Gene

KWMTBOMO15012  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA004872

Annotation

PREDICTED:_eukaryotic_translation_initiation_factor_2-alpha_kinase_4_[Amyelois_transitella]

Location

Bomo_Chr25(-):2407441-2433692      View in EpiBrowser

Full name

eIF-2-alpha kinase GCN2      

Alternative Name

Eukaryotic translation initiation factor 2-alpha kinase 4
GCN2-like protein

Location in the cell

Nuclear   Reliability : 2.939

CDS

ATGGCTGAAGAGAGCTACGAGGAGAGACAAAATAATGAGCTAACCGCCTTACAGGCTATATATGGTGATGCTGTTATTGATAATCGCGAAAACATTGCTTGGAAAGTATGGCGTCCGCTCGATATAATGTTGACGTTGAATCCACTTCACAACTCAGATATACAAGGTGTTCACTGCTCTGTAACATTGCATTTAAAATGTTGCAATAATTATCCTGACAAGCCACCAAGTCTAGCCATACACAAGATGCATGGATTATCCACAGACAATGCCACCAAATTATTGGCTGAATTGGAGACATTGTCACATCAATTGTGTGGTGAAGTTATGATATTCCAACTAGCCCAGCATGCACAGCAATTTCTGCACGATCACAATAAGCCTATATTGTCGTTTTACGATGAAATGCTGAAGCAGAAGAATGAAATGGAGAAACTGAAACTTCATGATTTACAAACCAAAGAGGAGGAAGAACGCCAAAAAATCAAAGATGAGATACAACGTCGTCAGGAGATACTCAAAGGTGCCGGAAGACAGCGTGTCCGAGTCTCCAGCCTCTGCCATGATAACAGCACGGAACAGGACTGCACTGATGAAAAGGTGGATGCACCAGAGCTTGTATTCTATGCGGACGATAAAATGTCGCCAGTAAAGAAATCAACACGTCTTCGAAACATGGAGGTTCCGTGCACGTGTAACACGCGAGGAGTGCAAGTGCTCAGAGTGACGCAACGGAACAACAAGAAGGTTTACATAGGGAGCTGTTTAGGACATTCATCGACCGGCGCGACAACATATCTAGCGATAGACGACGACACAGGGGAAAGTCTTATCGCAAAGAAGTGGAGCATCCCACCGGCTTCAGACTTCCAAACGAGAAACAAACAGCTTACATCGATACAGCAAGACGTGAAGTCGCTTGCCCGACTCAGCAACGCCTCCTTGATCCCATACGTTGCAATGGAGATGTGTAAAGAAGTAAACAAACGAACGTCAAAACAGTGCATTTATATATTCAGAAGTTTCGTTCTAGGGACGTCCTTGAAGAATCTAGTGAAAAAGTTGAGTGGTTTCAGTGATTGCTTTGAGGTTTTGGGCCTCTTGAGACATGTGGCTGACGGTGTTTTGAGTGCGTTAAACGAATTGCATGCAGCGAATATAATACATAGGGATGTTAGAAGTGAAAATGTATTCGTCGATGACGTTGGCCAAGTGAAGTTGGTTGGTGCTAGCTTGGACACCAGGTTGGCTGAAATGTTGGACAATGATAACTATTGTGATAAGCAAACCCCAGCCCAAGATATCTATGCGACCGGACAACTTCTGTTATCCATTGTTTGCAAAGAAAAATCGTATACAGAAATACCGCAGGAGCTCCCTTGCGTGGCAAAAGACTTCATATCCAGATGTTTAACAGAAGACGAACATTCGCAATGGTCGGCGAAGCAGTTGATGAGTCATTACTTCTTAGTCGAAGCTCCGACAAAGAAACCTTACGTCAAACGTGCCGACGACGGTGGAAGCGGTTCAGAGGACGACGACGCCGTCAAAAAGATTCGACACATGAGTTTTGCCAACAACGGGCTGTCGCGGCTGGACGCTGAGTTTGAGGTGCTAGCGTGGCTCGGGAAAGGCGCATTCGGTGATGTTTTGAAGGTAAAGAACAAACTGGACGGAGGTTTCTACGCGATAAAAAGAGTCCAATTGAATCCTGAAAGCGTTCAGCTCAACAAGAAGATAACAAGGGAAGTGAAACTCCTCTCCAGGCTCAACCACGAGAACGTAGTCCGCTATTACAACGCGTGGATCGAGTCGACAACTGAGCCGATAGACTGTGAGGAATCTCCCACCAAAACTCCTACCCGGAAACCCAGCTTGGAAGGTATTGTCGCGAAACTGGGACAAGAGGTCAAAGTGGAGTGGTCCATGTCAGAGGGACCGGCGCAGATGACGAATTCCACATCGGACACCGAAGATAGCGATGACGATGAACCGGATCCGTGGTTTAATATCATCAGCCCCGGTGACGAATCGAGCGAACTTATCGAATTCGAAAAGACCTCTGACGACGAAGAATCTCAGACGTTACCATCGGAAGACGTTGTCGACGCGCCGAGACCTCAATCCGAGCGTCTCAAGCAAGTCCTATACATCCAAATGGAATTTTGCGAGAAGCATACATTGAGACAAGCCATAGACAACGGCTTGTTCCAGGAACATTTCAGGGCGTGGAGGCTGTTCCGGGAGATCGTCGAGGGTCTGGCCCACGTGCATCAGAGAGGCATGATACACAGGGACCTCAAGCCTGTGAATATATTCTTGGACTCGAACGACCATGTCAAGATTGGAGACTTCGGACTAGCAACTAAGGCGTTCACGGGACTGCCGGTTGAAGATAAAACGAAACAAGAAGAAATAGGCGGTTCGCTAACTGGGCAAATAGGAACAGCCCTATACGTAGCTCCCGAACTACTCCAGTCTGCTACAAAGGTCATATACAATCAAAAAGTGGACATATATTCATTAGGCATAATATTGTTTGAAATGTTCCATCCGCCCCTCGAAACTGGAATGGAGAGAATGATGGTGCTCACCAATTTGAGGAGCAAGGATATCGTCATACCGAATAAGTTTGATGTCGACGAAAATGTGAAGCAGATTCATGTCATAAGATGGTTGCTGAACCACGAGGCGAGCCTGCGGCCCACGTGCGCGGAGCTGCTGGCCAGCGAGCACGTGCCGCGCGCCGTGCCCGAGGGCGCGCTGGCCGGGCTGCTGTCGCACGCGCTCAGCGACCGCACGGCGCGCGGCTACCAGCGCCTCGTGGCCGCCTGCCTCGACCAGAGGCCGTCCGCAGCCGAGGACTACACCTACCACAACGGGATGAAGACCAAGCCCGCCCGTCTCCTGGAGTTCGTCAAGGATGCTGTTGTCAAGGTATTCAAAAGTCACGGAGCTTTAGAGTTCGCTCCGCCGCTCCTTATACCGAGAGCGAGAGCCTGGGACCAGTATCCTAACGCTGTCAAAGTCATGACGTCATCGGGCTCGGTCTGTCATTTACCGCACGACTTGAGGCTGCCTTTCGCCAGGCACATAGCATACTCCGGTATAAAAAATCTCCGTCGTTTTATAGTCGATAGGGTTTATAGAGAGAAGCACGTTCAAGGTTTTCACCCGAAGGAAATTCTTGAATGTGCCTACGATATCGTCACCCCTAAAACTGACTCTCTATGGCCGGACGCAGAATTAATAGAGGTCGCAAGTAGAGCGGCATCGGAGTGTTCCCTCAAAGTGTCGATACAACTAAATCACACGGAACTGATTCGCGTCCTGCTACAGTCGTGCGGGGTACCGACAGACAAACAGGCTGATATATACCCTGTTTTGGTCGACGTCAGCTTCGGTCGCATAACGAGTCTGCAACTTCAAACACACTTGACGTCGCTCTGTATAACGAATCGTGACGTCACGAACCTGGTCCGCCTGATGGAGGCGGATGCGCCGGTCCAAGAGCTCCGGGAGCTGGTCACGCCTCTCGTCAAACAAGCGAAGTGCAGTAGGATCGCGAGTCAGGCCGTGCACGACCTGGAAGCCGTGTACAGGAACGCCAAGGCGCTGGGCTGTGAGTGCCCGATGACGGTGGCTCCGCTCTCGGCGTACAACGTGACGCAGCACAGCGGCGTGTTCTGGCAGATGTCCGTCGTGCGAAGCGAACAGAAGTCGATCACCAAACGACGTTCCGGGGACCTTATTGCGGCTGGCGGAAGATACGACGCTCTGGTCAAGGAGTTCTGGAATGTAGCGAGCGCGGAAAACGATCAAGACAGCGCCGATTTGAATGTGTGTTCGGTCGGGTTCTCGATGTCCCTCGAACGGATGGCGGCCTTCCTCAACAAACTGGAGACGCAAACGAACGTGCCGATCAAGAGTAACGAGACGCCGCTGGTGCACGTGCGCGTGTGGGGCGCGGTGGGCAGCGGGCGGGAGGGCGCGGCGGCGGCGCGGCGGGCGCAGCTGGCGCGCGATCTGTGGGCGGGCGGGCTGCGAGCCGGGCTGCACGCGGGGGACGCGCCCGACCTCGCGCCCGGCGCCGTGCTGGCCGAGCACGACCCGCCCCTCGTCCGGCTGTCCTGCTGGGACCAGGACAGGATCCGGGAACACAGGGTGCCCTACGTGGATGTTGTCGATTTCATCAAACAAAAAATTATCGGCGACTCGTCTCGGAATCCTGAAGGTTCTAGCACGAACCGATCGATAAGCTGGTCCGAAAGCTCCGAAAAATACAACAGTCCGAATATATCGGTCACTTTCATAACGGCCAGCGACAGAATGACGAAAAACTCGAAGAGGCACTGCGAGAATCAGATAAACACTCAAGTGACGTCGATTCTGGTAAGTCTGGGCCTCCTGCCGGTCATGGCGAGGGTGCGCGTCAACGTACTAGCCGTGGCCTGCGACTCCGCCTGCGTCAGGTACATGGCCTCGCAGCTGACGGCGCCATTAGATGCCGATGATCTGTCGCAAGCCTTCAGAAACGTTACGGAAATGTTCCCCAAACGTCAGGGCCTAATAGACGAAGCTCGCTCCGAGCTTTCGAGCTTATTGAAACAAACCAGCCCGAGTCGGAACAACGAAGAGACTCAAATATACGCCCTATATTCAATACCGGATTCATTGTGTCGACTTATTACTTGA

Protein

MAEESYEERQNNELTALQAIYGDAVIDNRENIAWKVWRPLDIMLTLNPLHNSDIQGVHCSVTLHLKCCNNYPDKPPSLAIHKMHGLSTDNATKLLAELETLSHQLCGEVMIFQLAQHAQQFLHDHNKPILSFYDEMLKQKNEMEKLKLHDLQTKEEEERQKIKDEIQRRQEILKGAGRQRVRVSSLCHDNSTEQDCTDEKVDAPELVFYADDKMSPVKKSTRLRNMEVPCTCNTRGVQVLRVTQRNNKKVYIGSCLGHSSTGATTYLAIDDDTGESLIAKKWSIPPASDFQTRNKQLTSIQQDVKSLARLSNASLIPYVAMEMCKEVNKRTSKQCIYIFRSFVLGTSLKNLVKKLSGFSDCFEVLGLLRHVADGVLSALNELHAANIIHRDVRSENVFVDDVGQVKLVGASLDTRLAEMLDNDNYCDKQTPAQDIYATGQLLLSIVCKEKSYTEIPQELPCVAKDFISRCLTEDEHSQWSAKQLMSHYFLVEAPTKKPYVKRADDGGSGSEDDDAVKKIRHMSFANNGLSRLDAEFEVLAWLGKGAFGDVLKVKNKLDGGFYAIKRVQLNPESVQLNKKITREVKLLSRLNHENVVRYYNAWIESTTEPIDCEESPTKTPTRKPSLEGIVAKLGQEVKVEWSMSEGPAQMTNSTSDTEDSDDDEPDPWFNIISPGDESSELIEFEKTSDDEESQTLPSEDVVDAPRPQSERLKQVLYIQMEFCEKHTLRQAIDNGLFQEHFRAWRLFREIVEGLAHVHQRGMIHRDLKPVNIFLDSNDHVKIGDFGLATKAFTGLPVEDKTKQEEIGGSLTGQIGTALYVAPELLQSATKVIYNQKVDIYSLGIILFEMFHPPLETGMERMMVLTNLRSKDIVIPNKFDVDENVKQIHVIRWLLNHEASLRPTCAELLASEHVPRAVPEGALAGLLSHALSDRTARGYQRLVAACLDQRPSAAEDYTYHNGMKTKPARLLEFVKDAVVKVFKSHGALEFAPPLLIPRARAWDQYPNAVKVMTSSGSVCHLPHDLRLPFARHIAYSGIKNLRRFIVDRVYREKHVQGFHPKEILECAYDIVTPKTDSLWPDAELIEVASRAASECSLKVSIQLNHTELIRVLLQSCGVPTDKQADIYPVLVDVSFGRITSLQLQTHLTSLCITNRDVTNLVRLMEADAPVQELRELVTPLVKQAKCSRIASQAVHDLEAVYRNAKALGCECPMTVAPLSAYNVTQHSGVFWQMSVVRSEQKSITKRRSGDLIAAGGRYDALVKEFWNVASAENDQDSADLNVCSVGFSMSLERMAAFLNKLETQTNVPIKSNETPLVHVRVWGAVGSGREGAAAARRAQLARDLWAGGLRAGLHAGDAPDLAPGAVLAEHDPPLVRLSCWDQDRIREHRVPYVDVVDFIKQKIIGDSSRNPEGSSTNRSISWSESSEKYNSPNISVTFITASDRMTKNSKRHCENQINTQVTSILVSLGLLPVMARVRVNVLAVACDSACVRYMASQLTAPLDADDLSQAFRNVTEMFPKRQGLIDEARSELSSLLKQTSPSRNNEETQIYALYSIPDSLCRLIT

Description

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability (PubMed:10504407, PubMed:10655230, PubMed:12176355, PubMed:12215525, PubMed:15213227, PubMed:16054071, PubMed:16176978, PubMed:16121183, PubMed:15774759, PubMed:16601681, PubMed:26102367). Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:10655230, PubMed:11106749, PubMed:12176355, PubMed:15213227, PubMed:16176978, PubMed:26102367). Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:16176978, PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (PubMed:16121183). Plays a role in neurite outgrowth inhibition (PubMed:23447528). Plays a role in feeding behavior to maintain amino acid homeostasis; contributes to the innate aversion toward diets of imbalanced amino acid composition (PubMed:16054071, PubMed:15774759). Plays a proapoptotic role in response to glucose deprivation (PubMed:20660158). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (PubMed:12176355).
(Microbial infection) Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication.
(Microbial infection) Plays a role in modulating the adaptive immune response to Yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation.
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory. Plays a role in neurite outgrowth inhibition. Plays a proapoptotic role in response to glucose deprivation. Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity).
(Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610).

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Subunit

Homodimer; homodimerization is important for kinase activation by uncharged tRNAs (By similarity). Interacts with GCN1; this interaction stimulates EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation (PubMed:24333428). Interacts with DNAJC3; this interaction inhibits EIF2AK4/GCN2 kinase activity during endoplasmic reticulum (ER), hypothermic and amino acid-starving stress conditions (PubMed:25329545).
Homodimer; homodimerization is important for kinase activation by uncharged tRNAs. Interacts with GCN1; this interaction stimulates EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Interacts with DNAJC3; this interaction inhibits EIF2AK4/GCN2 kinase activity during endoplasmic reticulum (ER), hypothermic and amino acid-starving stress conditions.

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.

Keywords

3D-structure   Acetylation   Activation of host autophagy by virus   Activator   Adaptive immunity   Alternative splicing   Antiviral defense   ATP-binding   Cell cycle   Coiled coil   Complete proteome   Cytoplasm   Differentiation   Direct protein sequencing   Growth arrest   Host-virus interaction   Immunity   Kinase   Neurogenesis   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat   RNA-binding   Stress response   Transferase   Translation regulation   tRNA-binding   Disease mutation   Polymorphism  

Feature

chain  eIF-2-alpha kinase GCN2
splice variant  In isoform 5.
sequence variant  In dbSNP:rs35509999.

Uniprot

H9J5T2   A0A2A4JSE2   A0A212FG33   A0A2H1V9T6   A0A2W1BXS8   A0A3S2LU79   + More
A0A232ESJ4   A0A151J0K5   A0A151I1P2   A0A158NAF7   A0A1Y1LNY7   A0A0C9QMU9   D6WSZ3   A0A0C9QMD1   A0A2J7Q260   T1IQL0   A0A088AEP3   A0A1I8NAC2   A0A1L8FAK5   A0A1Y1LP48   F7BV00   A0A1Q3F239   F7BH85   I3K2D0   A0A0M3QYL7   M3X137   G7MWM5   A0A096NTE4   A0A2K5NYZ9   A0A0D9R4Q6   A0A2K5ZJC5   A0A2J8T2Y6   H9GL93   A0A2K6NN09   A0A3L8SY72   A0A2K5E3L8   A0A3Q3C620   G3S852   A0A2R9AQ16   A0A2K5K4A5   Q9QZ05   Q9P2K8   H2Q956   A2AUM0   A0A2R9AQ06   E9G227   Q4RLP9   A0A3B3RFP2   U3FQ30   O01712   A0A218V8Q9   U3BNN6   A0A3B3RE15   Q9V9X8   L5K1I4   O61651   B4I024   Q9P2K8-2   H0ZMZ5   A0A3B4U648   A0A2J8QDB7   A0A2D0RNG7   A0A0B4KHX7   A0A0P5YXY2   A0A1S3AMM2   A0A1A7YRD5   A0A0N8A753   A0A0P5VZ04   A0A0P5AFM3   A0A0P4YHK3   A0A0P5U427   K7FQP3   A0A0N8D0E0   A0A286XMJ2   A0A0P4Y5R0   A0A087V2U7   A0A0P5XMK4   A0A3P9Q7K0   A0A0P5ZNA9   A0A091MTS3   A0A0P5X1S8   A0A3P9K4E3   A0A3Q2UGU9   A0A0N8EQA6   M3ZXB5   A0A1A7XTG5   A0A3Q2DB77   A0A3Q1BQ84   A0A091IWZ4   A0A0P5CMS7   A0A2C9KLS5   A0A2U9CJ75   I3MQ20   A0A146V5I0   A0A087XYY3   A0A0N7ZU46   A0A0P5D2A7   A0A146MR45   A0A2I0MP31   A0A3B3VZ94  

EC Number

2.7.11.1

Pubmed

19121390    22118469    28756777    28648823    21347285    28004739    + More
18362917    19820115    25315136    27762356    20431018    25186727    17975172    22002653    21881562    25362486    30282656    22398555    22722832    10504407    10655230    16141072    19468303    15489334    14621295    11106749    12176355    12215525    15213227    16054071    16176978    16121183    15774759    16601681    21183079    20660158    23447528    24333428    24310610    25329545    26102367    15273307    16572171    10718198    17974005    14702039    17081983    18691976    18669648    19369195    19608861    20068231    21269460    21406692    23186163    24135949    24292273    17344846    16136131    21292972    15496914    29240929    25243066    9139706    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    23258410    9649537    17994087    20360741    17381049    21993624    17554307    23542700    15562597    23371554   

EMBL

BABH01025161    BABH01025162    BABH01025163    BABH01025164    NWSH01000660    PCG74957.1    + More
AGBW02008725    OWR52683.1    ODYU01001427    SOQ37598.1    KZ149903    PZC78444.1    RSAL01000009    RVE53876.1    NNAY01002415    OXU21328.1    KQ980629    KYN15001.1    KQ976600    KYM79468.1    ADTU01010273    GEZM01050768    JAV75394.1    GBYB01001982    JAG71749.1    KQ971352    EFA06330.1    GBYB01004674    JAG74441.1    NEVH01019373    PNF22671.1    JH431312    CM004480    OCT68625.1    GEZM01050759    JAV75409.1    AAMC01063663    AAMC01063664    AAMC01063665    GFDL01013422    JAV21623.1    AERX01018652    AERX01018653    CP012526    ALC47839.1    AANG04001761    CM001259    EHH27200.1    AHZZ02030793    AHZZ02030794    AQIB01116350    AQIB01116351    AQIB01116352    NDHI03003524    PNJ27389.1    AAWZ02022551    QUSF01000004    RLW10462.1    CABD030095524    AJFE02093060    AJFE02093061    AJFE02093062    AJFE02093063    AJ243533    AF193342    AF193343    AF193344    AK011380    AK013758    AK077199    AL929163    BC023958    BC072637    AK129334    AC012377    AC025168    BC009350    BC078179    AB037759    AL137627    AL157497    AL832907    AK027011    AJ243428    AACZ04038090    AACZ04038091    GABC01006885    GABC01006884    GABC01006883    GABC01006882    GABC01006881    GABD01001668    GABD01001667    GABD01001666    GABD01001665    GABE01005382    GABE01005381    GABE01005380    GABE01005379    GABE01005378    GABE01005377    GABE01005376    NBAG03000046    JAA04453.1    JAA31432.1    JAA39357.1    PNI94271.1    GL732530    EFX86379.1    CAAE01015019    CAG10683.1    GAMS01003843    GAMS01003842    GAMR01003306    GAMP01004630    GAMP01004629    JAB19293.1    JAB30626.1    JAB48126.1    U80223    AAC47516.1    MUZQ01000033    OWK61992.1    GAMT01004457    JAB07404.1    AE014297    BT126024    AAF57150.1    ADY17723.1    AGB96520.1    KB031042    ELK05554.1    AF056302    AAC13490.1    CH480819    EDW53631.1    ABQF01002671    PNI94270.1    AGB96521.1    GDIP01052237    JAM51478.1    HADX01010885    SBP33117.1    GDIP01175913    JAJ47489.1    GDIP01107721    LRGB01002384    JAL95993.1    KZS07872.1    GDIP01199861    JAJ23541.1    GDIP01230861    JAI92540.1    GDIP01118422    JAL85292.1    AGCU01123582    AGCU01123583    AGCU01123584    AGCU01123585    AGCU01123586    AGCU01123587    AGCU01123588    AGCU01123589    AGCU01123590    GDIP01081127    JAM22588.1    AAKN02015867    AAKN02015868    GDIP01232108    JAI91293.1    KL477821    KFO06939.1    GDIP01069926    JAM33789.1    GDIP01041532    JAM62183.1    KL371374    KFP80691.1    GDIP01078626    JAM25089.1    GDIQ01004420    JAN90317.1    HADW01019971    SBP21371.1    KK501012    KFP12093.1    GDIP01168263    JAJ55139.1    CP026259    AWP16645.1    AGTP01002143    AGTP01002144    AGTP01002145    AGTP01002146    AGTP01002147    AGTP01002148    AGTP01002149    AGTP01002150    GCES01073633    JAR12690.1    AYCK01003405    GDIP01212369    JAJ11033.1    GDIP01167415    JAJ55987.1    GCES01165192    JAQ21130.1    AKCR02000005    PKK31430.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000283053    UP000215335    UP000078492    + More
UP000078540    UP000005205    UP000007266    UP000235965    UP000005203    UP000095301    UP000186698    UP000008143    UP000005207    UP000092553    UP000011712    UP000028761    UP000233060    UP000029965    UP000233140    UP000001646    UP000233200    UP000276834    UP000233020    UP000264840    UP000001519    UP000240080    UP000233080    UP000000589    UP000005640    UP000002277    UP000000305    UP000261540    UP000008225    UP000197619    UP000000803    UP000010552    UP000001292    UP000007754    UP000261420    UP000221080    UP000079721    UP000076858    UP000007267    UP000005447    UP000242638    UP000265180    UP000265000    UP000002852    UP000265020    UP000257160    UP000053119    UP000076420    UP000246464    UP000005215    UP000028760    UP000053872    UP000261500   

PRIDE

H9J5T2    Q9QZ05    Q9P2K8    A2AUM0    O01712    Q9V9X8    + More
O61651   

Pfam

PF05773   RWD        + More
PF13393   tRNA-synt_His
PF00069   Pkinase
PF12745   HGTP_anticodon2

Interpro

IPR041715   HisRS-like_core        + More
IPR020635   Tyr_kinase_cat_dom       
IPR016135   UBQ-conjugating_enzyme/RWD       
IPR000719   Prot_kinase_dom       
IPR011009   Kinase-like_dom_sf       
IPR006575   RWD-domain       
IPR016255   Gcn2       
IPR008266   Tyr_kinase_AS       
IPR008271   Ser/Thr_kinase_AS       
IPR017441   Protein_kinase_ATP_BS       
IPR036621   Anticodon-bd_dom_sf       
IPR001611   Leu-rich_rpt       
IPR024435   HisRS-related_dom       
IPR006195   aa-tRNA-synth_II       

SUPFAM

SSF56112   SSF56112        + More
SSF54495   SSF54495       

Gene 3D

3.10.110.10     3.40.50.800    

ProteinModelPortal

H9J5T2   A0A2A4JSE2   A0A212FG33   A0A2H1V9T6   A0A2W1BXS8   A0A3S2LU79   + More
A0A232ESJ4   A0A151J0K5   A0A151I1P2   A0A158NAF7   A0A1Y1LNY7   A0A0C9QMU9   D6WSZ3   A0A0C9QMD1   A0A2J7Q260   T1IQL0   A0A088AEP3   A0A1I8NAC2   A0A1L8FAK5   A0A1Y1LP48   F7BV00   A0A1Q3F239   F7BH85   I3K2D0   A0A0M3QYL7   M3X137   G7MWM5   A0A096NTE4   A0A2K5NYZ9   A0A0D9R4Q6   A0A2K5ZJC5   A0A2J8T2Y6   H9GL93   A0A2K6NN09   A0A3L8SY72   A0A2K5E3L8   A0A3Q3C620   G3S852   A0A2R9AQ16   A0A2K5K4A5   Q9QZ05   Q9P2K8   H2Q956   A2AUM0   A0A2R9AQ06   E9G227   Q4RLP9   A0A3B3RFP2   U3FQ30   O01712   A0A218V8Q9   U3BNN6   A0A3B3RE15   Q9V9X8   L5K1I4   O61651   B4I024   Q9P2K8-2   H0ZMZ5   A0A3B4U648   A0A2J8QDB7   A0A2D0RNG7   A0A0B4KHX7   A0A0P5YXY2   A0A1S3AMM2   A0A1A7YRD5   A0A0N8A753   A0A0P5VZ04   A0A0P5AFM3   A0A0P4YHK3   A0A0P5U427   K7FQP3   A0A0N8D0E0   A0A286XMJ2   A0A0P4Y5R0   A0A087V2U7   A0A0P5XMK4   A0A3P9Q7K0   A0A0P5ZNA9   A0A091MTS3   A0A0P5X1S8   A0A3P9K4E3   A0A3Q2UGU9   A0A0N8EQA6   M3ZXB5   A0A1A7XTG5   A0A3Q2DB77   A0A3Q1BQ84   A0A091IWZ4   A0A0P5CMS7   A0A2C9KLS5   A0A2U9CJ75   I3MQ20   A0A146V5I0   A0A087XYY3   A0A0N7ZU46   A0A0P5D2A7   A0A146MR45   A0A2I0MP31   A0A3B3VZ94  

PDB

1ZYD     E-value=4.18024e-42,     Score=437

KEGG

101741238    K16196 eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1] | (RefSeq) eukaryotic

PATHWAY

04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)

GO

GO:0000077   GO:0004713   GO:0004694   GO:0005524   GO:0003743   GO:0004672   GO:0022626   GO:0036492   GO:0060733   GO:0070417   GO:0006446   GO:1990138   GO:0010628   GO:0007050   GO:0032057   GO:0019081   GO:0007612   GO:0060259   GO:1990253   GO:0046777   GO:0030968   GO:0017148   GO:0006468   GO:0010998   GO:0002286   GO:0071264   GO:1900273   GO:0002250   GO:0045665   GO:0034644   GO:0032792   GO:0044828   GO:0004674   GO:0007616   GO:0034198   GO:0005844   GO:0009267   GO:0039520   GO:0034976   GO:0045947   GO:0043558   GO:0051607   GO:0002230   GO:0000049   GO:0071074   GO:0002821   GO:0045793   GO:0004686   GO:0005829   GO:0005515   GO:0003676   GO:0007154   GO:0016020   GO:0005112   GO:0015930  

Subcellular location

Cytoplasm  

Length:

1564

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.08324

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00157

outside

1  -  1564

 

 

Pi

187.810526

Theta

163.054302

Tajima's D

0.693894

CLR

0.280569

CSRT

0.574621268936553

Interpretation

Uncertain