Gene

KWMTBOMO14811

Pre Gene Modal

BGIBMGA012140

Annotation

PREDICTED:_syndetin_[Amyelois_transitella]

Location

Bomo_Chr24(+):15618840-15625808      View in EpiBrowser

Full name

Syndetin      

Alternative Name

Coiled-coil domain-containing protein 132
EARP/GARPII complex subunit VPS50

Location in the cell

Nuclear   Reliability : 3.021

CDS

ATGCTGTCCAATGATGTTGTCGAAAACCGCCGTGGTCCTCCCGGAGTCAACTCGAGGTCGCTCAGCTCTGCTCATTCTGCTGCTGATCTTGAGATCCTACGCGAAATCGAGAATGTTTATTTCTCGTCGCCGGTCGACTTCGACGCGGCTCGGTACGTGCTGGAGCACGCGCCCGCACCCCCGACCTGCGAGTCCATCGAGCATATGTTCACGAAGCTCAAGAGGCAGCAACAGGTGGTCTCTGGAAAAGCCCTCCATTTGATATCGCAACAGCGCGACAATTGCGACAAGGAATTTGCCGAGATCCAAAACATAAGGACCCAGCTCTCCTTAACGCTGCAAACGTGCAGGAAAGCTAGGGAACACTTGCGGACCGCATCGAACCACCTGACCATGTCGACTTTCGTCATATTAGCCAACTTTAGGAAACGTCAGATCATCAGATCGGTCCTGAAGTGCTTAGAACTGATCCGGAGTTTGAGGAGCGTCGAGAGTGACGTCACGGAGCTATTAAACAAAAAGGACTTTTACAGCGCCATCGAGCTAATCCTGAAGTCAAGGAAGGCAGCGGCCGCACACAAGGAGTACGCTTGCATAACGGACTTGTCCAATAGACTCCAAGACACGCTGGTTTTGACCGAGGAGAAACTGGATTCGGTCCTGTCTAGTTTGTGTTTCAAATTCGATAAGGACGTCTTCACGAAGCTGAGGAAAGCGTATGGCTTGCTGGGGAAGACGCAGGCCGCGATGGAGCAACTCCACATGCACTACTCGTCGGCGGTGAACGAGTCCTCGGTGGCCGCCTTGAAAAAGTACACCGGGGAAGCGTCTATAGACACAAAGTTCCAGAATTTGTGTGCTTCGGTACCGTCGGGCAAAGCGCCCGCTTGCGTCCTAGATCTGTGCGAGAATCTCTTTTATATAATGCGTAGTTATTATCTATTGGTCGATTGGCATTCGAAACACGACGAAGAGCCCGCCTGCACGAATGTTTTCGATATACAAAAGAACGTAAGCCGGGAGTACATAAGGCAGAAGTTGAAGGCCGGTCTGCTCAGGATATGGCACGACGTTCAAGGCAAAGTCTCTATATTCTTGAAGAGTTCAGGCCTAGAAGACTATCCGTTCGAGAAATTCGTACAAATATTAGGTGTGCTAAGGAAACTGACGCAGATAGGCGAAGTTTTCTGCGGCGATAAATCGGACGTGCTAGAGGACTTTATAAAGACCCAAAGCGTGGTTTACATACAGAACTATCATAGAGGCAGGCTGGAGGAATTGAAGTTGTTCCTCGAGAACGAAGCCTGGGAACAGTGCCCGGTCAAATCGACGTTCAATCTGCTGAATCTCCAAGAGTTCAAACAGTTCAAGAAGTACCTGAACAGATCTGATGGTGTGGTGACGAAAAATCAATCGGAGAACGCGTCCTCTGTCACATCGCAAGACGACAGCGTTTACGTAACGAAATATTTCAAATACGATACCTCTTCGAGTCCGTTCGATATGTTCCGAAACGAGAACACGACCAACGATGATATCTTCGGTCTGGAACCGGATATGCCGAGCGACGATTCCGAAGACGAACCGGACGAGCTGAAGCGCGACTTCGTCGAAGAGAACGACAGGCACGGATACGCCACGACGGGGAACAACGAAGCATTAAGTCCATCGAAAGTGAGGCACAGCGTTATCGTTGCCAACACGACGCTGTCCGTGTTGAGGAACTGCGGCCAGTACCTGCAGATATGCAGGTACCTGCCTCAAACTGCACTAGAAGTCGTGGTACTGATGAATCAATTGTACGACTATTATTTCTATACGGTCCATACGTTCTTCACTTCCGATCTGGACGTTAGCTCGACGACTTTGTACACGACGAAGCTGACGGCCCTTTTGAAGCGAATCACGAACAGCCTCGAGAATGGTGGAAGCGAAAACCGACATTTTGCAGGCCCAGAACAGCCTCACCACTTGGACTTGAGTAGCGAATCGAACCTTCACGGCTTGTCCGAACGAATCGTCGCCGTCGAAAGCGTTATTTTCTTAGCCAAACAATACGAAATGCTCCAACCGTATCTGGAAACTATGGTCGCGCCACACCAGCGTCTGATACTGGAGCACTTCCGCGATAACACCTTAGCCGTTGTCGCGGATCTGAGGACTCCGGTGTACATGTGCTCCGCTTCGAAGTCGGTCGACGCGAGGACCGCTTTGGTCGCGATGTCGCAAGTCAAATGGGACGTGAAGAACGTAGCCGTCGAGCACAGCCCGTACGTGGACATGGTCGTGAGGAAGCTGCAAGTGTACGCGTTGAGGATCGAGAATATATCAAACAGGGTGACGTTGAATCGCGAAGTTCTGAACTCCATATGGACCGTTGTCTCGAAATACGTGATACACTTACTAGTTGAGGGCTTCTCGAACGCGACCAAGTGCTCGAATGGGGGTAGAGGCCTGATGCAACTGGACTACACGCAGCTGCTGCTGAAATTGGAGAAGATATCCGGCCTGAAGCCGGTTCCGCATCAGGACTACGTTGACCGGTACGTAAAAGCGTACTATCTGCCGCGGAAGGGTCTCGAGGAGTTCGTCGTGGAGCACCCGGAGTATTCGACGAAGCATTTGGTCGCTCTAGTGTCCTGTGCCTGCGAAAACAAGAAGGACAGGCAGGCCCTGATCAGTCTGATCGAAGAGAAGGAGATACCGAATTGA

Protein

MLSNDVVENRRGPPGVNSRSLSSAHSAADLEILREIENVYFSSPVDFDAARYVLEHAPAPPTCESIEHMFTKLKRQQQVVSGKALHLISQQRDNCDKEFAEIQNIRTQLSLTLQTCRKAREHLRTASNHLTMSTFVILANFRKRQIIRSVLKCLELIRSLRSVESDVTELLNKKDFYSAIELILKSRKAAAAHKEYACITDLSNRLQDTLVLTEEKLDSVLSSLCFKFDKDVFTKLRKAYGLLGKTQAAMEQLHMHYSSAVNESSVAALKKYTGEASIDTKFQNLCASVPSGKAPACVLDLCENLFYIMRSYYLLVDWHSKHDEEPACTNVFDIQKNVSREYIRQKLKAGLLRIWHDVQGKVSIFLKSSGLEDYPFEKFVQILGVLRKLTQIGEVFCGDKSDVLEDFIKTQSVVYIQNYHRGRLEELKLFLENEAWEQCPVKSTFNLLNLQEFKQFKKYLNRSDGVVTKNQSENASSVTSQDDSVYVTKYFKYDTSSSPFDMFRNENTTNDDIFGLEPDMPSDDSEDEPDELKRDFVEENDRHGYATTGNNEALSPSKVRHSVIVANTTLSVLRNCGQYLQICRYLPQTALEVVVLMNQLYDYYFYTVHTFFTSDLDVSSTTLYTTKLTALLKRITNSLENGGSENRHFAGPEQPHHLDLSSESNLHGLSERIVAVESVIFLAKQYEMLQPYLETMVAPHQRLILEHFRDNTLAVVADLRTPVYMCSASKSVDARTALVAMSQVKWDVKNVAVEHSPYVDMVVRKLQVYALRIENISNRVTLNREVLNSIWTVVSKYVIHLLVEGFSNATKCSNGGRGLMQLDYTQLLLKLEKISGLKPVPHQDYVDRYVKAYYLPRKGLEEFVVEHPEYSTKHLVALVSCACENKKDRQALISLIEEKEIPN

Description

Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).

Subunit

Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (PubMed:25799061, PubMed:27440922). The EARP complex interacts with EIPR1 (PubMed:27440922).

Miscellaneous

Was named 'syndetin' after the Greek 'syndeo', which means 'connect' or 'tether'.

Similarity

Belongs to the syndetin family.

Keywords

Acetylation   Alternative splicing   Coiled coil   Complete proteome   Endosome   Isopeptide bond   Phosphoprotein   Protein transport   Reference proteome   Transport   Ubl conjugation  

Feature

chain  Syndetin
splice variant  In isoform 3.

Uniprot

H9JRI0   A0A3S2L5R4   A0A2A4KAQ4   A0A2W1BFB9   A0A0N0PD30   A0A2H1W8T3   + More
A0A0L7L2M5   A0A212FH68   A0A1W4WSK3   A0A2J7RFF2   A0A2A3EN90   A0A088A110   A0A0L7QUM6   A0A195ES34   A0A067QEM3   A0A151HYE1   F4X4R7   E9J4R6   A0A1B6C6F1   E2C8J2   A0A1B6JPM5   A0A026X1R5   E2AX36   U4USG7   A0A1Y1JZ83   A0A151IEF2   A0A0M9A7X8   A0A151WX31   A0A139WGA3   A0A0C9RNW1   A0A158NJ95   A0A3L8D3L2   E0VNM1   A0A1U7S5G2   A0A3B4BQM4   Q96JG6   A0A151MQ48   A0A023F035   A7MD03   Q96JG6-3   A0A0K8RWW1   A0A0C9Q2V8   F1R0A4   U3K730   A0A0A9XFR7   A0A210PIR4   G1KN98   A0A1L8FVT7   A0A3B1INV0   A0A3B4BM92   A0A3B1JFY8   V9KB61   A0A3B5PYQ1   A0A3P9N3I1   A0A3B3TJ55   A0A2D0PW65   A0A3P8TNA3   A0A146Z5U1   A0A3Q2QM11   A0A2I4CWE3   A0A3B1ISN4   A0A3P8TIB4   A0A286XAL2   A0A3Q1BCJ7   A0A3Q2ZFB4   A0A3Q3LUN5   A0A2P8XE36   A0A3B5Q050   A0A3Q2VXG7   A0A3Q2E8K8   A0A3Q1IWK5   A0A3P9N3D2   A0A3B4TSJ3   A0A3B4GR12   A0A1W4Y6U2   A0A3P8QZQ4   A0A3P9BLU7   K1QUS8   A0A3B3Y4B3   A0A3B3V2P3   I3JXL5   A0A3Q3K625   A0A3Q3GDV7   A0A146Z5K6   A0A0K8SN32   A0A3Q3KGB9   A0A3Q1EX54   A0A2I4CWH8   A0A2S2PLS1   A0A147B3R6   A0A3Q3GLD3   A0A3P8TFL2   A0A3Q2QM00   A0A3Q3LL46   A0A3Q1BAC1   A0A3Q2ZCD9   H2UPA6   A0A0S7KWQ7   A0A2D4F060  

Pubmed

19121390    28756777    26354079    26227816    22118469    24845553    + More
21719571    21282665    20798317    24508170    23537049    28004739    18362917    19820115    21347285    30249741    20566863    11347906    21472204    14702039    12853948    15489334    16964243    18691976    18669648    19413330    19690332    20068231    21269460    21406692    22814378    23186163    24275569    25218447    25114211    25799061    27440922    28112733    22293439    25474469    25727380    23594743    25401762    26823975    28812685    27762356    25329095    24402279    23542700    21993624    29403074    25186727    22992520    21551351   

EMBL

BABH01031884    BABH01031885    RSAL01000132    RVE46358.1    NWSH01000015    PCG80820.1    + More
KZ150242    PZC71897.1    KQ460396    KPJ15354.1    ODYU01007039    SOQ49433.1    JTDY01003416    KOB69591.1    AGBW02008539    OWR53067.1    NEVH01004413    PNF39556.1    KZ288215    PBC32609.1    KQ414735    KOC62274.1    KQ981993    KYN31065.1    KK853768    KDQ84117.1    KQ976730    KYM76464.1    GL888679    EGI58490.1    GL768112    EFZ12194.1    GEDC01028226    JAS09072.1    GL453666    EFN75722.1    GECU01006621    JAT01086.1    KK107061    EZA61334.1    GL443520    EFN61986.1    KB632344    ERL93045.1    GEZM01099035    JAV53548.1    KQ977894    KYM98947.1    KQ435716    KOX79057.1    KQ982669    KYQ52462.1    KQ971348    KYB26885.1    GBYB01010130    JAG79897.1    ADTU01017231    ADTU01017232    ADTU01017233    QOIP01000014    RLU14980.1    DS235340    EEB14977.1    AB058764    AB100163    AK027234    AK126478    AC002379    AC002453    CH236949    CH471091    BC108708    BC017888    BC132740    BC132742    AKHW03005461    KYO26666.1    GBBI01003859    JAC14853.1    BC152424    AAI52425.1    GBKC01000634    JAG45436.1    GBYB01008373    JAG78140.1    BX936336    CABZ01060507    CABZ01060508    CABZ01060509    CABZ01060510    CABZ01060511    CABZ01060512    CABZ01060513    CABZ01060514    CABZ01060515    AGTO01020338    GBHO01026001    GDHC01019479    JAG17603.1    JAP99149.1    NEDP02076632    OWF36363.1    CM004476    OCT75681.1    JW862452    AFO94969.1    GCES01024714    JAR61609.1    AAKN02016826    AAKN02016827    AAKN02016828    PYGN01002564    PSN30261.1    JH817539    EKC35019.1    AERX01044510    AERX01044511    AERX01044512    AERX01044513    AERX01044514    AERX01044515    GCES01024712    JAR61611.1    GBRD01011599    JAG54225.1    GGMR01017782    MBY30401.1    GCES01000894    JAR85429.1    GBYX01194305    GBYX01194297    JAO81727.1    IACJ01045605    LAA40877.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053240    UP000037510    UP000007151    + More
UP000192223    UP000235965    UP000242457    UP000005203    UP000053825    UP000078541    UP000027135    UP000078540    UP000007755    UP000008237    UP000053097    UP000000311    UP000030742    UP000078542    UP000053105    UP000075809    UP000007266    UP000005205    UP000279307    UP000009046    UP000189705    UP000261440    UP000005640    UP000050525    UP000000437    UP000016665    UP000242188    UP000001646    UP000186698    UP000018467    UP000002852    UP000242638    UP000261500    UP000221080    UP000265080    UP000265000    UP000192220    UP000005447    UP000257160    UP000264800    UP000261640    UP000245037    UP000264840    UP000265020    UP000265040    UP000261420    UP000261460    UP000192224    UP000265100    UP000265160    UP000005408    UP000261480    UP000005207    UP000261600    UP000261660    UP000257200    UP000005226   

PRIDE

H9JRI0    Q96JG6    A7MD03   

Pfam

PF10474   DUF2451        + More
PF10475   Vps54_N
PF00373   FERM_M
PF09380   FERM_C
PF09379   FERM_N

Interpro

IPR019515   VPS54_N        + More
IPR019514   Syndetin_C       
IPR040047   VPS50       
IPR018980   FERM_PH-like_C       
IPR000299   FERM_domain       
IPR029071   Ubiquitin-like_domsf       
IPR018979   FERM_N       
IPR019748   FERM_central       
IPR011993   PH-like_dom_sf       
IPR035963   FERM_2       
IPR014352   FERM/acyl-CoA-bd_prot_sf       
IPR019749   Band_41_domain       
IPR002475   Bcl2-like       

SUPFAM

SSF47031   SSF47031        + More
SSF54236   SSF54236       

Gene 3D

1.20.80.10     2.30.29.30    

CDD

cd14473  FERM_B-lobe

ProteinModelPortal

H9JRI0   A0A3S2L5R4   A0A2A4KAQ4   A0A2W1BFB9   A0A0N0PD30   A0A2H1W8T3   + More
A0A0L7L2M5   A0A212FH68   A0A1W4WSK3   A0A2J7RFF2   A0A2A3EN90   A0A088A110   A0A0L7QUM6   A0A195ES34   A0A067QEM3   A0A151HYE1   F4X4R7   E9J4R6   A0A1B6C6F1   E2C8J2   A0A1B6JPM5   A0A026X1R5   E2AX36   U4USG7   A0A1Y1JZ83   A0A151IEF2   A0A0M9A7X8   A0A151WX31   A0A139WGA3   A0A0C9RNW1   A0A158NJ95   A0A3L8D3L2   E0VNM1   A0A1U7S5G2   A0A3B4BQM4   Q96JG6   A0A151MQ48   A0A023F035   A7MD03   Q96JG6-3   A0A0K8RWW1   A0A0C9Q2V8   F1R0A4   U3K730   A0A0A9XFR7   A0A210PIR4   G1KN98   A0A1L8FVT7   A0A3B1INV0   A0A3B4BM92   A0A3B1JFY8   V9KB61   A0A3B5PYQ1   A0A3P9N3I1   A0A3B3TJ55   A0A2D0PW65   A0A3P8TNA3   A0A146Z5U1   A0A3Q2QM11   A0A2I4CWE3   A0A3B1ISN4   A0A3P8TIB4   A0A286XAL2   A0A3Q1BCJ7   A0A3Q2ZFB4   A0A3Q3LUN5   A0A2P8XE36   A0A3B5Q050   A0A3Q2VXG7   A0A3Q2E8K8   A0A3Q1IWK5   A0A3P9N3D2   A0A3B4TSJ3   A0A3B4GR12   A0A1W4Y6U2   A0A3P8QZQ4   A0A3P9BLU7   K1QUS8   A0A3B3Y4B3   A0A3B3V2P3   I3JXL5   A0A3Q3K625   A0A3Q3GDV7   A0A146Z5K6   A0A0K8SN32   A0A3Q3KGB9   A0A3Q1EX54   A0A2I4CWH8   A0A2S2PLS1   A0A147B3R6   A0A3Q3GLD3   A0A3P8TFL2   A0A3Q2QM00   A0A3Q3LL46   A0A3Q1BAC1   A0A3Q2ZCD9   H2UPA6   A0A0S7KWQ7   A0A2D4F060  

KEGG

101738657    K23288 syndetin | (RefSeq) coiled-coil domain-containing protein 132

GO

GO:0032456   GO:0042147   GO:0005829   GO:1990745   GO:0005856   GO:0015031   GO:0055037   GO:0070062   GO:0016020   GO:0000149   GO:0016021  

PANTHER

PTHR13258  

Subcellular location

Recycling endosome  

Length:

903

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.04641

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00218

outside

1  -  903

 

 

Pi

210.64978

Theta

153.419781

Tajima's D

1.118114

CLR

0.208188

CSRT

0.693265336733163

Interpretation

Uncertain