Gene

KWMTBOMO14959

Pre Gene Modal

BGIBMGA000816

Annotation

PREDICTED:_kinesin-like_protein_KIF16B_[Papilio_xuthus]

Location

Bomo_Chr25(+):1113073-1130747      View in EpiBrowser

Full name

Kinesin-like protein       + More
Kinesin-like protein Klp98A      

Location in the cell

Cytoplasmic   Reliability : 1.347 Mitochondrial   Reliability : 1.083 Nuclear   Reliability : 1.294

CDS

ATGACAATGGCCTCGGTAAAAGTTGCTGTAAGGGTTCGCCCGTTCAATCAAAGAGAAAAGGACATGGCCGCCAAACTCATAGTTCAGATGGAGGGAAAGAAAACGCGACTCCTTACCGTCAAAAGTAGCAAGGAACAAAATGAGGGTAGCCGTGAAAAGTACAAGGACTTCACGTTCGATCATTCTTACTGGTCATTCGACGGCGGCGACAAGCATTACGCTTCACAAGAACAGGTATTTTCCGACTTGGGTCTGGATGTGATAGACAGCGCTTTCGAAGGATACAATGCCTGTGTTTTCGCTTACGGTCAAACTGGAAGCGGGAAGACTTTCACCATGATGGGATCGCCGGAATGCCAAGGTCTGATACCGCGCATATGCCGGCAACTATTCTCCCGCGTGGCAGCCGGCAAGGAGTCAGGGGCTTCCTACCGCACCGAGGTCAGCTACTTAGAGATCTACAACGAAAGAGTGAAAGATCTGTTGTCAACGGATGCGGGACACTCCCTCAGGGTCAGGGAGCATCCGAAGCTGGGACCGTACGTTCAGGATCTGTCCAAGCACTTGGTCTCCGATTATGATGATATACAGGTGAGCAATTCAATATATGTAAACTGTACAGGAATAAAGAGATGA

Protein

MTMASVKVAVRVRPFNQREKDMAAKLIVQMEGKKTRLLTVKSSKEQNEGSREKYKDFTFDHSYWSFDGGDKHYASQEQVFSDLGLDVIDSAFEGYNACVFAYGQTGSGKTFTMMGSPECQGLIPRICRQLFSRVAAGKESGASYRTEVSYLEIYNERVKDLLSTDAGHSLRVREHPKLGPYVQDLSKHLVSDYDDIQVSNSIYVNCTGIKR

Description

Plus end-directed motor protein involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa side are disassembled by Klp10A, leading to the asymmetric delivery of Sara-expressing endosomes to the pIIa daughter cell (PubMed:26659188). Also plays a role in regulation of autophagosome formation, fusion and positioning and is required for normal localization of Rab14 (PubMed:26763909).

Subunit

Interacts with Atg8a and Rab14.

Similarity

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Keywords

Alternative splicing   ATP-binding   Autophagy   Coiled coil   Complete proteome   Endosome   Microtubule   Motor protein   Nucleotide-binding   Reference proteome   Transport  

Feature

chain  Kinesin-like protein Klp98A
splice variant  In isoform B.

Uniprot

A0A212EZN6   A0A2A4JGL4   A0A2A4JFR8   A0A194PFN7   A0A2W1BJL2   H9IU86   + More
A0A2J7PR34   A0A2A3ED30   A0A087ZTB7   A0A2H1VPS9   A0A232EWS6   A0A0C9R9J7   A0A3L8E2Q4   E2BSL5   A0A151JTB6   A0A2A4JFQ6   K7J3W7   A0A195DCZ0   A0A158NMP5   A0A1B6JJ36   A0A0C9QMU2   A0A226ETH9   A0A1B6EFZ0   F4X310   A0A151X1K7   A0A1B6KSV7   A0A0Q9XA93   A0A0Q9XBH7   B4KDX5   A0A0N8P1P8   B3LXJ5   B4NAQ0   B4JTD4   A0A034VYU4   B4G2L1   A0A0M5J1D2   A0A0R3NG26   Q29A93   A0A034W2C1   A0A3B0K3T0   A0A1W4URR2   A0A1W4UDB0   B3P603   Q9VB25-2   A0A0R1EA50   B4QXH5   A0A1W4UPV8   A0A1W4UQ51   Q9VB25   A0A3B0K4T6   B4PRQ1   A0A026WKY9   A0A0K8UNF4   E2AIY1   A0A0K8VF26   A0A0A1WE10   A0A1I8Q073   B4IGT3   A0A151I5Y6   A0A194RHV4   A0A1I8M6T3   A0A131XYU4   A0A1I8M6U7   A0A182KMW9   Q7PML3   B4M030   A0A1E1XEU5   A0A0K8TKQ0   A0A3R7LZJ8   A7SRC2   A0A084W920   A0A0T6AVX8   A0A3M6UGV7   A0A131YA00   A0A224YS54   A0A2B4RU09   A0A1A9WYT0   A0A2R5LPK0   W8AM04   W8AYA5   A0A1E1XLW9   A0A0P4WG05   A0A1J1J9V3   A0A131YJ83   L7M6K4   A0A0N0U647   T1JPN4   D6WQE7   A0A195C7R9   A0A1D2NAT5   S4RH81   A0A1Y1MTK4   R7TZ34   A0A2G8K9K7   A0A1B0FAF6   A0A1B0BUI8   A0A210QWK5   A0A1A9XIU4   A0A1A9ZAW3   A0A1A9US86  

Pubmed

22118469    26354079    28756777    19121390    28648823    30249741    + More
20798317    20075255    21347285    21719571    17994087    25348373    15632085    10731132    12537572    12537569    1924306    26659188    26763909    17550304    24508170    25830018    25315136    20966253    12364791    14747013    17210077    28503490    26369729    17615350    24438588    30382153    26830274    28797301    24495485    29209593    25576852    18362917    19820115    27289101    28004739    23254933    29023486    28812685   

EMBL

AGBW02011278    OWR46904.1    NWSH01001542    PCG70916.1    PCG70917.1    KQ459604    + More
KPI92102.1    KZ150248    PZC71853.1    BABH01034241    BABH01034242    NEVH01022633    PNF18789.1    KZ288292    PBC29119.1    ODYU01003717    SOQ42845.1    NNAY01001825    OXU22796.1    GBYB01004830    JAG74597.1    QOIP01000001    RLU27021.1    GL450241    EFN81261.1    KQ981936    KYN32776.1    PCG70915.1    AAZX01006133    AAZX01009857    KQ981010    KYN10304.1    ADTU01020662    ADTU01020663    ADTU01020664    GECU01008502    GECU01005620    JAS99204.1    JAT02087.1    GBYB01004829    JAG74596.1    LNIX01000002    OXA60508.1    GEDC01000450    JAS36848.1    GL888604    EGI59168.1    KQ982588    KYQ54134.1    GEBQ01025633    JAT14344.1    CH933806    KRG01303.1    KRG01304.1    EDW14972.1    CH902617    KPU80524.1    EDV43889.1    CH964232    EDW80864.1    CH916373    EDV95024.1    GAKP01010456    JAC48496.1    CH479179    EDW24056.1    CP012526    ALC45561.1    CM000070    KRT00039.1    EAL27457.1    GAKP01010455    JAC48497.1    OUUW01000005    SPP80639.1    CH954182    EDV53403.1    AE014297    AY070884    BT132947    M74432    AAA28659.1    AAL48506.1    AEW43887.1    CM000160    KRK04306.1    CM000364    EDX14661.1    SPP80636.1    EDW98494.1    KK107159    EZA56695.1    GDHF01024276    JAI28038.1    GL439921    EFN66570.1    GDHF01014833    JAI37481.1    GBXI01017150    GBXI01008102    JAC97141.1    JAD06190.1    CH480837    EDW49051.1    KQ976431    KYM87619.1    KQ460205    KPJ17019.1    GEFM01004368    JAP71428.1    AAAB01008978    EAA13643.5    CH940650    EDW68280.1    GFAC01001480    JAT97708.1    GDAI01002897    JAI14706.1    QCYY01002627    ROT68838.1    DS469760    EDO33740.1    ATLV01021573    KE525320    KFB46714.1    LJIG01022678    KRT79292.1    RCHS01001558    RMX52876.1    GEDV01012468    JAP76089.1    GFPF01009260    MAA20406.1    LSMT01000346    PFX19735.1    GGLE01007111    MBY11237.1    GAMC01016730    GAMC01016728    JAB89825.1    GAMC01016729    GAMC01016727    JAB89828.1    GFAA01003443    JAT99991.1    GDRN01025491    JAI67719.1    CVRI01000073    CRL07801.1    GEDV01010047    JAP78510.1    GACK01005369    JAA59665.1    KQ435736    KOX77052.1    CAEY01000428    KQ971354    EFA06082.2    KQ978231    KYM96211.1    LJIJ01000115    ODN02361.1    GEZM01024261    JAV87820.1    AMQN01010291    KB307500    ELT98872.1    MRZV01000763    PIK44649.1    CCAG010019388    JXJN01020709    JXJN01020710    NEDP02001506    OWF53130.1   

Proteomes

UP000007151    UP000218220    UP000053268    UP000005204    UP000235965    UP000242457    + More
UP000005203    UP000215335    UP000279307    UP000008237    UP000078541    UP000002358    UP000078492    UP000005205    UP000198287    UP000007755    UP000075809    UP000009192    UP000007801    UP000007798    UP000001070    UP000008744    UP000092553    UP000001819    UP000268350    UP000192221    UP000008711    UP000000803    UP000002282    UP000000304    UP000053097    UP000000311    UP000095300    UP000001292    UP000078540    UP000053240    UP000095301    UP000075882    UP000007062    UP000008792    UP000283509    UP000001593    UP000030765    UP000275408    UP000225706    UP000091820    UP000183832    UP000053105    UP000015104    UP000007266    UP000078542    UP000094527    UP000245300    UP000014760    UP000230750    UP000092444    UP000092460    UP000242188    UP000092443    UP000092445    UP000078200   

PRIDE

H9IU86    Q9VB25   

Pfam

PF00225   Kinesin        + More
PF00787   PX
PF00498   FHA

Interpro

IPR019821   Kinesin_motor_CS        + More
IPR027417   P-loop_NTPase       
IPR036961   Kinesin_motor_dom_sf       
IPR001752   Kinesin_motor_dom       
IPR027640   Kinesin-like_fam       
IPR036871   PX_dom_sf       
IPR008984   SMAD_FHA_dom_sf       
IPR000253   FHA_dom       
IPR001683   Phox       

SUPFAM

SSF64268   SSF64268        + More
SSF49879   SSF49879       
SSF52540   SSF52540       

Gene 3D

3.30.1520.10     3.40.850.10    

CDD

cd00060  FHA

ProteinModelPortal

A0A212EZN6   A0A2A4JGL4   A0A2A4JFR8   A0A194PFN7   A0A2W1BJL2   H9IU86   + More
A0A2J7PR34   A0A2A3ED30   A0A087ZTB7   A0A2H1VPS9   A0A232EWS6   A0A0C9R9J7   A0A3L8E2Q4   E2BSL5   A0A151JTB6   A0A2A4JFQ6   K7J3W7   A0A195DCZ0   A0A158NMP5   A0A1B6JJ36   A0A0C9QMU2   A0A226ETH9   A0A1B6EFZ0   F4X310   A0A151X1K7   A0A1B6KSV7   A0A0Q9XA93   A0A0Q9XBH7   B4KDX5   A0A0N8P1P8   B3LXJ5   B4NAQ0   B4JTD4   A0A034VYU4   B4G2L1   A0A0M5J1D2   A0A0R3NG26   Q29A93   A0A034W2C1   A0A3B0K3T0   A0A1W4URR2   A0A1W4UDB0   B3P603   Q9VB25-2   A0A0R1EA50   B4QXH5   A0A1W4UPV8   A0A1W4UQ51   Q9VB25   A0A3B0K4T6   B4PRQ1   A0A026WKY9   A0A0K8UNF4   E2AIY1   A0A0K8VF26   A0A0A1WE10   A0A1I8Q073   B4IGT3   A0A151I5Y6   A0A194RHV4   A0A1I8M6T3   A0A131XYU4   A0A1I8M6U7   A0A182KMW9   Q7PML3   B4M030   A0A1E1XEU5   A0A0K8TKQ0   A0A3R7LZJ8   A7SRC2   A0A084W920   A0A0T6AVX8   A0A3M6UGV7   A0A131YA00   A0A224YS54   A0A2B4RU09   A0A1A9WYT0   A0A2R5LPK0   W8AM04   W8AYA5   A0A1E1XLW9   A0A0P4WG05   A0A1J1J9V3   A0A131YJ83   L7M6K4   A0A0N0U647   T1JPN4   D6WQE7   A0A195C7R9   A0A1D2NAT5   S4RH81   A0A1Y1MTK4   R7TZ34   A0A2G8K9K7   A0A1B0FAF6   A0A1B0BUI8   A0A210QWK5   A0A1A9XIU4   A0A1A9ZAW3   A0A1A9US86  

PDB

2HXH     E-value=3.52353e-53,     Score=523

KEGG

101739780    K17916 kinesin family member 16B | (RefSeq) kinesin-like protein KIF16B

GO

GO:0035091   GO:0008017   GO:0003777   GO:0005524   GO:0007018   GO:0005874   GO:0016021   GO:0003774   GO:0008574   GO:0140024   GO:0032266   GO:0045167   GO:0005769   GO:1901981   GO:0045022   GO:0005871   GO:0005829   GO:0006914   GO:0016887   GO:0016192   GO:0030117   GO:0007154   GO:0016020   GO:0005112   GO:0015930  

PANTHER

PTHR24115  

Subcellular location

Early endosome  

Length:

211

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00315

Exp number, first 60 AAs:

0

Total prob of N-in:

0.18169

outside

1  -  211

 

 

Pi

24.050564

Theta

26.80106

Tajima's D

-1.130271

CLR

0.733684

CSRT

0.112744362781861

Interpretation

Uncertain