Gene

KWMTBOMO14916  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA000776

Annotation

PREDICTED:_juvenile_hormone_esterase-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr25(-):384494-392182      View in EpiBrowser

Full name

Carboxylic ester hydrolase       + More
Juvenile hormone esterase      

Location in the cell

PlasmaMembrane   Reliability : 2.366

CDS

ATGAGCCACTACACCACGGCTTTACTTGGTCTGCTTTTCGTCGTTTGTGGTGTATTCTGCAATGAGCAATGTGGGGTGTTGGTGAACATCGACTCTGGGCCTGTGTGCGGGAAGGTGGAGATTGCCGAAAACAGCACCAAATACTACAGCTTCCAGGGAATACCGTACGGGAAACCACCCACAGGAGCCAGGAGATTTGCAGAATTAGAGCCTGTGGAGCCATGGACTGATCTATTATATGCTTACGAAGAAGGACCAGCTTGTCCTTCGAGAGACATTATCTATGGCAGCATTACTATCAAGGCCAAGGGCGTCAGCGAAGACTGTATCTATGCCAATGTCTTTGTGCCCGCGACCGCTCAACTAAACACCGATGAACTCAGCGAAGTTAGTTTACTGCCCATACTGGTGAACATCCACGGGGGCGCCTTCAATGCAGGGTCGGGCAATCGGGATTTGCACGGACCAGAGTTATTGATGGTGAAAGATGTTATTGTGATCAATTTTAATTACAGATTGGCGGTTTTCGGATTTTTATCCCTTGCTTCGGATAAGATTCCGGGTAACAACGGTCTGCGCGACATGGTGACACTGCTACGCTGGGTTCAAAGAAACGCACGAGTCTTTGGGGGGGATCCTGATAAAGTGACAGTGCTCGGAGAGAGCGCTGGGGCTGCATCGGTTAATCTTTTAATGATGTCTGATGCCGCTAAGGGACTTTTCAACAAAGCCATAATAATGAGTGGTACAGCTTTTCCAAGCTTCTACAGCACCTCTGCGGTATACGCCAAATATGTCGCCGATTTTTTCCTCGGACAATTGGGTGTTAACTCTACTGATCCTGATGAAATTCATCAGATTTTAATTGAACTACCTTTAGAAGACATCATGAAGGCCAATGACGTGGTGCAATACAATTCAGGTATAGCCTCGTTCGTGCCGGTAGTGGAAATTGAAGGTCATAACTATACGAGGATTATTGATGACGACCCCATAGTTCTCATAGCAGAGGGTCGGGGTAAGGATATTCCCTTACTAATGGGTTTCAATCAGAATGAAGGAGAAACATTCAGGTGGCTTTTAACCATTATGGATGCGTTAACTCGTTACAAAACTAATCCGGCTGCTATATTATCACCGAGATTAGCTTACGAGTTATCGACAGAAGAAGCTTTGGCTAAAGCAGAATTAGTAGCGAAAAGATATTTTGACGGTGAAGTGACTATGGATGGTTTCATAAAAAGTGTAACAGATCAATTGTTCCAATATCCTATTATAAAACTAGCACAATGGAGAACATTGCTGAATTCAGCACCGACTTTTCTGTACGTATTTTCGTATCAGGGTGACATCAGCATTATAAAGAGATCTAACTGGTTAAGTTACAACGGTACAGGTCATGTCGAGGATCTGACGTACGTGTTTCGCACCACCACATTTCTCCGCGATCACGTATCGATTCCTCCTCAGACTAGGGATGATCACATGAGGGACTGGATGTCCACACTGTTCAGTAACTACGTAAAATGCAACAATCCGACATGCACAGAGTCTGATGATCCTCAGTGGCCACCGATCAATCAAACAGAGTTAATGTATCAACTCATTAAAGAGCCCAACGTCTACAGCCTGTCCGCTCTGTCTGATGAGTTCAAGACAATGGTTGAGTTCTGCGATAGCGTGGATGACCAAGTCAGGACACGTTCAGAGACTTTCAAGCAGCAACACGGTTAA

Protein

MSHYTTALLGLLFVVCGVFCNEQCGVLVNIDSGPVCGKVEIAENSTKYYSFQGIPYGKPPTGARRFAELEPVEPWTDLLYAYEEGPACPSRDIIYGSITIKAKGVSEDCIYANVFVPATAQLNTDELSEVSLLPILVNIHGGAFNAGSGNRDLHGPELLMVKDVIVINFNYRLAVFGFLSLASDKIPGNNGLRDMVTLLRWVQRNARVFGGDPDKVTVLGESAGAASVNLLMMSDAAKGLFNKAIIMSGTAFPSFYSTSAVYAKYVADFFLGQLGVNSTDPDEIHQILIELPLEDIMKANDVVQYNSGIASFVPVVEIEGHNYTRIIDDDPIVLIAEGRGKDIPLLMGFNQNEGETFRWLLTIMDALTRYKTNPAAILSPRLAYELSTEEALAKAELVAKRYFDGEVTMDGFIKSVTDQLFQYPIIKLAQWRTLLNSAPTFLYVFSYQGDISIIKRSNWLSYNGTGHVEDLTYVFRTTTFLRDHVSIPPQTRDDHMRDWMSTLFSNYVKCNNPTCTESDDPQWPPINQTELMYQLIKEPNVYSLSALSDEFKTMVEFCDSVDDQVRTRSETFKQQHG

Description

JH esterase plays a crucial role in the decrease of JH activity in lepidopteran insects, by hydrolyzing the methyl ester of JH. It is also involved in the transport of JH.

Catalytic Activity

H2O + juvenile hormone I = H(+) + juvenile hormone I carboxylate + methanol
H2O + juvenile hormone III = H(+) + juvenile hormone III carboxylate + methanol

Similarity

Belongs to the type-B carboxylesterase/lipase family.

Keywords

Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Serine esterase   Signal  

Feature

chain  Carboxylic ester hydrolase

Uniprot

H9IU46   E1CGA5   H9IU44   H9IU45   D3GDM6   A0A2W1BP85   + More
Q9GPG0   A0A2U3T8L0   A0A2W1BNZ2   Q7M4E5   E7E1H7   Q8WSJ5   H9IU42   Q6RVD1   A0A1U9X1Y0   A8VJM0   O44423   O44422   P12992   L7R4S7   A0A2W1BVG5   F8RGS7   A0A1Z2RRH5   C3VMY5   A0A212EHB6   A0A0L7LFR4   A0A0R6CIR0   A0A194RGX0   A0A1J0M116   A0A194PFJ1   A0A0G4DCW7   U5KKB9   B1Q145   E7E1H9   D3GDL3   A0A2H1WAN4   A0A2H1WHM9   A0A2H1WQU1   D5G3F5   E7E1H4   Q9XZN4   A0A0K0XRW8   A0A0L7LFI0   A0A0Y0BVU8   A0A3S2PFA1   A0A2S0D933   A0A3S2NFJ4   A0A1L8D6H3   A0A1L8D6I3   A0A1U9X1T9   A0A0L7LFZ6   A0A1L8D6V8   A0A1L8D6R0   A0A1U9X1S8   A0A1L8D6I6   A0A1U9X1U0   A0A1L8D6P7   A0A1U9X1X0   A0A0Y0BA98   A0A139WFP4   A0A2H1V381   A0A0K1YWC6   A0A194PTN5   V5GUX3   G3CM70   Q5ZEX6   A0A0K0XRV7   Q5ZEX7   A9LS22   A0A0K8TVA5   A0A291P117   H9JN84   A0A291P0V7   A0A1J0M1C9   A0A194R2U2   A0A109QN31   D3GDL4   A0A2S0D938   A0A2A4J274   A0A2J7RMU7   A0A2J7RMN7   A0A3S2NFG0   A0A2H1X0W5   D8UUL2   A0A0C5C1R4   A0A076FRM3   A0A0A7ENT2   A0A2H1VCP7   A0A0K8TV87   A0A1U9X1V9   E0VEL6   A0A2J7RMT5   F8V329   A0A0K0XRL5   A0A1J0M180   A0A2J7RMR6  

EC Number

3.1.1.-
3.1.1.59

Pubmed

19121390    21071843    28756777    11719069    12609517    16566578    + More
7945209    12020837    21549123    2745451    28605547    22118469    26227816    26354079    25727179    24053512    20005949    10221775    26198868    26778204    18362917    19820115    26017144    28986331    19802899    24817326    20566863    23603019   

EMBL

BABH01034170    BABH01034171    AB543061    BAJ11978.1    BABH01034174    FJ652458    + More
ACV60242.1    KZ149945    PZC76778.1    AF327882    AAG42021.2    KX015865    ARM65394.1    PZC76779.1    HQ588158    ADU25009.1    AF287267    AAL55240.1    BABH01034175    AY489292    AAR37335.1    KY021876    AQY62765.1    EU178813    ABW24129.1    AF037197    AAB96654.1    AF037196    AAC38822.1    J04955    JQ901384    AGB93712.1    PZC76780.1    HM588760    AEB77712.1    KY938807    ASA46448.1    FJ875998    ACO81854.2    AGBW02014918    OWR40861.1    JTDY01001282    KOB74302.1    KM926341    AJR27471.1    KQ460205    KPJ17063.1    KU375426    APD13868.1    KQ459604    KPI92141.1    LC012033    BAR88201.1    JX866744    AGS49148.1    EU523701    ACB12192.1    ADU25010.1    FJ652445    ACV60229.1    ODYU01007337    SOQ50016.1    ODYU01008725    SOQ52573.1    ODYU01010342    SOQ55377.1    FJ997319    ADF43484.1    HQ588155    ADU25006.1    AF153367    AAD34172.1    KP938886    AKS40367.1    KOB74303.1    KU215370    AMB19664.1    RSAL01000057    RVE49776.1    KX015857    ARM65386.1    RVE49777.1    GEYN01000073    JAV02056.1    GEYN01000067    JAV02062.1    KY021831    AQY62720.1    KOB74304.1    GEYN01000059    JAV02070.1    GEYN01000072    JAV02057.1    KY021830    AQY62719.1    GEYN01000063    JAV02066.1    KY021836    AQY62725.1    GEYN01000064    JAV02065.1    KY021861    AQY62750.1    KU215371    AMB19665.1    KQ971352    KYB26709.1    ODYU01000269    SOQ34744.1    KP859354    AKZ17664.1    KQ459592    KPI96776.1    GALX01003004    JAB65462.1    HQ122616    AEL33699.1    AJ845190    CAH60167.1    KP938875    AKS40356.1    AJ845189    CAH60166.1    EU255790    ABX46627.1    GCVX01000034    JAI18196.1    MF687633    ATJ44559.1    BABH01033219    MF687564    ATJ44490.1    KU375427    APD13869.1    KQ460845    KPJ12017.1    KU215373    AMB19667.1    FJ652446    ACV60230.1    KX015868    ARM65397.1    NWSH01003954    PCG65624.1    NEVH01002552    PNF42157.1    PNF42088.1    RSAL01000139    RVE46156.1    ODYU01012558    SOQ58953.1    GQ180944    ACT53736.1    KP001159    AJN91204.1    KF960791    AII21993.1    KM234964    AIY68378.1    ODYU01001848    SOQ38619.1    GCVX01000032    JAI18198.1    KY021856    AQY62745.1    DS235093    EEB11822.1    PNF42132.1    JN019808    AEJ18172.1    KP938878    AKS40359.1    KU375439    APD13881.1    PNF42130.1   

Proteomes

UP000005204    UP000007151    UP000037510    UP000053240    UP000053268    UP000283053    + More
UP000007266    UP000218220    UP000235965    UP000009046   

PRIDE

H9IU46    E1CGA5    H9IU44    H9IU45    Q8WSJ5    H9IU42    + More
Q6RVD1    P12992    A9LS22    H9JN84   

Pfam

PF00135   COesterase        + More
PF00083   Sugar_tr

Interpro

IPR002018   CarbesteraseB        + More
IPR029058   AB_hydrolase       
IPR019826   Carboxylesterase_B_AS       
IPR019819   Carboxylesterase_B_CS       
IPR005829   Sugar_transporter_CS       
IPR020846   MFS_dom       
IPR036259   MFS_trans_sf       
IPR005828   MFS_sugar_transport-like       
IPR000997   Cholinesterase       
IPR002168   Lipase_GDXG_HIS_AS       

SUPFAM

SSF53474   SSF53474        + More
SSF103473   SSF103473       

Gene 3D

3.40.50.1820    

CDD

cd06174  MFS

ProteinModelPortal

H9IU46   E1CGA5   H9IU44   H9IU45   D3GDM6   A0A2W1BP85   + More
Q9GPG0   A0A2U3T8L0   A0A2W1BNZ2   Q7M4E5   E7E1H7   Q8WSJ5   H9IU42   Q6RVD1   A0A1U9X1Y0   A8VJM0   O44423   O44422   P12992   L7R4S7   A0A2W1BVG5   F8RGS7   A0A1Z2RRH5   C3VMY5   A0A212EHB6   A0A0L7LFR4   A0A0R6CIR0   A0A194RGX0   A0A1J0M116   A0A194PFJ1   A0A0G4DCW7   U5KKB9   B1Q145   E7E1H9   D3GDL3   A0A2H1WAN4   A0A2H1WHM9   A0A2H1WQU1   D5G3F5   E7E1H4   Q9XZN4   A0A0K0XRW8   A0A0L7LFI0   A0A0Y0BVU8   A0A3S2PFA1   A0A2S0D933   A0A3S2NFJ4   A0A1L8D6H3   A0A1L8D6I3   A0A1U9X1T9   A0A0L7LFZ6   A0A1L8D6V8   A0A1L8D6R0   A0A1U9X1S8   A0A1L8D6I6   A0A1U9X1U0   A0A1L8D6P7   A0A1U9X1X0   A0A0Y0BA98   A0A139WFP4   A0A2H1V381   A0A0K1YWC6   A0A194PTN5   V5GUX3   G3CM70   Q5ZEX6   A0A0K0XRV7   Q5ZEX7   A9LS22   A0A0K8TVA5   A0A291P117   H9JN84   A0A291P0V7   A0A1J0M1C9   A0A194R2U2   A0A109QN31   D3GDL4   A0A2S0D938   A0A2A4J274   A0A2J7RMU7   A0A2J7RMN7   A0A3S2NFG0   A0A2H1X0W5   D8UUL2   A0A0C5C1R4   A0A076FRM3   A0A0A7ENT2   A0A2H1VCP7   A0A0K8TV87   A0A1U9X1V9   E0VEL6   A0A2J7RMT5   F8V329   A0A0K0XRL5   A0A1J0M180   A0A2J7RMR6  

PDB

2FJ0     E-value=1.18221e-140,     Score=1283

KEGG

101743778    no KO assigned | (RefSeq) juvenile hormone esterase-like

GO

GO:0016787   GO:0016021   GO:0004453   GO:0004104   GO:0005615   GO:0022857   GO:0052689   GO:0080030  

SignalP

Position:   1 - 20,         Likelihood:  0.992363

 

 

Length:

577

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

5.40696999999999

Exp number, first 60 AAs:

4.38823

Total prob of N-in:

0.18169

outside

1  -  577

 

 

Pi

235.751416

Theta

182.337678

Tajima's D

1.014156

CLR

0.07031

CSRT

0.666916654167292

Interpretation

Uncertain