Gene

KWMTBOMO15000

Pre Gene Modal

BGIBMGA004790

Annotation

PREDICTED:_cyclin-dependent_kinase-like_1_[Bombyx_mori]

Location

Bomo_Chr25(+):2089202-2100510      View in EpiBrowser

Full name

Cyclin-dependent kinase-like 1      

Alternative Name

Protein kinase p42 KKIALRE
Serine/threonine-protein kinase KKIALRE

Location in the cell

Mitochondrial   Reliability : 1.526 Nuclear   Reliability : 1.915

CDS

ATGAAGAATTCAGTGAACGAGGACACCTCGAAATTCAAATTGTGGAACAACGTGGCGTCCTGCATGGAGAAATGGTTCGGTGATAAACGGCTCTGGTTATTTGGCAACAACCTGCCGCTGTTACCGAGAAGGTCACGCGCCAGTAGCCGCGCAATGGAACGCTACGAGAAACTTGCCAAGCTAGGCGAGGGCTCCTACGGTCTGGTCTACAAGTGCCGCAACAGAGACACCGGCGAGATAGTCGCGGTGAAGAAGTTCGTTGAAAACGAAGACGATCCACTCATCAGGAAGATCGCTTTGCGGGAGATACGGATGTTGAAGAACTTGAAGCATCCGAACCTTGTTAATTTAATTGAAGTTTTTCGACGGAAGCGCAAACTGCATTTGGTGTTTGAATACTGTGACCACACGGTGCTGCACGAATTGGAAAAGTATCCAGCCGGCTGCCCCGAACTACTTTCAAAGCAGATAATCTGGCAGACTTTGCAAGGGGTCGCGTACTGCCATCGGCATAATTGTATCCACCGTGACGTCAAACCAGAGAACATACTCCTCACGAGCGACGGAGTCGTCAAGCTCTGTGACTTTGGATTCGCAAGGATGATCAGTGCGTATAAAAAATTATTTCAATTACTTAAGGGTTAA

Protein

MKNSVNEDTSKFKLWNNVASCMEKWFGDKRLWLFGNNLPLLPRRSRASSRAMERYEKLAKLGEGSYGLVYKCRNRDTGEIVAVKKFVENEDDPLIRKIALREIRMLKNLKHPNLVNLIEVFRRKRKLHLVFEYCDHTVLHELEKYPAGCPELLSKQIIWQTLQGVAYCHRHNCIHRDVKPENILLTSDGVVKLCDFGFARMISAYKKLFQLLKG

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Keywords

3D-structure   Alternative splicing   ATP-binding   Complete proteome   Cytoplasm   Kinase   Nucleotide-binding   Nucleus   Polymorphism   Reference proteome   Transferase  

Feature

chain  Cyclin-dependent kinase-like 1
splice variant  In isoform 2.
sequence variant  In dbSNP:rs11570814.

Uniprot

A0A2H1WWL6   A0A2A4JUQ8   A0A3S2LHD6   A0A194PH83   A0A0L7LID4   H9J5K0   + More
A0A212FPW4   D6WSF5   A0A158NAV6   A0A232EVU3   A0A0K8TJ02   A0A067R7U0   A0A2P8XRW4   A0A026WUU7   A0A2H8TLW9   E2AT42   A0A2S2NVL7   A0A1S4F8D7   A0A1B6CAC5   J9JXR5   E0VSK6   X2JD86   A0A0J9QWB6   A0A0P5K232   A0A0P5A5F0   A0A0P5CLC3   A0A182QK93   A0A0R3NZS1   A0A0P5JNY3   A0A1W4VBS3   A0A0P6AH56   A0A0P6GUD6   A0A2A3EJD4   A0A0N8EN14   A0A3L8D8P0   A0A182R375   A0A182XE57   U4U3Z9   A0A1Y1LJJ0   A0A1D2NE10   K7J404   N6TBM8   A0A2R7WIC0   A0A0K8TIH2   A0A310SXL0   A0A154P6C2   V9LIN5   F4X245   A0A195E4V6   A0A151I5W7   A0A0L7QK80   A0A195EVD1   A0A195CK25   E9G338   A0A1A9USN7   E2BPF6   A0A088ABR9   A0A0M9A4V5   A0A034V2J7   A0A2P6L9K2   A0A087UTB1   A0A226DFG1   A0A182H5B4   A0A1B0G098   A0A1B0ANU1   A0A1L8F0A6   A0A1V4KZW4   T1E1S1   E1C5K5   A0A226N981   A0A1I8MCK0   F6QN31   A0A1A9X053   A0A2K5MNC2   A0A1A9Y9D1   A0A093GBR7   A0A1I8P510   A0A3P8YXR4   A0A250XYX8   W8BLI5   A0A1L8F9V6   A0A226NZN2   A0A1I8P562   A0A0L0BX11   Q0IFK7   A0A084WE48   A0A250XZA3   A0A182J1V0   A0A2K5IJJ4   A0A2J8WKH2   A0A2K6D4B2   A0A2K5WC89   A0A2K5YIX4   F7H9C7   A0A2J8WKG5   A0A2R9C6X5   H2Q899   A0A182NFT3   G3RYF2   Q00532-3  

EC Number

2.7.11.22

Pubmed

26354079    26227816    19121390    22118469    18362917    19820115    + More
21347285    28648823    24845553    29403074    24508170    20798317    20566863    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    22936249    15632085    17994087    30249741    23537049    28004739    27289101    20075255    24402279    21719571    21292972    25348373    26483478    27762356    15592404    25315136    20431018    25069045    28087693    24495485    24621616    26108605    17510324    24438588    17431167    22722832    16136131    22398555    1639063    12508121    14702039    15489334    9000130    29420175    17344846   

EMBL

ODYU01011565    SOQ57382.1    NWSH01000577    PCG75539.1    RSAL01000009    RVE53868.1    + More
KQ459604    KPI92064.1    JTDY01001012    KOB75129.1    BABH01025204    BABH01025205    BABH01025206    AGBW02000220    OWR55802.1    KQ971352    EFA06376.2    ADTU01010316    ADTU01010317    NNAY01001957    OXU22456.1    GBRD01000415    JAG65406.1    KK852683    KDR18537.1    PYGN01001453    PSN34748.1    KK107105    EZA59436.1    GFXV01003214    MBW15019.1    GL442489    EFN63396.1    GGMR01008620    MBY21239.1    GEDC01027098    JAS10200.1    ABLF02020383    ABLF02020384    ABLF02038505    ABLF02038519    ABLF02057788    DS235751    EEB16362.1    AE014134    AHN54150.1    CM002910    KMY88350.1    KMY88351.1    GDIQ01195791    JAK55934.1    GDIP01208232    JAJ15170.1    GDIP01168895    JAJ54507.1    AXCN02000244    CH379061    KRT04765.1    GDIQ01197341    JAK54384.1    GDIP01030816    JAM72899.1    GDIQ01029523    LRGB01000512    JAN65214.1    KZS18439.1    KZ288239    PBC31309.1    GDIQ01010756    JAN83981.1    QOIP01000011    RLU16887.1    KB632083    ERL88619.1    GEZM01055704    JAV72978.1    LJIJ01000071    ODN03489.1    AAZX01001010    APGK01036456    KB740940    ENN77679.1    KK854877    PTY19394.1    GBRD01000414    JAG65407.1    KQ759796    OAD62826.1    KQ434809    KZC06690.1    JW880723    AFP13240.1    GL888565    EGI59461.1    KQ979609    KYN20220.1    KQ976413    KYM90415.1    KQ414983    KOC59014.1    KQ981954    KYN32220.1    KQ977642    KYN01085.1    GL732530    EFX86396.1    GL449633    EFN82360.1    KQ435733    KOX77277.1    GAKP01023193    JAC35763.1    MWRG01000796    PRD35248.1    KK121490    KFM80600.1    LNIX01000022    OXA43447.1    JXUM01111200    JXUM01111201    KQ565480    KXJ70927.1    CCAG010018487    JXJN01001010    JXJN01001011    CM004481    OCT65003.1    LSYS01000634    OPJ90029.1    GAKT01000040    JAA93022.1    AADN05000303    MCFN01000133    OXB64058.1    AAMC01077504    AAMC01077505    KL215798    KFV66633.1    GFFV01003381    JAV36564.1    GAMC01016056    JAB90499.1    CM004480    OCT68318.1    AWGT02000251    OXB72810.1    JRES01001211    KNC24550.1    CH477312    EAT43896.1    ATLV01023139    KE525341    KFB48492.1    GFFV01003320    JAV36625.1    NDHI03003386    PNJ70268.1    AQIA01064846    AQIA01064847    JSUE03039704    PNJ70265.1    AJFE02112170    AJFE02112171    AJFE02112172    AJFE02112173    AJFE02112174    AACZ04008568    NBAG03000214    PNI83323.1    CABD030092265    CABD030092266    CABD030092267    X66358    X66359    AF390028    AY525548    AL118556    AL359397    AK308732    BC104977   

Proteomes

UP000218220    UP000283053    UP000053268    UP000037510    UP000005204    UP000007151    + More
UP000007266    UP000005205    UP000215335    UP000027135    UP000245037    UP000053097    UP000000311    UP000007819    UP000009046    UP000000803    UP000075886    UP000001819    UP000192221    UP000076858    UP000242457    UP000279307    UP000075900    UP000076407    UP000030742    UP000094527    UP000002358    UP000019118    UP000076502    UP000007755    UP000078492    UP000078540    UP000053825    UP000078541    UP000078542    UP000000305    UP000078200    UP000008237    UP000005203    UP000053105    UP000054359    UP000198287    UP000069940    UP000249989    UP000092444    UP000092460    UP000186698    UP000190648    UP000000539    UP000198323    UP000095301    UP000008143    UP000091820    UP000233060    UP000092443    UP000053875    UP000095300    UP000265140    UP000198419    UP000037069    UP000008820    UP000030765    UP000075880    UP000233080    UP000233120    UP000233100    UP000233140    UP000006718    UP000240080    UP000002277    UP000075884    UP000001519    UP000005640   

PRIDE

H9J5K0    Q00532   

Pfam

PF00069   Pkinase        + More
PF04042   DNA_pol_E_B
PF12213   Dpoe2NT
PF03178   CPSF_A

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR000719   Prot_kinase_dom       
IPR024639   DNA_pol_e_bsu_N       
IPR007185   DNA_pol_a/d/e_bsu       
IPR036322   WD40_repeat_dom_sf       
IPR004871   Cleavage/polyA-sp_fac_asu_C       
IPR031297   DDB1       
IPR015943   WD40/YVTN_repeat-like_dom_sf       

SUPFAM

SSF56112   SSF56112        + More
SSF50978   SSF50978       

Gene 3D

2.130.10.10    

ProteinModelPortal

A0A2H1WWL6   A0A2A4JUQ8   A0A3S2LHD6   A0A194PH83   A0A0L7LID4   H9J5K0   + More
A0A212FPW4   D6WSF5   A0A158NAV6   A0A232EVU3   A0A0K8TJ02   A0A067R7U0   A0A2P8XRW4   A0A026WUU7   A0A2H8TLW9   E2AT42   A0A2S2NVL7   A0A1S4F8D7   A0A1B6CAC5   J9JXR5   E0VSK6   X2JD86   A0A0J9QWB6   A0A0P5K232   A0A0P5A5F0   A0A0P5CLC3   A0A182QK93   A0A0R3NZS1   A0A0P5JNY3   A0A1W4VBS3   A0A0P6AH56   A0A0P6GUD6   A0A2A3EJD4   A0A0N8EN14   A0A3L8D8P0   A0A182R375   A0A182XE57   U4U3Z9   A0A1Y1LJJ0   A0A1D2NE10   K7J404   N6TBM8   A0A2R7WIC0   A0A0K8TIH2   A0A310SXL0   A0A154P6C2   V9LIN5   F4X245   A0A195E4V6   A0A151I5W7   A0A0L7QK80   A0A195EVD1   A0A195CK25   E9G338   A0A1A9USN7   E2BPF6   A0A088ABR9   A0A0M9A4V5   A0A034V2J7   A0A2P6L9K2   A0A087UTB1   A0A226DFG1   A0A182H5B4   A0A1B0G098   A0A1B0ANU1   A0A1L8F0A6   A0A1V4KZW4   T1E1S1   E1C5K5   A0A226N981   A0A1I8MCK0   F6QN31   A0A1A9X053   A0A2K5MNC2   A0A1A9Y9D1   A0A093GBR7   A0A1I8P510   A0A3P8YXR4   A0A250XYX8   W8BLI5   A0A1L8F9V6   A0A226NZN2   A0A1I8P562   A0A0L0BX11   Q0IFK7   A0A084WE48   A0A250XZA3   A0A182J1V0   A0A2K5IJJ4   A0A2J8WKH2   A0A2K6D4B2   A0A2K5WC89   A0A2K5YIX4   F7H9C7   A0A2J8WKG5   A0A2R9C6X5   H2Q899   A0A182NFT3   G3RYF2   Q00532-3  

PDB

4AGU     E-value=9.64519e-71,     Score=675

KEGG

101735958    K08824 cyclin-dependent kinase-like [EC:2.7.11.22] | (RefSeq) cyclin-dependent kinase-like 1

GO

GO:0004674   GO:0005524   GO:0004693   GO:0005634   GO:0006468   GO:0000281   GO:0005737   GO:0004672   GO:0006260   GO:0003677   GO:0003887   GO:0003676   GO:0006281   GO:0005654   GO:0007507   GO:0043231   GO:0035869   GO:0070062   GO:1902017   GO:0030366   GO:0006419   GO:0007154   GO:0016020   GO:0005112   GO:0015930  

PANTHER

PTHR10644:SF3  

Subcellular location

Cytoplasm  
Nucleus  

Length:

214

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02927

Exp number, first 60 AAs:

0.00116

Total prob of N-in:

0.21118

outside

1  -  214

 

 

Pi

185.037024

Theta

173.597671

Tajima's D

0.233605

CLR

1.164633

CSRT

0.43832808359582

Interpretation

Uncertain