Gene

KWMTBOMO15020

Pre Gene Modal

BGIBMGA004868

Annotation

acyl-CoA_delta-11_desaturase_isoform_1_[Bombyx_mori]

Location

Bomo_Chr25(-):2687864-2689972      View in EpiBrowser

Full name

Acyl-CoA Delta(11) desaturase      

Alternative Name

Acyl-CoA Delta-11 desaturase
SlsZ/E11
Acyl-CoA Z/E11 desaturase

Location in the cell

PlasmaMembrane   Reliability : 3.061

CDS

ATGTTTTATGGCCTATATCTTTGTTGTACGACAGCGAAGTGGCCTTCAGTTGGATTCGCGTACCTGTGTTATGTAGCAGCAACGATTGGCGTTACAGCTGGAGCTCACAGACTGTGGTCCCACAAATCATACAAAGCAAGATTACCTCTTCAAATCCTACTAATGGTCTTTCTTTCACTGGCCAATCAAAGAGCCACCCATTGGGTTCGAGACCATAGAGTCCATCACAAGTACAGCGATACGGACGCAGATCCACATAACGCAAGCCGTGGCTTCTTTTATTCTCATATAGGTTGGTTGTTCGTCAGAAAACACCCTGAAGTTAAGAAGAAAGGAAAACTAATAGACCTTTCGGATTTGTTCGATAATCCTGCATTAATGTTTCAGCACAGGTATTCGAAAACATTCATCCCTATTGTCTGCTTTGGACTCCCAACAATACTTCCAGTAATATTATGGGATGAATTGTTAGTAGTCGCCTGGAACCTCACCATCATGAGATACGTTATCAACTTCCACGTATTCTTCTTAGTGAACAGTGTCGCTCACATCTGGGGCAACAAGCCTTATGATAAGACAATCAAATCAGCTGAAAACAATCTGGTGGCGTTCGCTACTTTAGGGGAAGGATATCATAATTACCATCATGTATTCCCTTGGGATTACCGGTGCACAGAATTAGGAAGGACCTGGCTAAACTATACAAAGCTCTTCATTGATTTGTGCGCGAAAGTTGGATTGGCGTACGATCTTAAAGTGGTTTCTGATGATGTGATATTAAGACGAGTGAAAAGGACTGGGGATAGATCACACTTTATTGAAAACTAG

Protein

MFYGLYLCCTTAKWPSVGFAYLCYVAATIGVTAGAHRLWSHKSYKARLPLQILLMVFLSLANQRATHWVRDHRVHHKYSDTDADPHNASRGFFYSHIGWLFVRKHPEVKKKGKLIDLSDLFDNPALMFQHRYSKTFIPIVCFGLPTILPVILWDELLVVAWNLTIMRYVINFHVFFLVNSVAHIWGNKPYDKTIKSAENNLVAFATLGEGYHNYHHVFPWDYRCTELGRTWLNYTKLFIDLCAKVGLAYDLKVVSDDVILRRVKRTGDRSHFIEN

Description

Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland.
Catalyzes the formation of delta(11) fatty acyl precursors in the pheromone gland, and has high activity towards palmitic acid and stearic acid.
Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland, with a preference for myristic acid.

Catalytic Activity

2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O

Cofactor

Fe cation

Similarity

Belongs to the fatty acid desaturase type 1 family.

Keywords

Endoplasmic reticulum   Fatty acid biosynthesis   Fatty acid metabolism   Iron   Lipid biosynthesis   Lipid metabolism   Membrane   Metal-binding   Oxidoreductase   Transmembrane   Transmembrane helix  

Feature

chain  Acyl-CoA Delta(11) desaturase

Uniprot

Q2F669   Q2F668   Q2F667   H9J5S8   Q9NB26   A0A291P0P5   + More
A0A0U2F3E1   A0A0U2F3F2   Q8MZZ2   M4PTD0   A0A1V0M868   A9YRX6   Q2YHQ4   A0A0N1PJV1   D2SNV3   G8FQ78   T1RU40   O44390   U5KFQ4   A0A0K2GV16   A0A2A4JG15   A0A1L8D6M1   A0A076FRH6   A8QVZ1   A0A068FKA4   Q6US81   Q4A181   G8FQ76   G8FQ79   G8FQ77   Q75PL5   Q6A4M5   Q95VE7   A0A0K0N452   Q95UJ3   B7SB74   W5QM97   Q8ISS3   T1RTF9   T1RTE1   H9JF74   A0A1L8D6C0   A0A0L7L2G4   S4WAY4   A0A0K8TSL7   B6CBS5   A0A1L8D6L2   A0A075BRA0   A0A1L8E961   D8L7A6   W6ACM3   A0A0M3L9E8   A0A1L8EEG9   A6P6Z1   A0A023EPC8   A0A195BV85   Q17G31   D3TP66   A0A336M2F9   A0A195FTA2   Q6US82   A9YRX5   A0A194Q9S9   A0A336MXG6   G8FQ80   Q4A182   A0A151X3A2   A0A0F7R6V7   I3QPX9   Q75PL6   A0A195CWI5   H9JLG4   B7SB75   A0A0J7KMY0   B3M2R7   A0A1A9Z238   A4KWG3   A0A2H1V8Q0   B7SB77   U5KFT8   A0A212FG51   A0A1I8NWA7   B7SB73   A0A026W4N9   G8FQ63   A0A3L8DXQ3   A0A0A1XD14   A0A1L8D6B5   A0A1A9WBD6   B7SB76   Q8ITE5   B4PPA5   A0A0U2F3B3   Q8MZZ4   T1RTF5   I7B370   T1RTD3   Q9NB25   A0A0U2F3B9   A0A291P0G3  

EC Number

1.14.19.5

Pubmed

19121390    11483431    28986331    12524345    12770579    28349297    + More
18405835    25796477    26417103    26354079    20074338    22291612    24500170    9860961    24053512    24817326    17921252    26385554    15544945    17517337    15527989    11805319    20403437    24862548    15455060    26227816    24569486    26369729    18831750    17916502    24945155    17510324    20353571    17994087    18057021    17360547    22118469    24508170    30249741    25830018    17550304    28756777   

EMBL

DQ311203    ABD36148.1    DQ311204    ABD36149.1    DQ311205    ABD36150.1    + More
BABH01025135    AF272342    AAF81787.1    MF687528    ATJ44454.1    KP008117    AKU76404.1    KP008124    MF687587    AKU76411.1    ATJ44513.1    AF482908    AAM28483.2    KC422668    AGH12217.1    KU755471    ARD71181.1    EU285580    KM283200    ABX90049.1    AIU96339.1    AM158251    CAJ43430.2    KQ460301    KPJ16138.1    EZ407237    ACX53794.1    JN022488    AER29853.1    JX531654    AGO45839.1    AF035375    AF297114    AF297113    JX989153    AGR49312.1    KP890026    ALA65425.1    NWSH01001511    PCG71017.1    GEYN01000135    JAV01994.1    KF960741    AII21943.1    EF150363    ABO43722.1    KJ622051    AID66659.1    AY362879    AM076339    CAJ27976.2    JN022486    AER29851.1    JN022489    AER29854.1    JN022487    AER29852.1    BABH01040457    AB166853    BAD18124.1    AF518014    AAQ12891.1    AF416738    AAL16642.1    KM378664    AKJ32408.1    AY049741    AAL11496.1    EU152400    FJ466458    ABX71809.1    ACS69071.1    JQ978772    AGD98720.1    AF545481    FJ999625    JX531668    AGO45853.1    JX531667    AGO45852.1    BABH01026838    BABH01026839    BABH01026840    GEYN01000123    JAV02006.1    JTDY01003403    KOB69615.1    JX964774    AGO96562.1    GDAI01000236    JAI17367.1    EU152335    ABX71630.1    GEYN01000122    JAV02007.1    JX679209    AGP26038.1    GFDG01003677    JAV15122.1    FJ999626    ADC53486.1    KF835695    AHI54575.1    KM366790    AIM40220.1    GFDG01001755    JAV17044.1    AB300221    BAF69118.1    GAPW01002266    JAC11332.1    KQ976407    KYM91395.1    CH477266    EAT45554.1    EAT45555.1    CCAG010012100    EZ423218    ADD19494.1    UFQT01000109    SSX20158.1    KQ981276    KYN43683.1    AY362878    AAQ74258.1    EU285579    ABX90048.1    KQ459249    KPJ02273.1    UFQS01001440    UFQT01001440    SSX10910.1    SSX30588.1    JN022490    AER29859.1    AM076338    CAJ27975.1    KQ982566    KYQ54759.1    LC020024    BAR72989.1    JQ729998    AFK13830.1    JQ729997    AB166852    AFK13829.1    BAD18123.1    KQ977220    KYN04897.1    BABH01005826    EU152401    ABX71810.1    LBMM01005260    KMQ91667.1    CH902617    EDV42388.1    KPU79686.1    KPU79687.1    EF113404    ABO45242.1    ODYU01001259    SOQ37220.1    EU152403    ABX71812.1    JX989152    AGR49311.1    AGBW02008720    OWR52703.1    EU152399    FJ466456    FJ466457    ABX71808.1    ACS69069.1    ACS69070.1    KK107419    EZA51017.1    JN022473    AER29842.1    QOIP01000003    RLU25072.1    GBXI01005435    JAD08857.1    GEYN01000136    JAV01993.1    EU152402    ABX71811.1    AF518020    AAN39700.1    CM000160    EDW97111.1    KRK03534.1    KP008113    AKU76400.1    AF482906    AAM28481.2    JX531653    NWSH01001519    AGO45838.1    PCG70996.1    JX126483    AFO38464.1    JX531660    AGO45845.1    AF272343    AAF81788.1    KP008120    MF687582    AKU76407.1    ATJ44508.1    MF687527    KZ149911    ATJ44453.1    PZC78117.1   

Proteomes

UP000005204    UP000053240    UP000218220    UP000037510    UP000078540    UP000008820    + More
UP000092444    UP000078541    UP000053268    UP000075809    UP000078542    UP000036403    UP000007801    UP000092445    UP000007151    UP000095300    UP000053097    UP000279307    UP000091820    UP000002282   

PRIDE

Q2F669    Q2F668    Q2F667    H9J5S8    Q75PL5    T1RTF9    + More
T1RTE1    H9JF74    Q75PL6    H9JLG4   

Pfam

PF00487   FA_desaturase

Interpro

IPR005804   FA_desaturase_dom        + More
IPR015876   Acyl-CoA_DS       
IPR001522   FADS-1_CS       
IPR009160   Acyl-CoA_deSatase_haem/ster-bd       

CDD

cd03505  Delta9-FADS-like

ProteinModelPortal

Q2F669   Q2F668   Q2F667   H9J5S8   Q9NB26   A0A291P0P5   + More
A0A0U2F3E1   A0A0U2F3F2   Q8MZZ2   M4PTD0   A0A1V0M868   A9YRX6   Q2YHQ4   A0A0N1PJV1   D2SNV3   G8FQ78   T1RU40   O44390   U5KFQ4   A0A0K2GV16   A0A2A4JG15   A0A1L8D6M1   A0A076FRH6   A8QVZ1   A0A068FKA4   Q6US81   Q4A181   G8FQ76   G8FQ79   G8FQ77   Q75PL5   Q6A4M5   Q95VE7   A0A0K0N452   Q95UJ3   B7SB74   W5QM97   Q8ISS3   T1RTF9   T1RTE1   H9JF74   A0A1L8D6C0   A0A0L7L2G4   S4WAY4   A0A0K8TSL7   B6CBS5   A0A1L8D6L2   A0A075BRA0   A0A1L8E961   D8L7A6   W6ACM3   A0A0M3L9E8   A0A1L8EEG9   A6P6Z1   A0A023EPC8   A0A195BV85   Q17G31   D3TP66   A0A336M2F9   A0A195FTA2   Q6US82   A9YRX5   A0A194Q9S9   A0A336MXG6   G8FQ80   Q4A182   A0A151X3A2   A0A0F7R6V7   I3QPX9   Q75PL6   A0A195CWI5   H9JLG4   B7SB75   A0A0J7KMY0   B3M2R7   A0A1A9Z238   A4KWG3   A0A2H1V8Q0   B7SB77   U5KFT8   A0A212FG51   A0A1I8NWA7   B7SB73   A0A026W4N9   G8FQ63   A0A3L8DXQ3   A0A0A1XD14   A0A1L8D6B5   A0A1A9WBD6   B7SB76   Q8ITE5   B4PPA5   A0A0U2F3B3   Q8MZZ4   T1RTF5   I7B370   T1RTD3   Q9NB25   A0A0U2F3B9   A0A291P0G3  

PDB

4YMK     E-value=2.71834e-73,     Score=698

KEGG

692831    K00507 stearoyl-CoA desaturase (Delta-9 desaturase) [EC:1.14.19.1] | (RefSeq) acyl-CoA delta-11 desa

PATHWAY

01040    Biosynthesis of unsaturated fatty acids - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01212    Fatty acid metabolism - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0016717   GO:0006633   GO:0004768   GO:0017105   GO:0046872   GO:0005789   GO:0042811   GO:0006631   GO:0055114   GO:0006636   GO:0045793   GO:0031410   GO:0042594   GO:0006723   GO:0010506   GO:0070328   GO:0045572   GO:0009744   GO:0060179   GO:0040018   GO:0042593   GO:0048047   GO:0019216   GO:0005783   GO:0016491   GO:0006629   GO:0008270   GO:0004180   GO:0005515   GO:0003676   GO:0007154   GO:0016020   GO:0005112   GO:0015930  

PANTHER

PTHR11351  

Subcellular location

Endoplasmic reticulum membrane  
Membrane  

Length:

275

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

71.1296499999999

Exp number, first 60 AAs:

27.43175

Total prob of N-in:

0.42154

POSSIBLE N-term signal

sequence

outside

1  -  14

TMhelix

15  -  37

inside

38  -  135

TMhelix

136  -  153

outside

154  -  162

TMhelix

163  -  185

inside

186  -  275

 

 

Pi

129.366104

Theta

134.055

Tajima's D

0.085427

CLR

0.309656

CSRT

0.395180240987951

Interpretation

Uncertain