Gene

KWMTBOMO14910

Pre Gene Modal

BGIBMGA000779

Annotation

PREDICTED:_protein_kinase_C_[Bombyx_mori]

Location

Bomo_Chr25(-):247894-260292      View in EpiBrowser

Full name

Protein kinase C       + More
Calcium-independent protein kinase C      
Protein kinase C-like 1B      

Alternative Name

dPKC98F
APL II

Location in the cell

Cytoplasmic   Reliability : 2.393

CDS

ATGGCCTTTGGAAAGCCAGACGATCAGCCGATAGACCCTTACGTCTCAATAGATGCCGACGAGCACCACCTGGACCGTTCCAGCACCAAAGCCAAAACATTTGATCCTGTCTGGAACGAGACATTTACACACGACGTTCACAATGTTTCCAGTTTGGGGATCACAGTATTTCATGATGCGGCTATCCCTCCTGATGACTTTGTTGCAAATTGCACAATATCTTTTGAGGATCTGATGCTGCGAGATAAGGATGCCACAGACTTTTGGGTGGACCTAGAGCCGCAGGGGAAACTGCATCTGAAAATAGATCTGAAATGGCATTCTCAAGGTTCAGGCGAGGGCGGCGGCGGGGGCGGCGGGGGGACGCGCGGAGTGCGCGGGGGGCGCGGCGCTCCCCGGGAGTTCAAGGAGGGGGCGGGGTTCGCCCGGCGCCGCGGGGCCATGCGTCGCCGCGTGCACCAGGTCAACGGACACAAGTTCATGGCCACCTTCCTGCGACAACCCACCTTCTGCAGCCTCTGTCGGGAGTTCATATGGGGCATCGGCAAGCAAGGATACCAGTGTCAAGTTTGCACCTGCGTGCTGCATAAGCGATGTCATTCCCTTATCGTCACGAAGTGTCCCGGCATGAAGGAGGAGGCGGGCGCGGGCGCGGTGGGGCAGGGCTTCAGCGTGAACGTGCCGCACCGCTTCGTGGTGCACTCCTACAAGCGGTTCACCTTCTGCGACCACTGCGGCTCGCTGCTCTACGGACTCATCAAGCAGGGACTGCAGTGCGAAGCGTGTTCAATGAACGTCCACAAGCGGTGCCAGAAGAACGTGGCCAACAACTGCGGGACCAACACCAAGGCCATGGCGGCTCTGCTCAACGAGATGGGGATATCGCCCGACAAGAACCCCAGACCGAAGACCTTTAAGTATCTCAACCCCGCCCTGCTCGAAGGATCCTCGGAGCTGTCGTCGTCCGGGGACTCCGAGTCGAAGGACGCAGGGGACAAACAAGACGATAAAGGGGACACAGAATGCGGAGGGTTAAAGAAGCCATCTCTCGAGGACTTCACGTTCATCAAGGTCCTCGGGAAAGGATCTTTCGGAAAAGTGATGTTGGCCGAAAGGCGCGGCACGGAGGAGGTGTTCGCCGTGAAGGTCCTGAAGAAGGACGCCATCCTGCAGGACGACGACGCGGAGTGCACGCTCGCCGAGAGACGCGTGCTGGCCCTGGCGGCCGCGCATCCCTTCCTCACGGCGCTGCACTGTGCCTTCCAGACCAGGGACCGTCTGTTCTTCGTCATGGAGTACGTGGACGGGGGGGACTTGATGTTTCAGATCCAGCGAGCGCGCAAGTTCGACGAGCCTCGCGCCAGGTTCTACGCGGCGGAAGTCACCTTGGCGCTGGAGTTCCTGCACGAGCACGGCGTCATCTACCGCGACCTCAAGCTCGACAACATCCTGCTCGACTCCGAGGGACACTGCAAGCTCGCCGACTTCGGCATGTGCAAGGAGGGCATCATCGACGGCGTGACCACCACCACGTTCTGCGGGACCCCGGACTACATCGCGCCAGAGATCCTGCAGGAGCAGGAGTACGGCTGCAGCGTGGACTGGTGGGCGCTGGGCGTGCTGCTGTACGAGATGCTGGCGGGACAGCCGCCCTTCGAGGCCGACAACGAGGACGACCTGTTCGAGTCCATCCTGCACGACGACGTGCTCTACCCCGTGTGGCTCTCGCGCGACGCCGTCTCCATACTCAAAGGGTTCATGACGAAGGCGCCGAGCCGGCGGCTGGGCGTGTGCGGCGGCGCGGCGGGCATCAAGGCGCACGCGTTCTTCCGCGACGTGGACTGGGACGCGCTCGCCCAGAGGAAGCTGCGGCCGCCCTTCCGCCCCAAGAAGAGCAAGCGCGAGGCCGTCAACTTCGACGCGGAGTTCACCAAGGAGGAGCCCGTGCTCACGCCCGTCGCGCCGGACGTGCTGCGGACCATCAACCAGGAGGAGTTCCGAGGATTCTCGTTCGTGAACAAGGATTTCAACCCCCTGCCCGCCGCCTGA

Protein

MAFGKPDDQPIDPYVSIDADEHHLDRSSTKAKTFDPVWNETFTHDVHNVSSLGITVFHDAAIPPDDFVANCTISFEDLMLRDKDATDFWVDLEPQGKLHLKIDLKWHSQGSGEGGGGGGGGTRGVRGGRGAPREFKEGAGFARRRGAMRRRVHQVNGHKFMATFLRQPTFCSLCREFIWGIGKQGYQCQVCTCVLHKRCHSLIVTKCPGMKEEAGAGAVGQGFSVNVPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCEACSMNVHKRCQKNVANNCGTNTKAMAALLNEMGISPDKNPRPKTFKYLNPALLEGSSELSSSGDSESKDAGDKQDDKGDTECGGLKKPSLEDFTFIKVLGKGSFGKVMLAERRGTEEVFAVKVLKKDAILQDDDAECTLAERRVLALAAAHPFLTALHCAFQTRDRLFFVMEYVDGGDLMFQIQRARKFDEPRARFYAAEVTLALEFLHEHGVIYRDLKLDNILLDSEGHCKLADFGMCKEGIIDGVTTTTFCGTPDYIAPEILQEQEYGCSVDWWALGVLLYEMLAGQPPFEADNEDDLFESILHDDVLYPVWLSRDAVSILKGFMTKAPSRRLGVCGGAAGIKAHAFFRDVDWDALAQRKLRPPFRPKKSKREAVNFDAEFTKEEPVLTPVAPDVLRTINQEEFRGFSFVNKDFNPLPAA

Description

PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity).
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Involved in neuropeptide secretion in motor axons. Likely to act via the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway in the signaling response to various sensory neurons; temperature, odor, taste, and osmolality. Its role in regulation differs depending on the neuron in which it is acting; thermosensation in AFD neurons, osmolality in ASH neurons, olfactory perception in AWA and AWC neurons. Promotes dauer formation mediated by the insulin/IGF pathway. Required for resistance to antimitotic toxins.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Miscellaneous

This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.

Similarity

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Belongs to the protein kinase superfamily.

Keywords

ATP-binding   Calcium   Complete proteome   Kinase   Metal-binding   Nucleotide-binding   Reference proteome   Repeat   Transferase   Zinc   Zinc-finger   Membrane   Alternative splicing   Cytoplasm   Cytoskeleton  

Feature

chain  Protein kinase C
splice variant  In isoform b.

Uniprot

A0A2W1BYE0   H9IU49   A0A0A9WHM6   A0A1B6IQE8   A0A1B6L1S0   A0A1Y1K6T6   + More
A0A1B6CGL1   A0A1W4WS74   D6WT86   A0A1S4MWU8   W8BIJ8   E9GB27   B4K7W3   P13678   A0A0B4LI13   D6WT87   K7J3W5   A0A232ETC5   A0A034W9K4   A0A0K8W8R7   A0A0C9R752   A0A0A1XNA7   A0A0C9R9P0   B7PJ72   A0A1A9VBC4   A0A0Q9W9V5   B4M5Q0   I5ANU0   A0A0L7QM63   A0A0F7VJE7   B4JH25   A0A1A9YG52   A0A2C9MAA3   B4G4X0   A0A2A3EDM8   A0A2C9M9X3   A0A034WEN5   A0A0N0BI09   Q16975   A0A1W4UCR4   A0A1V9XVV5   V3Z9N9   A0A0R1E572   B4PQ84   A0A087UYK1   A0A2H8TJ78   A0A3Q1HFT0   F1KX43   A0A3Q4BFC4   A0A3B4FYG4   A0A346T655   A0A3Q2P187   A0A3Q3KMC3   A0A2A2JAF9   A0A1B6HPC9   A0A1B6H4Y9   A0A1A9WJD1   A0A3P9MCV9   A0A3B4BUQ1   A0A2A6CRU5   A0A3B3BRE8   A0A3Q3GYI7   A0A3P9IU80   A0A1I8AL22   G0NGV5   A0A2G5TGR7   A0A1I8AJW7   A0A1I7TP01   A8Y443   A0A2H2IM83   E3LPX1   W5NHU0   A0A3P8A667   P34885-2   A0A0K0FY66   A0A0T6B3N4   A0A0N5B845   A0A0N4ZJB4   A0A0K0DVL7   A0A1L8DLE3   A0A1I8CWN0   A0A3Q3RUI5   A0A3B4FDF9   A0A3Q2V9E4   A0A3P8NBM1   A0A3Q4MLM9   A0A087X5V6   A0A0Q9X8D8   A0A0C9QXV2   Q4QQA3   Q95T78   A0A3Q1MF74   A0A2K5YJ45   A0A2I3S492   A0A151NWR5   A0A0A1XH88   A0A2K6GJ98   A0A034WEN9   A0A091CL19   A0A2K5JTX0  

EC Number

2.7.11.13

Pubmed

28756777    19121390    25401762    28004739    18362917    19820115    + More
20566863    24495485    21292972    17994087    18057021    2720775    10731132    12537572    12537568    12537573    12537574    16110336    17569856    17569867    20075255    28648823    25348373    25830018    15632085    15562597    1869917    8449941    8346555    9668085    9477951    28327890    23254933    17550304    21685128    17554307    18806794    29451363    26392177    14624247    8132661    9851916    15920475    17128266    20837997    20089839    21933341    21143768    26829753    25186727    26109357    26109356    19393038    16136131    22293439   

EMBL

KZ149945    PZC76783.1    BABH01034158    BABH01034159    BABH01034160    BABH01034161    + More
GBHO01039239    JAG04365.1    GECU01018589    JAS89117.1    GEBQ01022315    JAT17662.1    GEZM01094115    JAV55920.1    GEDC01024808    JAS12490.1    KQ971354    EFA07407.1    AAZO01006252    GAMC01008003    JAB98552.1    GL732537    EFX83361.1    CH933806    EDW14297.2    KRG00960.1    J04848    AE014297    AHN57575.1    EFA07406.1    AAZX01005146    NNAY01002292    OXU21603.1    GAKP01006736    JAC52216.1    GDHF01017658    GDHF01004837    GDHF01003186    JAI34656.1    JAI47477.1    JAI49128.1    GBYB01008632    JAG78399.1    GBXI01003105    GBXI01001957    JAD11187.1    JAD12335.1    GBYB01009642    JAG79409.1    ABJB010352954    ABJB010430981    ABJB010543414    ABJB010882327    DS724548    EEC06644.1    CH940652    KRF78625.1    EDW58976.1    CM000070    EIM52625.2    KQ414894    KOC59733.1    LN830722    CFW94231.1    CH916369    EDV92716.1    CH479179    EDW24636.1    KZ288292    PBC29121.1    GAKP01006739    JAC52213.1    KQ435736    KOX77054.1    M94884    MNPL01003339    OQR77609.1    KB202849    ESO87648.1    CM000160    KRK04233.1    EDW98353.1    KK122296    KFM82440.1    GFXV01002361    MBW14166.1    JI167351    ADY42447.1    MF683955    AXU05739.1    LIAE01010561    PAV58736.1    GECU01031168    JAS76538.1    GECZ01000033    JAS69736.1    ABKE03000021    PDM80751.1    GL379883    EGT60265.1    PDUG01000005    PIC26413.1    HE601533    CAP39663.2    DS268412    EFP05630.1    AHAT01001684    AHAT01001685    AHAT01001686    UZAH01028226    VDO98629.1    U00181    U00965    Z75953    Z81497    LJIG01016052    KRT81758.1    GFDF01006808    JAV07276.1    AYCK01018246    AYCK01018247    AYCK01018248    AYCK01018249    AYCK01018250    AYCK01018251    AYCK01018252    AYCK01018253    AYCK01018254    AYCK01018255    KRG00958.1    GBYB01008624    JAG78391.1    BT023513    AAY84913.1    ACZ95061.1    AY060293    AAL25332.1    AACZ04001943    AACZ04001944    AKHW03001657    KYO41238.1    GBXI01003961    JAD10331.1    GAKP01006737    GAKP01006734    JAC52218.1    KN125406    KFO18442.1   

Proteomes

UP000005204    UP000192223    UP000007266    UP000000305    UP000009192    UP000000803    + More
UP000002358    UP000215335    UP000001555    UP000078200    UP000008792    UP000001819    UP000053825    UP000001070    UP000092443    UP000076420    UP000008744    UP000242457    UP000053105    UP000192221    UP000192247    UP000030746    UP000002282    UP000054359    UP000265040    UP000261620    UP000261460    UP000265000    UP000261640    UP000218231    UP000091820    UP000265180    UP000261440    UP000232936    UP000261560    UP000261660    UP000265200    UP000095287    UP000008068    UP000230233    UP000095282    UP000008549    UP000005237    UP000008281    UP000018468    UP000001940    UP000035680    UP000046392    UP000038045    UP000035681    UP000095286    UP000264840    UP000265100    UP000261580    UP000028760    UP000009136    UP000233140    UP000002277    UP000050525    UP000233160    UP000028990    UP000233080   

PRIDE

H9IU49    P13678    Q4QQA3    Q95T78   

Pfam

PF00069   Pkinase        + More
PF00433   Pkinase_C
PF00168   C2
PF00130   C1_1

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR000719   Prot_kinase_dom       
IPR017892   Pkinase_C       
IPR020454   DAG/PE-bd       
IPR000961   AGC-kinase_C       
IPR002219   PE/DAG-bd       
IPR014376   Prot_kin_PKC_delta       
IPR017441   Protein_kinase_ATP_BS       
IPR000008   C2_dom       
IPR008271   Ser/Thr_kinase_AS       
IPR035892   C2_domain_sf       
IPR034669   nPKC_epsilon       

SUPFAM

SSF56112   SSF56112       

Gene 3D

2.60.40.150    

CDD

cd00029  C1
cd05591  STKc_nPKC_epsilon

ProteinModelPortal

A0A2W1BYE0   H9IU49   A0A0A9WHM6   A0A1B6IQE8   A0A1B6L1S0   A0A1Y1K6T6   + More
A0A1B6CGL1   A0A1W4WS74   D6WT86   A0A1S4MWU8   W8BIJ8   E9GB27   B4K7W3   P13678   A0A0B4LI13   D6WT87   K7J3W5   A0A232ETC5   A0A034W9K4   A0A0K8W8R7   A0A0C9R752   A0A0A1XNA7   A0A0C9R9P0   B7PJ72   A0A1A9VBC4   A0A0Q9W9V5   B4M5Q0   I5ANU0   A0A0L7QM63   A0A0F7VJE7   B4JH25   A0A1A9YG52   A0A2C9MAA3   B4G4X0   A0A2A3EDM8   A0A2C9M9X3   A0A034WEN5   A0A0N0BI09   Q16975   A0A1W4UCR4   A0A1V9XVV5   V3Z9N9   A0A0R1E572   B4PQ84   A0A087UYK1   A0A2H8TJ78   A0A3Q1HFT0   F1KX43   A0A3Q4BFC4   A0A3B4FYG4   A0A346T655   A0A3Q2P187   A0A3Q3KMC3   A0A2A2JAF9   A0A1B6HPC9   A0A1B6H4Y9   A0A1A9WJD1   A0A3P9MCV9   A0A3B4BUQ1   A0A2A6CRU5   A0A3B3BRE8   A0A3Q3GYI7   A0A3P9IU80   A0A1I8AL22   G0NGV5   A0A2G5TGR7   A0A1I8AJW7   A0A1I7TP01   A8Y443   A0A2H2IM83   E3LPX1   W5NHU0   A0A3P8A667   P34885-2   A0A0K0FY66   A0A0T6B3N4   A0A0N5B845   A0A0N4ZJB4   A0A0K0DVL7   A0A1L8DLE3   A0A1I8CWN0   A0A3Q3RUI5   A0A3B4FDF9   A0A3Q2V9E4   A0A3P8NBM1   A0A3Q4MLM9   A0A087X5V6   A0A0Q9X8D8   A0A0C9QXV2   Q4QQA3   Q95T78   A0A3Q1MF74   A0A2K5YJ45   A0A2I3S492   A0A151NWR5   A0A0A1XH88   A0A2K6GJ98   A0A034WEN9   A0A091CL19   A0A2K5JTX0  

PDB

3TXO     E-value=2.48066e-128,     Score=1177

KEGG

101737153    K18050 novel protein kinase C epsilon type [EC:2.7.11.13] | (RefSeq) protein kinase C

PATHWAY

04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0004697   GO:0005524   GO:0046872   GO:0035556   GO:0004674   GO:0006468   GO:0005737   GO:0005634   GO:0018105   GO:0008285   GO:0007616   GO:0009950   GO:0034389   GO:0045471   GO:0007030   GO:0005886   GO:0016020   GO:0003094   GO:0072015   GO:0040012   GO:0007269   GO:0006935   GO:0098793   GO:0050920   GO:0007218   GO:0008306   GO:0016079   GO:0007635   GO:0040024   GO:0050975   GO:0050927   GO:1902074   GO:0007606   GO:0048009   GO:0000165   GO:1990504   GO:0050893   GO:0005856   GO:0005623   GO:2001024   GO:0032467   GO:0019899   GO:2001031   GO:0090303   GO:0010634   GO:0005783   GO:0005829   GO:0008047   GO:0005515   GO:0004672   GO:0007154   GO:0005112   GO:0015930  

Subcellular location

Membrane  
Cytoplasm  
Cytoskeleton  

Length:

682

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00850999999999998

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00019

outside

1  -  682

 

 

Pi

21.022457

Theta

184.130146

Tajima's D

0.608002

CLR

0.304867

CSRT

0.542322883855807

Interpretation

Uncertain