Gene

KWMTBOMO14917  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000775

Annotation

PREDICTED:_juvenile_hormone_esterase-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr25(-):396762-401172      View in EpiBrowser

Full name

Carboxylic ester hydrolase       + More
Juvenile hormone esterase      

Location in the cell

PlasmaMembrane   Reliability : 2.826

CDS

ATGGATTTAGAGACATCTGTATTTATAACAGCAGTATATGGAGAGTTCTGCATCACAGAATGTGAGGTTCCAGTGAATATCGACTCAGGACCAGTGTGCGGGAGAGAAGAAACTGCAGAGAACAATACGAAATACTACAGCTTTCAAGGTATTCCGTATGCGAAACCACCGGTAGGATCCAAGAGATTTGCGGAACTAGAACCTATTGAGTCGTGGAGTGATCCATTTTATGCTTACGAGGAAGGACCGGCTTGTCCATCAAGAGACCTTGTCTACGGCAGCATCACCGTGAAACCTAAAGGCATGAGTGAAGACTGTATCTATGTTAACGTCTTTGTACCGGCCACTGCATGTTTGGACTGTGATTGTCTTAAGGACGACCTACTGCCTATACTGGTGAACATTCACGGAGGTACATTCAATACTGGGTCTGGAAATAGAGATTTGCATGGACCAGAATTATTAATGGTGAAAAATGTCATTGTAATTAATTTTAACTTCAGGTTGGCAGTATTTGGATACTTGTCTCTTGCCTCTGGCAAGATCCCAGGTAACAACAGTCTGCGCGACATGGTCACACTGTTACAGTGGGTTCAGAGAAACGCGCGCGCCTTTGGAGGGGATCCTAGACGAGTGACATTGCTTGGAGAAAGTTCTGGAGCAGCATCGGTTCACCTTTTAATGTTATCCCAAGCCGCTAGAGGACTTTTCGAGAAAGGTATAATAATGAGTGGCTCCGCTATGGCAAATTTCTACACTGCATCTCCAATATACGCTAAAATGATCGCCGAAATGTTCCTCCAAGAACTGGGTTTGAATTGTACTGATCCTGATGAAATTCATAAGACACTGACTGAACTACCTTTAGAAGATATAATGAGAGCCAATGATGTTGTGCAATATAAAACAGGTCCCACCTCGTTCGCACCGGTCGTTGAGATAGAGGATCACGAATATACCAGAATTATTGACGATGACCCCATAGCTCTCATCGCACAAGGTCGAGCAAAAGATATTCCACTACTAATGGGTTTCAATCGCGATGAAGGAGAATTTGCCAAATGGATTATAATGATTTTGGATGTTGTGAATCGTTATAAAAGTAATCCTGCAATCATATTAGGACTAAGACTAGCGTACGCATTGCCTTCTGAGGAAGCTTTCGCGAAAGGAAGGTTTGTGGGAAAAAGATATTTTGATGGTGAACCCACATTGGATGGGTTAGCAAAAAGTATGACGGATATTCTATTTCAATATTCTATGATAAAACTGGCACAATGGAGAGTATTGTTGAGATCAGCGCCGACGTATTTCTACCTATTTTCGTATGAGAGTGATTTTAGCAGTGTAAAGAGAGCCAACTGGTTAAGTTACAAAGGAACGGCCCACGTCGAGGATCTGACGTACGTGTTTCGCACCACTACATTTCTTCGCGATCACGTGTCGATTCCTCCTCAGACTAGGGATGATCACATGAGGGATTGGATGTCCACTTTGTTCAGTAACTACGTAAAATGCAAGTCAGTATTGTTCTTTCATACAAAATGCACGATGGTTCTTGGCTTGGTTCACCTGATCGTGGACTCACGTTTGAAGTTTTGTTTCAGTAACCCGACATGCACTGAGCTCGATGATCCTCGGTGGCCCCCCACCGATATGAAAGAGTTGATGTATCAAGTCATTCGAGAGCCTCATGTTTACAATATGTCCACTCTATCCGACGAGTTGATGGAAATGGTGGAGTTTGTCGACAGCGTCGACGACCAAGTCAGGAAAGGACTGTCTGACTTCATTGTTTAG

Protein

MDLETSVFITAVYGEFCITECEVPVNIDSGPVCGREETAENNTKYYSFQGIPYAKPPVGSKRFAELEPIESWSDPFYAYEEGPACPSRDLVYGSITVKPKGMSEDCIYVNVFVPATACLDCDCLKDDLLPILVNIHGGTFNTGSGNRDLHGPELLMVKNVIVINFNFRLAVFGYLSLASGKIPGNNSLRDMVTLLQWVQRNARAFGGDPRRVTLLGESSGAASVHLLMLSQAARGLFEKGIIMSGSAMANFYTASPIYAKMIAEMFLQELGLNCTDPDEIHKTLTELPLEDIMRANDVVQYKTGPTSFAPVVEIEDHEYTRIIDDDPIALIAQGRAKDIPLLMGFNRDEGEFAKWIIMILDVVNRYKSNPAIILGLRLAYALPSEEAFAKGRFVGKRYFDGEPTLDGLAKSMTDILFQYSMIKLAQWRVLLRSAPTYFYLFSYESDFSSVKRANWLSYKGTAHVEDLTYVFRTTTFLRDHVSIPPQTRDDHMRDWMSTLFSNYVKCKSVLFFHTKCTMVLGLVHLIVDSRLKFCFSNPTCTELDDPRWPPTDMKELMYQVIREPHVYNMSTLSDELMEMVEFVDSVDDQVRKGLSDFIV

Description

JH esterase plays a crucial role in the decrease of JH activity in lepidopteran insects, by hydrolyzing the methyl ester of JH. It is also involved in the transport of JH.

Catalytic Activity

H2O + juvenile hormone I = H(+) + juvenile hormone I carboxylate + methanol
H2O + juvenile hormone III = H(+) + juvenile hormone III carboxylate + methanol

Similarity

Belongs to the type-B carboxylesterase/lipase family.

Keywords

Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Serine esterase   Signal  

Feature

chain  Carboxylic ester hydrolase

Uniprot

H9IU45   H9IU44   E1CGA5   H9IU46   D3GDM6   Q7M4E5   + More
A0A2W1BP85   E7E1H7   A0A2W1BNZ2   A0A2U3T8L0   A8VJM0   Q9GPG0   A0A1U9X1Y0   Q8WSJ5   H9IU42   A0A212EHB6   Q6RVD1   A0A0L7LFR4   U5KKB9   E7E1H9   O44423   O44422   A0A2W1BVG5   P12992   A0A1J0M116   E7E1H4   F8RGS7   L7R4S7   A0A2H1WQU1   A0A194PFJ1   D3GDL3   A0A194RGX0   A0A0L7LFI0   A0A2H1WAN4   A0A1Z2RRH5   A0A0G4DCW7   A0A2H1WHM9   D5G3F5   C3VMY5   A0A0R6CIR0   B1Q145   A0A0Y0BVU8   Q9XZN4   A0A2S0D933   A0A3S2PFA1   A0A0K0XRW8   E7E1H5   A0A3S2NFJ4   A0A1L8D6H3   E7E1H8   A0A1U9X1T9   A0A1L8D6I3   A0A0L7LFZ6   A0A1L8D6V8   A0A1U9X1U0   A0A1L8D6R0   A0A1L8D6I6   A0A1U9X1S8   A0A1L8D6P7   A0A1U9X1X0   Q5ZEX7   Q5ZEX6   Q5ZEX9   Q5ZEX8   Q5GN70   V5GUX3   A0A0Y0BA98   A0A109QN31   A0A139WFP4   A0A194RDD6   D6WU45   A0A182VPK2   A0A2J7RMN7   A0A084VDQ4   A0A182PZ50   A0A1B6LQA7   A0A182IIK4   A0A1B6MMM2   A0A182QA60   A0A2A4J274   A0A291P0V7   A0A1J1IS39   A0A182XUK3   A0A2H1V381   Q5ZEX5   A0A291P117   Q7QCY4   D8UUL2   G3CM70   F8V329   A0A0K1YWC6   A0A2J7RMN3   A0A194PTN5   A0A2J7RMP3   A0A2J7RMQ5   A0A1W4XHU4   A0A0A7ENT2  

EC Number

3.1.1.-
3.1.1.59

Pubmed

19121390    21071843    7945209    28756777    21549123    11719069    + More
12609517    16566578    12020837    22118469    26227816    24053512    2745451    26354079    28605547    25727179    20005949    26778204    10221775    26198868    15946860    18362917    19820115    24438588    28986331    12364791    14747013    17210077    19802899    23603019   

EMBL

BABH01034171    BABH01034174    AB543061    BAJ11978.1    BABH01034170    FJ652458    + More
ACV60242.1    KZ149945    PZC76778.1    HQ588158    ADU25009.1    PZC76779.1    KX015865    ARM65394.1    EU178813    ABW24129.1    AF327882    AAG42021.2    KY021876    AQY62765.1    AF287267    AAL55240.1    BABH01034175    AGBW02014918    OWR40861.1    AY489292    AAR37335.1    JTDY01001282    KOB74302.1    JX866744    AGS49148.1    ADU25010.1    AF037197    AAB96654.1    AF037196    AAC38822.1    PZC76780.1    J04955    KU375426    APD13868.1    HQ588155    ADU25006.1    HM588760    AEB77712.1    JQ901384    AGB93712.1    ODYU01010342    SOQ55377.1    KQ459604    KPI92141.1    FJ652445    ACV60229.1    KQ460205    KPJ17063.1    KOB74303.1    ODYU01007337    SOQ50016.1    KY938807    ASA46448.1    LC012033    BAR88201.1    ODYU01008725    SOQ52573.1    FJ997319    ADF43484.1    FJ875998    ACO81854.2    KM926341    AJR27471.1    EU523701    ACB12192.1    KU215370    AMB19664.1    AF153367    AAD34172.1    KX015857    ARM65386.1    RSAL01000057    RVE49776.1    KP938886    AKS40367.1    HQ588156    ADU25007.1    RVE49777.1    GEYN01000073    JAV02056.1    ADU25011.1    KY021831    AQY62720.1    GEYN01000067    JAV02062.1    KOB74304.1    GEYN01000059    JAV02070.1    KY021836    AQY62725.1    GEYN01000072    JAV02057.1    GEYN01000063    JAV02066.1    KY021830    AQY62719.1    GEYN01000064    JAV02065.1    KY021861    AQY62750.1    AJ845189    CAH60166.1    AJ845190    CAH60167.1    AJ845187    CAH60164.1    AJ845188    CAH60165.1    AJ844897    CAH59956.1    GALX01003004    JAB65462.1    KU215371    AMB19665.1    KU215373    AMB19667.1    KQ971352    KYB26709.1    KQ460323    KPJ15853.1    EFA06763.1    NEVH01002552    PNF42088.1    ATLV01011653    KE524705    KFB36098.1    GEBQ01014077    JAT25900.1    APCN01000584    GEBQ01002779    JAT37198.1    AXCN02000324    NWSH01003954    PCG65624.1    MF687564    ATJ44490.1    CVRI01000059    CRL02968.1    ODYU01000269    SOQ34744.1    AJ845191    CAH60168.1    MF687633    ATJ44559.1    AAAB01008859    EAA07742.3    GQ180944    ACT53736.1    HQ122616    AEL33699.1    JN019808    AEJ18172.1    KP859354    AKZ17664.1    PNF42097.1    KQ459592    KPI96776.1    PNF42100.1    PNF42099.1    KM234964    AIY68378.1   

Proteomes

UP000005204    UP000007151    UP000037510    UP000053268    UP000053240    UP000283053    + More
UP000007266    UP000075903    UP000235965    UP000030765    UP000075885    UP000075840    UP000075886    UP000218220    UP000183832    UP000076407    UP000007062    UP000192223   

PRIDE

H9IU45    H9IU44    E1CGA5    H9IU46    Q8WSJ5    H9IU42    + More
Q6RVD1    P12992   

Pfam

PF00135   COesterase        + More
PF00083   Sugar_tr
PF10300   DUF3808

Interpro

IPR029058   AB_hydrolase        + More
IPR002018   CarbesteraseB       
IPR019826   Carboxylesterase_B_AS       
IPR019819   Carboxylesterase_B_CS       
IPR000997   Cholinesterase       
IPR005829   Sugar_transporter_CS       
IPR020846   MFS_dom       
IPR036259   MFS_trans_sf       
IPR005828   MFS_sugar_transport-like       
IPR002168   Lipase_GDXG_HIS_AS       
IPR019412   Iml2/TPR_39       
IPR011990   TPR-like_helical_dom_sf       

SUPFAM

SSF53474   SSF53474        + More
SSF103473   SSF103473       
SSF48452   SSF48452       

Gene 3D

3.40.50.1820     1.25.40.10    

CDD

cd06174  MFS

ProteinModelPortal

H9IU45   H9IU44   E1CGA5   H9IU46   D3GDM6   Q7M4E5   + More
A0A2W1BP85   E7E1H7   A0A2W1BNZ2   A0A2U3T8L0   A8VJM0   Q9GPG0   A0A1U9X1Y0   Q8WSJ5   H9IU42   A0A212EHB6   Q6RVD1   A0A0L7LFR4   U5KKB9   E7E1H9   O44423   O44422   A0A2W1BVG5   P12992   A0A1J0M116   E7E1H4   F8RGS7   L7R4S7   A0A2H1WQU1   A0A194PFJ1   D3GDL3   A0A194RGX0   A0A0L7LFI0   A0A2H1WAN4   A0A1Z2RRH5   A0A0G4DCW7   A0A2H1WHM9   D5G3F5   C3VMY5   A0A0R6CIR0   B1Q145   A0A0Y0BVU8   Q9XZN4   A0A2S0D933   A0A3S2PFA1   A0A0K0XRW8   E7E1H5   A0A3S2NFJ4   A0A1L8D6H3   E7E1H8   A0A1U9X1T9   A0A1L8D6I3   A0A0L7LFZ6   A0A1L8D6V8   A0A1U9X1U0   A0A1L8D6R0   A0A1L8D6I6   A0A1U9X1S8   A0A1L8D6P7   A0A1U9X1X0   Q5ZEX7   Q5ZEX6   Q5ZEX9   Q5ZEX8   Q5GN70   V5GUX3   A0A0Y0BA98   A0A109QN31   A0A139WFP4   A0A194RDD6   D6WU45   A0A182VPK2   A0A2J7RMN7   A0A084VDQ4   A0A182PZ50   A0A1B6LQA7   A0A182IIK4   A0A1B6MMM2   A0A182QA60   A0A2A4J274   A0A291P0V7   A0A1J1IS39   A0A182XUK3   A0A2H1V381   Q5ZEX5   A0A291P117   Q7QCY4   D8UUL2   G3CM70   F8V329   A0A0K1YWC6   A0A2J7RMN3   A0A194PTN5   A0A2J7RMP3   A0A2J7RMQ5   A0A1W4XHU4   A0A0A7ENT2  

PDB

2FJ0     E-value=2.50468e-128,     Score=1176

KEGG

101737581    no KO assigned | (RefSeq) juvenile hormone esterase-like

GO

GO:0016787   GO:0016021   GO:0004453   GO:0080030   GO:0004104   GO:0005615   GO:0022857   GO:0052689  

PANTHER

PTHR31859  

Length:

599

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.80856

Exp number, first 60 AAs:

0.00143

Total prob of N-in:

0.00820

outside

1  -  599

 

 

Pi

176.738796

Theta

170.308987

Tajima's D

0.650854

CLR

0.628512

CSRT

0.55647217639118

Interpretation

Uncertain