2M3ZG43   A0A3P9IBG6   B9EL12   A0A084VZC5   A0A1Y1JWT5   A0A3P9K396   H2MR87   A0A2M3Z1D7   Q6NSN5   A0A0K8TT85   A0A3Q0S720   A0A0C9Q2C0   A0A3Q0S6F6   I3K2F0   A0A2R7WE21   H3DJA4   Q4RLN9   A0A1S6KZC4   A0A3P8UCN4   A0A3Q1B364   A0A3P8RK35  

PDB

2DGN     E-value=2.72852e-51,     Score=504

KEGG

101739576    K01939 adenylosuccinate synthase [EC:6.3.4.4] | (RefSeq) adenylosuccinate synthetase-like

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00250    Alanine, aspartate and glutamate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004019   GO:0005525   GO:0044208   GO:0005737   GO:0000287   GO:0046872   GO:0048741   GO:0046716   GO:0046040   GO:0016021   GO:0006164   GO:0004180   GO:0005515   GO:0003676   GO:0007154   GO:0016020   GO:0005112   GO:0015930  

PANTHER

PTHR11846  

Subcellular location

Cytoplasm  

Length:

142

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03612

Exp number, first 60 AAs:

0

Total prob of N-in:

0.39919

outside

1  -  142

 

 

Pi

222.188762

Theta

159.154098

Tajima's D

1.880068

CLR

0.359958

CSRT

0.860806959652017

Interpretation

Uncertain