Gene

KWMTBOMO14759  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA003817

Annotation

UDP-glycosyltransferase_UGT41A2_precursor_[Bombyx_mori]

Location

Bomo_Chr24(-):14502337-14539326      View in EpiBrowser

Full name

UDP-glucuronosyltransferase      

Location in the cell

PlasmaMembrane   Reliability : 4.241

CDS

ATGAGGTGTCTCCAGTTGCTGCTCTTCTTGGTGTGTGTTGTGACGTCAGCGCGCGCGTACCACGTGCTCTGCGTGTTCCCGATACCTTCACGCAGCCACAACTCCCTCGGCAAAGGGATAGTCGACGCCTTGCTTGGAGCTGGCCACGAGGTAACATGGGCGACTCCGTTCCCTCCTAAAGAATCGACTAAAGGCCTGAAAATAATCGATGTTAGCGCCACAGCTTCTGTAAGTGAAATGATTGACATGAACGACCAAAGAAACGCTGATGCTGGTATCGCGTTGATCAGGACCTTCGCTGCCAATATCACGAGGCTGTCCCTCTCGGTACCAGCGCTGCAGCAGGCGATCGTCAGCGGGAAATACGACGCGGTCGTCACGGAGTCCTTCTTCAACGATGCCGAGGCGGGCTACGGGGCAGTACTTCAAGTGCCCTGGATCCTGTTGTCCAGCGTCTCCATAATGCCCCACTTGGAAGCCATCATCGATGAGGTGCGGTCGATTACCACCATACCGCTGCTGTTCAACAACGCCCCAACCCCCATGGGCTTCTGGGACAGGCTGACAAATATCTTCATCTACAGCGCCATGACGATATCTAATTGGCTAGAGCGCCCAAACACGGTGGCATTCTACGAATCCCTGTTCGCGCCGCTGGCCGCCGCCCGGGGGATCGCGCTGCCCCCCTTCGAGGAAGCCCTGTACAACGTATCGGTGCTACTTGTGAACTCCCACCCGGCGTTCGCTCCGCCCATGAGCTTGCCCCCGAACGTTGTCGAGATCGGGGGCTACCACATCAACCCAGAAACACCCCCCTTGCCGAAGGACCTGCAGCACATCCTGGACTCGTCGCCACAGGGCGTGGTGTACTTCAGCATGGGCTCAGTGCTCAAGTCGTCCAGACTGTCCGAACGAACTAGACGAGAGATATTGGAAGTGTTCGGGTCATTGTCGCAGACGGTGCTGTGGAAATTCGAGGAGGAGCTCAAGGATCTACCGAAGAACGTTATCGTTCGACCATGGATGCCACAGTCCAGCATCTTGGCTCATCCGAACGTGAAGGTCTTCATCACGCACGGCGGCTTGCTCAGCACCCTCGAGACCTTGCATTACGGGGTACCGATCCTCGCTGTGCCGGTGTTCGGGGACCAGCCCTCGAACGCCGACAGGGCTGTCCGTCACGGATTTGCGAAAAGCATACAGTACAAGCCTGATATGGCTAATGACATGAAGGTGGCTCTCAATGAAATGCTGAGCAATGATAGTTACTACACGCGTGCGAGATATCTGTCGAAGATCTTCGGCGATAAGTTGGTGCCGCCGGCCAAGCTGATATCGCATTACGTGAAGGTCGCCATCGAAACTAATGGAGCCTACCATCTGCGCTCTAAGAGCCTGCTCTATCCGTGGTACCAGCGTTGGCTCGTGGACATCATAGCGGCGCTGTTGCTGGCGTGCCTCGCGGTGTACGTAGCGGCCAGGAGGGTCTTGTGTTACCTCTGGAGCTCCGTGAACGGCGGTGACTGTAACAGGATTAAAGTCAAGAAAAACTAA

Protein

MRCLQLLLFLVCVVTSARAYHVLCVFPIPSRSHNSLGKGIVDALLGAGHEVTWATPFPPKESTKGLKIIDVSATASVSEMIDMNDQRNADAGIALIRTFAANITRLSLSVPALQQAIVSGKYDAVVTESFFNDAEAGYGAVLQVPWILLSSVSIMPHLEAIIDEVRSITTIPLLFNNAPTPMGFWDRLTNIFIYSAMTISNWLERPNTVAFYESLFAPLAAARGIALPPFEEALYNVSVLLVNSHPAFAPPMSLPPNVVEIGGYHINPETPPLPKDLQHILDSSPQGVVYFSMGSVLKSSRLSERTRREILEVFGSLSQTVLWKFEEELKDLPKNVIVRPWMPQSSILAHPNVKVFITHGGLLSTLETLHYGVPILAVPVFGDQPSNADRAVRHGFAKSIQYKPDMANDMKVALNEMLSNDSYYTRARYLSKIFGDKLVPPAKLISHYVKVAIETNGAYHLRSKSLLYPWYQRWLVDIIAALLLACLAVYVAARRVLCYLWSSVNGGDCNRIKVKKN

Catalytic Activity

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP

Similarity

Belongs to the UDP-glycosyltransferase family.

Feature

chain  UDP-glucuronosyltransferase

Uniprot

G9LPV3   G9LPV4   G9LPV2   H9J2T0   H9J2U8   H9IVQ7   + More
G9LPR1   A0A2W1BAL9   A0A024AGL8   A0A2A4JV21   A0A2W1BD64   A0A2A4JD43   A0A140EA38   G9LPQ8   A0A0N0PBY8   A0A1L8D6F2   A0A2H1VNG6   A0A286MXP3   G9LPR0   A0A2W1BBU4   A0A140EA39   A0A2H4WB50   A0A212EW66   A0A2A4JVG7   A0A2A4JUA9   G9LPQ9   A0A2W1BEH1   A0A2H4WB58   A0A2A4J6T0   A0A191T1M8   A0A2H4WB67   A0A140EA37   G9LPQ6   A0A191T2G6   A0A191T1M6   A0A194Q0G5   A0A2H1VVH6   A0A024AGG4   A0A2H4WB53   D6RUU7   A0A2A4J0B4   G9LPQ4   A0A3S2NJP8   A0A2H1WNF9   A0A194RDA8   G9LPU4   A0A024AH17   A0A212FKT5   G9LPQ3   A0A191T2J8   G9LPU6   A0A2W1BQJ5   A0A2W1BQJ6   A0A2H1V1W5   G9LPU3   G9LPQ0   A0A1L8D6E4   A0A1L8D6H0   A0A191T2K2   Q8WPG4   A0A2A4K2B6   A0A2H4WB78   A0A2W1BXG7   A0A2W1BQS6   A0A194RKU4   A0A3S2LD93   G9LPU0   G9LPQ7   D6RUU6   A0A2A4J419   G9LPU8   A0A2A4J325   D6RUV0   G9LPU7   A0A024AHN0   A0A194RKA9   A0A024AG04   A0A194R8C7   A0A3S2LTQ3   A0A0N1IN21   I4DN89   A0A2W1BVZ0   G9LPQ5   A0A1L8D6R9   A0A191T2K0   A0A2W1BX32   A0A212FD09   A0A140EA36   A0A194Q5Q0   G9LPQ1   A0A191T1P1   H9JL88   D6RUV1   A0A2A4K0I8   A0A2H1X1Y8   D6RUV2  

EC Number

2.4.1.17

Pubmed

22155036    19121390    28756777    24698447    26873292    26354079    + More
19954531    25299618    29027758    22118469    20534444    11846783    22651552   

EMBL

JQ070260    AEW43176.1    JQ070261    AEW43177.1    JQ070259    AEW43175.1    + More
BABH01036935    BABH01036936    BABH01036937    BABH01036929    BABH01036930    BABH01042490    JQ070218    AEW43134.1    KZ150343    PZC71295.1    KF777117    AHY99688.1    NWSH01000566    PCG75616.1    KZ150120    PZC73179.1    NWSH01001859    PCG69891.1    KU214509    AMK97475.1    JQ070215    AEW43131.1    KQ460735    KPJ12633.1    GEYN01000097    JAV02032.1    ODYU01003485    SOQ42346.1    MF684361    ASX93995.1    JQ070217    AEW43133.1    PZC71294.1    KU214510    AMK97476.1    KY202927    AUC64271.1    AGBW02012074    OWR45723.1    PCG75614.1    PCG75617.1    JQ070216    AEW43132.1    PZC71296.1    KY202932    AUC64276.1    NWSH01002698    PCG67661.1    KU680303    ANI22009.1    KY202937    AUC64281.1    KU214508    AMK97474.1    JQ070213    AEW43129.1    KU680295    ANI22001.1    KU680302    ANI22008.1    KQ459582    KPI98793.1    ODYU01004685    SOQ44830.1    KF777115    AHY99686.1    KY202925    AUC64269.1    JQ070252    AB539964    AEW43168.1    BAJ08154.1    NWSH01003979    PCG65597.1    JQ070211    AEW43127.1    RSAL01000067    RVE49308.1    ODYU01009829    SOQ54516.1    KQ460597    KPJ13896.1    JQ070251    AEW43167.1    KF777116    AHY99687.1    AGBW02007992    OWR54346.1    JQ070210    AEW43126.1    KU680294    ANI22000.1    JQ070253    AEW43169.1    KZ149930    PZC77369.1    PZC77372.1    ODYU01000116    SOQ34342.1    JQ070250    AEW43166.1    JQ070207    AEW43123.1    GEYN01000100    JAV02029.1    GEYN01000076    JAV02053.1    KU680304    ANI22010.1    AF324465    AAL55994.1    NWSH01000282    PCG77782.1    KY202946    AUC64290.1    PZC77366.1    PZC77368.1    KQ460075    KPJ17950.1    RSAL01000210    RVE44216.1    JQ070247    AEW43163.1    JQ070214    AEW43130.1    AB539963    BAJ08153.1    NWSH01003535    PCG66153.1    JQ070255    AEW43171.1    NWSH01003818    PCG65793.1    AB539967    BAJ08157.1    JQ070254    AEW43170.1    KF777113    AHY99684.1    KPJ17977.1    KF777114    AHY99685.1    KPJ13897.1    RVE44215.1    KQ459356    KPJ01283.1    AK402777    BAM19379.1    PZC77367.1    JQ070212    AEW43128.1    GEYN01000085    JAV02044.1    KU680299    ANI22005.1    PZC77370.1    AGBW02009118    OWR51610.1    KU214507    AMK97473.1    KPI98725.1    JQ070208    AEW43124.1    KU680301    ANI22007.1    BABH01011785    BABH01011786    BABH01011787    JQ070258    AB539968    AEW43174.1    BAJ08158.1    PCG77781.1    ODYU01012744    SOQ59206.1    JQ070256    AB539969    AEW43172.1    BAJ08159.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000283053    + More

PRIDE

G9LPV3    G9LPV4    G9LPV2    H9J2T0    H9J2U8    H9IVQ7    + More
D6RUU7    G9LPU4    G9LPU6    G9LPU3    Q8WPG4    G9LPU0    D6RUU6    G9LPU8    D6RUV0    G9LPU7    H9JL88    D6RUV1    D6RUV2   

Pfam

PF00201   UDPGT

Interpro

IPR035595   UDP_glycos_trans_CS        + More
IPR002213   UDP_glucos_trans       

ProteinModelPortal

G9LPV3   G9LPV4   G9LPV2   H9J2T0   H9J2U8   H9IVQ7   + More
G9LPR1   A0A2W1BAL9   A0A024AGL8   A0A2A4JV21   A0A2W1BD64   A0A2A4JD43   A0A140EA38   G9LPQ8   A0A0N0PBY8   A0A1L8D6F2   A0A2H1VNG6   A0A286MXP3   G9LPR0   A0A2W1BBU4   A0A140EA39   A0A2H4WB50   A0A212EW66   A0A2A4JVG7   A0A2A4JUA9   G9LPQ9   A0A2W1BEH1   A0A2H4WB58   A0A2A4J6T0   A0A191T1M8   A0A2H4WB67   A0A140EA37   G9LPQ6   A0A191T2G6   A0A191T1M6   A0A194Q0G5   A0A2H1VVH6   A0A024AGG4   A0A2H4WB53   D6RUU7   A0A2A4J0B4   G9LPQ4   A0A3S2NJP8   A0A2H1WNF9   A0A194RDA8   G9LPU4   A0A024AH17   A0A212FKT5   G9LPQ3   A0A191T2J8   G9LPU6   A0A2W1BQJ5   A0A2W1BQJ6   A0A2H1V1W5   G9LPU3   G9LPQ0   A0A1L8D6E4   A0A1L8D6H0   A0A191T2K2   Q8WPG4   A0A2A4K2B6   A0A2H4WB78   A0A2W1BXG7   A0A2W1BQS6   A0A194RKU4   A0A3S2LD93   G9LPU0   G9LPQ7   D6RUU6   A0A2A4J419   G9LPU8   A0A2A4J325   D6RUV0   G9LPU7   A0A024AHN0   A0A194RKA9   A0A024AG04   A0A194R8C7   A0A3S2LTQ3   A0A0N1IN21   I4DN89   A0A2W1BVZ0   G9LPQ5   A0A1L8D6R9   A0A191T2K0   A0A2W1BX32   A0A212FD09   A0A140EA36   A0A194Q5Q0   G9LPQ1   A0A191T1P1   H9JL88   D6RUV1   A0A2A4K0I8   A0A2H1X1Y8   D6RUV2  

PDB

2O6L     E-value=1.24985e-21,     Score=256

KEGG

100862815    K00699 glucuronosyltransferase [EC:2.4.1.17] | (RefSeq) UGT41A2; UDP-glycosyltransferase UGT41A2

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00830    Retinol metabolism - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
00980    Metabolism of xenobiotics by cytochrome P450 - Bombyx mori (domestic silkworm)
00982    Drug metabolism - cytochrome P450 - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0015020   GO:0016758   GO:0016740   GO:0008152   GO:0050482   GO:0009451   GO:0009982   GO:0006355   GO:0003824   GO:0016491   GO:0015930  

Subcellular location

Membrane  

SignalP

Position:   1 - 19,         Likelihood:  0.997812

 

 

Length:

517

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

28.8594

Exp number, first 60 AAs:

7.37507

Total prob of N-in:

0.32570

outside

1  -  469

TMhelix

470  -  492

inside

493  -  517

 

 

Pi

232.005448

Theta

158.117375

Tajima's D

1.169459

CLR

0.403787

CSRT

0.710264486775661

Interpretation

Uncertain