Gene

KWMTBOMO14868  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012188

Annotation

PREDICTED:_UDP-glucose_6-dehydrogenase_[Papilio_polytes]

Location

Bomo_Chr24(-):16737260-16738695      View in EpiBrowser

Full name

UDP-glucose 6-dehydrogenase      

Alternative Name

Protein sugarless
Protein suppenkasper

Location in the cell

Cytoplasmic   Reliability : 1.779

CDS

ATGGTGATACAAAAAATCTGCTGTTTAGGAGCTGGTTATGTCGGCGGTCCAACCTGCAGTGTTATAGCACTGAAATGCCCCAATATTAAGGTAACGGTTTGCGACAAAAGCGAAGAGAGGATAAAGCAATGGAACTCTGATAAGCTACCGATTTACGAGCCTGGCCTAGACGATGTAGTCCGCGAATGTAGAGGTAAAAATTTATTTTTCTCAACGAACATCGCCGAAAGCATTCGGGAAGCCGATTTAATATTTATATCCGTTAACACGCCCACGAAGACAATAGGTAATGGGAAAGGGCGAGCTGCAGACTTGAAGTACATAGAGAGCGCAGCCCGCATGATAGCGGATCTGGCCACCAGCAATAAGATTGTCGTCGAGAAATCGACTGTTCCAGTCAAAGCTGCTGAAATTATTATGAAAATCCTTCGTGCCAATACCAAACCTGGCGTTGAGTACCAGATCCTGTCGAACCCTGAGTTTTTAGCAGAGGGAACCGCTATAGTTGATCTTGTTGAGGCTGAAAGAGTTCTGATCGGCGGGGAAGACACCCCAGAAGGCCAGAAAGCTGTTCAGGAACTATGCTGGGTGTACGAACACTGGATCCCGGCGAAGAACATCCTGACAACCAATACTTGGAGTTCAGAGCTGTCTAAACTTGCAGCAAATGCCTTCCTTGCCCAACGAATATCGAGCATCAACTCGTTATCAGCTGTCTGTGAAGCAACAGGTGCTGATGTGTCAGAAGTGGCCAGAGCTGTTGGTAGGGACTCTCGTATTGGCCCCAAGTTCCTTGAGGCTTCCATCGGCTTTGGGGGCAGTTGTTTCCAGAAAGATATATTAAATTTGATTTATTTGTGTGAATGCTTGAATCTGCCAGAAGTGGCAGCCTACTGGCAGCAAGTGGTGAGCTTAAACGACTACCAGAAGACCAGGTTCACTCGGAAAGTAATTGAGGCACTCTTCAATACAGTATCAGATAAGAAAATAGCTATACTCGGATTCTCATTCAAGAAGAACACAGGGGACACAAGAGAGTCTCCTGCCATATATGTCTGCAGTACGTTATTAGACGAAGGTGCAAAGCTGCACATTTATGATCCGAAGGTGGAGCACGACCAGATATACTATGAGCTGACCAATCCCTATGTTACCTCAGAGCCTGAGAAAGTGAGTTTTTTTCTCTTTTTTGAAGTACTTATTATTTTAGATTATTTTTTTATAAAGAATTTGGCTCCAATGCCTTAG

Protein

MVIQKICCLGAGYVGGPTCSVIALKCPNIKVTVCDKSEERIKQWNSDKLPIYEPGLDDVVRECRGKNLFFSTNIAESIREADLIFISVNTPTKTIGNGKGRAADLKYIESAARMIADLATSNKIVVEKSTVPVKAAEIIMKILRANTKPGVEYQILSNPEFLAEGTAIVDLVEAERVLIGGEDTPEGQKAVQELCWVYEHWIPAKNILTTNTWSSELSKLAANAFLAQRISSINSLSAVCEATGADVSEVARAVGRDSRIGPKFLEASIGFGGSCFQKDILNLIYLCECLNLPEVAAYWQQVVSLNDYQKTRFTRKVIEALFNTVSDKKIAILGFSFKKNTGDTRESPAIYVCSTLLDEGAKLHIYDPKVEHDQIYYELTNPYVTSEPEKVSFFLFFEVLIILDYFFIKNLAPMP

Description

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate and heparan sulfate. Required for wingless signaling in different tissues.

Catalytic Activity

H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate

Similarity

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Keywords

Complete proteome   NAD   Oxidoreductase   Reference proteome   Wnt signaling pathway  

Feature

chain  UDP-glucose 6-dehydrogenase

Uniprot

H9JRM8   A0A0N1I5K8   A0A0N1IQ45   A0A2A4J5K4   A0A2H1VCB3   A0A2W1B998   + More
A0A212EYQ8   A0A0L7L164   A0A069DTZ0   A0A023F4G4   T1HCB1   K7J7N2   E2AU70   A0A088A2I2   A0A0P4VSK8   A0A0L7RFR4   A0A3L8E056   A0A0M8ZTR8   A0A026WY78   A0A1B6EEU7   A0A1B6C766   A0A154PBN6   A0A067QJ98   A0A195D392   A0A151IUV5   A0A195FIM5   F4WUT5   A0A182IXV5   A0A158P2E7   A0A151WUA5   A0A182V600   A0A232EJ91   A0A182M7Y0   A0A3F2Z265   A0A182LKK2   A0A182I4B9   Q7Q5B2   A0A084WMM0   A0A1B6K9V5   A0A0L0CRF4   A0A2M4AS70   A0A2M4BLH3   B0W850   E9IGD4   A0A1Q3FDH8   A0A2M4BL57   Q16QM2   A0A182GFB1   A0A2M4CTW7   T1PAR7   W8BHI9   A0A1B6IHH1   A0A182NIV9   A0A195BTG4   A0A0A1XMV6   A0A310SE40   A0A182FFE3   A0A182QE10   A0A2M4CTX6   A0A1I8PLC7   A0A0K8W820   A0A1W4UX18   B4HUZ8   B3NFK6   B4QJV3   O02373   A0A0M4EZF1   B4LF30   B4PJT5   B4J387   A0A2J7QSV3   B3M9F6   B4MKT9   A0A1Y1N4K7   A0A1B0D3J1   A0A1A9X520   A0A3B0KN01   A0A1L8E1X7   A0A1B0GJL9   A0A023ESW2   W8H0S7   A0A1W4WEY7   B4KZU4   Q29F37   A0A1A9UXX4   A0A1B0B9F7   A0A1A9Z3J4   A0A1A9Y9H5   A0A1W4WPX2   A0A0C9RD46   A0A0C9RM96   A0A3Q0ILJ3   T1IY28   J3JZE6   A0A146LDX8   E0VZ63   A0A182WBV8   A0A1B0FC52   A0A1J1HZZ0   A0A2A3EB85  

EC Number

1.1.1.22

Pubmed

19121390    26354079    28756777    22118469    26227816    26334808    + More
25474469    20075255    20798317    27129103    30249741    24508170    24845553    21719571    21347285    28648823    20966253    12364791    14747013    17210077    24438588    26108605    21282665    17510324    26483478    25315136    24495485    25830018    17994087    22936249    9217004    9342049    9272947    10731132    12537572    12537569    17550304    28004739    24945155    15632085    22516182    26823975    20566863   

EMBL

BABH01031771    BABH01031772    BABH01031773    KQ458863    KPJ04714.1    KQ459988    + More
KPJ18783.1    NWSH01002937    PCG67251.1    ODYU01001796    SOQ38488.1    KZ150412    PZC70975.1    AGBW02011451    OWR46628.1    JTDY01003777    KOB69019.1    GBGD01001316    JAC87573.1    GBBI01002292    JAC16420.1    ACPB03000774    AAZX01012151    GL442807    EFN63018.1    GDKW01001144    JAI55451.1    KQ414601    KOC69675.1    QOIP01000002    RLU26084.1    KQ435881    KOX69806.1    KK107069    EZA60783.1    GEDC01026031    GEDC01000868    JAS11267.1    JAS36430.1    GEDC01028034    GEDC01007246    JAS09264.1    JAS30052.1    KQ434869    KZC09261.1    KK853297    KDR08787.1    KQ976885    KYN07380.1    KQ980945    KYN11251.1    KQ981523    KYN40221.1    GL888375    EGI62082.1    ADTU01007246    ADTU01007247    KQ982753    KYQ51215.1    NNAY01004096    OXU18371.1    AXCM01000272    AXCM01000273    APCN01002300    APCN01002301    AAAB01008960    EAA11440.4    ATLV01024482    KE525352    KFB51464.1    GEBQ01031751    JAT08226.1    JRES01000122    KNC34014.1    GGFK01010117    MBW43438.1    GGFJ01004670    MBW53811.1    DS231857    EDS38675.1    GL762997    EFZ20353.1    GFDL01009493    JAV25552.1    GGFJ01004669    MBW53810.1    CH477744    EAT36695.1    JXUM01000833    JXUM01000834    JXUM01000835    JXUM01000836    GGFL01004527    MBW68705.1    KA645799    AFP60428.1    GAMC01008343    JAB98212.1    GECU01021334    GECU01005295    JAS86372.1    JAT02412.1    KQ976408    KYM91226.1    GBXI01001981    JAD12311.1    KQ771508    OAD52535.1    AXCN02000476    GGFL01004551    MBW68729.1    GDHF01005289    JAI47025.1    CH480817    EDW50769.1    CH954178    EDV50548.1    CM000363    CM002912    EDX09494.1    KMY97976.1    AF007870    AF000570    AF009013    AF001310    AH007072    AE014296    AY052137    CP012525    ALC43757.1    CH940647    EDW69199.1    CM000159    EDW93684.1    CH916366    EDV96158.1    NEVH01011219    PNF31655.1    CH902618    EDV41169.1    CH963847    EDW72795.1    GEZM01013056    JAV92794.1    AJVK01023578    AJVK01023579    OUUW01000009    SPP85188.1    GFDF01001344    JAV12740.1    AJWK01021979    GAPW01001208    JAC12390.1    KF986615    AHK26793.1    CH933809    EDW17956.1    CH379068    EAL31235.1    JXJN01010371    GBYB01014514    JAG84281.1    GBYB01014512    JAG84279.1    JH431669    BT128627    AEE63584.1    GDHC01012201    JAQ06428.1    DS235849    EEB18669.1    CCAG010016068    CVRI01000035    CRK92884.1    KZ288311    PBC28446.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000007151    UP000037510    + More
UP000015103    UP000002358    UP000000311    UP000005203    UP000053825    UP000279307    UP000053105    UP000053097    UP000076502    UP000027135    UP000078542    UP000078492    UP000078541    UP000007755    UP000075880    UP000005205    UP000075809    UP000075903    UP000215335    UP000075883    UP000076407    UP000075882    UP000075840    UP000007062    UP000030765    UP000037069    UP000002320    UP000008820    UP000069940    UP000095301    UP000075884    UP000078540    UP000069272    UP000075886    UP000095300    UP000192221    UP000001292    UP000008711    UP000000304    UP000000803    UP000092553    UP000008792    UP000002282    UP000001070    UP000235965    UP000007801    UP000007798    UP000092462    UP000091820    UP000268350    UP000092461    UP000192223    UP000009192    UP000001819    UP000078200    UP000092460    UP000092445    UP000092443    UP000079169    UP000009046    UP000075920    UP000092444    UP000183832    UP000242457   

PRIDE

H9JRM8    O02373   

Pfam

PF03721   UDPG_MGDP_dh_N        + More
PF00984   UDPG_MGDP_dh
PF03720   UDPG_MGDP_dh_C
PF02104   SURF1

Interpro

IPR028356   UDPglc_DH_euk        + More
IPR014027   UDP-Glc/GDP-Man_DH_C       
IPR017476   UDP-Glc/GDP-Man       
IPR036220   UDP-Glc/GDP-Man_DH_C_sf       
IPR014026   UDP-Glc/GDP-Man_DH_dimer       
IPR008927   6-PGluconate_DH-like_C_sf       
IPR036291   NAD(P)-bd_dom_sf       
IPR001732   UDP-Glc/GDP-Man_DH_N       
IPR002994   Surf1/Shy1       
IPR013087   Znf_C2H2_type       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR036322   WD40_repeat_dom_sf       

SUPFAM

SSF48179   SSF48179        + More
SSF51735   SSF51735       
SSF52413   SSF52413       
SSF50978   SSF50978       

Gene 3D

2.130.10.10    

CDD

cd06662  SURF1

ProteinModelPortal

H9JRM8   A0A0N1I5K8   A0A0N1IQ45   A0A2A4J5K4   A0A2H1VCB3   A0A2W1B998   + More
A0A212EYQ8   A0A0L7L164   A0A069DTZ0   A0A023F4G4   T1HCB1   K7J7N2   E2AU70   A0A088A2I2   A0A0P4VSK8   A0A0L7RFR4   A0A3L8E056   A0A0M8ZTR8   A0A026WY78   A0A1B6EEU7   A0A1B6C766   A0A154PBN6   A0A067QJ98   A0A195D392   A0A151IUV5   A0A195FIM5   F4WUT5   A0A182IXV5   A0A158P2E7   A0A151WUA5   A0A182V600   A0A232EJ91   A0A182M7Y0   A0A3F2Z265   A0A182LKK2   A0A182I4B9   Q7Q5B2   A0A084WMM0   A0A1B6K9V5   A0A0L0CRF4   A0A2M4AS70   A0A2M4BLH3   B0W850   E9IGD4   A0A1Q3FDH8   A0A2M4BL57   Q16QM2   A0A182GFB1   A0A2M4CTW7   T1PAR7   W8BHI9   A0A1B6IHH1   A0A182NIV9   A0A195BTG4   A0A0A1XMV6   A0A310SE40   A0A182FFE3   A0A182QE10   A0A2M4CTX6   A0A1I8PLC7   A0A0K8W820   A0A1W4UX18   B4HUZ8   B3NFK6   B4QJV3   O02373   A0A0M4EZF1   B4LF30   B4PJT5   B4J387   A0A2J7QSV3   B3M9F6   B4MKT9   A0A1Y1N4K7   A0A1B0D3J1   A0A1A9X520   A0A3B0KN01   A0A1L8E1X7   A0A1B0GJL9   A0A023ESW2   W8H0S7   A0A1W4WEY7   B4KZU4   Q29F37   A0A1A9UXX4   A0A1B0B9F7   A0A1A9Z3J4   A0A1A9Y9H5   A0A1W4WPX2   A0A0C9RD46   A0A0C9RM96   A0A3Q0ILJ3   T1IY28   J3JZE6   A0A146LDX8   E0VZ63   A0A182WBV8   A0A1B0FC52   A0A1J1HZZ0   A0A2A3EB85  

PDB

5W4X     E-value=1.58623e-167,     Score=1513

KEGG

101740272    K00012 UDPglucose 6-dehydrogenase [EC:1.1.1.22] | (RefSeq) UDP-glucose 6-dehydrogenase

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00520    Amino sugar and nucleotide sugar metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0051287   GO:0003979   GO:0006024   GO:0005634   GO:0005829   GO:0016021   GO:0016020   GO:0003676   GO:0008543   GO:0030206   GO:0007509   GO:0007367   GO:0015014   GO:0007427   GO:0016055   GO:0006065   GO:0016616   GO:0006508   GO:0016701   GO:0006355   GO:0003824   GO:0008152   GO:0016491   GO:0015930   GO:0055114  

PANTHER

PTHR11374  

Length:

415

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

5.10674

Exp number, first 60 AAs:

0.31921

Total prob of N-in:

0.11371

outside

1  -  415

 

 

Pi

222.702548

Theta

189.30514

Tajima's D

0.59448

CLR

0.307851

CSRT

0.543172841357932

Interpretation

Uncertain