Gene

KWMTBOMO14893

Pre Gene Modal

BGIBMGA012178

Annotation

PREDICTED:_suppressor_of_fused_homolog_[Papilio_machaon]

Location

Bomo_Chr24(-):17210174-17220580      View in EpiBrowser

Full name

Suppressor of fused homolog      

Location in the cell

Nuclear   Reliability : 1.139

CDS

ATGTCCTGTCCGAGTGGCCCAAGGGCTCCTCATTCGTCGGGGGTGCCTTGCAACAGTGCCCTGTCATTCGTTGCGTCTGCGCAGCGAGTTCATGGACCGGAAAATGACGCTTGCAAACCTCAAGATGCCAAACAATCTGAACAACTAGTACCAGTAGCTCCGGCTGGCTTGAAAGCATTATGTGATGCTTGTTCCCAGCTGTACCCAGACCAGCCTAACCCTCTGCAGGTCACGACCAGGCTCAAATATTGGTTGGGAGGACAAGATCCTTTAGACTACATCAGCATGTACCGGAACCCAGGGAAACCGGAGGAAAATATACCACCACATTGGCACTACATCAGTTTCGGTCTGTCAGACCTTCACGGGGATGGGAGGGTCCACCCTCCGCCGGATCGCGCGGCGCTGTCCGCGGGCGCGCCCCTGCCGTCTGGCTGCGGCATCGAGCTGACGTTCCGGCTCGCGGCTGACGGGGCAGAGCACCCCCCGCTGTGGCCGGCGGCTCTCTTGCAGGCCTTGGCCAGATACGTGTTCACTACAGGTAACAAGCTGTGCGCCGGGGACCACATATCGTGGCATCGTCCGCTGGACGGCGAGAGGTCCGGGGGCCGCATGCGACACCTGCTGGTCGCGACAGAGCCGCAGCTGCGACACGCTCGCACGCCGCACGGCATCGTCACCTTCCTACAGATGGTGGGCTGCACCAGCAGAGAACTGAGGGCGGCCCAGAGGAGCTCCGTCTGCGAGGTACTGAAACTCATAGCGCAGGACCCGAGGTGCGGCGGGTGCTGGCTGGTGACGCGCATGGAGCGGCGGGTGTCGGTGCGGGCGGGGGGCGGCGCGGGGGGCGCGCTGGCGCAGCTGGCCGGCGTCTCCTGCGACGTGCGCTGGGCCGCGTGGGAGGATTCGACTGGTGAGTCGGTGGGCCGGGAGGATGCACAGGGGCTCGCCCACCTGGAGACCACGGTCACCGGACACATGTCCACGGACAGCTTCGGGATGTCGAGCATGGGAGAGGCGCTGGCGAAGCTCTCTGCCGAGGACCTCCCTGGGGATCCGGTGCAGTACCTGAGCGGGGTCCACGTCGTCCTGAGCCCGGAAGGCGCCGCCCTGCTGCCCCTGGCCGTCGAGGGCCGCATTCTACACGGAGCGCACTTCACGTGGCGCGGCGAGTCGGCGGCCGTCACGCTGGTGGCGCCCGGCGTGCACGGCTGCTTCGTGAGCACCGACGCGCCGCGCGCCGCCCGGGGCTCCTGGCTGCAGATATTAGTGAACAAGAGCCTCGCCTCGGATATACTGGCCCAGCGGAGCGCCCTCTGTGACGACGCGCACTCCGACAGCGAGGAGGACGCCCCCGCCCCCGCCCCCGCGCCCCCCCGCACCGTGCGCTGGCCCGAGCACGGGCTGGCCATCACCGTGCGCGCCTGA

Protein

MSCPSGPRAPHSSGVPCNSALSFVASAQRVHGPENDACKPQDAKQSEQLVPVAPAGLKALCDACSQLYPDQPNPLQVTTRLKYWLGGQDPLDYISMYRNPGKPEENIPPHWHYISFGLSDLHGDGRVHPPPDRAALSAGAPLPSGCGIELTFRLAADGAEHPPLWPAALLQALARYVFTTGNKLCAGDHISWHRPLDGERSGGRMRHLLVATEPQLRHARTPHGIVTFLQMVGCTSRELRAAQRSSVCEVLKLIAQDPRCGGCWLVTRMERRVSVRAGGGAGGALAQLAGVSCDVRWAAWEDSTGESVGREDAQGLAHLETTVTGHMSTDSFGMSSMGEALAKLSAEDLPGDPVQYLSGVHVVLSPEGAALLPLAVEGRILHGAHFTWRGESAAVTLVAPGVHGCFVSTDAPRAARGSWLQILVNKSLASDILAQRSALCDDAHSDSEEDAPAPAPAPPRTVRWPEHGLAITVRA

Description

Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:16155214, PubMed:16459298). Down-regulates GLI1-mediated transactivation of target genes (PubMed:11960000). Part of a corepressor complex that acts on DNA-bound GLI1 (PubMed:11960000). May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (By similarity). Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10531011, PubMed:16459298). Negative regulator of beta-catenin signaling (PubMed:11477086). Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL) (PubMed:10531011, PubMed:20360384). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state (PubMed:10531011, PubMed:20360384). Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R (PubMed:10531011, PubMed:20360384). When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A) (PubMed:10531011, PubMed:20360384). Required for normal embryonic development (PubMed:16155214, PubMed:16459298). Required for the proper formation of hair follicles and the control of epidermal differentiation (PubMed:16155214, PubMed:16459298, PubMed:23034632).
Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).

Subunit

May form homodimers (By similarity). Interacts with ULK3; inactivating the protein kinase activity of ULK3. Interacts with RAB23 (By similarity). Part of a DNA-bound corepressor complex containing SAP18, GLI1 and SIN3 (PubMed:11960000). Part of a complex containing CTNNB1 (PubMed:11477086). Binds BTRC, GLI2, GLI3, SAP18 and STK36 (PubMed:20360384, PubMed:23034632). Binds both free and DNA-bound GLI1 (PubMed:10531011). Interacts with KIF7 (PubMed:19592253). Interacts with GLI3FL and this interaction regulates the formation of either repressor or activator forms of GLI3 (PubMed:20360384). Its association with GLI3FL is regulated by Hh signaling and dissociation of the SUFU-GLI3 interaction requires the presence of the ciliary motor KIF3A (PubMed:20360384).

Similarity

Belongs to the SUFU family.

Keywords

Acetylation   Alternative splicing   Complete proteome   Cytoplasm   Developmental protein   Isopeptide bond   Nucleus   Phosphoprotein   Reference proteome   Ubl conjugation  

Feature

chain  Suppressor of fused homolog
splice variant  In isoform 2.

Uniprot

H9JRL8   A0A2H1V7Q8   S4NSH3   A0A0N1IA38   A0A212EJU1   A0A0N1PG72   + More
B0W2C6   A0A1W4XHY0   A0A1Y1N1A7   A0A182PQV3   A0A084VS45   V4AT21   A0A0P4W721   A0A182GH08   Q17FL2   A0A2S2R1B4   A0A182I0B1   A0A182RXK3   A0A182VR28   Q7PYI0   A0A182KLZ3   A0A182U4W4   A0A182XBH1   A0A182JR76   A0A182VAV4   A0A023F1Y6   A0A182MI26   A0A2G8L5D3   D1LXF3   T1I0U2   A0A0V0GCH3   A0A3R7M5B9   A0A224XQB4   A0A182J8K8   A0A182N4B4   A0A182QI59   A0A1W2WEY3   V8PFR0   A0A2C9JDF8   A0A0A9YJX6   A0A146LDP5   A0A0K8TGC4   A0A2M4CZF7   A0A139WMW0   H2YPK1   A0A3B4VMG5   A0A3Q3L3C0   F6Z6K5   A0A3Q3KSD7   A0A3Q3L3Q4   A0A210Q2A3   A0A3B3S7Y6   W4XDB0   E9FSV5   A0A1X7VXQ0   A0A2M4AX36   A0A0P4VQE8   U3K235   A0A2L2YFU1   Q9Z0P7-4   Q3U0Z8   A0A2U4BQG9   Q9Z0P7   Q4V8C6   A0A2Y9N5Y6   A0A093PQE9   A0A2Y9FMI7   A0A384AJ11   A0A1S3WKV4   A0A340YDG8   G3SVH6   A0A3Q0CYP9   A0A3Q7RT42   A0A3Q7W554   G3R6K6   A0A2U4BQN1   A0A2K6CAP0   A0A2K5WNJ5   A0A096P6F4   A0A2K5N8H0   H2Q2H8   A0A2K6NDB1   A0A2K6TU03   A0A1S3F8U5   A0A1S3A7Y4   G1RYV3   U3EN30   A0A2Y9MRM2   A0A2Y9J8H7   A0A340YBN2   A0A2Y9FN18   A0A384AIX4   G7N110  

Pubmed

19121390    23622113    26354079    22118469    28004739    24438588    + More
23254933    26483478    17510324    12364791    14747013    17210077    20966253    25474469    29023486    24297900    15562597    25401762    26823975    18362917    19820115    12481130    15114417    28812685    29240929    21292972    27129103    26561354    10531011    11252182    11557033    16141072    15489334    11477086    11960000    16155214    16459298    19592253    21183079    20360384    23034632    10349636    11042159    11076861    11217851    12466851    12040188    16141073    15057822    15632090    28071753    22398555    16136131    25362486    25243066    22002653   

EMBL

BABH01031732    BABH01031733    BABH01031734    ODYU01001096    SOQ36847.1    GAIX01014097    + More
JAA78463.1    KQ459988    KPJ18793.1    AGBW02014393    OWR41757.1    KQ458863    KPJ04723.1    DS231826    EDS28741.1    GEZM01020189    JAV89327.1    ATLV01015809    KE525036    KFB40789.1    KB201362    ESO96856.1    GDRN01086756    JAI61123.1    JXUM01062750    KQ562214    KXJ76391.1    CH477270    EAT45331.1    GGMS01014573    MBY83776.1    APCN01002058    AAAB01008987    EAA01100.1    GBBI01003145    JAC15567.1    AXCM01008324    MRZV01000214    PIK55464.1    GU076130    ACY92659.1    ACPB03010575    GECL01000607    JAP05517.1    QCYY01002039    ROT73307.1    GFTR01006235    JAW10191.1    AXCN02000031    AZIM01000124    ETE73185.1    GBHO01017376    GBHO01013779    GBHO01013772    JAG26228.1    JAG29825.1    JAG29832.1    GDHC01013004    JAQ05625.1    GBRD01001183    JAG64638.1    GGFL01006433    MBW70611.1    KQ971312    KYB29272.1    EAAA01002614    NEDP02005207    OWF42883.1    AAGJ04030573    GL732524    EFX89751.1    GGFK01011837    MBW45158.1    GDKW01003205    JAI53390.1    AGTO01020393    LC379607    IAAA01021144    BBD75244.1    LAA06988.1    AF134893    AJ131692    AJ308625    AJ308626    AJ308627    AJ308628    AJ308629    AJ308630    AJ308632    AJ308634    AJ308635    AJ308633    AJ308631    AK015885    AK047603    BC048168    BC056997    AK156410    CH466534    BAE33703.1    EDL42000.1    AC097694    BC097447    CH473986    AAH97447.1    EDL94350.1    KL669486    KFW76470.1    CABD030075842    CABD030075843    CABD030075844    CABD030075845    CABD030075846    CABD030075847    CABD030075848    CABD030075849    AQIA01072379    AQIA01072380    AQIA01072381    AHZZ02035970    AACZ04051127    AACZ04051128    AACZ04051129    ADFV01163581    ADFV01163582    ADFV01163583    ADFV01163584    ADFV01163585    ADFV01163586    ADFV01163587    ADFV01163588    ADFV01163589    ADFV01163590    GAMR01010612    JAB23320.1    CM001261    EHH19335.1   

Proteomes

UP000005204    UP000053240    UP000007151    UP000053268    UP000002320    UP000192223    + More
UP000075885    UP000030765    UP000030746    UP000069940    UP000249989    UP000008820    UP000075840    UP000075900    UP000075920    UP000007062    UP000075882    UP000075902    UP000076407    UP000075881    UP000075903    UP000075883    UP000230750    UP000015103    UP000283509    UP000075880    UP000075884    UP000075886    UP000076420    UP000007266    UP000007875    UP000261420    UP000261640    UP000008144    UP000242188    UP000261540    UP000007110    UP000000305    UP000007879    UP000016665    UP000000589    UP000245320    UP000002494    UP000248483    UP000053258    UP000261681    UP000079721    UP000265300    UP000007646    UP000189706    UP000286640    UP000286642    UP000001519    UP000233120    UP000233100    UP000028761    UP000233060    UP000002277    UP000233200    UP000233220    UP000081671    UP000001073    UP000248482   

PRIDE

H9JRL8    Q9Z0P7   

Pfam

PF05076   SUFU        + More
PF12470   SUFU_C
PF00567   TUDOR

Interpro

IPR007768   Suppressor_of_fused        + More
IPR020941   SUFU-like_domain       
IPR038489   SUFU_C_sf       
IPR024314   SUFU_C       
IPR037181   SUFU_N       
IPR016591   Suppressor_of_fused_euk       
IPR002999   Tudor       

SUPFAM

SSF103359   SSF103359       

Gene 3D

3.30.1360.230    

ProteinModelPortal

H9JRL8   A0A2H1V7Q8   S4NSH3   A0A0N1IA38   A0A212EJU1   A0A0N1PG72   + More
B0W2C6   A0A1W4XHY0   A0A1Y1N1A7   A0A182PQV3   A0A084VS45   V4AT21   A0A0P4W721   A0A182GH08   Q17FL2   A0A2S2R1B4   A0A182I0B1   A0A182RXK3   A0A182VR28   Q7PYI0   A0A182KLZ3   A0A182U4W4   A0A182XBH1   A0A182JR76   A0A182VAV4   A0A023F1Y6   A0A182MI26   A0A2G8L5D3   D1LXF3   T1I0U2   A0A0V0GCH3   A0A3R7M5B9   A0A224XQB4   A0A182J8K8   A0A182N4B4   A0A182QI59   A0A1W2WEY3   V8PFR0   A0A2C9JDF8   A0A0A9YJX6   A0A146LDP5   A0A0K8TGC4   A0A2M4CZF7   A0A139WMW0   H2YPK1   A0A3B4VMG5   A0A3Q3L3C0   F6Z6K5   A0A3Q3KSD7   A0A3Q3L3Q4   A0A210Q2A3   A0A3B3S7Y6   W4XDB0   E9FSV5   A0A1X7VXQ0   A0A2M4AX36   A0A0P4VQE8   U3K235   A0A2L2YFU1   Q9Z0P7-4   Q3U0Z8   A0A2U4BQG9   Q9Z0P7   Q4V8C6   A0A2Y9N5Y6   A0A093PQE9   A0A2Y9FMI7   A0A384AJ11   A0A1S3WKV4   A0A340YDG8   G3SVH6   A0A3Q0CYP9   A0A3Q7RT42   A0A3Q7W554   G3R6K6   A0A2U4BQN1   A0A2K6CAP0   A0A2K5WNJ5   A0A096P6F4   A0A2K5N8H0   H2Q2H8   A0A2K6NDB1   A0A2K6TU03   A0A1S3F8U5   A0A1S3A7Y4   G1RYV3   U3EN30   A0A2Y9MRM2   A0A2Y9J8H7   A0A340YBN2   A0A2Y9FN18   A0A384AIX4   G7N110  

PDB

4BLA     E-value=7.58403e-77,     Score=731

KEGG

101746466    K06229 suppressor of fused | (RefSeq) suppressor of fused homolog

PATHWAY

04341    Hedgehog signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0008134   GO:0005737   GO:0005634   GO:0043433   GO:0042994   GO:0016021   GO:0002088   GO:0030097   GO:0033333   GO:0007224   GO:0008270   GO:0035301   GO:0045879   GO:1901621   GO:0008013   GO:0019901   GO:0043588   GO:0035904   GO:0000122   GO:2000059   GO:0021775   GO:0005929   GO:0001843   GO:0060976   GO:0021776   GO:0001947   GO:0003281   GO:0005829   GO:0007368   GO:0021513   GO:0007275   GO:0005515   GO:0006457   GO:0051082   GO:0003676   GO:0016701   GO:0006355   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR10928  

Subcellular location

Cytoplasm  
Nucleus  

Length:

475

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01873

Exp number, first 60 AAs:

0.00019

Total prob of N-in:

0.00125

outside

1  -  475

 

 

Pi

23.689637

Theta

168.162872

Tajima's D

0.117889

CLR

0.177558

CSRT

0.407629618519074

Interpretation

Uncertain