Gene

KWMTBOMO14919  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000772

Annotation

juvenile_hormone_esterase_1_precursor_[Bombyx_mori]

Location

Bomo_Chr25(-):430284-446812      View in EpiBrowser

Full name

Carboxylic ester hydrolase       + More
Juvenile hormone esterase      

Location in the cell

PlasmaMembrane   Reliability : 2.766

CDS

ATGTGTACCAAATTCGCTGTATTACTATATTACGTTATCGTGGGCTTAGTAAGGGCATATTCAAGCCCAGCAGCGTCGCCGCCCTCGTCGTGCAATGTGGTCGCGCAGACGGAGTCAGGCTGGGTGTGTGGCCGTAGTCGCCGGGCGGAAGCAAGCACTTTATACGCCAGTTTCCGGGGAGTGCCTTATGCCAAGCAACCAGTCGGAGAACTTCGATTTAAGGAATTACAACCAGCAGAGCCATGGACCGACTACCTAGATGCCACCGAGGAAGGTCCAGTTTGCTACCAGACAGACGTTCTTTATGGAAGTCTGATGAAACCTCACGGCATGAATGAGGCATGCATCTACGCCAATATACATGTGCCTTTGTACGCCCTGCCGGCAGCTGGTGAGACGCCTACGAAGCCTGGTCTTCCAATATTAGTCTTTATTCACGGAGGTGGCTTCGCGTTTGGATCTGGTGATGCTGACCTATATGGACCGGAGTATCTTGTCACAAGAAACGTTGTTGTCATCACTTTTAACTACAGGTTGAATTTCTTTGGATTTTTCTCGTTGGATACTCCTAAAGTCCCCGGAAACAATGGTCTTAGGGACATGGTGACTCTGCTCCGTTGGGTGAAGAGAAACGCCAGGGCCTTTGGAGGTAATCCTGACAACGTGACCTTAGCGGGCCAGAGCGCTGGGGCCGCTGCTGCTCACCTTCTCACCTTATCCAAGGCCACTGAAGGCTTAGTTTCAAGGGCTATATTGATGAGCGGCGCTGGAACGTCCACTTTCTTTACAACATCTCCTATCTTCTCCCAGTCCATCAACAAACTCTTGTTTTCCATCCTTGGCGTCAACTCAACTAATCCTGATGAGATACACGAGAAACTCGTCGCCATGCCGGTTGAAAAACTGAATGAAGCCAACAGAATATTGATTGATCAAATCGGCCTTACCACTTTTTTCCCAGTGGTGGAAACACCGCATCCCGGAATAACCACTATATTAGATGAAGATCCAAATATTCTGGTCCAGCAAGGCCGCGGTAAAGACATACCCTTGATTATAGGTTTCACGAATTCTGAATGCCATATGTTCCAGCGTAGATTTGAACAGATCGATATAGTATCTAAGATCAATGAAAATCCAGCAATCTTAGTTCCTTCCAATCTACTGTACTCCTCGACTCCTGAGACGATTGCTTTGGTCTCGAATCAAATCAGCCAAAGATACTTCAATGGTAGCGTAGATCTGGAGGGCTTTATCAATATGTGTACCGATAGTTACTACAAGTACCCAGCCTTGAATTTGGCCGAGAAGAGATCTACGGCAGGTGATGCTCCGGTATTTCTGTACCAGTTCTCTTACGACGGTTACAGCGTGTTCAAGCAAGCCTTTCATTTGCATTTCAACGGTGCCGGACACGCGGACGACTTGACATACGTGCTGAAAGTGAATTCTGCGTCAGGGACTAGTTCATCACAAAAAGCAGACGATGAAATGAAATATTGGATGACGACGTTCGTCACAAACTTTATGCGATGCAGTGCTCCTATGTGCGATGAAACCACAGCGTGGCCACCAGTTACACCGCGGGAACTACAATACCAAGACATTATTACACCCAACTTATGCCACCAAACTAGTCTTACCAAAGAACAACTCGAAATGAAGAATTTCTTCGATAAGATCCATAACGGAGGTGAAAGCAGACTTAAGTAA

Protein

MCTKFAVLLYYVIVGLVRAYSSPAASPPSSCNVVAQTESGWVCGRSRRAEASTLYASFRGVPYAKQPVGELRFKELQPAEPWTDYLDATEEGPVCYQTDVLYGSLMKPHGMNEACIYANIHVPLYALPAAGETPTKPGLPILVFIHGGGFAFGSGDADLYGPEYLVTRNVVVITFNYRLNFFGFFSLDTPKVPGNNGLRDMVTLLRWVKRNARAFGGNPDNVTLAGQSAGAAAAHLLTLSKATEGLVSRAILMSGAGTSTFFTTSPIFSQSINKLLFSILGVNSTNPDEIHEKLVAMPVEKLNEANRILIDQIGLTTFFPVVETPHPGITTILDEDPNILVQQGRGKDIPLIIGFTNSECHMFQRRFEQIDIVSKINENPAILVPSNLLYSSTPETIALVSNQISQRYFNGSVDLEGFINMCTDSYYKYPALNLAEKRSTAGDAPVFLYQFSYDGYSVFKQAFHLHFNGAGHADDLTYVLKVNSASGTSSSQKADDEMKYWMTTFVTNFMRCSAPMCDETTAWPPVTPRELQYQDIITPNLCHQTSLTKEQLEMKNFFDKIHNGGESRLK

Description

JH esterase plays a crucial role in the decrease of JH activity in lepidopteran insects, by hydrolyzing the methyl ester of JH. It is also involved in the transport of JH.

Catalytic Activity

H2O + juvenile hormone I = H(+) + juvenile hormone I carboxylate + methanol
H2O + juvenile hormone III = H(+) + juvenile hormone III carboxylate + methanol

Similarity

Belongs to the type-B carboxylesterase/lipase family.

Keywords

Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Serine esterase   Signal  

Feature

chain  Carboxylic ester hydrolase

Uniprot

Q6RVD1   Q8WSJ5   H9IU42   Q9GPG0   O44422   P12992   + More
O44423   L7R4S7   A0A2W1BVG5   F8RGS7   A0A1Z2RRH5   A0A194PFJ1   A0A1U9X1Y0   B1Q145   A0A1J0M116   D3GDL3   A0A0G4DCW7   A0A2H1WHM9   A0A2W1BP85   A0A194RGX0   A0A0L7LFR4   A0A0K0XRW8   Q7M4E5   C3VMY5   A0A0R6CIR0   D5G3F5   Q9XZN4   D3GDM6   A0A2W1BNZ2   E7E1H7   A8VJM0   A0A3S2PFA1   A0A0Y0BVU8   A0A212EHB6   H9IU46   A0A1L8D6I6   A0A3S2NFJ4   E7E1H9   H9IU44   E1CGA5   A0A1U9X1T9   U5KKB9   E7E1H4   A0A2H1WQU1   A0A2H1WAN4   A0A2U3T8L0   A0A1L8D6V8   A0A1L8D6R0   A0A1L8D6I3   A0A1L8D6H3   A0A0L7LFI0   A0A1U9X1U0   A0A1U9X1S8   A0A1L8D6P7   A0A0L7LFZ6   E7E1H5   E7E1H8   A0A2S0D933   A0A2S0D881   A0A291P123   A0A0K8TVU9   A0A2U3T8L5   A0A1U9X1V7   A0A2W1BKQ4   A0A2W1BR44   A0A0K8TUL7   F1C4B8   A0A1U9X1X0   J7HWI3   H9JN84   D3GDL4   A0A2W1BKK3   A9LS22   A0A2A4JEW3   A0A109QN31   A0A0K1YWC6   A0A2A4JFQ0   A0A1J0M1C9   A0A139WFP4   A0A0Y0B016   A0A2U3T8J6   A0A1L8D6K5   A0A1L8D6L5   A0A2W1B1E5   D5G3E6   A0A2A4JYH8   A0A0K8TVV4   A0A0K0XRV7   A0A2A4JX20   A0A2H1VCP7   A0A1U9X1T3   A0A291P117   A0A0K8TVA5   A0A291P0V7   A0A3S2NFG0   G3CM70  

EC Number

3.1.1.-
3.1.1.59

Pubmed

12020837    19121390    11719069    12609517    16566578    2745451    + More
28756777    28605547    26354079    25727179    26227816    26198868    7945209    20005949    10221775    21549123    26778204    22118469    21071843    24053512    28986331    26017144    18362917    19820115   

EMBL

AY489292    AAR37335.1    AF287267    AAL55240.1    BABH01034175    AF327882    + More
AAG42021.2    AF037196    AAC38822.1    J04955    AF037197    AAB96654.1    JQ901384    AGB93712.1    KZ149945    PZC76780.1    HM588760    AEB77712.1    KY938807    ASA46448.1    KQ459604    KPI92141.1    KY021876    AQY62765.1    EU523701    ACB12192.1    KU375426    APD13868.1    FJ652445    ACV60229.1    LC012033    BAR88201.1    ODYU01008725    SOQ52573.1    PZC76778.1    KQ460205    KPJ17063.1    JTDY01001282    KOB74302.1    KP938886    AKS40367.1    FJ875998    ACO81854.2    KM926341    AJR27471.1    FJ997319    ADF43484.1    AF153367    AAD34172.1    FJ652458    ACV60242.1    PZC76779.1    HQ588158    ADU25009.1    EU178813    ABW24129.1    RSAL01000057    RVE49776.1    KU215370    AMB19664.1    AGBW02014918    OWR40861.1    BABH01034170    BABH01034171    GEYN01000063    JAV02066.1    RVE49777.1    ADU25010.1    BABH01034174    AB543061    BAJ11978.1    KY021831    AQY62720.1    JX866744    AGS49148.1    HQ588155    ADU25006.1    ODYU01010342    SOQ55377.1    ODYU01007337    SOQ50016.1    KX015865    ARM65394.1    GEYN01000059    JAV02070.1    GEYN01000072    JAV02057.1    GEYN01000067    JAV02062.1    GEYN01000073    JAV02056.1    KOB74303.1    KY021836    AQY62725.1    KY021830    AQY62719.1    GEYN01000064    JAV02065.1    KOB74304.1    HQ588156    ADU25007.1    ADU25011.1    KX015857    ARM65386.1    KX015872    ARM65401.1    MF687624    ATJ44550.1    GCVX01000040    JAI18190.1    KX015873    ARM65402.1    KY021851    AQY62740.1    KZ150061    PZC74214.1    PZC74213.1    GCVX01000041    JAI18189.1    HQ199328    ADX30519.1    KY021861    AQY62750.1    JX489387    GEYN01000055    AFQ20792.1    JAV02074.1    BABH01033219    FJ652446    ACV60230.1    PZC74215.1    EU255790    ABX46627.1    NWSH01001642    PCG70597.1    KU215373    AMB19667.1    KP859354    AKZ17664.1    PCG70596.1    KU375427    APD13869.1    KQ971352    KYB26709.1    KU215369    AMB19663.1    KX015845    ARM65374.1    GEYN01000043    JAV02086.1    GEYN01000033    JAV02096.1    KZ150466    PZC70779.1    FJ997310    ADF43475.1    NWSH01000416    PCG76543.1    GCVX01000035    JAI18195.1    KP938875    AKS40356.1    PCG76541.1    ODYU01001848    SOQ38619.1    KY021826    AQY62715.1    MF687633    ATJ44559.1    GCVX01000034    JAI18196.1    MF687564    ATJ44490.1    RSAL01000139    RVE46156.1    HQ122616    AEL33699.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000037510    UP000283053    UP000007151    + More
UP000218220    UP000007266   

PRIDE

Q6RVD1    Q8WSJ5    H9IU42    P12992    H9IU46    H9IU44    + More
E1CGA5    H9JN84    A9LS22   

Pfam

PF00135   COesterase        + More
PF00083   Sugar_tr

Interpro

IPR029058   AB_hydrolase        + More
IPR019826   Carboxylesterase_B_AS       
IPR002018   CarbesteraseB       
IPR019819   Carboxylesterase_B_CS       
IPR000997   Cholinesterase       
IPR005829   Sugar_transporter_CS       
IPR020846   MFS_dom       
IPR036259   MFS_trans_sf       
IPR005828   MFS_sugar_transport-like       
IPR011049   Serralysin-like_metalloprot_C       

SUPFAM

SSF53474   SSF53474        + More
SSF103473   SSF103473       

Gene 3D

3.40.50.1820     2.150.10.10    

CDD

cd06174  MFS

ProteinModelPortal

Q6RVD1   Q8WSJ5   H9IU42   Q9GPG0   O44422   P12992   + More
O44423   L7R4S7   A0A2W1BVG5   F8RGS7   A0A1Z2RRH5   A0A194PFJ1   A0A1U9X1Y0   B1Q145   A0A1J0M116   D3GDL3   A0A0G4DCW7   A0A2H1WHM9   A0A2W1BP85   A0A194RGX0   A0A0L7LFR4   A0A0K0XRW8   Q7M4E5   C3VMY5   A0A0R6CIR0   D5G3F5   Q9XZN4   D3GDM6   A0A2W1BNZ2   E7E1H7   A8VJM0   A0A3S2PFA1   A0A0Y0BVU8   A0A212EHB6   H9IU46   A0A1L8D6I6   A0A3S2NFJ4   E7E1H9   H9IU44   E1CGA5   A0A1U9X1T9   U5KKB9   E7E1H4   A0A2H1WQU1   A0A2H1WAN4   A0A2U3T8L0   A0A1L8D6V8   A0A1L8D6R0   A0A1L8D6I3   A0A1L8D6H3   A0A0L7LFI0   A0A1U9X1U0   A0A1U9X1S8   A0A1L8D6P7   A0A0L7LFZ6   E7E1H5   E7E1H8   A0A2S0D933   A0A2S0D881   A0A291P123   A0A0K8TVU9   A0A2U3T8L5   A0A1U9X1V7   A0A2W1BKQ4   A0A2W1BR44   A0A0K8TUL7   F1C4B8   A0A1U9X1X0   J7HWI3   H9JN84   D3GDL4   A0A2W1BKK3   A9LS22   A0A2A4JEW3   A0A109QN31   A0A0K1YWC6   A0A2A4JFQ0   A0A1J0M1C9   A0A139WFP4   A0A0Y0B016   A0A2U3T8J6   A0A1L8D6K5   A0A1L8D6L5   A0A2W1B1E5   D5G3E6   A0A2A4JYH8   A0A0K8TVV4   A0A0K0XRV7   A0A2A4JX20   A0A2H1VCP7   A0A1U9X1T3   A0A291P117   A0A0K8TVA5   A0A291P0V7   A0A3S2NFG0   G3CM70  

PDB

2FJ0     E-value=0,     Score=1640

KEGG

692579    no KO assigned | (RefSeq) jhe1, Bmjhe1, Jhe; juvenile hormone esterase 1

GO

GO:0016787   GO:0004453   GO:0016021   GO:0004104   GO:0005615   GO:0022857   GO:0052689  

SignalP

Position:   1 - 21,         Likelihood:  0.975178

 

 

Length:

570

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.44527999999998

Exp number, first 60 AAs:

4.24375

Total prob of N-in:

0.23107

outside

1  -  570

 

 

Pi

194.316043

Theta

164.315339

Tajima's D

0.787133

CLR

0.040256

CSRT

0.593770311484426

Interpretation

Uncertain