Gene

KWMTBOMO14922

Pre Gene Modal

BGIBMGA000791

Annotation

PREDICTED:_serine/threonine-protein_kinase_D1_[Bombyx_mori]

Location

Bomo_Chr25(+):480043-495423      View in EpiBrowser

Full name

Serine/threonine-protein kinase       + More
Serine/threonine-protein kinase D1      

Alternative Name

Protein kinase C mu type
Protein kinase D
nPKC-D1
nPKC-mu

Location in the cell

Nuclear   Reliability : 2.777

CDS

ATGTGCCCCAAACCGAGGTCGGGCAATCGAACGGTAGATGAGCACGTCAGCACGCGACGGGTGCCTGAATCGGAATGTTGCGGGTTGAACTACCACAAGCGTTGCGCGGTGAAGGTTCCGTCGAACTGCGCGTCGGCGTGCGCGGGCGGGGCGGCGGGCGGTGCGGGGGGCGCGGGCAGCACGCGGCGCCCCTCCGCCGCCGCCCCCCGCAGCCCGTCGCGCTCCTCCCAGCACAGCCACGCCTCGCACGACGACTCGCTGGTGGTAAACAAAAGAAGCAAATCCCCTTCTCGTGTGGTCTGGCCTCTGGGCCAAGGCAGCTCCCTCGGCATTCCTCATACCTTCGAAGTCCACACGTATACCCGGCCTACGGTTTGTCGCCATTGCAAGAAACTACTTCGAGGACTGTTCAAGCAAGGTCTTCAGTGTCGAGATTGTCATTACAATGCGCACAGGAAGTGTCTGCCCTTCGTGCCTAAGGATTGTGGAGGGGAGATACGAGACCAGCACGGAGAAGCGGACAGCGGGACCGGCAGTGAGCTATCGGAGACAGCGCCATTGCTGGACGAGTCTGACGAGGAAGCAACTCCTGATCACGCCGATCGAAATAGCGTGGATGAGGAGGTACAACTACGAAGACAAAGGGATGAGGATTCGGATGAACCGCAACGTGACACACTGCCGGAGCGTTCGGCGAGCCGACCCAGCAGTTCATCGTCATCACCCAGCGCGAACATCCCGCTGATGAGGATAGTGCAGTCGGTGAAGCACACCAAGAAACGGGAGGGACAATGGCTTAAGGAGGGCTGGCTTGTTCACTTTACTAATAAGGATAAGACGCTGAGACGTCACTACTGGCGCCTGGACAGCAAGTCGATAACCCTGTTCACATCGGACCAGGGCACCAAGTACTACAAGGAGATACCGCTCAATGAGATCCTGGCGATCGACACGGCCAGGCAGCCGCAGTCAGAGGTGATGCACTGCTTCGAGCTGCGCACGGCCAACGTGGACTATCTGGTGGGCGCGGAGGCAGGCCCGGGCGGCGCCGTGCCCTCCTCCGGCCTCGGCGCCTACCTCGCGCGCCCCTGGGAGACCGCTCTGCGTCACGCGCTCATGCCCGTGACGCACCACACGCGTCACGCACATCACGCGGTGGATGGCGGGTCGGGGAGTAGCGGGGCCGAGGGCGGGGCTGAAGGCGGGGCTGCGGGGGCCGACGGCGGGGAGGGGGGCGCGGCCTGCGCGGAGGAGAGGGTGACGGATATGGCGCAGCTCTACCACATCCACCCCGACGAGGTGCTGGGGTCTGGCCAGTTTGGAATCGTATACGGCGGCCTGCACCGGAGGACGGACAGACCTGTCGCCATTAAAGTAATAGATAAACTCCGCTTCCCGACCAAACAAGAGGCGCAACTGAAGAATGAAGTGGCCATTCTTCAGAACCTGTCCCACCCCGGCGTCGTGAACCTCGAGAGGATGTTCGAGACCCCGGAGCGGATCTTCGTGGTGATGGAGAAGCTGAAGGGGGACATGCTGGAGATGATCCTCTCGCACGAGAGGGGAAGACTCACCGAGCGAATCACCAAGTTCCTGGTCGCACAGATCCTGGTGGCCCTGAAGCATCTCCACGAGAAGAACATCGTGCACTGCGACCTGAAGCCGGAGAACGTGCTGCTGTCCACGGACGACGAGTTCCCGCAAGTCAAGCTCTGCGACTTCGGGTTCGCGCGCATCATCGGCGAGAAGTCATTCCGGAGATCCGTCGTGGGGACGCCGGCCTACCTGGCTCCGGAAGTGTTGCGCAACAAGGGCTACAACCGCTCGCTCGACATGTGGTCCGTGGGCGTCATCATCTACGTGTCGCTGTCCGGGACGTTCCCCTTCAACGAGGACGAGGACATCAACGAGCAGATACAGAACGCTGCCTTCATGTACCCGCCCGCGCCCTGGAGGGAGATCTCCGCCGAGGCAATCGACCTCATAAACAACCTGTTGCAAGTGAAGCAACGCAAGCGGCTGTCCGTGGACAAGTCCGTGTCCCACTGCTGGCTGCAGACGCGCGAGGCATGGCAGGACCTGCGCGCCCTCGAGCGCCGAGTCGGCACCCGCTACCTCACGCACCCCAGCGACGACGCACGCTGGACACGCTGA

Protein

MCPKPRSGNRTVDEHVSTRRVPESECCGLNYHKRCAVKVPSNCASACAGGAAGGAGGAGSTRRPSAAAPRSPSRSSQHSHASHDDSLVVNKRSKSPSRVVWPLGQGSSLGIPHTFEVHTYTRPTVCRHCKKLLRGLFKQGLQCRDCHYNAHRKCLPFVPKDCGGEIRDQHGEADSGTGSELSETAPLLDESDEEATPDHADRNSVDEEVQLRRQRDEDSDEPQRDTLPERSASRPSSSSSSPSANIPLMRIVQSVKHTKKREGQWLKEGWLVHFTNKDKTLRRHYWRLDSKSITLFTSDQGTKYYKEIPLNEILAIDTARQPQSEVMHCFELRTANVDYLVGAEAGPGGAVPSSGLGAYLARPWETALRHALMPVTHHTRHAHHAVDGGSGSSGAEGGAEGGAAGADGGEGGAACAEERVTDMAQLYHIHPDEVLGSGQFGIVYGGLHRRTDRPVAIKVIDKLRFPTKQEAQLKNEVAILQNLSHPGVVNLERMFETPERIFVVMEKLKGDMLEMILSHERGRLTERITKFLVAQILVALKHLHEKNIVHCDLKPENVLLSTDDEFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINEQIQNAAFMYPPAPWREISAEAIDLINNLLQVKQRKRLSVDKSVSHCWLQTREAWQDLRALERRVGTRYLTHPSDDARWTR

Description

Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-469 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenetic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells (By similarity). Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection (By similarity).

Catalytic Activity

ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]

Cofactor

Mg(2+)

Subunit

Interacts (via N-terminus) with ADAP1/CENTA1. Interacts with MAPK13. Interacts with DAPK1 in an oxidative stress-regulated manner. Interacts with USP28; the interaction induces phosphorylation of USP28 and activated KRAS-mediated stabilization of ZNF304 (By similarity). Interacts with AKAP13 (via C-terminal domain) (By similarity).

Similarity

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.

Keywords

Angiogenesis   Apoptosis   ATP-binding   Cell membrane   Complete proteome   Cytoplasm   Differentiation   Golgi apparatus   Immunity   Inflammatory response   Innate immunity   Kinase   Magnesium   Membrane   Metal-binding   Neurogenesis   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat   Transferase   Zinc   Zinc-finger  

Feature

chain  Serine/threonine-protein kinase

Uniprot

H9IU61   A0A3S2M2I1   A0A194PM08   A0A2H1W480   A0A026VV67   Q17GS6   + More
A0A1S4F342   A0A2W1BP91   U5Q3U4   A0A139WES9   A0A182H9Q1   N6SYX1   F4X1E6   A0A195FRL9   A0A2M4ACC2   A0A2M4ACC3   A0A151WX40   A0A2M4ADM9   A0A195BK94   A0A232EIM1   A0A2M3ZGT9   A0A182M5B1   A0A195DLS6   A0A195CVA2   A0A158NA49   A0A182FJE3   A0A2M4BCQ5   A0A182KA76   A0A1Q3FXD5   A0A182YCM5   E2BAK2   A0A182RZ35   W5JDN3   A0A139WF71   A0A2M4CPE6   A0A182VVP2   A0A088A8E8   A0A0C9QSD0   A0A1W4WN85   A0A2A3E987   A0A1B6DCZ5   A0A0N0BHP1   A0A310SWG2   A0A0L7QR25   A0A182N023   A0A1L8DKS6   A0A154PFX7   A0A1L8DL51   A0A0A9XVX8   A0A1Y1M919   A0A2J7Q1W3   A0A224XJG3   A0A023F3P7   A0A0P4VZQ6   A0A3R7SUA9   A0A0N7ZCN2   A0A2I0UTW7   A0A226ETX1   A0A1V4KFB8   G1TPY2   B4M405   E9G2E3   B4K940   B4JF29   A0A341C9W6   A0A2Y9LQ04   W5MU06   A0A1U7QP75   W5MTZ8   A0A2Y9THQ4   A0A2K5KM13   A0A384A039   A0A0P5C5F1   A0A2Y9TFV5   A0A0P5GEL0   A0A0P6HXR5   A0A0N8AU91   A0A2K6K1X8   A0A2Y9DKX1   A0A2K5KM23   F6R5K3   A0A0P6DSL2   U6DFF8   A0A340YCC6   F7I1N3   A0A0N8ATC7   A0A0P6FU07   W5P4Q9   A0A0P6BHC7   A0A0P5NFS2   A0A2K5EB98   A0A2I3SNQ8   A0A2K6V3G4   A0A0P5W1R9   A0A2K5WZ23   A0A2K5WZC4   A0A2K5EBA4   A0A1D5QQ16   A0A0P5A541   Q9WTQ1  

EC Number

2.7.11.13

Pubmed

19121390    26354079    24508170    30249741    17510324    28756777    + More
24146884    18362917    19820115    26483478    23537049    21719571    28648823    21347285    25244985    20798317    20920257    23761445    25401762    26823975    28004739    25474469    27129103    21993624    17994087    21292972    18464734    20809919    16136131    17431167    15057822    10412981    15514163    15145937    15367659    18784310    22673903   

EMBL

BABH01034181    BABH01034182    RSAL01000057    RVE49778.1    KQ459604    KPI92140.1    + More
ODYU01006241    SOQ47900.1    KK107796    QOIP01000013    EZA47622.1    RLU15226.1    CH477256    EAT45861.1    KZ149945    PZC76788.1    KC896834    AGY49605.1    KQ971354    KYB26446.1    JXUM01121273    KQ566481    KXJ70098.1    APGK01051641    KB741198    ENN72969.1    GL888529    EGI59741.1    KQ981305    KYN42932.1    GGFK01005123    MBW38444.1    GGFK01005124    MBW38445.1    KQ982686    KYQ52327.1    GGFK01005562    MBW38883.1    KQ976455    KYM85112.1    NNAY01004210    OXU18195.1    GGFM01006944    MBW27695.1    AXCM01006825    KQ980734    KYN13796.1    KQ977276    KYN04467.1    ADTU01009967    GGFJ01001662    MBW50803.1    GFDL01002933    JAV32112.1    GL446764    EFN87279.1    ADMH02001467    ETN62472.1    KYB26447.1    GGFL01002883    MBW67061.1    GBYB01006644    JAG76411.1    KZ288325    PBC28034.1    GEDC01013749    JAS23549.1    KQ435747    KOX76512.1    KQ759883    OAD62173.1    KQ414786    KOC60946.1    GFDF01007015    JAV07069.1    KQ434896    KZC10786.1    GFDF01007014    JAV07070.1    GBHO01020581    GDHC01016161    JAG23023.1    JAQ02468.1    GEZM01036985    GEZM01036984    JAV82292.1    NEVH01019377    PNF22567.1    GFTR01007694    JAW08732.1    GBBI01002692    JAC16020.1    GDKW01001588    JAI55007.1    QCYY01001774    ROT75419.1    GDRN01063911    JAI64920.1    KZ505637    PKU49503.1    LNIX01000002    OXA60504.1    LSYS01003385    OPJ83132.1    AAGW02023970    AAGW02023971    AAGW02023972    AAGW02023973    AAGW02023974    AAGW02023975    CH940652    EDW59366.2    GL732530    EFX86325.1    CH933806    EDW14453.2    CH916369    EDV93310.1    AHAT01003849    GDIP01179515    JAJ43887.1    GDIQ01243592    JAK08133.1    GDIQ01020520    JAN74217.1    GDIQ01242331    JAK09394.1    AAPN01002929    AAPN01002930    GDIQ01087885    JAN06852.1    HAAF01009517    CCP81341.1    GDIQ01244843    JAK06882.1    GDIQ01053805    JAN40932.1    AMGL01042243    AMGL01042244    AMGL01042245    AMGL01042246    AMGL01042247    AMGL01042248    AMGL01042249    AMGL01042250    GDIP01014565    JAM89150.1    GDIQ01149470    JAL02256.1    AACZ04059434    AACZ04059435    AACZ04059436    AACZ04059437    AACZ04059438    GDIP01093084    JAM10631.1    AQIA01064312    AQIA01064313    AQIA01064314    AQIA01064315    AQIA01064316    AQIA01064317    AQIA01064318    AQIA01064319    AQIA01064320    AQIA01064321    JSUE03039390    JSUE03039391    JSUE03039392    JSUE03039393    JSUE03039394    JSUE03039395    JSUE03039396    JSUE03039397    GDIP01205016    JAJ18386.1    AABR03048549    AABR03048623    AABR03048825    AABR03049215    AABR03049278    AABR03050321    AABR03052344    AB020616   

Proteomes

UP000005204    UP000283053    UP000053268    UP000053097    UP000279307    UP000008820    + More
UP000007266    UP000069940    UP000249989    UP000019118    UP000007755    UP000078541    UP000075809    UP000078540    UP000215335    UP000075883    UP000078492    UP000078542    UP000005205    UP000069272    UP000075881    UP000076408    UP000008237    UP000075900    UP000000673    UP000075920    UP000005203    UP000192223    UP000242457    UP000053105    UP000053825    UP000075884    UP000076502    UP000235965    UP000283509    UP000198287    UP000190648    UP000001811    UP000008792    UP000000305    UP000009192    UP000001070    UP000252040    UP000248483    UP000018468    UP000189706    UP000233060    UP000261681    UP000248484    UP000233180    UP000248480    UP000002279    UP000265300    UP000008225    UP000002356    UP000233020    UP000002277    UP000233220    UP000233100    UP000006718    UP000002494   

PRIDE

H9IU61    Q9WTQ1   

Pfam

PF00069   Pkinase        + More
PF00169   PH
PF00130   C1_1

Interpro

IPR001849   PH_domain        + More
IPR011009   Kinase-like_dom_sf       
IPR000719   Prot_kinase_dom       
IPR020454   DAG/PE-bd       
IPR002219   PE/DAG-bd       
IPR017441   Protein_kinase_ATP_BS       
IPR011993   PH-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR015727   Protein_Kinase_C_mu-related       

SUPFAM

SSF56112   SSF56112       

Gene 3D

2.30.29.30    

CDD

cd00029  C1

ProteinModelPortal

H9IU61   A0A3S2M2I1   A0A194PM08   A0A2H1W480   A0A026VV67   Q17GS6   + More
A0A1S4F342   A0A2W1BP91   U5Q3U4   A0A139WES9   A0A182H9Q1   N6SYX1   F4X1E6   A0A195FRL9   A0A2M4ACC2   A0A2M4ACC3   A0A151WX40   A0A2M4ADM9   A0A195BK94   A0A232EIM1   A0A2M3ZGT9   A0A182M5B1   A0A195DLS6   A0A195CVA2   A0A158NA49   A0A182FJE3   A0A2M4BCQ5   A0A182KA76   A0A1Q3FXD5   A0A182YCM5   E2BAK2   A0A182RZ35   W5JDN3   A0A139WF71   A0A2M4CPE6   A0A182VVP2   A0A088A8E8   A0A0C9QSD0   A0A1W4WN85   A0A2A3E987   A0A1B6DCZ5   A0A0N0BHP1   A0A310SWG2   A0A0L7QR25   A0A182N023   A0A1L8DKS6   A0A154PFX7   A0A1L8DL51   A0A0A9XVX8   A0A1Y1M919   A0A2J7Q1W3   A0A224XJG3   A0A023F3P7   A0A0P4VZQ6   A0A3R7SUA9   A0A0N7ZCN2   A0A2I0UTW7   A0A226ETX1   A0A1V4KFB8   G1TPY2   B4M405   E9G2E3   B4K940   B4JF29   A0A341C9W6   A0A2Y9LQ04   W5MU06   A0A1U7QP75   W5MTZ8   A0A2Y9THQ4   A0A2K5KM13   A0A384A039   A0A0P5C5F1   A0A2Y9TFV5   A0A0P5GEL0   A0A0P6HXR5   A0A0N8AU91   A0A2K6K1X8   A0A2Y9DKX1   A0A2K5KM23   F6R5K3   A0A0P6DSL2   U6DFF8   A0A340YCC6   F7I1N3   A0A0N8ATC7   A0A0P6FU07   W5P4Q9   A0A0P6BHC7   A0A0P5NFS2   A0A2K5EB98   A0A2I3SNQ8   A0A2K6V3G4   A0A0P5W1R9   A0A2K5WZ23   A0A2K5WZC4   A0A2K5EBA4   A0A1D5QQ16   A0A0P5A541   Q9WTQ1  

PDB

2YCR     E-value=1.16055e-48,     Score=490

KEGG

101737860    K06070 protein kinase D [EC:2.7.11.13] | (RefSeq) serine/threonine-protein kinase D1

GO

GO:0035556   GO:0046872   GO:0004697   GO:0005524   GO:0004674   GO:0005737   GO:0089700   GO:0016021   GO:0010837   GO:0005802   GO:0005911   GO:0005886   GO:0045669   GO:0005634   GO:0042307   GO:0005829   GO:0005938   GO:0050829   GO:0051279   GO:0048193   GO:1901490   GO:0045765   GO:0051092   GO:0006954   GO:0043123   GO:0007030   GO:0010595   GO:0001525   GO:0035924   GO:0046777   GO:0045087   GO:0010976   GO:0045766   GO:0006915   GO:0007265   GO:0031647   GO:0060548   GO:0034599   GO:0004672   GO:0006468   GO:0007154   GO:0016020   GO:0005112   GO:0015930  

PANTHER

PTHR22968  

Subcellular location

Cytoplasm  
Cell membrane   Translocation to the cell membrane is required for kinase activation.   With evidence from 2 publications.
Golgi apparatus   Translocation to the cell membrane is required for kinase activation.   With evidence from 2 publications.
trans-Golgi network   Translocation to the cell membrane is required for kinase activation.   With evidence from 2 publications.

Length:

717

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.237960000000001

Exp number, first 60 AAs:

0.11891

Total prob of N-in:

0.00643

outside

1  -  717

 

 

Pi

243.921366

Theta

172.716745

Tajima's D

1.19921

CLR

0.484629

CSRT

0.712764361781911

Interpretation

Uncertain