Gene

KWMTBOMO14935  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000802

Annotation

PREDICTED:_atlastin-like_[Amyelois_transitella]

Location

Bomo_Chr25(+):700103-709307      View in EpiBrowser

Full name

Atlastin      

Location in the cell

Cytoplasmic   Reliability : 3.012

CDS

ATGTCTAGTAAAACGGAAACATTGAAATCCGGATGGGGAATTCAAGTGGTGGTTCCAGGTCCAGAGCACACTTTTACCCTGGATGAGGAGGCTCTCACTGCACTCCTGCTCCGCGAGGATATAAAGGACCGAGCTGTGGTTATCATATCGGTTGCTGGAGCCTTTCGGAAAGGAAAGTCCTTTTTGTTGGACTTCTTTCTTAGATATTTACAGCACAAGTACGTCCTTGGTGAAAGCGGTGGAGAATGGATTGGTGTTGAAGATGAACCTTTAGAAGGTTTCAAATGGCGAGGAGGATCTGAGAGAGAAACCACAGGCTTGCTGCTATGGTCGCAGCCTTTTAAAGCAACTTTAGCGAATGGCGAAAAGGTGGTGATATTTCTGATGGATACGCAAGGAACGTTCGACAGTCAGTCCACTGTGCGAGACAACGCCACAGTGTTCGCTCTCTCCACGCTGATATCTTCCGTTCAAATTTACAACTTGTCGCAGAACATTGAAGAAGACGACTTACAGCATTTGCAGTTGTTCACGGACTACGGTCAGCTAGCACAAGAGAGCAGTTCCGGAAGGCCCTTCCAGAGGCTGCAGTTTCTGGTTCGAGACTGGAGCTTCCCGTACGACCATCCGTATGGCGCTCTGGGCGGTCAACAGCTTCTGAAGAAACGGCTCCAGATTCATGAAGGACAGCATCCAGAGCTTCAGAACCTCAGAGAGTACGTAACAAGGATATTTGATGAGATCGCTTGCTTCCTGATGCCTCATCCGGGCCTCAAGGTCGCTACGAACCCTGACTTCAACGGGAAACTAGCCGATATCAGTCCAGAATTCAAAGATAGTTTGAAGCAGTTGTTACCGATGTTGCTCGCCCCTGAGAATCTAGTCCCGAAGCTGATCGAAGGCCAGAAGGTCAAAGCTAAGGATCTGCTGCTCTATTTCAAGACCTACATGAAGGTGTTCAATGGAACGGAGCTGCCGGAGCCACGGACCATTCTAGCGGCGACGTCAGAAGCCAACAATCTCTCAGCAGTGGCTGAAGCGCGCGAGGTGTACGAAACTCTGATGGAGGAGATCTGCGGTGGCACCAGACCCTACGTGCAGCCCAGACAACTAGAGGAAGAACATCACAGGGTCATGAACAAGGCAATACACGCGTTTGACAGCAAAAAGAAGATGGGTGGTAAGGAGCTGGCTGATGGGTACAAGGCTGAGCTGGAGAAGGAGCTAGAAGAGTTGTTCGAGCAGCTGAGATCGCACAACGAAGCGAAGAACATTTACCGCATGATCGGAACGCCTGTCGTGTTCGCGACGGTGGCCGTGCTCGCGTACATGCTGGTCGTGCTCGGCAACATGTTCGGCGTGCAGACGGTGGTGGCGGCGGGGCAGGCCGCCGTGGTAGGGGCACTCGTCATGATCGCCGTGTGGATCTATTCAAGAACTACCGGACAAATGAGGGACGTAGGAGCACAATTAGATGAAATAGCCGATTCAATTCGTAGTTACATTCTCAACCAAGCGTTCGACTCGATGCGAAGTCGCGCGACCGCCGCGGCTGTCGGCTACGGCGCGGACAAGAAGCGCACTTAG

Protein

MSSKTETLKSGWGIQVVVPGPEHTFTLDEEALTALLLREDIKDRAVVIISVAGAFRKGKSFLLDFFLRYLQHKYVLGESGGEWIGVEDEPLEGFKWRGGSERETTGLLLWSQPFKATLANGEKVVIFLMDTQGTFDSQSTVRDNATVFALSTLISSVQIYNLSQNIEEDDLQHLQLFTDYGQLAQESSSGRPFQRLQFLVRDWSFPYDHPYGALGGQQLLKKRLQIHEGQHPELQNLREYVTRIFDEIACFLMPHPGLKVATNPDFNGKLADISPEFKDSLKQLLPMLLAPENLVPKLIEGQKVKAKDLLLYFKTYMKVFNGTELPEPRTILAATSEANNLSAVAEAREVYETLMEEICGGTRPYVQPRQLEEEHHRVMNKAIHAFDSKKKMGGKELADGYKAELEKELEELFEQLRSHNEAKNIYRMIGTPVVFATVAVLAYMLVVLGNMFGVQTVVAAGQAAVVGALVMIAVWIYSRTTGQMRDVGAQLDEIADSIRSYILNQAFDSMRSRATAAAVGYGADKKRT

Description

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate microtubule polymerization and Golgi biogenesis. Required for dopaminergic neurons survival and the growth of muscles and synapses at neuromuscular junctions.

Subunit

Homooligomer; trans-homooligomer between proteins on adjacent membranes. Interacts with spas; interaction may regulate microtubule dynamics.

Similarity

Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.

Keywords

3D-structure   Complete proteome   Endoplasmic reticulum   Golgi apparatus   GTP-binding   Hydrolase   Membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Atlastin

Uniprot

H9IU72   A0A2H1WM56   A0A212EHC2   A0A2W1BYF7   A0A2A4JDX6   A0A1E1W9U5   + More
A0A1E1VXT1   H9IU37   A0A2A4JE55   A0A2W1BT43   A0A2M3Z0Q2   A0A182VZ50   A0A182MAV6   A0A182P550   Q17GF2   A0A1Q3G2Q7   A0A2M4BJH5   W5JH04   A0A182X0D2   A0A182TUD6   A0A2M4A1J4   A0A2M4A1Q3   A0A182Q5E4   Q7PUS9   T1DN87   A0A1Q3FBH4   A0A182LR64   A0A182T9R3   A0A084VG42   A0A1Y1KJA0   A0A182N454   A0A182K3G1   A0A1Y1KFA2   A0A182I021   A0A182R689   B0WND1   A0A182FNI8   A0A182GUP1   A0A023EUV9   A0A182IZZ3   D6WQT2   A0A182VG90   E0VUN4   K7IUU5   A0A1B6FS83   E2AR16   A0A1L8DFN1   A0A1L8DFC2   A0A1B6HGP8   A0A154P404   A0A1B6HYL4   A0A034W9U4   A0A1W4VPR3   A0A0A9XY37   Q29BY7   A0A195BG18   B4GPG3   A0A0M4EDL5   B3M050   B4PVR8   F4X8E3   B4HH45   B3P712   A0A0K8V1U1   A0A0A1WFI4   I3RSF4   A0A151J9D5   A0A0B4LHV8   Q9VC57   A0A195FDX7   B4LW27   A0A0K8TP26   A0A1B6BYG1   A0A195CBN9   A0A158NBV9   B4JEK1   B4K505   A0A1B6C1Y7   A0A3B0JFY6   A0A151X9P7   W8BN84   E2B5K9   A0A0L0C6K7   A0A146LV81   A0A0C9QVF4   A0A0C9QJW0   A0A158NBW0   B4N8U3   A0A2S2QTC8   A0A1I8Q5V2   D3TMN5   A0A1B0FBF0   A0A1I8MAE9   A0A1A9ZZN1   A0A0K8VPT2   N6TK58   A0A1D2MFP5   A0A2A3ET24   B4QTP6   A0A0J7L9I2  

EC Number

3.6.5.-

Pubmed

19121390    22118469    28756777    17510324    20920257    23761445    + More
12364791    14747013    17210077    20966253    24438588    28004739    26483478    24945155    18362917    19820115    20566863    20075255    20798317    25348373    25401762    26823975    15632085    17994087    18057021    17550304    21719571    25830018    22328714    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    18327897    17030474    19341724    19633650    26369729    21347285    24495485    26108605    20353571    25315136    23537049    27289101   

EMBL

BABH01034202    ODYU01009603    SOQ54149.1    AGBW02014918    OWR40878.1    KZ149945    + More
PZC76803.1    NWSH01001828    PCG69986.1    GDQN01007282    GDQN01004744    JAT83772.1    JAT86310.1    GDQN01011573    GDQN01000546    JAT79481.1    JAT90508.1    BABH01034204    PCG69988.1    PZC76805.1    GGFM01001358    MBW22109.1    AXCM01017510    CH477262    EAT45634.1    GFDL01000940    JAV34105.1    GGFJ01004064    MBW53205.1    ADMH02001421    ETN62603.1    GGFK01001301    MBW34622.1    GGFK01001358    MBW34679.1    AXCN02000025    AAAB01008987    EAA01072.3    GAMD01003100    JAA98490.1    GFDL01010176    JAV24869.1    ATLV01012626    KE524806    KFB36936.1    GEZM01087174    JAV58867.1    GEZM01087172    JAV58870.1    APCN01002031    DS232010    EDS31585.1    JXUM01019135    JXUM01019136    JXUM01019137    JXUM01019138    JXUM01061069    JXUM01061070    KQ562133    KXJ76608.1    GAPW01000826    JAC12772.1    KQ971354    EFA07005.1    DS235787    EEB17090.1    AAZX01002640    GECZ01016693    JAS53076.1    GL441846    EFN64162.1    GFDF01008914    JAV05170.1    GFDF01008925    JAV05159.1    GECU01033826    JAS73880.1    KQ434809    KZC06646.1    GECU01027952    JAS79754.1    GAKP01007876    GAKP01007875    JAC51077.1    GBHO01021429    GBRD01002498    GDHC01012112    JAG22175.1    JAG63323.1    JAQ06517.1    CM000070    EAL26859.1    KQ976500    KYM83149.1    CH479186    EDW39046.1    CP012526    ALC45916.1    CH902617    EDV42007.2    KPU79506.1    CM000160    EDW98917.2    KRK04548.1    GL888932    EGI57148.1    CH480815    EDW43521.1    CH954182    EDV53832.1    GDHF01022865    GDHF01019425    JAI29449.1    JAI32889.1    GBXI01017553    GBXI01016851    GBXI01009293    JAC96738.1    JAC97440.1    JAD04999.1    JQ611724    AFK29239.1    KQ979433    KYN21563.1    AE014297    AHN57505.1    AY069079    BT004893    KQ981673    KYN38407.1    CH940650    EDW66532.1    KRF82754.1    GDAI01001685    JAI15918.1    GEDC01031239    GEDC01019967    GEDC01002587    JAS06059.1    JAS17331.1    JAS34711.1    KQ978068    KYM97528.1    ADTU01011332    ADTU01011333    ADTU01011334    CH916369    EDV93132.1    CH933806    EDW13976.2    KRG00752.1    GEDC01030063    GEDC01024076    GEDC01009683    JAS07235.1    JAS13222.1    JAS27615.1    OUUW01000005    SPP81304.1    KQ982373    KYQ57054.1    GAMC01015402    GAMC01015401    JAB91154.1    GL445852    EFN89021.1    JRES01000835    KNC27900.1    GDHC01008359    JAQ10270.1    GBYB01004652    JAG74419.1    GBYB01003799    JAG73566.1    CH964232    EDW81544.2    KRF99479.1    KRF99480.1    GGMS01011823    MBY81026.1    EZ422687    ADD18963.1    CCAG010007921    GDHF01011418    JAI40896.1    APGK01035351    KB740923    KB632333    ENN78293.1    ERL92718.1    LJIJ01001415    ODM91805.1    KZ288191    PBC34452.1    CM000364    EDX14250.1    LBMM01000159    KMR04695.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000075920    UP000075883    UP000075885    + More
UP000008820    UP000000673    UP000076407    UP000075902    UP000075886    UP000007062    UP000075882    UP000075901    UP000030765    UP000075884    UP000075881    UP000075840    UP000075900    UP000002320    UP000069272    UP000069940    UP000249989    UP000075880    UP000007266    UP000075903    UP000009046    UP000002358    UP000000311    UP000076502    UP000192221    UP000001819    UP000078540    UP000008744    UP000092553    UP000007801    UP000002282    UP000007755    UP000001292    UP000008711    UP000078492    UP000000803    UP000078541    UP000008792    UP000078542    UP000005205    UP000001070    UP000009192    UP000268350    UP000075809    UP000008237    UP000037069    UP000007798    UP000095300    UP000092444    UP000095301    UP000092445    UP000019118    UP000030742    UP000094527    UP000242457    UP000000304    UP000036403   

PRIDE

H9IU72    H9IU37    Q9VC57   

Pfam

PF02263   GBP        + More
PF02841   GBP_C

Interpro

IPR027417   P-loop_NTPase        + More
IPR030386   G_GB1_RHD3_dom       
IPR015894   Guanylate-bd_N       
IPR036543   Guanylate-bd_C_sf       
IPR003191   Guanylate-bd/ATL_C       
IPR000408   Reg_chr_condens       

SUPFAM

SSF48340   SSF48340        + More
SSF52540   SSF52540       

ProteinModelPortal

H9IU72   A0A2H1WM56   A0A212EHC2   A0A2W1BYF7   A0A2A4JDX6   A0A1E1W9U5   + More
A0A1E1VXT1   H9IU37   A0A2A4JE55   A0A2W1BT43   A0A2M3Z0Q2   A0A182VZ50   A0A182MAV6   A0A182P550   Q17GF2   A0A1Q3G2Q7   A0A2M4BJH5   W5JH04   A0A182X0D2   A0A182TUD6   A0A2M4A1J4   A0A2M4A1Q3   A0A182Q5E4   Q7PUS9   T1DN87   A0A1Q3FBH4   A0A182LR64   A0A182T9R3   A0A084VG42   A0A1Y1KJA0   A0A182N454   A0A182K3G1   A0A1Y1KFA2   A0A182I021   A0A182R689   B0WND1   A0A182FNI8   A0A182GUP1   A0A023EUV9   A0A182IZZ3   D6WQT2   A0A182VG90   E0VUN4   K7IUU5   A0A1B6FS83   E2AR16   A0A1L8DFN1   A0A1L8DFC2   A0A1B6HGP8   A0A154P404   A0A1B6HYL4   A0A034W9U4   A0A1W4VPR3   A0A0A9XY37   Q29BY7   A0A195BG18   B4GPG3   A0A0M4EDL5   B3M050   B4PVR8   F4X8E3   B4HH45   B3P712   A0A0K8V1U1   A0A0A1WFI4   I3RSF4   A0A151J9D5   A0A0B4LHV8   Q9VC57   A0A195FDX7   B4LW27   A0A0K8TP26   A0A1B6BYG1   A0A195CBN9   A0A158NBV9   B4JEK1   B4K505   A0A1B6C1Y7   A0A3B0JFY6   A0A151X9P7   W8BN84   E2B5K9   A0A0L0C6K7   A0A146LV81   A0A0C9QVF4   A0A0C9QJW0   A0A158NBW0   B4N8U3   A0A2S2QTC8   A0A1I8Q5V2   D3TMN5   A0A1B0FBF0   A0A1I8MAE9   A0A1A9ZZN1   A0A0K8VPT2   N6TK58   A0A1D2MFP5   A0A2A3ET24   B4QTP6   A0A0J7L9I2  

PDB

3X1D     E-value=1.37724e-153,     Score=1394

KEGG

101745423    K17339 atlastin [EC:3.6.5.-] | (RefSeq) atlastin-like

GO

GO:0005525   GO:0003924   GO:0016021   GO:0051260   GO:0007029   GO:0031114   GO:0042803   GO:0007517   GO:0031227   GO:0008582   GO:0016320   GO:0005874   GO:0005794   GO:0051124   GO:0048691   GO:0007030   GO:0007019   GO:0061025   GO:0032561   GO:0005737   GO:0012505   GO:0007528   GO:0000139   GO:0005783   GO:0016020   GO:0042802   GO:0015031   GO:0006886   GO:0016192   GO:0030117   GO:0007154   GO:0005112   GO:0015930  

Subcellular location

Endoplasmic reticulum membrane  
Golgi apparatus membrane  

Length:

528

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

43.82762

Exp number, first 60 AAs:

0.08092

Total prob of N-in:

0.89394

inside

1  -  423

TMhelix

424  -  446

outside

447  -  455

TMhelix

456  -  478

inside

479  -  528

 

 

Pi

210.182123

Theta

167.636847

Tajima's D

1.751896

CLR

0.014291

CSRT

0.835108244587771

Interpretation

Uncertain