Gene

KWMTBOMO14997

Pre Gene Modal

BGIBMGA004788

Annotation

PREDICTED:_intraflagellar_transport_protein_46_homolog_[Bombyx_mori]

Location

Bomo_Chr25(+):2001757-2005414      View in EpiBrowser

Full name

Intraflagellar transport protein 46 homolog      

Location in the cell

Cytoplasmic   Reliability : 1.686 Nuclear   Reliability : 1.59

CDS

ATGAATATCTTTTACAAGATAAAAATCTCTTCTAGATACACACCGCAGAAGATAGACATTGACTTCAAGCTGCAACCGTTTGTGCCGGAATATGTGCCGGCTGTTGGTGACATTGACGCCTTCCTAAAGGTGACGACGCCGGCGTGCGACGTGCGAGGGGGCCAGCTAGCCGAACAAGTACTCGAACACATCGACAACTTGGGGCTGACGGTACTGGACGAGCCGTCGGCCGAACAAAGCGACTCGGCGCTTTTACACTTGCAGCTGAGGGCTATATCGAAGACGAATCATTCTAAAACCACCGTGTTGACGAAGAAGATTGACAATCCGGAGAGCAATCCCAAAGCGATCGACCGTTGGATCAAGGACGTGGCTGAGCTGCACCTCTCGAAGCCAGCGCCCACGGTCTCCTATACCAGCAAGATGCCGGACATAGACACTCTGATGGAGGAGTGGCCGGAGTCGATGGAGGAGGCGCTGAACGAGGTCGGCTTCCCCTCGGCCTCGTTGGACTGCAGCTTGTCCCAGTACTGCGAGCTGGTCTGCGGGATGTTTGACGTGCCGGTGGTGGGGAGCGGTGCACCCGGCCGCATCCAGGCTGTGCACCAGCTGTTCACGCTGTACTGCGCCGTCAAGCACTCGCAGCTCTACGCCGATAGGATTAAGGAGACAAGTGAAGGAGTTTCATAG

Protein

MNIFYKIKISSRYTPQKIDIDFKLQPFVPEYVPAVGDIDAFLKVTTPACDVRGGQLAEQVLEHIDNLGLTVLDEPSAEQSDSALLHLQLRAISKTNHSKTTVLTKKIDNPESNPKAIDRWIKDVAELHLSKPAPTVSYTSKMPDIDTLMEEWPESMEEALNEVGFPSASLDCSLSQYCELVCGMFDVPVVGSGAPGRIQAVHQLFTLYCAVKHSQLYADRIKETSEGVS

Description

Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Plays a role in early embryonic development.
Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity).

Subunit

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT57, IFT88 and DAW1. Interacts with ARL13B. Interacts with TTC26/IFT56 (By similarity). Interacts with TTC25 (By similarity).
Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25/HSPB11, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT57, IFT88 and DAW1. Interacts with TTC26/IFT56 (By similarity). Interacts with ARL13B. Interacts with TTC25 (PubMed:25860617).

Similarity

Belongs to the IFT46 family.

Keywords

Cell projection   Cilium   Complete proteome   Cytoplasm   Cytoskeleton   Reference proteome   Phosphoprotein   Alternative splicing   Polymorphism  

Feature

chain  Intraflagellar transport protein 46 homolog
splice variant  In isoform 2.
sequence variant  In dbSNP:rs11552421.

Uniprot

H9J5J8   A0A2A4JUG3   A0A2A4JU25   A0A2H1WSQ0   A0A212EV10   A0A2J7RTK1   + More
A0A2J7RTJ4   A0A067RCK8   A0A2G8JXG6   A0A0T6AZD0   A0A1B6FMJ2   A0A087T0D9   A0A1B6F9M9   A0A224XTP6   A0A2L2YEK0   A0A1B6LSB8   T1IGF9   A0A3S0ZVG2   D6X3W9   R7UK87   T2M5G9   A0A1B6D7T4   A0A3M6TPS9   A0A2B4RA82   A0A0A9ZFP2   A0A0A9ZI17   A0A2L2YBW3   B3RU97   T1J6N3   A0A1W5A484   A0A3B1JWB2   A0A1W4WGI9   A0A146KPS5   A7MBP4   A0A1W5ABD5   A0A1W5AD45   A0A3P9A8T3   W5UJX3   A0A2D0SPK5   F1QMN4   H2YTM0   A0A2C9M2P9   C1BGP3   A0A2C9M300   A0A1S3LP80   A0A2C9M2N5   A0A2C9M2S3   A0A2C9M2J7   A0A2J8X128   A0A3P8YJG7   A0A1S3LPZ5   A0A0B7A5U1   A0A3Q7QT02   A0A0B7A7P8   A0A3B4BSQ3   A0A3B4BPM9   A0A1X7ULK6   D2HYG8   F6ZM09   A0A2K5C659   A0A2I3GX77   A0A1S3EPE3   M3WFS5   A0A1Y1LHJ5   A0A0R3X348   U6CVG0   A0A2Y9KAJ3   A0A3P4M3W7   A0A2Y9E2J0   K9K4J2   W5PL42   Q1LZB4   H0X0E4   A0A1U7U5C5   F7CT47   A0A250YF41   A0A2J8X0X4   A0A2K6CRN6   G3S8A9   A0A2K5NIL8   A0A2R9ADB5   A0A2I3MRG1   K7B6M9   A0A2K5YB96   A0A2U3WTQ6   A0A3Q7QVC5   A0A2U3ZT59   A0A2T7P1E7   A0A1U7TTC5   Q9NQC8   L5LZU6   A0A3Q7SFA0   A0A2K5HX39   A0A3Q2I0H0   E2R0U7   A0A384C1B4   A0A3Q7W984   A0A2K6QAH0   A0A2Y9RVM5   A0A3B4DL95  

Pubmed

19121390    22118469    24845553    29023486    26561354    18362917    + More
19820115    23254933    24065732    30382153    25401762    18719581    25329095    26823975    23594743    17720815    25069045    23127152    15562597    20010809    20431018    17975172    28004739    20809919    18464734    28087693    22398555    22722832    16136131    10873569    11230166    14702039    16554811    15489334    24339792    25860617    19892987    16341006    24813606    25362486   

EMBL

BABH01025215    NWSH01000636    PCG75123.1    PCG75124.1    ODYU01010736    SOQ56037.1    + More
AGBW02012265    OWR45319.1    NEVH01000001    PNF44163.1    PNF44162.1    KK852790    KDR16498.1    MRZV01001124    PIK40433.1    LJIG01022458    KRT80476.1    GECZ01018351    JAS51418.1    KK112794    KFM58578.1    GECZ01022827    JAS46942.1    GFTR01004626    JAW11800.1    IAAA01018161    LAA05635.1    GEBQ01013422    JAT26555.1    ACPB03009001    RQTK01000225    RUS83913.1    KQ971379    EEZ97358.1    AMQN01007364    KB300512    ELU06595.1    HAAD01000918    CDG67150.1    GEDC01015554    GEDC01003120    JAS21744.1    JAS34178.1    RCHS01003199    RMX43413.1    LSMT01000762    PFX14561.1    GBHO01001332    GBHO01001331    GBRD01005344    JAG42272.1    JAG42273.1    JAG60477.1    GBHO01001329    GBHO01001327    GBRD01005345    JAG42275.1    JAG42277.1    JAG60476.1    IAAA01018160    LAA05633.1    DS985244    EDV25774.1    JH431880    GDHC01020118    JAP98510.1    CU570991    BC122332    BC151861    AAI22333.1    AAI51862.1    JT412758    JT418769    AHH39982.1    CU861448    BT073772    ACO08196.1    NDHI03003374    PNJ75676.1    HACG01029127    CEK75992.1    HACG01029125    CEK75990.1    GL193703    EFB18348.1    AAMC01039969    AAMC01039970    AAMC01039971    AAMC01039972    ADFV01057013    AANG04000369    GEZM01058189    GEZM01058188    JAV71810.1    UYWX01020399    VDM32179.1    HAAF01002478    CCP74304.1    CYRY02005710    VCW70107.1    JL616376    AEH58583.1    AMGL01031503    BC116107    AAQR03130853    AAQR03130854    GFFW01002624    JAV42164.1    PNJ75671.1    CABD030081794    CABD030081795    AJFE02068666    AJFE02068667    AJFE02068668    AJFE02068669    AHZZ02007705    AACZ04006746    GABC01003841    GABF01006277    GABD01008319    GABE01009568    NBAG03000239    JAA07497.1    JAA15868.1    JAA24781.1    JAA35171.1    PNI65996.1    PZQS01000007    PVD27249.1    AJ249980    AL136934    AK025480    AK289521    CR457344    AP000941    BC011647    BC012802    BC022856    KB105943    ELK31959.1    AAEX03003446   

Proteomes

UP000005204    UP000218220    UP000007151    UP000235965    UP000027135    UP000230750    + More
UP000054359    UP000015103    UP000271974    UP000007266    UP000014760    UP000275408    UP000225706    UP000009022    UP000192224    UP000018467    UP000192223    UP000000437    UP000265140    UP000221080    UP000007875    UP000076420    UP000087266    UP000286641    UP000261440    UP000007879    UP000008143    UP000233020    UP000001073    UP000081671    UP000011712    UP000046396    UP000274429    UP000248482    UP000248480    UP000002356    UP000009136    UP000005225    UP000189704    UP000002279    UP000233120    UP000001519    UP000233060    UP000240080    UP000028761    UP000002277    UP000233140    UP000245340    UP000245119    UP000005640    UP000286640    UP000233080    UP000002281    UP000002254    UP000261680    UP000291021    UP000286642    UP000233200   

PRIDE

H9J5J8    Q9NQC8   

Pfam

PF12317   IFT46_B_C        + More
PF05010   TACC_C

Interpro

IPR022088   Intraflagellar_transp_cmplxB        + More
IPR007707   TACC_C       

ProteinModelPortal

H9J5J8   A0A2A4JUG3   A0A2A4JU25   A0A2H1WSQ0   A0A212EV10   A0A2J7RTK1   + More
A0A2J7RTJ4   A0A067RCK8   A0A2G8JXG6   A0A0T6AZD0   A0A1B6FMJ2   A0A087T0D9   A0A1B6F9M9   A0A224XTP6   A0A2L2YEK0   A0A1B6LSB8   T1IGF9   A0A3S0ZVG2   D6X3W9   R7UK87   T2M5G9   A0A1B6D7T4   A0A3M6TPS9   A0A2B4RA82   A0A0A9ZFP2   A0A0A9ZI17   A0A2L2YBW3   B3RU97   T1J6N3   A0A1W5A484   A0A3B1JWB2   A0A1W4WGI9   A0A146KPS5   A7MBP4   A0A1W5ABD5   A0A1W5AD45   A0A3P9A8T3   W5UJX3   A0A2D0SPK5   F1QMN4   H2YTM0   A0A2C9M2P9   C1BGP3   A0A2C9M300   A0A1S3LP80   A0A2C9M2N5   A0A2C9M2S3   A0A2C9M2J7   A0A2J8X128   A0A3P8YJG7   A0A1S3LPZ5   A0A0B7A5U1   A0A3Q7QT02   A0A0B7A7P8   A0A3B4BSQ3   A0A3B4BPM9   A0A1X7ULK6   D2HYG8   F6ZM09   A0A2K5C659   A0A2I3GX77   A0A1S3EPE3   M3WFS5   A0A1Y1LHJ5   A0A0R3X348   U6CVG0   A0A2Y9KAJ3   A0A3P4M3W7   A0A2Y9E2J0   K9K4J2   W5PL42   Q1LZB4   H0X0E4   A0A1U7U5C5   F7CT47   A0A250YF41   A0A2J8X0X4   A0A2K6CRN6   G3S8A9   A0A2K5NIL8   A0A2R9ADB5   A0A2I3MRG1   K7B6M9   A0A2K5YB96   A0A2U3WTQ6   A0A3Q7QVC5   A0A2U3ZT59   A0A2T7P1E7   A0A1U7TTC5   Q9NQC8   L5LZU6   A0A3Q7SFA0   A0A2K5HX39   A0A3Q2I0H0   E2R0U7   A0A384C1B4   A0A3Q7W984   A0A2K6QAH0   A0A2Y9RVM5   A0A3B4DL95  

PDB

4UZZ     E-value=2.65404e-19,     Score=231

KEGG

101736085    K19682 intraflagellar transport protein 46 | (RefSeq) intraflagellar transport protein 46 homolog

GO

GO:0042073   GO:0005929   GO:0031514   GO:0030992   GO:0060271   GO:0005813   GO:0048793   GO:0036064   GO:0005737   GO:0060041   GO:0048264   GO:0007224   GO:0008022   GO:0050821   GO:0097542   GO:0035735   GO:0005829   GO:0019008   GO:0030366   GO:0006419   GO:0003676   GO:0007154   GO:0016020   GO:0005112   GO:0015930  

PANTHER

PTHR13376  

Subcellular location

Cytoplasm  
Cytoskeleton  
Cilium basal body  
Cell projection  
Cilium  

Length:

229

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0036

Exp number, first 60 AAs:

0.00012

Total prob of N-in:

0.09978

outside

1  -  229

 

 

Pi

42.16251

Theta

28.859444

Tajima's D

-0.92978

CLR

20.474998

CSRT

0.147542622868857

Interpretation

Uncertain