Gene

KWMTBOMO14979

Pre Gene Modal

BGIBMGA004886

Annotation

homothorax?_isoform_F_[Danaus_plexippus]

Location

Bomo_Chr25(-):1628486-1675346      View in EpiBrowser

Full name

Homeobox protein homothorax      

Alternative Name

Homeobox protein dorsotonals

Location in the cell

Nuclear   Reliability : 2.567

CDS

ATGAGTGTATTAGTGAACCCTCTGTGTGTGTGTCGGAGCACGAGTGTGTGTTACGACGAGAGCCTCCACGGCGGAGGTTACATGGAGGGGGGAGCGATGTACCACGAGCACAGGCTGACCCATCCCCACCTGGCTCCAGTGCACTACCCCCCGCCGGCAGCACCCGCTCACGCCCTCCCCGGGGAACCACTAGTCCACAAGAGAGACAAAGACGCTATTTACGGGCATCCCCTGTTCCCCCTGCTGGCTCTGATCTTCGAAAAGTGTGAGCTAGCGACCTGTACCCCCCGGGACCCTGGCGTGGCGGGCGGAGACGTGTGCTCCTCGGAGTCTTTCAACGAAGACATTGCGGTATTCAGCAAACAGATACGTCAAGAGAAACCGTATTACATAGCGGATCCAGAGGTCGACTCATTAATGGTGCAAGCGATACAAGTACTACGGTTTCACCTCTTAGAATTAGAAAAAGTCCATGAGCTATGCGACAACTTCTGTCACCGCTACATCAGCTGTCTGAAGGGCAAGATGCCCATTGACCTGGTGATCGACGAGCGGGAGACGGCCCGGCCGCCGGACGCGAACGGCGAGCCCCGGTCGGCGCCGGACAGCAGTCACGACGGCGCCTCCACCCCCGACGTCGTGAGTACCCCCTACACCAAGTCCCATCTCATTCAGAGGCGTGATCCCCAGCTTGCACCCAACTCGACCACGAGCTACCTCGTGCACCCCTGTTCTTAG

Protein

MSVLVNPLCVCRSTSVCYDESLHGGGYMEGGAMYHEHRLTHPHLAPVHYPPPAAPAHALPGEPLVHKRDKDAIYGHPLFPLLALIFEKCELATCTPRDPGVAGGDVCSSESFNEDIAVFSKQIRQEKPYYIADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERETARPPDANGEPRSAPDSSHDGASTPDVVSTPYTKSHLIQRRDPQLAPNSTTSYLVHPCS

Description

All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt the polarization-sensitive 'dorsal rim area' (DRA) of the eye fate instead of the color-sensitive default state. This occurs by increasing rhabdomere size and uncoupling R7-R8 communication to allow both cells to express the same opsin rather than different ones as required for color vision.

Subunit

Interacts with exd; required for nuclear translocation of exd.

Similarity

Belongs to the TALE/MEIS homeobox family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   DNA-binding   Homeobox   Nucleus   Reference proteome  

Feature

chain  Homeobox protein homothorax
splice variant  In isoform H.

Uniprot

A0A2W1BPR6   W6JHY5   Q16PH1   A0A1W7R5Q6   T1DD83   A0A2M4ALS2   + More
A0A2M4BXD3   A0A1S4FU61   A0A1Q3EUT9   A0A1L8DIS6   A0A0K8TLU4   O46339-6   A0A034V4B8   A0A0K8V138   A0A0A1X4P8   T1E260   A0A2M3Z7W5   A0A2M4CTY6   A0A2M3Z7T1   A0A2M4CSM0   A0A067YMR8   A0A0K2V4D9   D6WTI5  

Pubmed

28756777    24333180    17510324    24330624    26369729    9346235    + More
9463350    9450936    10731132    12537572    14636555    16778079    25348373    25830018    24886828    18362917    19820115   

EMBL

KZ150023    PZC74866.1    AB841083    BAO48186.1    CH477782    EAT36258.1    + More
GEHC01001184    JAV46461.1    GALA01001512    JAA93340.1    GGFK01008376    MBW41697.1    GGFJ01008604    MBW57745.1    GFDL01016077    JAV18968.1    GFDF01007824    JAV06260.1    GDAI01002256    JAI15347.1    AF026788    AF032865    AF035825    AF036584    AE014297    BT010238    BT024210    BT029117    AAB88514.1    AAB97169.1    AAC47759.1    AAN13474.1    ABC86272.1    GAKP01022554    JAC36398.1    GDHF01032627    GDHF01032133    GDHF01020513    GDHF01019743    GDHF01010786    GDHF01008308    JAI19687.1    JAI20181.1    JAI31801.1    JAI32571.1    JAI41528.1    JAI44006.1    GBXI01008190    GBXI01007237    JAD06102.1    JAD07055.1    GALA01001510    JAA93342.1    GGFM01003844    MBW24595.1    GGFL01004634    MBW68812.1    GGFM01003810    MBW24561.1    GGFL01004135    MBW68313.1    KF630596    AHC98627.1    HACA01027636    CDW44997.1    KQ971354    EFA07405.2   

Proteomes

UP000008820    UP000000803    UP000007266   

PRIDE

W6JHY5    O46339   

Pfam

PF16493   Meis_PKNOX_N        + More
PF05920   Homeobox_KN

Interpro

IPR032453   PKNOX/Meis_N        + More
IPR008422   Homeobox_KN_domain       
IPR001356   Homeobox_dom       
IPR009057   Homeobox-like_sf       

SUPFAM

SSF46689   SSF46689       

CDD

cd00086  homeodomain

ProteinModelPortal

A0A2W1BPR6   W6JHY5   Q16PH1   A0A1W7R5Q6   T1DD83   A0A2M4ALS2   + More
A0A2M4BXD3   A0A1S4FU61   A0A1Q3EUT9   A0A1L8DIS6   A0A0K8TLU4   O46339-6   A0A034V4B8   A0A0K8V138   A0A0A1X4P8   T1E260   A0A2M3Z7W5   A0A2M4CTY6   A0A2M3Z7T1   A0A2M4CSM0   A0A067YMR8   A0A0K2V4D9   D6WTI5  

KEGG

101737806    K16672 homeobox protein homothorax | (RefSeq) Hth, homothorax; homeobox protein homothorax-like

PATHWAY

04391    Hippo signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0006355   GO:0003677   GO:0005634   GO:2000497   GO:0007420   GO:0007432   GO:0045664   GO:0005737   GO:0048749   GO:0007525   GO:0005654   GO:0005829   GO:0090098   GO:0001223   GO:0034504   GO:0001654   GO:0001742   GO:0035326   GO:0007422   GO:0000981   GO:0006357   GO:0008134   GO:0007479   GO:0072002   GO:0005667   GO:0032993   GO:0035282   GO:0007480   GO:0003700   GO:0001752   GO:0090575   GO:0007380   GO:0007383   GO:0060323   GO:0046982   GO:0045944   GO:0007476   GO:0042659   GO:0001158   GO:0010092   GO:0048735   GO:0009954  

Subcellular location

Nucleus  

Length:

245

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00209

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01459

outside

1  -  245

 

 

Pi

210.738265

Theta

165.966474

Tajima's D

0.663133

CLR

0.423934

CSRT

0.567521623918804

Interpretation

Uncertain