Gene

KWMTBOMO14936  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000767

Annotation

PREDICTED:_atlastin_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr25(-):718976-728662      View in EpiBrowser

Full name

Atlastin      

Location in the cell

Cytoplasmic   Reliability : 1.496

CDS

ATGATGGCACATGTGACAGAGAAGCCGGCGCCGGCACCGCGTGGGCCGCACGGTGTCCAGGTCGTCGACACCGGCCCCGACCATACGTTCACCCTGGACGAGGAGGCCCTCAAGTCTCTGCTCCTGAAAGAAGATGTCAGAGACAGAGCCGTGGTCGTTATATCAGTTGCCGGAGCCTTCAGGAAAGGAAAGTCCTTCTTATTGGACTTCTTCCTGAGATATATGCACTATAAGTACGGCGCAGGCGGCGGCGGGAGCGAGTGGCTCGGTAGCGAGGAGGACCCCCTCCAGGGCTTCAGCTGGCGAGGGGGCTCCGAGAGGGACACGACCGGCATACTCATGTGGTCCGAGATATTCAAAGCGACGCTCGATGATGGTGAAAAGGTAGCGATAATATTGCTAGACACGCAAGGCGCCTTCGACAGTGAATCCACGGTGCGAGACTGCGCGACCGTGTTCGCTCTGTCCACGATGCTGTCGTCCGTTCAGATATACAACCTCTCGCAAAACATCCAGGAGGACGACCTCCAGCACCTTCAATTGTTCACAGAGTACGGTCGGCTGGCGCTCGAGGACGGGGGCCGGACTCCCTTCCAGCGGCTGCAGTTCCTCGTGCGCGACTGGAGCTTCCCCTACGAAGCGCCCTACGGAGCGGACGGCGGCATGCAGATACTGTCAAGAAGATTAAAGGTATCAGACAAACAGCATCCAGAGCTGCAGTCCCTCCGCAAGCACATAACGGCGTGCTTCTCGGAGCTGGCCTGCTTCCTCATGCCGCACCCGGGACTCAAAGTGGCCACCAACCCACAATTTGACGGCAGACTTGCAGATATCGAATCAGAGTTCAAACGCTCCCTCCAGCAGTTCGTGCCGATGCTGCTGGCTCCCGAGAACCTGGTGCCGAAGCTCATCAACGGTCAGAAGGTCAAGGCCAAGGACCTGGTCCAGTACTTCAAGTCGTACATGAACATCTACAAGGGCAACGAACTGCCCGAGCCCAAGAGCATGCTTGTGGCGACAGCGGAAGCCAACAACTTGACAGCTGTGGCGGAGGCCAAGGAGGTGTACACGCGGCTCATGGAGGAGGTGTGCGGGGGTGGGCGGCCCTACTTGCACGCCGACCTGCTGCTGACGGAGCACCAGCGCGTGCGGGACAAGGCCATGTACGCCTTCAACGCCAAGCGGAAGATGGGCGGCCGGGACTTCAGCCAGGCCTACTTCGACCAACTCGCACAGGACTTGGAGGAGCAGTTCCTGCAGTTCAAGGCGCACAACGAGAGCAAGAACATCTTCAAGGCGGCCCGGACGCCCTCCGTGTTCTTCGCGGTGGCGCTGTTCTTCTACGTGCTCAGCGGAGTGTTCGGGCTGCTGGGCCTCTACCCGCTCGCCAACGTCGCCAACTTCGCCATGGGCCTGGCCCTCCTCACGCTCGTGCTCTGGGCATACATCAGGTACAGCGGCGAGATGAGAGAGTTCGGCGTAACCATAGACGACACTGCGACGGTCATGTGGGATAATGTCCTGAAGCCGATGTACCAGACGTGCCTCGAGAAGGGCATGGAGCACGCGGCGGCGGCGGCCGTGGCGCCCCCCTCCCCCGCCCCCGGCGCCGCGCCCCCCGCCTTCGCGCACAACGGGAAGCACAAGCACTTGTGA

Protein

MMAHVTEKPAPAPRGPHGVQVVDTGPDHTFTLDEEALKSLLLKEDVRDRAVVVISVAGAFRKGKSFLLDFFLRYMHYKYGAGGGGSEWLGSEEDPLQGFSWRGGSERDTTGILMWSEIFKATLDDGEKVAIILLDTQGAFDSESTVRDCATVFALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALEDGGRTPFQRLQFLVRDWSFPYEAPYGADGGMQILSRRLKVSDKQHPELQSLRKHITACFSELACFLMPHPGLKVATNPQFDGRLADIESEFKRSLQQFVPMLLAPENLVPKLINGQKVKAKDLVQYFKSYMNIYKGNELPEPKSMLVATAEANNLTAVAEAKEVYTRLMEEVCGGGRPYLHADLLLTEHQRVRDKAMYAFNAKRKMGGRDFSQAYFDQLAQDLEEQFLQFKAHNESKNIFKAARTPSVFFAVALFFYVLSGVFGLLGLYPLANVANFAMGLALLTLVLWAYIRYSGEMREFGVTIDDTATVMWDNVLKPMYQTCLEKGMEHAAAAAVAPPSPAPGAAPPAFAHNGKHKHL

Description

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions.

Subunit

Homooligomer; trans-homooligomer between proteins on adjacent membranes. Interacts with spas; interaction may regulate microtubule dynamics.

Similarity

Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.

Keywords

3D-structure   Complete proteome   Endoplasmic reticulum   Golgi apparatus   GTP-binding   Hydrolase   Membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Atlastin

Uniprot

H9IU37   A0A1E1W9U5   A0A1E1VXT1   A0A2A4JE55   A0A2W1BT43   A0A182IZZ3   + More
A0A182Q5E4   A0A182VZ50   Q17GF2   A0A182P550   A0A182N454   A0A182MAV6   A0A182K3G1   A0A182TUD6   Q7PUS9   A0A023EUV9   A0A084VG42   A0A1Y1KJA0   A0A182GUP1   A0A1Y1KFA2   A0A182R689   A0A2M3Z0Q2   A0A2M4A1J4   W5JH04   A0A2M4A1Q3   A0A2M4BJH5   T1DN87   A0A182FNI8   A0A182YAR7   A0A182X0D2   A0A182LR64   A0A1Q3G2Q7   A0A182I021   A0A0K8V1U1   A0A182VG90   W8BN84   B4JEK1   A0A034W9U4   A0A154P404   B3P712   A0A182T9R3   B4K505   B4PVR8   B4LW27   A0A1W4VPR3   B4HH45   B3M050   A0A0A1WFI4   A0A0B4LHV8   A0A0K8TP26   B4N8U3   Q9VC57   A0A1L8DFC2   Q29BY7   B4GPG3   A0A1L8DFN1   A0A3B0JFY6   I3RSF4   A0A0M4EDL5   K7IUU5   A0A0L0C6K7   E2AR16   D6WQT2   A0A1I8Q5V2   A0A1I8MAE9   A0A195BG18   F4X8E3   A0A195FDX7   E2B5K9   B0WND1   A0A1Q3FBH4   A0A151J9D5   A0A0C9QVF4   A0A151X9P7   A0A0C9QJW0   A0A195CBN9   A0A1B6BYG1   A0A1B6C1Y7   A0A2S2QTC8   A0A0A9XY37   A0A158NBV9   A0A026X1X4   A0A1A9ZZN1   V9IF45   A0A087ZZN6   A0A2A3ET24   D3TMN5   A0A1B0FBF0   A0A158NBW0   A0A146LV81   A0A212EHB8   U5EXR1   N6TK58   A0A0L7QTT4   A0A0M9A692   A0A067RT26   A0A1B6FS83   A0A1A9XTA1   A0A1A9V4Y1   A0A1B0CGH0  

EC Number

3.6.5.-

Pubmed

19121390    28756777    17510324    12364791    14747013    17210077    + More
24945155    24438588    28004739    26483478    20920257    23761445    25244985    20966253    24495485    17994087    25348373    18057021    17550304    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26369729    18327897    17030474    19341724    19633650    15632085    22328714    20075255    26108605    20798317    18362917    19820115    25315136    21719571    25401762    26823975    21347285    24508170    30249741    20353571    22118469    23537049    24845553   

EMBL

BABH01034204    GDQN01007282    GDQN01004744    JAT83772.1    JAT86310.1    GDQN01011573    + More
GDQN01000546    JAT79481.1    JAT90508.1    NWSH01001828    PCG69988.1    KZ149945    PZC76805.1    AXCN02000025    CH477262    EAT45634.1    AXCM01017510    AAAB01008987    EAA01072.3    GAPW01000826    JAC12772.1    ATLV01012626    KE524806    KFB36936.1    GEZM01087174    JAV58867.1    JXUM01019135    JXUM01019136    JXUM01019137    JXUM01019138    JXUM01061069    JXUM01061070    KQ562133    KXJ76608.1    GEZM01087172    JAV58870.1    GGFM01001358    MBW22109.1    GGFK01001301    MBW34622.1    ADMH02001421    ETN62603.1    GGFK01001358    MBW34679.1    GGFJ01004064    MBW53205.1    GAMD01003100    JAA98490.1    GFDL01000940    JAV34105.1    APCN01002031    GDHF01022865    GDHF01019425    JAI29449.1    JAI32889.1    GAMC01015402    GAMC01015401    JAB91154.1    CH916369    EDV93132.1    GAKP01007876    GAKP01007875    JAC51077.1    KQ434809    KZC06646.1    CH954182    EDV53832.1    CH933806    EDW13976.2    KRG00752.1    CM000160    EDW98917.2    KRK04548.1    CH940650    EDW66532.1    KRF82754.1    CH480815    EDW43521.1    CH902617    EDV42007.2    KPU79506.1    GBXI01017553    GBXI01016851    GBXI01009293    JAC96738.1    JAC97440.1    JAD04999.1    AE014297    AHN57505.1    GDAI01001685    JAI15918.1    CH964232    EDW81544.2    KRF99479.1    KRF99480.1    AY069079    BT004893    GFDF01008925    JAV05159.1    CM000070    EAL26859.1    CH479186    EDW39046.1    GFDF01008914    JAV05170.1    OUUW01000005    SPP81304.1    JQ611724    AFK29239.1    CP012526    ALC45916.1    AAZX01002640    JRES01000835    KNC27900.1    GL441846    EFN64162.1    KQ971354    EFA07005.1    KQ976500    KYM83149.1    GL888932    EGI57148.1    KQ981673    KYN38407.1    GL445852    EFN89021.1    DS232010    EDS31585.1    GFDL01010176    JAV24869.1    KQ979433    KYN21563.1    GBYB01004652    JAG74419.1    KQ982373    KYQ57054.1    GBYB01003799    JAG73566.1    KQ978068    KYM97528.1    GEDC01031239    GEDC01019967    GEDC01002587    JAS06059.1    JAS17331.1    JAS34711.1    GEDC01030063    GEDC01024076    GEDC01009683    JAS07235.1    JAS13222.1    JAS27615.1    GGMS01011823    MBY81026.1    GBHO01021429    GBRD01002498    GDHC01012112    JAG22175.1    JAG63323.1    JAQ06517.1    ADTU01011332    ADTU01011333    ADTU01011334    KK107036    QOIP01000004    EZA62001.1    RLU23239.1    JR040781    AEY59292.1    KZ288191    PBC34452.1    EZ422687    ADD18963.1    CCAG010007921    GDHC01008359    JAQ10270.1    AGBW02014918    OWR40879.1    GANO01000820    JAB59051.1    APGK01035351    KB740923    KB632333    ENN78293.1    ERL92718.1    KQ414740    KOC62077.1    KQ435741    KOX76783.1    KK852433    KDR23965.1    GECZ01016693    JAS53076.1    AJWK01011095    AJWK01011096   

Proteomes

UP000005204    UP000218220    UP000075880    UP000075886    UP000075920    UP000008820    + More
UP000075885    UP000075884    UP000075883    UP000075881    UP000075902    UP000007062    UP000030765    UP000069940    UP000249989    UP000075900    UP000000673    UP000069272    UP000076408    UP000076407    UP000075882    UP000075840    UP000075903    UP000001070    UP000076502    UP000008711    UP000075901    UP000009192    UP000002282    UP000008792    UP000192221    UP000001292    UP000007801    UP000000803    UP000007798    UP000001819    UP000008744    UP000268350    UP000092553    UP000002358    UP000037069    UP000000311    UP000007266    UP000095300    UP000095301    UP000078540    UP000007755    UP000078541    UP000008237    UP000002320    UP000078492    UP000075809    UP000078542    UP000005205    UP000053097    UP000279307    UP000092445    UP000005203    UP000242457    UP000092444    UP000007151    UP000019118    UP000030742    UP000053825    UP000053105    UP000027135    UP000092443    UP000078200    UP000092461   

PRIDE

H9IU37    Q9VC57   

Pfam

PF02263   GBP        + More
PF02841   GBP_C

Interpro

IPR036543   Guanylate-bd_C_sf        + More
IPR027417   P-loop_NTPase       
IPR030386   G_GB1_RHD3_dom       
IPR015894   Guanylate-bd_N       
IPR003191   Guanylate-bd/ATL_C       
IPR000408   Reg_chr_condens       

SUPFAM

SSF48340   SSF48340        + More
SSF52540   SSF52540       

ProteinModelPortal

H9IU37   A0A1E1W9U5   A0A1E1VXT1   A0A2A4JE55   A0A2W1BT43   A0A182IZZ3   + More
A0A182Q5E4   A0A182VZ50   Q17GF2   A0A182P550   A0A182N454   A0A182MAV6   A0A182K3G1   A0A182TUD6   Q7PUS9   A0A023EUV9   A0A084VG42   A0A1Y1KJA0   A0A182GUP1   A0A1Y1KFA2   A0A182R689   A0A2M3Z0Q2   A0A2M4A1J4   W5JH04   A0A2M4A1Q3   A0A2M4BJH5   T1DN87   A0A182FNI8   A0A182YAR7   A0A182X0D2   A0A182LR64   A0A1Q3G2Q7   A0A182I021   A0A0K8V1U1   A0A182VG90   W8BN84   B4JEK1   A0A034W9U4   A0A154P404   B3P712   A0A182T9R3   B4K505   B4PVR8   B4LW27   A0A1W4VPR3   B4HH45   B3M050   A0A0A1WFI4   A0A0B4LHV8   A0A0K8TP26   B4N8U3   Q9VC57   A0A1L8DFC2   Q29BY7   B4GPG3   A0A1L8DFN1   A0A3B0JFY6   I3RSF4   A0A0M4EDL5   K7IUU5   A0A0L0C6K7   E2AR16   D6WQT2   A0A1I8Q5V2   A0A1I8MAE9   A0A195BG18   F4X8E3   A0A195FDX7   E2B5K9   B0WND1   A0A1Q3FBH4   A0A151J9D5   A0A0C9QVF4   A0A151X9P7   A0A0C9QJW0   A0A195CBN9   A0A1B6BYG1   A0A1B6C1Y7   A0A2S2QTC8   A0A0A9XY37   A0A158NBV9   A0A026X1X4   A0A1A9ZZN1   V9IF45   A0A087ZZN6   A0A2A3ET24   D3TMN5   A0A1B0FBF0   A0A158NBW0   A0A146LV81   A0A212EHB8   U5EXR1   N6TK58   A0A0L7QTT4   A0A0M9A692   A0A067RT26   A0A1B6FS83   A0A1A9XTA1   A0A1A9V4Y1   A0A1B0CGH0  

PDB

3X1D     E-value=0,     Score=1901

KEGG

101745564    K17339 atlastin [EC:3.6.5.-] | (RefSeq) atlastin

GO

GO:0005525   GO:0003924   GO:0016021   GO:0051260   GO:0007029   GO:0031227   GO:0031114   GO:0007517   GO:0042803   GO:0008582   GO:0016320   GO:0005874   GO:0005794   GO:0048691   GO:0051124   GO:0007019   GO:0007030   GO:0061025   GO:0032561   GO:0005737   GO:0012505   GO:0007528   GO:0000139   GO:0005783   GO:0016020   GO:0042802   GO:0015031   GO:0006886   GO:0016192   GO:0030117   GO:0007154   GO:0005112   GO:0015930  

Subcellular location

Endoplasmic reticulum membrane  
Golgi apparatus membrane  

Length:

551

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

42.7457700000001

Exp number, first 60 AAs:

0.07813

Total prob of N-in:

0.37136

outside

1  -  437

TMhelix

438  -  460

inside

461  -  464

TMhelix

465  -  483

outside

484  -  551

 

 

Pi

231.492391

Theta

158.941265

Tajima's D

1.673696

CLR

0.109186

CSRT

0.826158692065397

Interpretation

Uncertain