Gene

KWMTBOMO14826  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012145

Annotation

PREDICTED:_probable_tyrosyl-DNA_phosphodiesterase_[Amyelois_transitella]

Location

Bomo_Chr24(+):15875187-15890342      View in EpiBrowser

Full name

Mitochondrial genome maintenance exonuclease 1       + More
Probable tyrosyl-DNA phosphodiesterase      

Alternative Name

Protein glaikit

Location in the cell

Nuclear   Reliability : 2.803

CDS

ATGAACCCTTCCCTAAAGCGACGAGGAACTATGCAAGAAAATGAGACAAAAAGAGTAAAAAAGGTTTGTGATTATGGCGAAAAATGCTACAGAATGAATCCTGTACATTTCCGTGAATTTAGTCATCCGCATTTGGAATCTATATTGGATAACCATGCCAGTGGTGGAGATTACCCTATCCCAGATAAATACAATCTCCAGAAGAAATTGATCACTGAACAGCTAGATCTTATAATCGAAAAGGGATTCTATGCTCCTCGGAACAATGTACAAAACAACCCAAAACAAATTGAAAACAAACAAGAAAGAGACAGCGACAGACGAGTAGGGAAAAATGTGGAACCGGAGGCAAGTTCTGCTAGTCATCAAAAAGTACCGGACAAACCTGAAAATACAAAAACAATGTTTTCAAATAATGAAGCCAAAATTAAGACACCTGTTGATAGAGGGGGAGTTGTTAAAGAGAAATCCACTAACTCAGATTATCGTCCCATAATACCTCCGACTCGACGTGTAGAAGATTATTTGAACGTTGTAAGACCTAAAGGGCGAATGGCTGCAAAGCACGAAGCCAGTGCGCCCTTTTATATTTTTTACACAACAATCACGGCGGCAAAGGAAACTCATTCGCAGCCGTTCTCTATAACATTCCAAGAAATTTTAGATAGAAGCTTAGGCGAGTTGAAGTGTTCGTTGCAAATCAATTTTATGGTCGAACTTGGATGGCTCTTGGCTCAGTACTACTTCGCTGGTTACAGCGAGAAGAAGCTAACGATATTGTACGGTGAGGATTCTCAGGATTTAAGGACGATCAGCCAGAAGAAGCCACACGTTGACGCTCACCTGGTGCCGATGGCGACTCCGTTCGGTAAACATCACACTAAAATGATGATCTTGTGTTACGAAGATGGGTCACTTCGCGTTGTAGTATCGACAGCCAATCTGTATATTGATGACTGGGAGAACCGAACGCAAGGTCTATGGTTCAGTCCAAAATGCCCAGAGTTGCCGCCGGAAGCGATGCCTCATGATGGAGAGTCTCCTACGATGTTCAAAAAGTCTCTGTTACGCTATTTGAATCACTATCATATGCCTTATCTCACCTACTACGTTGAAAGAGTGAAGAGATCGGATTTCAGTCATATTAATGTTTTCTTAGTAGCATCGGCTCCTGGATCTCATTTTGACATGGACTGGGGCATGACCCGTGTGGGCTCATTACTGCGGCAGCACTGCTGTATACCACCCGAGGAACAGCTCCAGTGGCCCCTGGTGGCACAGGCCAGCAGCCTGGGTAGTTACGGCAAGGATCCGAAGCTCTGGTTGACCGGAGATTTCCTTCACAACTTCACGAAAATCAAGAACCAATCGCAGATGTTGTCGTCTCCGCCTACTTTGAAACTGATTTATCCATCTTTAGAAAACGTCAAACAATCTCACGACGATTTGTTAGGAGGCGGTTGCTTGCCTTACGCAGCCGAAGCGCATTCGAAACAACCTTGGCTAAATAGCTTTTTATATCAATGGCGAGCTGCGTCCACGAATCGAAACCGGGCGATGCCCCACATAAAGTCCTACACCCGGGTGTCGAAGGACGGCAGGAAGGCAGCGTACTACCTGCTCACGTCGGGGAACGTCAGCAAGGCGGCCTGGGGCTCGACGAACAAAGGAAACGGAGCGCTCAGGATAATGAGTTACGAAGCCGGCGTGCTGTTCCTGCCAAAGTTCATTACCAACGAAGATTACTTCTGTCTAGAACAAAACGCCCCGAACCGGCTTATCGTGCCATACGACTTACCGCCAGTCAAATATACGGATGGCATGTCGCCCTGGGTCTCTGATTACCTCATGTGA

Protein

MNPSLKRRGTMQENETKRVKKVCDYGEKCYRMNPVHFREFSHPHLESILDNHASGGDYPIPDKYNLQKKLITEQLDLIIEKGFYAPRNNVQNNPKQIENKQERDSDRRVGKNVEPEASSASHQKVPDKPENTKTMFSNNEAKIKTPVDRGGVVKEKSTNSDYRPIIPPTRRVEDYLNVVRPKGRMAAKHEASAPFYIFYTTITAAKETHSQPFSITFQEILDRSLGELKCSLQINFMVELGWLLAQYYFAGYSEKKLTILYGEDSQDLRTISQKKPHVDAHLVPMATPFGKHHTKMMILCYEDGSLRVVVSTANLYIDDWENRTQGLWFSPKCPELPPEAMPHDGESPTMFKKSLLRYLNHYHMPYLTYYVERVKRSDFSHINVFLVASAPGSHFDMDWGMTRVGSLLRQHCCIPPEEQLQWPLVAQASSLGSYGKDPKLWLTGDFLHNFTKIKNQSQMLSSPPTLKLIYPSLENVKQSHDDLLGGGCLPYAAEAHSKQPWLNSFLYQWRAASTNRNRAMPHIKSYTRVSKDGRKAAYYLLTSGNVSKAAWGSTNKGNGALRIMSYEAGVLFLPKFITNEDYFCLEQNAPNRLIVPYDLPPVKYTDGMSPWVSDYLM

Description

Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity). Required for normal polarization of epidermal cells, correct subcellular location of the Crb complex to the apical lateral membrane, and for normal neuronal development during embryonic development.

Similarity

Belongs to the MGME1 family.
Belongs to the tyrosyl-DNA phosphodiesterase family.

Keywords

Complete proteome   Cytoplasm   DNA damage   DNA repair   Exonuclease   Hydrolase   Nuclease   Nucleus   Reference proteome   Repeat  

Feature

chain  Probable tyrosyl-DNA phosphodiesterase

Uniprot

H9JRI5   A0A0N0PDC5   A0A212FLB5   S4NP13   A0A2W1BI46   A0A1B0DJS2   + More
Q5TSF5   A0A1Y9GLD9   A0A182G8A8   B4KEU9   A0A182VGJ1   W5JHK8   A0A182S510   A0A182YA38   B4Q941   A0A1Q3EYJ2   A0A1Q3EYJ3   B4MWZ6   A0A182LQ33   A0A182QUU8   A0A3B0KF10   A0A084WI56   B4NXE5   A0A1I8PBS7   B3NAR4   Q9VQM4   A0A182ITF6   B3N203   Q29L30   B4JAN6   A0A182X1U4   A0A0M4EP57   B4LU32   A0A182FV04   A0A1W4V7I2   A0A182TNC9   A0A182JRK8   A0A1I8N345   A0A182P8G8   A0A336LXP3   A0A0L0CE48   A0A1B0A4S1   A0A182VTC3   A0A1A9W6E8   A0A1J1J5J5   A0A1B6IMP2   A0A0A1XHB1   A0A2M4APZ2   A0A2M4APT8   A0A2M4APZ9   A0A182SYC7   A0A0K8VE29   A0A1B6ES60   A0A1A9YKG6   A0A034WEA8   Q16PH5   Q16EJ4   A0A1B0FC16   A0A146MFD4   A0A0A9XGY5   A0A182MYE1   B0WGW2   A0A0K8SQK4   A0A2J7PZ96   A0A1I8N346   A0A067R8H0   A0A1B0BPX4   A0A1A9USD2   W8BSM7   A0A1B6HXL7   E9J172   F4W9G0   A0A023F0N4   A0A154NXS3   A0A146MAD7   E1ZZ54   A0A2M4ASB2   A0A0V0GAW7   A0A1Y9GKN2   A0A158N984   A0A026W3D2   T1H9D3   B4I2W4   A0A1S4HEZ1   A0A0L7RKH2   A0A088AUJ5   A0A0P5FIR5   A0A158N982   A0A0M8ZWA3   A0A0P6ACI7   A0A195C978   A0A2A3ESN6   E2B964   A0A1W4XJL3  

EC Number

3.1.-.-
3.1.4.-

Pubmed

19121390    26354079    22118469    23622113    28756777    12364791    + More
26483478    17994087    20920257    23761445    25244985    22936249    20966253    24438588    17550304    10940635    10731132    12537572    12537569    15556867    15632085    25315136    26108605    25830018    25348373    17510324    26823975    25401762    24845553    24495485    21282665    21719571    25474469    20798317    21347285    24508170    30249741   

EMBL

BABH01031850    BABH01031851    BABH01031852    BABH01031853    BABH01031854    KQ460396    + More
KPJ15335.1    AGBW02007808    OWR54526.1    GAIX01012039    JAA80521.1    KZ150076    PZC73951.1    AJVK01001043    AAAB01008933    EAL40355.3    APCN01005565    JXUM01151776    KQ571296    KXJ68209.1    CH933807    EDW12999.1    ADMH02001479    ETN62390.1    CM000361    CM002910    EDX03580.1    KMY87828.1    GFDL01014674    JAV20371.1    GFDL01014671    JAV20374.1    CH963857    EDW76635.1    AXCN02001048    OUUW01000006    SPP82198.1    ATLV01023914    KE525347    KFB49900.1    CM000157    EDW87502.1    CH954177    EDV57587.1    AJ277122    AE014134    AY051884    AY060810    CH902667    EDV30613.1    CH379061    EAL32995.1    CH916368    EDW03844.1    CP012523    ALC38575.1    CH940649    EDW65085.1    UFQT01000279    SSX22705.1    JRES01000507    KNC30525.1    CVRI01000070    CRL07226.1    GECU01019521    JAS88185.1    GBXI01004002    JAD10290.1    GGFK01009544    MBW42865.1    GGFK01009485    MBW42806.1    GGFK01009545    MBW42866.1    GDHF01015186    JAI37128.1    GECZ01029008    JAS40761.1    GAKP01005928    JAC53024.1    CH477781    EAT36273.1    CH478692    EAT32652.1    CCAG010017571    GDHC01001319    JAQ17310.1    GBHO01025551    JAG18053.1    DS231930    EDS27256.1    GBRD01010415    JAG55409.1    NEVH01020337    PNF21657.1    KK852631    KDR19846.1    JXJN01018248    JXJN01023093    GAMC01010272    GAMC01010269    GAMC01010266    JAB96286.1    GECU01028321    JAS79385.1    GL767586    EFZ13407.1    GL888030    EGI69135.1    GBBI01003660    JAC15052.1    KQ434778    KZC04352.1    GDHC01001916    JAQ16713.1    GL435311    EFN73469.1    GGFK01010301    MBW43622.1    GECL01001062    JAP05062.1    ADTU01008925    KK107453    QOIP01000004    EZA50582.1    RLU23592.1    ACPB03026116    ACPB03026117    CH480820    EDW54109.1    KQ414572    KOC71313.1    GDIP01147644    LRGB01003123    JAJ75758.1    KZS04356.1    ADTU01008920    KQ435850    KOX70913.1    GDIP01031548    JAM72167.1    KQ978068    KYM97377.1    KZ288192    PBC34292.1    GL446459    EFN87770.1   

Proteomes

UP000005204    UP000053240    UP000007151    UP000092462    UP000007062    UP000075840    + More
UP000069940    UP000249989    UP000009192    UP000075903    UP000000673    UP000075900    UP000076408    UP000000304    UP000007798    UP000075882    UP000075886    UP000268350    UP000030765    UP000002282    UP000095300    UP000008711    UP000000803    UP000075880    UP000007801    UP000001819    UP000001070    UP000076407    UP000092553    UP000008792    UP000069272    UP000192221    UP000075902    UP000075881    UP000095301    UP000075885    UP000037069    UP000092445    UP000075920    UP000091820    UP000183832    UP000075901    UP000092443    UP000008820    UP000092444    UP000075884    UP000002320    UP000235965    UP000027135    UP000092460    UP000078200    UP000007755    UP000076502    UP000000311    UP000005205    UP000053097    UP000279307    UP000015103    UP000001292    UP000053825    UP000005203    UP000076858    UP000053105    UP000078542    UP000242457    UP000008237    UP000192223   

PRIDE

H9JRI5    Q9VQM4   

Pfam

PF10191   COG7        + More
PF10283   zf-CCHH
PF06087   Tyr-DNA_phospho
PF12705   PDDEXK_1
PF02931   Neur_chan_LBD
PF12248   Methyltransf_FA

Interpro

IPR010347   Tdp1        + More
IPR019406   APLF_PBZ       
IPR019335   COG7       
IPR027415   TDP_C       
IPR026970   MGME1       
IPR038726   PDDEXK_AddAB-type       
IPR022041   Methyltransf_FA       
IPR006202   Neur_chan_lig-bd       
IPR036734   Neur_chan_lig-bd_sf       

SUPFAM

SSF63712   SSF63712       

Gene 3D

3.30.870.20     2.70.170.10    

ProteinModelPortal

H9JRI5   A0A0N0PDC5   A0A212FLB5   S4NP13   A0A2W1BI46   A0A1B0DJS2   + More
Q5TSF5   A0A1Y9GLD9   A0A182G8A8   B4KEU9   A0A182VGJ1   W5JHK8   A0A182S510   A0A182YA38   B4Q941   A0A1Q3EYJ2   A0A1Q3EYJ3   B4MWZ6   A0A182LQ33   A0A182QUU8   A0A3B0KF10   A0A084WI56   B4NXE5   A0A1I8PBS7   B3NAR4   Q9VQM4   A0A182ITF6   B3N203   Q29L30   B4JAN6   A0A182X1U4   A0A0M4EP57   B4LU32   A0A182FV04   A0A1W4V7I2   A0A182TNC9   A0A182JRK8   A0A1I8N345   A0A182P8G8   A0A336LXP3   A0A0L0CE48   A0A1B0A4S1   A0A182VTC3   A0A1A9W6E8   A0A1J1J5J5   A0A1B6IMP2   A0A0A1XHB1   A0A2M4APZ2   A0A2M4APT8   A0A2M4APZ9   A0A182SYC7   A0A0K8VE29   A0A1B6ES60   A0A1A9YKG6   A0A034WEA8   Q16PH5   Q16EJ4   A0A1B0FC16   A0A146MFD4   A0A0A9XGY5   A0A182MYE1   B0WGW2   A0A0K8SQK4   A0A2J7PZ96   A0A1I8N346   A0A067R8H0   A0A1B0BPX4   A0A1A9USD2   W8BSM7   A0A1B6HXL7   E9J172   F4W9G0   A0A023F0N4   A0A154NXS3   A0A146MAD7   E1ZZ54   A0A2M4ASB2   A0A0V0GAW7   A0A1Y9GKN2   A0A158N984   A0A026W3D2   T1H9D3   B4I2W4   A0A1S4HEZ1   A0A0L7RKH2   A0A088AUJ5   A0A0P5FIR5   A0A158N982   A0A0M8ZWA3   A0A0P6ACI7   A0A195C978   A0A2A3ESN6   E2B964   A0A1W4XJL3  

PDB

5NWA     E-value=3.62306e-74,     Score=710

KEGG

101737342    K10862 tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-] | (RefSeq) probable tyrosyl-DNA phosphodiesteras

GO

GO:0017119   GO:0006886   GO:0006281   GO:0008081   GO:0005634   GO:0000012   GO:0003697   GO:0017005   GO:0006302   GO:0003690   GO:0007417   GO:0045197   GO:0043504   GO:0008297   GO:0005739   GO:0005737   GO:0004527   GO:0016021   GO:0005230   GO:0008270   GO:0016701   GO:0006355   GO:0003824   GO:0008152   GO:0016491   GO:0015930  

PANTHER

PTHR12415  

Subcellular location

Mitochondrion  
Nucleus  
Cytoplasm  

Length:

617

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0610900000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00387

outside

1  -  617

 

 

Pi

203.074771

Theta

180.04293

Tajima's D

0.733226

CLR

0.174142

CSRT

0.588220588970552

Interpretation

Uncertain