Gene

KWMTBOMO15022

Annotation

PREDICTED:_mast_cell_carboxypeptidase_A-like_[Bombyx_mori]

Location

Bomo_Chr25(+):2728773-2736172      View in EpiBrowser

Full name

Mast cell carboxypeptidase A      

Alternative Name

Carboxypeptidase A3

Location in the cell

PlasmaMembrane   Reliability : 0.989

CDS

ATGTCTAATTTCGTGAGAAACCACAGTAACCATCTGGAATACTATTTGGCCTTCCATTCGTACGGGCAAGCCATGATCCTGCCTTACGCGAATACAAGAGCTCACATGGAAAATTTTGATACTGTGGCAGCCATGGCTAAACAAGCAGCAGACCACATAGCTCTCAGATACAATACCAGATACGTGTATGGAACAGCTTATGACACTGTAGGTTACGTGACATCCGGCGTCAGTGGTTGCTGGGTCAAAGAAACATTTAGTGTTCCGTACGTCCTTACATTTGAACTTCCCGACCGAGGGCAATATGGTTTCGCTCTGCCCAATGAGAAGATCACGCCAACATGTATAGAAACCATGGATGGTGTTTTGTCACTATTGAAACCTCGCACGAAAATTTACGATAAACTAAGACACGAGCACAGGGGTTTCGATGACGGTCAAAGGACGAAGTTTTTGGATAAATTGGTGATCCTTTTTAATGTGTGCCTGTTTGTTATTGCTCGTTTTGATTAA

Protein

MSNFVRNHSNHLEYYLAFHSYGQAMILPYANTRAHMENFDTVAAMAKQAADHIALRYNTRYVYGTAYDTVGYVTSGVSGCWVKETFSVPYVLTFELPDRGQYGFALPNEKITPTCIETMDGVLSLLKPRTKIYDKLRHEHRGFDDGQRTKFLDKLVILFNVCLFVIARFD

Catalytic Activity

Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M14 family.

Keywords

Carboxypeptidase   Complete proteome   Cytoplasmic vesicle   Direct protein sequencing   Disulfide bond   Hydrolase   Metal-binding   Metalloprotease   Polymorphism   Protease   Reference proteome   Signal   Zinc   Zymogen  

Feature

propeptide  Activation peptide
chain  Mast cell carboxypeptidase A
sequence variant  In dbSNP:rs2270523.

Uniprot

A0A194RGY2   A0A212F6I3   A0A2A4J3C4   A0A2W1BJL8   K7IN13   A0A310SEP0   + More
A0A088A4S2   V5G180   A0A2A3E2U1   A0A067RGG5   V5I8H1   V5I8J9   A0A154PKT4   A0A182LX23   B0WS12   A0A0L7R9B9   A0A195BNW8   A0A195CUQ5   A0A158NTV3   A0A2K6V6C3   A0A2K5PME4   A0A1V1FIW8   A0A0C9RFV3   A0A158NQ44   A0A2A4JQ49   A0A195CTS9   D2A3Y2   N6T3L7   U4UC85   K7IQY4   A0A182P9F1   F4WMS6   F7HXH8   A0A2K5EUS2   A0A182YDB7   A0A0M8ZXY7   A0A1L8DR93   A0A1L8DQV7   A1XGA1   A0A182LT40   A1XGA0   A1XG97   H2PBP8   A0A0L7R992   A0A2W1BNU0   K7JA32   A1XG98   A0A195BHV6   A0A232EGG7   A0A232F1J1   K7IY61   L5JVM8   A0A182QAV5   A0A310SCR6   A0A0J7KVA1   A0A2I3TU16   A1XGA3   A0A2R9CAY4   A0A3Q0D5I3   A0A096P028   A0A0L7KXG1   H2QNJ6   A0A195FPB2   S7MU95   A0A2K6KUE9   A0A2R9CLS4   A0A2J8P2V4   B2R941   P15088   A0A158NQ85   A1XGA2   A0A2K6C4D9   G7MJJ7   H9J5L1   G7NZN8   F7GFE7   A0A2K5WCY7   Q542E3   P15089   G3S533   A0A2K6LW11   A0A2K6LVY0   A0A0D9RG95   A0A2K5JGG1   A0A3G5BIF5   A0A2K5CNU8   A0A151WLL6   L5MAR4   A0A151J021   A0A2S2N6Y1   A0A2K5R360   A0A2K5CNV4   A0A341B9Q3   A0A2K6NNH6  

EC Number

3.4.17.1

Pubmed

26354079    22118469    28756777    20075255    24845553    21347285    + More
28410430    18362917    19820115    23537049    21719571    25244985    17651235    28648823    23258410    16136131    22722832    26319212    26227816    2594780    1729276    16641997    15489334    1629626    2708524    22002653    19121390    17431167    10349636    11042159    11076861    11217851    12466851    12040188    16141073    2584208    22398555    30400621    25362486   

EMBL

KQ460205    KPJ17078.1    AGBW02010033    OWR49319.1    NWSH01003708    PCG65902.1    + More
KZ150003    PZC75272.1    KQ769940    OAD52755.1    GALX01004696    JAB63770.1    KZ288417    PBC26020.1    KK852482    KDR22872.1    GALX01004695    JAB63771.1    GALX01004555    JAB63911.1    KQ434938    KZC12084.1    AXCM01002791    DS232063    EDS33630.1    KQ414627    KOC67443.1    KQ976435    KYM87054.1    KQ977279    KYN04252.1    ADTU01026166    FX985401    BAX07414.1    GBYB01012027    JAG81794.1    ADTU01022957    NWSH01000796    PCG74167.1    KYN04096.1    KQ971348    EFA05749.1    APGK01045325    APGK01045326    KB741033    ENN74749.1    KB631976    ERL87560.1    GL888218    EGI64553.1    KQ435828    KOX71863.1    GFDF01005229    JAV08855.1    GFDF01005228    JAV08856.1    DQ356060    ABC88775.1    AXCM01005733    DQ356059    ABC88774.1    DQ356056    ABC88771.1    ABGA01105389    ABGA01105390    NDHI03003379    PNJ72804.1    KOC67445.1    PZC75275.1    AAZX01005059    AAZX01016347    DQ356057    ABC88772.1    KQ976464    KYM84415.1    NNAY01004759    OXU17455.1    NNAY01001310    OXU24399.1    KB031134    ELK02358.1    AXCN02002112    OAD52756.1    LBMM01002732    KMQ94422.1    AACZ04048256    DQ356062    ABC88777.1    AJFE02092719    AHZZ02020796    JTDY01004606    KOB67958.1    KQ981382    KYN42152.1    KE162362    EPQ07864.1    NBAG03000220    PNI78351.1    AK313628    BAG36388.1    M27717    M73720    M73716    M73717    M73718    M73719    AC092979    BC012613    S40234    DQ356061    ABC88776.1    CM001254    EHH16689.1    BABH01025123    BABH01025124    CM001277    EHH51597.1    JSUE03024456    AQIA01038222    AK088906    CH466530    BAC40646.1    EDL34896.1    J05118    CABD030024742    AQIB01076104    MK075163    AYV99566.1    KQ982959    KYQ48754.1    KB102464    ELK35370.1    KQ980658    KYN14778.1    GGMR01000219    MBY12838.1   

Proteomes

UP000053240    UP000007151    UP000218220    UP000002358    UP000005203    UP000242457    + More
UP000027135    UP000076502    UP000075883    UP000002320    UP000053825    UP000078540    UP000078542    UP000005205    UP000233220    UP000233040    UP000007266    UP000019118    UP000030742    UP000075885    UP000007755    UP000008225    UP000233020    UP000076408    UP000053105    UP000001595    UP000215335    UP000010552    UP000075886    UP000036403    UP000002277    UP000240080    UP000189706    UP000028761    UP000037510    UP000078541    UP000233180    UP000005640    UP000233120    UP000005204    UP000009130    UP000006718    UP000233100    UP000000589    UP000001519    UP000029965    UP000233080    UP000075809    UP000078492    UP000252040    UP000233200   

PRIDE

A0A088A4S2    B2R941    P15088    H9J5L1    Q542E3    P15089    + More

Pfam

PF02244   Propep_M14        + More
PF00246   Peptidase_M14
PF00405   Transferrin

Interpro

IPR000834   Peptidase_M14        + More
IPR034223   IGCP-like_CPD       
IPR003146   M14A_act_pep       
IPR036990   M14A-like_propep       
IPR001156   Transferrin-like_dom       
IPR034253   CPB_M14_CPD       
IPR033850   Carboxypeptidase_O       

Gene 3D

3.30.70.340    

CDD

cd03860  M14_CP_A-B_like
cd03871  M14_CPB
cd06247  M14_CPO

ProteinModelPortal

A0A194RGY2   A0A212F6I3   A0A2A4J3C4   A0A2W1BJL8   K7IN13   A0A310SEP0   + More
A0A088A4S2   V5G180   A0A2A3E2U1   A0A067RGG5   V5I8H1   V5I8J9   A0A154PKT4   A0A182LX23   B0WS12   A0A0L7R9B9   A0A195BNW8   A0A195CUQ5   A0A158NTV3   A0A2K6V6C3   A0A2K5PME4   A0A1V1FIW8   A0A0C9RFV3   A0A158NQ44   A0A2A4JQ49   A0A195CTS9   D2A3Y2   N6T3L7   U4UC85   K7IQY4   A0A182P9F1   F4WMS6   F7HXH8   A0A2K5EUS2   A0A182YDB7   A0A0M8ZXY7   A0A1L8DR93   A0A1L8DQV7   A1XGA1   A0A182LT40   A1XGA0   A1XG97   H2PBP8   A0A0L7R992   A0A2W1BNU0   K7JA32   A1XG98   A0A195BHV6   A0A232EGG7   A0A232F1J1   K7IY61   L5JVM8   A0A182QAV5   A0A310SCR6   A0A0J7KVA1   A0A2I3TU16   A1XGA3   A0A2R9CAY4   A0A3Q0D5I3   A0A096P028   A0A0L7KXG1   H2QNJ6   A0A195FPB2   S7MU95   A0A2K6KUE9   A0A2R9CLS4   A0A2J8P2V4   B2R941   P15088   A0A158NQ85   A1XGA2   A0A2K6C4D9   G7MJJ7   H9J5L1   G7NZN8   F7GFE7   A0A2K5WCY7   Q542E3   P15089   G3S533   A0A2K6LW11   A0A2K6LVY0   A0A0D9RG95   A0A2K5JGG1   A0A3G5BIF5   A0A2K5CNU8   A0A151WLL6   L5MAR4   A0A151J021   A0A2S2N6Y1   A0A2K5R360   A0A2K5CNV4   A0A341B9Q3   A0A2K6NNH6  

PDB

5MRV     E-value=4.26837e-20,     Score=236

KEGG

101746091    no KO assigned | (RefSeq) mast cell carboxypeptidase A-like

GO

GO:0004181   GO:0008270   GO:0016021   GO:0002002   GO:0006508   GO:0005615   GO:0004180   GO:0002003   GO:0062023   GO:0030133   GO:0030141   GO:0005576   GO:0008233   GO:0046658   GO:0005515   GO:0003676   GO:0007154   GO:0016020   GO:0005112   GO:0015930  

Subcellular location

  

Length:

170

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

5.1002

Exp number, first 60 AAs:

0.91849

Total prob of N-in:

0.38997

outside

1  -  170

 

 

Pi

172.861931

Theta

162.908028

Tajima's D

-1.330247

CLR

3.953233

CSRT

0.0825958702064897

Interpretation

Uncertain