SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO14935  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA000802
Annotation
PREDICTED:_atlastin-like_[Amyelois_transitella]
Full name
Atlastin      
Location in the cell
Cytoplasmic   Reliability : 3.012
 

Sequence

CDS
ATGTCTAGTAAAACGGAAACATTGAAATCCGGATGGGGAATTCAAGTGGTGGTTCCAGGTCCAGAGCACACTTTTACCCTGGATGAGGAGGCTCTCACTGCACTCCTGCTCCGCGAGGATATAAAGGACCGAGCTGTGGTTATCATATCGGTTGCTGGAGCCTTTCGGAAAGGAAAGTCCTTTTTGTTGGACTTCTTTCTTAGATATTTACAGCACAAGTACGTCCTTGGTGAAAGCGGTGGAGAATGGATTGGTGTTGAAGATGAACCTTTAGAAGGTTTCAAATGGCGAGGAGGATCTGAGAGAGAAACCACAGGCTTGCTGCTATGGTCGCAGCCTTTTAAAGCAACTTTAGCGAATGGCGAAAAGGTGGTGATATTTCTGATGGATACGCAAGGAACGTTCGACAGTCAGTCCACTGTGCGAGACAACGCCACAGTGTTCGCTCTCTCCACGCTGATATCTTCCGTTCAAATTTACAACTTGTCGCAGAACATTGAAGAAGACGACTTACAGCATTTGCAGTTGTTCACGGACTACGGTCAGCTAGCACAAGAGAGCAGTTCCGGAAGGCCCTTCCAGAGGCTGCAGTTTCTGGTTCGAGACTGGAGCTTCCCGTACGACCATCCGTATGGCGCTCTGGGCGGTCAACAGCTTCTGAAGAAACGGCTCCAGATTCATGAAGGACAGCATCCAGAGCTTCAGAACCTCAGAGAGTACGTAACAAGGATATTTGATGAGATCGCTTGCTTCCTGATGCCTCATCCGGGCCTCAAGGTCGCTACGAACCCTGACTTCAACGGGAAACTAGCCGATATCAGTCCAGAATTCAAAGATAGTTTGAAGCAGTTGTTACCGATGTTGCTCGCCCCTGAGAATCTAGTCCCGAAGCTGATCGAAGGCCAGAAGGTCAAAGCTAAGGATCTGCTGCTCTATTTCAAGACCTACATGAAGGTGTTCAATGGAACGGAGCTGCCGGAGCCACGGACCATTCTAGCGGCGACGTCAGAAGCCAACAATCTCTCAGCAGTGGCTGAAGCGCGCGAGGTGTACGAAACTCTGATGGAGGAGATCTGCGGTGGCACCAGACCCTACGTGCAGCCCAGACAACTAGAGGAAGAACATCACAGGGTCATGAACAAGGCAATACACGCGTTTGACAGCAAAAAGAAGATGGGTGGTAAGGAGCTGGCTGATGGGTACAAGGCTGAGCTGGAGAAGGAGCTAGAAGAGTTGTTCGAGCAGCTGAGATCGCACAACGAAGCGAAGAACATTTACCGCATGATCGGAACGCCTGTCGTGTTCGCGACGGTGGCCGTGCTCGCGTACATGCTGGTCGTGCTCGGCAACATGTTCGGCGTGCAGACGGTGGTGGCGGCGGGGCAGGCCGCCGTGGTAGGGGCACTCGTCATGATCGCCGTGTGGATCTATTCAAGAACTACCGGACAAATGAGGGACGTAGGAGCACAATTAGATGAAATAGCCGATTCAATTCGTAGTTACATTCTCAACCAAGCGTTCGACTCGATGCGAAGTCGCGCGACCGCCGCGGCTGTCGGCTACGGCGCGGACAAGAAGCGCACTTAG
Protein
MSSKTETLKSGWGIQVVVPGPEHTFTLDEEALTALLLREDIKDRAVVIISVAGAFRKGKSFLLDFFLRYLQHKYVLGESGGEWIGVEDEPLEGFKWRGGSERETTGLLLWSQPFKATLANGEKVVIFLMDTQGTFDSQSTVRDNATVFALSTLISSVQIYNLSQNIEEDDLQHLQLFTDYGQLAQESSSGRPFQRLQFLVRDWSFPYDHPYGALGGQQLLKKRLQIHEGQHPELQNLREYVTRIFDEIACFLMPHPGLKVATNPDFNGKLADISPEFKDSLKQLLPMLLAPENLVPKLIEGQKVKAKDLLLYFKTYMKVFNGTELPEPRTILAATSEANNLSAVAEAREVYETLMEEICGGTRPYVQPRQLEEEHHRVMNKAIHAFDSKKKMGGKELADGYKAELEKELEELFEQLRSHNEAKNIYRMIGTPVVFATVAVLAYMLVVLGNMFGVQTVVAAGQAAVVGALVMIAVWIYSRTTGQMRDVGAQLDEIADSIRSYILNQAFDSMRSRATAAAVGYGADKKRT

Summary

Description
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions.
Subunit
Homooligomer; trans-homooligomer between proteins on adjacent membranes. Interacts with spas; interaction may regulate microtubule dynamics.
Similarity
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Keywords
3D-structure   Complete proteome   Endoplasmic reticulum   Golgi apparatus   GTP-binding   Hydrolase   Membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   Transmembrane   Transmembrane helix  
Feature
chain  Atlastin
EC Number
3.6.5.-
EMBL
BABH01034202    ODYU01009603    SOQ54149.1    AGBW02014918    OWR40878.1    KZ149945    + More
PZC76803.1    NWSH01001828    PCG69986.1    GDQN01007282    GDQN01004744    JAT83772.1    JAT86310.1    GDQN01011573    GDQN01000546    JAT79481.1    JAT90508.1    BABH01034204    PCG69988.1    PZC76805.1    GGFM01001358    MBW22109.1    AXCM01017510    CH477262    EAT45634.1    GFDL01000940    JAV34105.1    GGFJ01004064    MBW53205.1    ADMH02001421    ETN62603.1    GGFK01001301    MBW34622.1    GGFK01001358    MBW34679.1    AXCN02000025    AAAB01008987    EAA01072.3    GAMD01003100    JAA98490.1    GFDL01010176    JAV24869.1    ATLV01012626    KE524806    KFB36936.1    GEZM01087174    JAV58867.1    GEZM01087172    JAV58870.1    APCN01002031    DS232010    EDS31585.1    JXUM01019135    JXUM01019136    JXUM01019137    JXUM01019138    JXUM01061069    JXUM01061070    KQ562133    KXJ76608.1    GAPW01000826    JAC12772.1    KQ971354    EFA07005.1    DS235787    EEB17090.1    AAZX01002640    GECZ01016693    JAS53076.1    GL441846    EFN64162.1    GFDF01008914    JAV05170.1    GFDF01008925    JAV05159.1    GECU01033826    JAS73880.1    KQ434809    KZC06646.1    GECU01027952    JAS79754.1    GAKP01007876    GAKP01007875    JAC51077.1    GBHO01021429    GBRD01002498    GDHC01012112    JAG22175.1    JAG63323.1    JAQ06517.1    CM000070    EAL26859.1    KQ976500    KYM83149.1    CH479186    EDW39046.1    CP012526    ALC45916.1    CH902617    EDV42007.2    KPU79506.1    CM000160    EDW98917.2    KRK04548.1    GL888932    EGI57148.1    CH480815    EDW43521.1    CH954182    EDV53832.1    GDHF01022865    GDHF01019425    JAI29449.1    JAI32889.1    GBXI01017553    GBXI01016851    GBXI01009293    JAC96738.1    JAC97440.1    JAD04999.1    JQ611724    AFK29239.1    KQ979433    KYN21563.1    AE014297    AHN57505.1    AY069079    BT004893    KQ981673    KYN38407.1    CH940650    EDW66532.1    KRF82754.1    GDAI01001685    JAI15918.1    GEDC01031239    GEDC01019967    GEDC01002587    JAS06059.1    JAS17331.1    JAS34711.1    KQ978068    KYM97528.1    ADTU01011332    ADTU01011333    ADTU01011334    CH916369    EDV93132.1    CH933806    EDW13976.2    KRG00752.1    GEDC01030063    GEDC01024076    GEDC01009683    JAS07235.1    JAS13222.1    JAS27615.1    OUUW01000005    SPP81304.1    KQ982373    KYQ57054.1    GAMC01015402    GAMC01015401    JAB91154.1    GL445852    EFN89021.1    JRES01000835    KNC27900.1    GDHC01008359    JAQ10270.1    GBYB01004652    JAG74419.1    GBYB01003799    JAG73566.1    CH964232    EDW81544.2    KRF99479.1    KRF99480.1    GGMS01011823    MBY81026.1    EZ422687    ADD18963.1    CCAG010007921    GDHF01011418    JAI40896.1    APGK01035351    KB740923    KB632333    ENN78293.1    ERL92718.1    LJIJ01001415    ODM91805.1    KZ288191    PBC34452.1    CM000364    EDX14250.1    LBMM01000159    KMR04695.1   
Pfam
PF02263   GBP        + More
PF02841   GBP_C
Interpro
IPR027417   P-loop_NTPase        + More
IPR030386   G_GB1_RHD3_dom       
IPR015894   Guanylate-bd_N       
IPR036543   Guanylate-bd_C_sf       
IPR003191   Guanylate-bd/ATL_C       
IPR000408   Reg_chr_condens       
SUPFAM
SSF48340   SSF48340        + More
SSF52540   SSF52540       
PDB
3X1D     E-value=1.37724e-153,     Score=1394

Ontologies

Topology

Subcellular location
Endoplasmic reticulum membrane  
Golgi apparatus membrane  
Length:
528
Number of predicted TMHs:
2
Exp number of AAs in TMHs:
43.82762
Exp number, first 60 AAs:
0.08092
Total prob of N-in:
0.89394
inside
1  -  423
TMhelix
424  -  446
outside
447  -  455
TMhelix
456  -  478
inside
479  -  528
 
 

Population Genetic Test Statistics

Pi
210.182123
Theta
167.636847
Tajima's D
1.751896
CLR
0.014291
CSRT
0.835108244587771
Interpretation
Uncertain

Multiple alignment of Orthologues

 
 

Gene Tree

 
 
Peptides ×
Source Sequence Identity Evalue
28467696 EVVTVGEWTDR 95.24 2e-09
26822097 TIIAATSEANNISAVAEAR 100.00 2e-04
28467696 DWQQTEHIVTNTPTFQPYK 100.00 2e-04
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