Pre Gene Modal
BGIBMGA004858
Annotation
PREDICTED:_adenylosuccinate_synthetase-like_[Bombyx_mori]
Full name
Adenylosuccinate synthetase
Alternative Name
IMP--aspartate ligase
Location in the cell
Cytoplasmic Reliability : 2.25
Sequence
CDS
ATGACTGATTCAGGACGATGATACCGGACCCTTGTGGCCTCGTACAAACGCATGTTCCCGGCATTAGAGTTGAACATCGATAGCGAGCTGTCGAAGTACCGAGCGTACGCCGATCTGGTCCGGCCGATGGTCAAGGATACGGTCTCGTACCTGCACAGGGAGATCGGCTCCGGCAGGAAGGTGCTAGTCGAGGGAGCGAATGCCGCCATGCTGGATATAGATTTCGGTACCTATCCGTACGTGACGTCATCGAATTGCAGCATAGGCGGCGTGTTGACCGGTCTCGGCCTACCCCCCAACGTGATCGGGAACGTTCTGGGCGTCGTGAAGGCGTACACGACGCGCGTGGGCGACGGACCCTTCCCGACGGAGCTGCACGATGAGACCGGTCAGCTACTCCAGGAGCGAGGGCACGAGGTCGGCGTCACCACCAGACGCGTCCGGCGCTGCGGCTGGCTCGACCTGGTCGTTGTCCGCTACACCGCCATGGTCAACGGGTACACGTCATTGTGCCTAACGAAACTGGATATTTTGGATACCCTGAAGGAAATAAAAGTCGGTGTCGCTTACAAACTGAATGGCAAGAAGATTGATTATTTCCCGTCTTCGATGGTGGAACTTAGTAATGTAGAGGTGGAATACATTAGTTTACCCGGTTGGGCGTGCAGTATAGAGCACGTGCGAGAGCTGGACAAGCTGCCGGCGGAGGCCCGCGCCTACGTGAAGGCCATCGAGGACTTCCTGCAGGTGCCCGTTAAATACATTGGCGTGGGTCAAGGACGGGAGTCGATAATCAGCGTCGACTAA
Protein
MTDSGRXYRTLVASYKRMFPALELNIDSELSKYRAYADLVRPMVKDTVSYLHREIGSGRKVLVEGANAAMLDIDFGTYPYVTSSNCSIGGVLTGLGLPPNVIGNVLGVVKAYTTRVGDGPFPTELHDETGQLLQERGHEVGVTTRRVRRCGWLDLVVVRYTAMVNGYTSLCLTKLDILDTLKEIKVGVAYKLNGKKIDYFPSSMVELSNVEVEYISLPGWACSIEHVRELDKLPAEARAYVKAIEDFLQVPVKYIGVGQGRESIISVD
Summary
Description
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Plays a role in the regulation of adult life span.
Catalytic Activity
GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate
Cofactor
Mg(2+)
Subunit
Homodimer.
Similarity
Belongs to the adenylosuccinate synthetase family.
Keywords
Complete proteome
Cytoplasm
GTP-binding
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Purine biosynthesis
Reference proteome
Feature
chain Adenylosuccinate synthetase
Uniprot
A0A2H1W6Y8
A0A2A4JGV4
A0A212ETE7
A0A2W1BYQ8
A0A220K8N8
A0A3S2PKC8
+ More
A0A182Y4J1 A0A182NKU2 A0A1Q3F2Z8 T1DU11 B0W9B4 A0A182MWH9 A0A182W0L2 A0A023ETL6 A0A182GDW5 A0A182PS43 A0A182R802 Q17G75 A0A1I9WLK5 A0A084VZC5 A0A1Y1JWT5 A0A182QYP9 T1D2C0 W5JQH0 A0A336KE12 A0A182K9Z2 A0A336LZ54 T1D2A9 E2A7N5 A0A139WFS9 A0A154PDF2 A0A182FA55 A0A182TV68 Q7QDK6 A0A182HJR0 A0A2M4BML8 A0A1S6KZC4 A0A087ZXT6 A0A2M3ZG43 A0A2M3Z1D7 A0A2M3Z1E3 A0A182VNT6 A0A2M4AA55 A0A2A3EAG2 A0A182KWY5 A0A0M9ABW0 A0A182JBY9 A0A2M4CUQ0 A0A2M4CV48 A0A1B6JPN6 A0A2J7R6M2 E2BWT4 U5EUC9 A0A2M4CUS8 A0A067QMR7 A0A195CK02 A0A151X5C1 A0A195EVK5 A0A182T1X5 A0A151I0Q4 A0A2J7R6L9 A0A158NAF0 A0A026WH21 A0A1L8DXQ5 A0A0C9Q2C0 A0A336LYM2 F4WMJ2 A0A2M4AGK3 A0A2S2R4Q7 A0A2H8TGQ9 A0A0T6BFZ8 K7J1I5 W8C7X6 X1WJ57 A0A0K8VAV1 A0A232FJJ7 A0A0K8TT85 B4K8W7 E9HG20 B4R1R4 Q9Y0Y2 Q299D3 B4G518 B4NFS5 A0A0P9C8A6 A0A2H8TMR0 B4II68 F0JAP3 A0A0J7KG59 A0A1W4UXH8 A0A0P5GEF2 B4LWK0 A0A1J1HRZ5 A0A0A1XPA3 B4JUE4 A0A0P6AFQ1 A0A0P5VK77 A0A0N8CGG2 A0A182XK78 A0A1I8MQJ4
A0A182Y4J1 A0A182NKU2 A0A1Q3F2Z8 T1DU11 B0W9B4 A0A182MWH9 A0A182W0L2 A0A023ETL6 A0A182GDW5 A0A182PS43 A0A182R802 Q17G75 A0A1I9WLK5 A0A084VZC5 A0A1Y1JWT5 A0A182QYP9 T1D2C0 W5JQH0 A0A336KE12 A0A182K9Z2 A0A336LZ54 T1D2A9 E2A7N5 A0A139WFS9 A0A154PDF2 A0A182FA55 A0A182TV68 Q7QDK6 A0A182HJR0 A0A2M4BML8 A0A1S6KZC4 A0A087ZXT6 A0A2M3ZG43 A0A2M3Z1D7 A0A2M3Z1E3 A0A182VNT6 A0A2M4AA55 A0A2A3EAG2 A0A182KWY5 A0A0M9ABW0 A0A182JBY9 A0A2M4CUQ0 A0A2M4CV48 A0A1B6JPN6 A0A2J7R6M2 E2BWT4 U5EUC9 A0A2M4CUS8 A0A067QMR7 A0A195CK02 A0A151X5C1 A0A195EVK5 A0A182T1X5 A0A151I0Q4 A0A2J7R6L9 A0A158NAF0 A0A026WH21 A0A1L8DXQ5 A0A0C9Q2C0 A0A336LYM2 F4WMJ2 A0A2M4AGK3 A0A2S2R4Q7 A0A2H8TGQ9 A0A0T6BFZ8 K7J1I5 W8C7X6 X1WJ57 A0A0K8VAV1 A0A232FJJ7 A0A0K8TT85 B4K8W7 E9HG20 B4R1R4 Q9Y0Y2 Q299D3 B4G518 B4NFS5 A0A0P9C8A6 A0A2H8TMR0 B4II68 F0JAP3 A0A0J7KG59 A0A1W4UXH8 A0A0P5GEF2 B4LWK0 A0A1J1HRZ5 A0A0A1XPA3 B4JUE4 A0A0P6AFQ1 A0A0P5VK77 A0A0N8CGG2 A0A182XK78 A0A1I8MQJ4
EC Number
6.3.4.4
Pubmed
22118469
28756777
28630352
25244985
24945155
26483478
+ More
17510324 27538518 24438588 28004739 24330624 20920257 23761445 20798317 18362917 19820115 12364791 14747013 17210077 24330026 20966253 24845553 21347285 24508170 30249741 21719571 20075255 24495485 28648823 26369729 17994087 21292972 10731132 12537572 10731138 12537569 23312286 15632085 25830018 25315136
17510324 27538518 24438588 28004739 24330624 20920257 23761445 20798317 18362917 19820115 12364791 14747013 17210077 24330026 20966253 24845553 21347285 24508170 30249741 21719571 20075255 24495485 28648823 26369729 17994087 21292972 10731132 12537572 10731138 12537569 23312286 15632085 25830018 25315136
EMBL
ODYU01006731
SOQ48840.1
NWSH01001636
PCG70622.1
AGBW02012595
OWR44749.1
+ More
KZ149918 PZC77826.1 MF319738 ASJ26452.1 RSAL01000008 RVE53928.1 GFDL01013177 JAV21868.1 GAMD01000579 JAB01012.1 DS231863 AXCM01000236 GAPW01001382 JAC12216.1 JXUM01056782 JXUM01056783 JXUM01056784 KQ561925 KXJ77138.1 CH477265 KU932389 APA34025.1 ATLV01018738 ATLV01018739 ATLV01018740 KE525248 KFB43319.1 GEZM01098728 JAV53784.1 AXCN02000306 GALA01001673 JAA93179.1 ADMH02000756 ETN65150.1 UFQS01000309 UFQT01000309 SSX02707.1 SSX23081.1 SSX02706.1 SSX23080.1 GALA01001688 JAA93164.1 GL437365 EFN70556.1 KQ971352 KYB26701.1 KQ434869 KZC09288.1 AAAB01008851 EAA07403.5 APCN01002206 GGFJ01005179 MBW54320.1 KC223176 AQT27079.1 GGFM01006751 MBW27502.1 GGFM01001591 MBW22342.1 GGFM01001582 MBW22333.1 GGFK01004301 MBW37622.1 KZ288308 PBC28708.1 KQ435689 KOX81300.1 GGFL01004894 MBW69072.1 GGFL01004893 MBW69071.1 GECU01006502 JAT01205.1 NEVH01006756 PNF36479.1 GL451188 EFN79798.1 GANO01001537 JAB58334.1 GGFL01004895 MBW69073.1 KK853153 KDR10573.1 KQ977642 KYN01043.1 KQ982519 KYQ55489.1 KQ981954 KYN32176.1 KQ976600 KYM79472.1 PNF36482.1 ADTU01010272 KK107231 QOIP01000009 EZA54971.1 RLU18603.1 GFDF01002844 JAV11240.1 GBYB01008148 JAG77915.1 SSX02708.1 SSX23082.1 GL888217 EGI64603.1 GGFK01006585 MBW39906.1 GGMS01015773 MBY84976.1 GFXV01001424 GFXV01001837 MBW13229.1 LJIG01000663 KRT86277.1 GAMC01003349 JAC03207.1 ABLF02037444 ABLF02037451 GDHF01016311 JAI36003.1 NNAY01000155 OXU30487.1 GDAI01000242 JAI17361.1 CH933806 GL732638 EFX69335.1 CM000364 EDX12173.1 AE014297 AF145694 AY113428 CM000070 CH479179 CH964251 CH902617 KPU79723.1 GFXV01003648 MBW15453.1 CH480842 BT126085 ADY17784.1 LBMM01008054 KMQ89186.1 GDIQ01245903 GDIQ01245902 LRGB01003375 JAK05823.1 KZS03008.1 CH940650 CVRI01000010 CRK88969.1 GBXI01001525 JAD12767.1 CH916374 GDIP01031300 JAM72415.1 GDIP01100389 JAM03326.1 GDIP01134151 JAL69563.1
KZ149918 PZC77826.1 MF319738 ASJ26452.1 RSAL01000008 RVE53928.1 GFDL01013177 JAV21868.1 GAMD01000579 JAB01012.1 DS231863 AXCM01000236 GAPW01001382 JAC12216.1 JXUM01056782 JXUM01056783 JXUM01056784 KQ561925 KXJ77138.1 CH477265 KU932389 APA34025.1 ATLV01018738 ATLV01018739 ATLV01018740 KE525248 KFB43319.1 GEZM01098728 JAV53784.1 AXCN02000306 GALA01001673 JAA93179.1 ADMH02000756 ETN65150.1 UFQS01000309 UFQT01000309 SSX02707.1 SSX23081.1 SSX02706.1 SSX23080.1 GALA01001688 JAA93164.1 GL437365 EFN70556.1 KQ971352 KYB26701.1 KQ434869 KZC09288.1 AAAB01008851 EAA07403.5 APCN01002206 GGFJ01005179 MBW54320.1 KC223176 AQT27079.1 GGFM01006751 MBW27502.1 GGFM01001591 MBW22342.1 GGFM01001582 MBW22333.1 GGFK01004301 MBW37622.1 KZ288308 PBC28708.1 KQ435689 KOX81300.1 GGFL01004894 MBW69072.1 GGFL01004893 MBW69071.1 GECU01006502 JAT01205.1 NEVH01006756 PNF36479.1 GL451188 EFN79798.1 GANO01001537 JAB58334.1 GGFL01004895 MBW69073.1 KK853153 KDR10573.1 KQ977642 KYN01043.1 KQ982519 KYQ55489.1 KQ981954 KYN32176.1 KQ976600 KYM79472.1 PNF36482.1 ADTU01010272 KK107231 QOIP01000009 EZA54971.1 RLU18603.1 GFDF01002844 JAV11240.1 GBYB01008148 JAG77915.1 SSX02708.1 SSX23082.1 GL888217 EGI64603.1 GGFK01006585 MBW39906.1 GGMS01015773 MBY84976.1 GFXV01001424 GFXV01001837 MBW13229.1 LJIG01000663 KRT86277.1 GAMC01003349 JAC03207.1 ABLF02037444 ABLF02037451 GDHF01016311 JAI36003.1 NNAY01000155 OXU30487.1 GDAI01000242 JAI17361.1 CH933806 GL732638 EFX69335.1 CM000364 EDX12173.1 AE014297 AF145694 AY113428 CM000070 CH479179 CH964251 CH902617 KPU79723.1 GFXV01003648 MBW15453.1 CH480842 BT126085 ADY17784.1 LBMM01008054 KMQ89186.1 GDIQ01245903 GDIQ01245902 LRGB01003375 JAK05823.1 KZS03008.1 CH940650 CVRI01000010 CRK88969.1 GBXI01001525 JAD12767.1 CH916374 GDIP01031300 JAM72415.1 GDIP01100389 JAM03326.1 GDIP01134151 JAL69563.1
Proteomes
UP000218220
UP000007151
UP000283053
UP000076408
UP000075884
UP000002320
+ More
UP000075883 UP000075920 UP000069940 UP000249989 UP000075885 UP000075900 UP000008820 UP000030765 UP000075886 UP000000673 UP000075881 UP000000311 UP000007266 UP000076502 UP000069272 UP000075902 UP000007062 UP000075840 UP000005203 UP000075903 UP000242457 UP000075882 UP000053105 UP000075880 UP000235965 UP000008237 UP000027135 UP000078542 UP000075809 UP000078541 UP000075901 UP000078540 UP000005205 UP000053097 UP000279307 UP000007755 UP000002358 UP000007819 UP000215335 UP000009192 UP000000305 UP000000304 UP000000803 UP000001819 UP000008744 UP000007798 UP000007801 UP000001292 UP000036403 UP000192221 UP000076858 UP000008792 UP000183832 UP000001070 UP000076407 UP000095301
UP000075883 UP000075920 UP000069940 UP000249989 UP000075885 UP000075900 UP000008820 UP000030765 UP000075886 UP000000673 UP000075881 UP000000311 UP000007266 UP000076502 UP000069272 UP000075902 UP000007062 UP000075840 UP000005203 UP000075903 UP000242457 UP000075882 UP000053105 UP000075880 UP000235965 UP000008237 UP000027135 UP000078542 UP000075809 UP000078541 UP000075901 UP000078540 UP000005205 UP000053097 UP000279307 UP000007755 UP000002358 UP000007819 UP000215335 UP000009192 UP000000305 UP000000304 UP000000803 UP000001819 UP000008744 UP000007798 UP000007801 UP000001292 UP000036403 UP000192221 UP000076858 UP000008792 UP000183832 UP000001070 UP000076407 UP000095301
PRIDE
Pfam
PF00709 Adenylsucc_synt
Interpro
SUPFAM
SSF52540
SSF52540
Gene 3D
CDD
ProteinModelPortal
A0A2H1W6Y8
A0A2A4JGV4
A0A212ETE7
A0A2W1BYQ8
A0A220K8N8
A0A3S2PKC8
+ More
A0A182Y4J1 A0A182NKU2 A0A1Q3F2Z8 T1DU11 B0W9B4 A0A182MWH9 A0A182W0L2 A0A023ETL6 A0A182GDW5 A0A182PS43 A0A182R802 Q17G75 A0A1I9WLK5 A0A084VZC5 A0A1Y1JWT5 A0A182QYP9 T1D2C0 W5JQH0 A0A336KE12 A0A182K9Z2 A0A336LZ54 T1D2A9 E2A7N5 A0A139WFS9 A0A154PDF2 A0A182FA55 A0A182TV68 Q7QDK6 A0A182HJR0 A0A2M4BML8 A0A1S6KZC4 A0A087ZXT6 A0A2M3ZG43 A0A2M3Z1D7 A0A2M3Z1E3 A0A182VNT6 A0A2M4AA55 A0A2A3EAG2 A0A182KWY5 A0A0M9ABW0 A0A182JBY9 A0A2M4CUQ0 A0A2M4CV48 A0A1B6JPN6 A0A2J7R6M2 E2BWT4 U5EUC9 A0A2M4CUS8 A0A067QMR7 A0A195CK02 A0A151X5C1 A0A195EVK5 A0A182T1X5 A0A151I0Q4 A0A2J7R6L9 A0A158NAF0 A0A026WH21 A0A1L8DXQ5 A0A0C9Q2C0 A0A336LYM2 F4WMJ2 A0A2M4AGK3 A0A2S2R4Q7 A0A2H8TGQ9 A0A0T6BFZ8 K7J1I5 W8C7X6 X1WJ57 A0A0K8VAV1 A0A232FJJ7 A0A0K8TT85 B4K8W7 E9HG20 B4R1R4 Q9Y0Y2 Q299D3 B4G518 B4NFS5 A0A0P9C8A6 A0A2H8TMR0 B4II68 F0JAP3 A0A0J7KG59 A0A1W4UXH8 A0A0P5GEF2 B4LWK0 A0A1J1HRZ5 A0A0A1XPA3 B4JUE4 A0A0P6AFQ1 A0A0P5VK77 A0A0N8CGG2 A0A182XK78 A0A1I8MQJ4
A0A182Y4J1 A0A182NKU2 A0A1Q3F2Z8 T1DU11 B0W9B4 A0A182MWH9 A0A182W0L2 A0A023ETL6 A0A182GDW5 A0A182PS43 A0A182R802 Q17G75 A0A1I9WLK5 A0A084VZC5 A0A1Y1JWT5 A0A182QYP9 T1D2C0 W5JQH0 A0A336KE12 A0A182K9Z2 A0A336LZ54 T1D2A9 E2A7N5 A0A139WFS9 A0A154PDF2 A0A182FA55 A0A182TV68 Q7QDK6 A0A182HJR0 A0A2M4BML8 A0A1S6KZC4 A0A087ZXT6 A0A2M3ZG43 A0A2M3Z1D7 A0A2M3Z1E3 A0A182VNT6 A0A2M4AA55 A0A2A3EAG2 A0A182KWY5 A0A0M9ABW0 A0A182JBY9 A0A2M4CUQ0 A0A2M4CV48 A0A1B6JPN6 A0A2J7R6M2 E2BWT4 U5EUC9 A0A2M4CUS8 A0A067QMR7 A0A195CK02 A0A151X5C1 A0A195EVK5 A0A182T1X5 A0A151I0Q4 A0A2J7R6L9 A0A158NAF0 A0A026WH21 A0A1L8DXQ5 A0A0C9Q2C0 A0A336LYM2 F4WMJ2 A0A2M4AGK3 A0A2S2R4Q7 A0A2H8TGQ9 A0A0T6BFZ8 K7J1I5 W8C7X6 X1WJ57 A0A0K8VAV1 A0A232FJJ7 A0A0K8TT85 B4K8W7 E9HG20 B4R1R4 Q9Y0Y2 Q299D3 B4G518 B4NFS5 A0A0P9C8A6 A0A2H8TMR0 B4II68 F0JAP3 A0A0J7KG59 A0A1W4UXH8 A0A0P5GEF2 B4LWK0 A0A1J1HRZ5 A0A0A1XPA3 B4JUE4 A0A0P6AFQ1 A0A0P5VK77 A0A0N8CGG2 A0A182XK78 A0A1I8MQJ4
PDB
2DGN
E-value=7.65292e-85,
Score=798
Ontologies
KEGG
PATHWAY
GO
PANTHER
Topology
Subcellular location
Cytoplasm
Length:
268
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
1.66559
Exp number, first 60 AAs:
0.00116
Total prob of N-in:
0.21371
outside
1 - 268
Population Genetic Test Statistics
Pi
211.899087
Theta
152.088196
Tajima's D
1.474837
CLR
0.479186
CSRT
0.777611119444028
Interpretation
Uncertain
