Gene

KWMTBOMO14977

Annotation

PREDICTED:_homeobox_protein_homothorax_[Bombyx_mori]

Location

Bomo_Chr25(-):1305225-1316281      View in EpiBrowser

Full name

Homeobox protein homothorax      

Alternative Name

Homeobox protein dorsotonals

Location in the cell

Mitochondrial   Reliability : 1.076 Nuclear   Reliability : 1.734

CDS

ATGCCCGTGTTGCCAGGGTTCATAAACGCGAGACGTAGGATAGTCCAACCAATGATCGACCAATCAAATAGAGCAGTGTTCTACCCGTCAGTGTTCCCGCACGCCGGCCCCAGCGGCGCGTACAGTCCCGAGGCGACCATGGGCTACATGATGGACGGGCAGCAGATGATGCACAGGCCGCCCACAGACCCCGCCTTCCACCAGGGCTACGCGCACTACCCGGCCGAGTATTACGGACACCACCTCTAA

Protein

MPVLPGFINARRRIVQPMIDQSNRAVFYPSVFPHAGPSGAYSPEATMGYMMDGQQMMHRPPTDPAFHQGYAHYPAEYYGHHL

Description

All isoforms are required for patterning of the embryonic cuticle. Acts with exd to delimit the eye field and prevent inappropriate eye development. Isoforms that carry the homeodomain are required for proper localization of chordotonal organs within the peripheral nervous system and antennal identity; required to activate antennal-specific genes, such as sal and to repress the leg-like expression of dac. Necessary for the nuclear localization of the essential HOX cofactor, extradenticle (exd). Both necessary and sufficient for inner photoreceptors to adopt the polarization-sensitive 'dorsal rim area' (DRA) of the eye fate instead of the color-sensitive default state. This occurs by increasing rhabdomere size and uncoupling R7-R8 communication to allow both cells to express the same opsin rather than different ones as required for color vision.

Subunit

Interacts with exd; required for nuclear translocation of exd.

Similarity

Belongs to the TALE/MEIS homeobox family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   DNA-binding   Homeobox   Nucleus   Reference proteome  

Feature

chain  Homeobox protein homothorax
splice variant  In isoform H.

Uniprot

A0A2H1WZX5   A0A2W1BJ35   A0A194PLV9   W6JHY5   A0A146M5Y1   A0A1Y1NAU0   + More
A0A1Y1NBD1   Q70WC9   A0A1Y1NAU2   A0A1Y1NBY5   A0A0T6BAJ6   A0A3S2LTK6   A0A194RGQ9   A0A1U9WT16   A0A2R7WY80   A0A0C9RA77   A0A1B6CLX0   K7J253   A0A2S2QAQ8   T1H986   A0A088AB67   D8WUS7   A0A1B6H219   A0A2S2NNU6   A0A2S2R2C6   A0A1B6M0P5   A0A1B6MGF9   A0A2S2NQA2   J9K747   A0A2H8TJ49   A0A2H8TNK5   A0A1B6JR31   A0A1B6HQ36   A0A0C9RBF5   A0A1B6H5I3   A0A2M4BS80   A0A1B6GVZ1   A0A1B6IB01   A0A1B6GZW6   A0A1B6I2X4   A0A3L8D3I0   A0A2M3Z7T1   A0A0A9Z869   A0A2M4CSM0   T1GP55   A0A1Q3EUL3   A0A1W4U7A3   A0A1A9YE24   A0A0Q9WUH6   B4G681   I5ANA8   A0A023F5M7   A0A069DUQ5   A0A1A9ZWP5   B4JIJ5   A0A1A9WLB9   A0A3B0K029   A0A0Q9WPM1   B4K5K2   I5ANA3   A0A0R1E2S0   A0A0N8P183   B4QV74   B4PKQ5   B4HIS7   B3P1M7   B3LVY3   O46339   B4LWF2   A0A0Q9WYN2   I5ANA2   O46339-8   A0A182TYU8   A0A182VBJ9   A0A182XWI4   A0A182QPG7   O46339-2   A0A182M9S4   A0A182XR57   A0A1I8NMA7   A0A182WNJ1   A0A034WMA3   A0A0A1WYB3   B0WZR3   A0A1I8NMA8   A0A1I8N1L0   A0A034WQT8   A0A0A1XGW8   A0A182LQQ6   A0A1I8N1K7   A0A1I8N1J4   A0A084VRF8   A0A0L0C0P1   A0A0A9ZB98   A0A182IT36   Q7QK70   A0A0K8VYR1   A0A2M4CTY6   A0A0K8V4R9   W8BUB9  

Pubmed

28756777    26354079    24333180    26823975    28004739    14623236    + More
20075255    30249741    25401762    17994087    15632085    25474469    26334808    17550304    18057021    9346235    9463350    9450936    10731132    12537572    14636555    16778079    25244985    25348373    25830018    25315136    20966253    24438588    26108605    12364791    24495485   

EMBL

ODYU01012287    SOQ58516.1    KZ150023    PZC74868.1    KQ459604    KPI92090.1    + More
AB841083    BAO48186.1    GDHC01004649    JAQ13980.1    GEZM01007633    JAV95032.1    GEZM01007636    JAV95029.1    AJ518941    CAD57735.1    GEZM01007634    JAV95031.1    GEZM01007637    JAV95028.1    LJIG01002582    KRT84358.1    RSAL01000216    RVE44127.1    KQ460205    KPJ17003.1    KX364396    AQY56477.1    KK855959    PTY24496.1    GBYB01009952    JAG79719.1    GEDC01022824    JAS14474.1    GGMS01005636    MBY74839.1    ACPB03016680    ACPB03016681    ACPB03016682    ACPB03016683    ACPB03016684    ACPB03016685    ACPB03016686    ACPB03016687    ACPB03016688    ACPB03016689    GU324093    ADI56665.1    GECZ01001046    JAS68723.1    GGMR01006188    MBY18807.1    GGMS01014891    MBY84094.1    GEBQ01010527    JAT29450.1    GEBQ01004992    JAT34985.1    GGMR01006679    MBY19298.1    ABLF02036466    GFXV01002331    MBW14136.1    GFXV01003948    MBW15753.1    GECU01033470    GECU01006101    JAS74236.1    JAT01606.1    GECU01030914    JAS76792.1    GBYB01004206    JAG73973.1    GECU01037741    JAS69965.1    GGFJ01006507    MBW55648.1    GECZ01013947    GECZ01003170    JAS55822.1    JAS66599.1    GECU01024555    GECU01023585    GECU01005424    GECU01003745    JAS83151.1    JAS84121.1    JAT02283.1    JAT03962.1    GECZ01003932    GECZ01001828    JAS65837.1    JAS67941.1    GECU01026433    GECU01009424    JAS81273.1    JAS98282.1    QOIP01000014    RLU15057.1    GGFM01003810    MBW24561.1    GBHO01003005    GBRD01001265    GDHC01003815    JAG40599.1    JAG64556.1    JAQ14814.1    GGFL01004135    MBW68313.1    CAQQ02055217    CAQQ02055218    CAQQ02055219    CAQQ02055220    CAQQ02055221    GFDL01016035    JAV19010.1    CH964251    KRF99692.1    CH479179    EDW23848.1    CM000070    EIM52443.2    GBBI01002245    JAC16467.1    GBGD01001482    JAC87407.1    CH916369    EDV93076.1    OUUW01000013    SPP87677.1    CH940650    KRF82820.1    CH933806    EDW14039.2    EIM52438.1    CM000160    KRK03375.1    CH902617    KPU79204.1    CM000364    EDX13480.1    EDW96814.1    CH480815    EDW42724.1    CH954181    EDV49626.1    EDV41516.1    KPU79200.1    KPU79202.1    AF026788    AF032865    AF035825    AF036584    AE014297    BT010238    BT024210    BT029117    AAB88514.1    AAB97169.1    AAC47759.1    AAN13474.1    ABC86272.1    EDW66589.2    KRG00821.1    EIM52437.2    AXCN02001551    AXCM01004490    GAKP01002276    JAC56676.1    GBXI01010904    JAD03388.1    DS232214    EDS37738.1    GAKP01002275    JAC56677.1    GBXI01004554    JAD09738.1    ATLV01015636    ATLV01015637    ATLV01015638    ATLV01015639    ATLV01015640    ATLV01015641    ATLV01015642    ATLV01015643    ATLV01015644    ATLV01015645    KE525025    KFB40552.1    JRES01001160    KNC25019.1    GBHO01003006    GBRD01001264    GDHC01017526    JAG40598.1    JAG64557.1    JAQ01103.1    AAAB01008799    EAA03775.5    GDHF01028057    GDHF01026463    GDHF01008307    JAI24257.1    JAI25851.1    JAI44007.1    GGFL01004634    MBW68812.1    GDHF01030431    GDHF01028885    GDHF01018443    JAI21883.1    JAI23429.1    JAI33871.1    GAMC01009649    JAB96906.1   

Proteomes

UP000053268    UP000283053    UP000053240    UP000002358    UP000015103    UP000005203    + More
UP000007819    UP000279307    UP000015102    UP000192221    UP000092443    UP000007798    UP000008744    UP000001819    UP000092445    UP000001070    UP000091820    UP000268350    UP000008792    UP000009192    UP000002282    UP000007801    UP000000304    UP000001292    UP000008711    UP000000803    UP000075902    UP000075903    UP000076408    UP000075886    UP000075883    UP000076407    UP000095300    UP000075920    UP000002320    UP000095301    UP000075882    UP000030765    UP000037069    UP000075880    UP000007062   

PRIDE

W6JHY5    O46339   

Pfam

PF05920   Homeobox_KN        + More
PF16493   Meis_PKNOX_N

Interpro

IPR008422   Homeobox_KN_domain        + More
IPR001356   Homeobox_dom       
IPR009057   Homeobox-like_sf       
IPR032453   PKNOX/Meis_N       

SUPFAM

SSF46689   SSF46689       

CDD

cd00086  homeodomain

ProteinModelPortal

A0A2H1WZX5   A0A2W1BJ35   A0A194PLV9   W6JHY5   A0A146M5Y1   A0A1Y1NAU0   + More
A0A1Y1NBD1   Q70WC9   A0A1Y1NAU2   A0A1Y1NBY5   A0A0T6BAJ6   A0A3S2LTK6   A0A194RGQ9   A0A1U9WT16   A0A2R7WY80   A0A0C9RA77   A0A1B6CLX0   K7J253   A0A2S2QAQ8   T1H986   A0A088AB67   D8WUS7   A0A1B6H219   A0A2S2NNU6   A0A2S2R2C6   A0A1B6M0P5   A0A1B6MGF9   A0A2S2NQA2   J9K747   A0A2H8TJ49   A0A2H8TNK5   A0A1B6JR31   A0A1B6HQ36   A0A0C9RBF5   A0A1B6H5I3   A0A2M4BS80   A0A1B6GVZ1   A0A1B6IB01   A0A1B6GZW6   A0A1B6I2X4   A0A3L8D3I0   A0A2M3Z7T1   A0A0A9Z869   A0A2M4CSM0   T1GP55   A0A1Q3EUL3   A0A1W4U7A3   A0A1A9YE24   A0A0Q9WUH6   B4G681   I5ANA8   A0A023F5M7   A0A069DUQ5   A0A1A9ZWP5   B4JIJ5   A0A1A9WLB9   A0A3B0K029   A0A0Q9WPM1   B4K5K2   I5ANA3   A0A0R1E2S0   A0A0N8P183   B4QV74   B4PKQ5   B4HIS7   B3P1M7   B3LVY3   O46339   B4LWF2   A0A0Q9WYN2   I5ANA2   O46339-8   A0A182TYU8   A0A182VBJ9   A0A182XWI4   A0A182QPG7   O46339-2   A0A182M9S4   A0A182XR57   A0A1I8NMA7   A0A182WNJ1   A0A034WMA3   A0A0A1WYB3   B0WZR3   A0A1I8NMA8   A0A1I8N1L0   A0A034WQT8   A0A0A1XGW8   A0A182LQQ6   A0A1I8N1K7   A0A1I8N1J4   A0A084VRF8   A0A0L0C0P1   A0A0A9ZB98   A0A182IT36   Q7QK70   A0A0K8VYR1   A0A2M4CTY6   A0A0K8V4R9   W8BUB9  

PDB

3K2A     E-value=0.000352596,     Score=97

KEGG

101740186    K16672 homeobox protein homothorax | (RefSeq) homeobox protein homothorax

GO

GO:0003677   GO:0006355   GO:0005634   GO:0007383   GO:0090575   GO:0046982   GO:0045944   GO:0060323   GO:0007476   GO:0048735   GO:0042659   GO:0001158   GO:0000981   GO:0072002   GO:0032993   GO:0007480   GO:0001752   GO:0001742   GO:0007422   GO:2000497   GO:0007420   GO:0045664   GO:0007525   GO:0005737   GO:0001223   GO:0034504   GO:0090098   GO:0003700   GO:0035282   GO:0005667   GO:0007479   GO:0008134   GO:0006357   GO:0010092   GO:0009954   GO:0007380   GO:0005829   GO:0048749   GO:0005654   GO:0007432   GO:0035326   GO:0001654  

Subcellular location

Nucleus  

Length:

82

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03599

Exp number, first 60 AAs:

0.03599

Total prob of N-in:

0.04303

outside

1  -  82

 

 

Pi

216.573717

Theta

168.904629

Tajima's D

0.369518

CLR

1.565168

CSRT

0.47647617619119

Interpretation

Uncertain